Matrix Elasticity Directs Stem Cell Lineage Specification

[1]  Clive L. Dym,et al.  Introduction to Engineering Mechanics: A Continuum Approach , 2008 .

[2]  Albert J. Keung,et al.  Substrate modulus directs neural stem cell behavior. , 2008, Biophysical journal.

[3]  A. Rowlands,et al.  Directing osteogenic and myogenic differentiation of MSCs: interplay of stiffness and adhesive ligand presentation. , 2008, American journal of physiology. Cell physiology.

[4]  P. Reimann,et al.  Refined procedure of evaluating experimental single-molecule force spectroscopy data. , 2008, Physical review. E, Statistical, nonlinear, and soft matter physics.

[5]  Viola Vogel,et al.  Force-Induced Unfolding of Fibronectin in the Extracellular Matrix of Living Cells , 2007, PLoS biology.

[6]  Shelly R. Peyton,et al.  The regulation of osteogenesis by ECM rigidity in MC3T3‐E1 cells requires MAPK activation , 2007, Journal of cellular physiology.

[7]  Anne E Carpenter,et al.  CellProfiler: image analysis software for identifying and quantifying cell phenotypes , 2006, Genome Biology.

[8]  Adam J. Engler,et al.  Mesenchymal stem cell injection after myocardial infarction improves myocardial compliance , 2006 .

[9]  David F Meaney,et al.  Matrices with compliance comparable to that of brain tissue select neuronal over glial growth in mixed cortical cultures. , 2006, Biophysical journal.

[10]  D. Steindler,et al.  Mesenchymal Stem Cells Spontaneously Express Neural Proteins in Culture and Are Neurogenic after Transplantation , 2006, Stem cells.

[11]  P. Frenette,et al.  Signals from the Sympathetic Nervous System Regulate Hematopoietic Stem Cell Egress from Bone Marrow , 2006, Cell.

[12]  Adam J. Engler,et al.  Supplemental Data Matrix Elasticity Directs Stem Cell Lineage Specification , 2006 .

[13]  S. Wislet-Gendebien,et al.  Astrocytic and neuronal fate of mesenchymal stem cells expressing nestin , 2005, Brain Research Bulletin.

[14]  P. Janmey,et al.  Tissue Cells Feel and Respond to the Stiffness of Their Substrate , 2005, Science.

[15]  S. Cannistraro,et al.  Single molecule recognition between cytochrome C 551 and gold-immobilized azurin by force spectroscopy. , 2005, Biophysical journal.

[16]  A. Chakravarti,et al.  Genomic alterations in cultured human embryonic stem cells , 2005, Nature Genetics.

[17]  Cynthia A. Reinhart-King,et al.  Tensional homeostasis and the malignant phenotype. , 2005, Cancer cell.

[18]  S. Kawamoto,et al.  Disease-associated Mutations and Alternative Splicing Alter the Enzymatic and Motile Activity of Nonmuscle Myosins II-B and II-C* , 2005, Journal of Biological Chemistry.

[19]  C. D. Reyes,et al.  Bio-adhesive Surfaces to Promote Osteoblast Differentiation and Bone Formation , 2005, Journal of dental research.

[20]  Takako Kondo,et al.  Sonic hedgehog and retinoic acid synergistically promote sensory fate specification from bone marrow-derived pluripotent stem cells. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[21]  Eben Alsberg,et al.  FRET measurements of cell-traction forces and nano-scale clustering of adhesion ligands varied by substrate stiffness. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[22]  I. Rayment,et al.  The structural basis of blebbistatin inhibition and specificity for myosin II , 2005, Nature Structural &Molecular Biology.

[23]  Dennis E. Discher,et al.  Adhesion-contractile balance in myocyte differentiation , 2004, Journal of Cell Science.

[24]  Yasuhiro Sawada,et al.  Activation of a signaling cascade by cytoskeleton stretch. , 2004, Developmental cell.

[25]  Joyce Y. Wong,et al.  Surface probe measurements of the elasticity of sectioned tissue, thin gels and polyelectrolyte multilayer films : correlations between substrate stiffness and cell adhesion , 2004 .

[26]  Kenneth M. Yamada,et al.  Defects in Cell Adhesion and the Visceral Endoderm following Ablation of Nonmuscle Myosin Heavy Chain II-A in Mice* , 2004, Journal of Biological Chemistry.

[27]  Adam J. Engler,et al.  Myotubes differentiate optimally on substrates with tissue-like stiffness , 2004, The Journal of cell biology.

[28]  D. Helfman,et al.  Modulation of acto-myosin contractility in skeletal muscle myoblasts uncouples growth arrest from differentiation , 2004, Journal of Cell Science.

[29]  Gianluca Gallo,et al.  Reevaluation of in vitro differentiation protocols for bone marrow stromal cells: Disruption of actin cytoskeleton induces rapid morphological changes and mimics neuronal phenotype , 2004, Journal of neuroscience research.

[30]  S. Hwang,et al.  Skeletal Myogenic Differentiation of Mesenchymal Stem Cells Isolated from Human Umbilical Cord Blood , 2004, Stem cells.

[31]  David A. Williams,et al.  Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts , 2004, Nature.

[32]  Christopher S. Chen,et al.  Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment. , 2004, Developmental cell.

[33]  Jean-Pierre Julien,et al.  Functions of intermediate filaments in neuronal development and disease. , 2004, Journal of neurobiology.

[34]  A. Straight,et al.  Specificity of blebbistatin, an inhibitor of myosin II , 2004, Journal of Muscle Research & Cell Motility.

[35]  Michael Lill,et al.  Stem cell transplantation for myocardial infarction? , 2004, Reviews in cardiovascular medicine.

[36]  Dennis Discher,et al.  Substrate compliance versus ligand density in cell on gel responses. , 2004, Biophysical journal.

[37]  N. Balaban,et al.  Adhesion-dependent cell mechanosensitivity. , 2003, Annual review of cell and developmental biology.

[38]  Radhika Desai,et al.  ROCK-generated contractility regulates breast epithelial cell differentiation in response to the physical properties of a three-dimensional collagen matrix , 2003, The Journal of cell biology.

[39]  M. Noda,et al.  Osteopontin Expression in Osteoblasts and Osteocytes During Bone Formation Under Mechanical Stress in the Calvarial Suture In Vivo , 2003, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[40]  S. Rosenfeld,et al.  Myosin IIB Is Unconventionally Conventional* , 2003, Journal of Biological Chemistry.

[41]  Timothy J Mitchison,et al.  Dissecting Temporal and Spatial Control of Cytokinesis with a Myosin II Inhibitor , 2003, Science.

[42]  T C Lubensky,et al.  Microrheology, stress fluctuations, and active behavior of living cells. , 2003, Physical review letters.

[43]  Lisa A Flanagan,et al.  Neurite branching on deformable substrates , 2002, Neuroreport.

[44]  Nathan Christopher Shaner,et al.  Myofibrillogenesis in skeletal muscle cells. , 2002, Clinical orthopaedics and related research.

[45]  I. Black,et al.  Adult bone marrow stromal stem cells express germline, ectodermal, endodermal, and mesodermal genes prior to neurogenesis , 2002, Journal of neuroscience research.

[46]  B. Hinz,et al.  Myofibroblasts and mechano-regulation of connective tissue remodelling , 2002, Nature Reviews Molecular Cell Biology.

[47]  Viola Vogel,et al.  Fibronectin extension and unfolding within cell matrix fibrils controlled by cytoskeletal tension , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[48]  J. Paul Robinson,et al.  Tensile mechanical properties of three-dimensional type I collagen extracellular matrices with varied microstructure. , 2002, Journal of biomechanical engineering.

[49]  D. Stamenović,et al.  Cell prestress. I. Stiffness and prestress are closely associated in adherent contractile cells. , 2002, American journal of physiology. Cell physiology.

[50]  A. Manira,et al.  Marrow stromal cells form guiding strands in the injured spinal cord and promote recovery , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[51]  D. Ingber,et al.  Mechanotransduction: All Signals Point to Cytoskeleton, Matrix, and Integrins , 2002, Science's STKE.

[52]  G. Stein,et al.  Expression of the Osteoblast Differentiation Factor RUNX2 (Cbfa1/AML3/Pebp2αA) Is Inhibited by Tumor Necrosis Factor-α* , 2002, The Journal of Biological Chemistry.

[53]  E. Furst,et al.  Motor-driven dynamics in actin-myosin networks. , 2001, Physical review letters.

[54]  G. Stein,et al.  Expression of the osteoblast differentiation factor RUNX2 (Cbfa1/AML3/Pebp2alpha A) is inhibited by tumor necrosis factor-alpha. , 2002, The Journal of biological chemistry.

[55]  N. Takahashi,et al.  Bone Morphogenetic Protein-2 Converts the Differentiation Pathway of C2C12 Myoblasts into the Osteoblast Lineage , 2002 .

[56]  Kenneth M. Yamada,et al.  Taking Cell-Matrix Adhesions to the Third Dimension , 2001, Science.

[57]  B. Hinz,et al.  Alpha-smooth muscle actin expression upregulates fibroblast contractile activity. , 2001, Molecular biology of the cell.

[58]  J. Andrades,et al.  Selection and amplification of a bone marrow cell population and its induction to the chondro-osteogenic lineage by rhOP-1: an in vitro and in vivo study. , 2001, The International journal of developmental biology.

[59]  K. Beningo,et al.  Nascent Focal Adhesions Are Responsible for the Generation of Strong Propulsive Forces in Migrating Fibroblasts , 2001, The Journal of cell biology.

[60]  M. Dembo,et al.  Cell movement is guided by the rigidity of the substrate. , 2000, Biophysical journal.

[61]  Peter G. Schultz,et al.  Myoseverin, a microtubule-binding molecule with novel cellular effects , 2000, Nature Biotechnology.

[62]  L. Vico,et al.  Mineralization and Alkaline Phosphatase Activity in Collagen Lattices Populated by Human Osteoblasts , 2000, Calcified Tissue International.

[63]  J. Ward,et al.  MT1-MMP-Deficient Mice Develop Dwarfism, Osteopenia, Arthritis, and Connective Tissue Disease due to Inadequate Collagen Turnover , 1999, Cell.

[64]  L. Raisz Physiology and pathophysiology of bone remodeling. , 1999, Clinical chemistry.

[65]  M. Pittenger,et al.  Multilineage potential of adult human mesenchymal stem cells. , 1999, Science.

[66]  C. Rotsch,et al.  Dimensional and mechanical dynamics of active and stable edges in motile fibroblasts investigated by using atomic force microscopy. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[67]  N. Stellwagen Apparent pore size of polyacrylamide gels: Comparison of gels cast and run in Tris‐acetate‐EDTA and Tris‐borate‐EDTA buffers , 1998, Electrophoresis.

[68]  G Cossu,et al.  Muscle regeneration by bone marrow-derived myogenic progenitors. , 1998, Science.

[69]  Y. Wang,et al.  Cell locomotion and focal adhesions are regulated by substrate flexibility. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[70]  S. Bruder,et al.  Osteogenic differentiation of purified, culture‐expanded human mesenchymal stem cells in vitro , 1997, Journal of cellular biochemistry.

[71]  T. Deacon,et al.  Embryonic stem cells differentiated in vitro as a novel source of cells for transplantation. , 1996, Cell transplantation.

[72]  Y. Capetanaki,et al.  Cytoskeletal control of myogenesis: a desmin null mutation blocks the myogenic pathway during embryonic stem cell differentiation. , 1995, Developmental biology.

[73]  T. Svitkina,et al.  Myosin II filament assemblies in the active lamella of fibroblasts: their morphogenesis and role in the formation of actin filament bundles , 1995, The Journal of cell biology.

[74]  R M Nerem,et al.  Application of the micropipette technique to the measurement of cultured porcine aortic endothelial cell viscoelastic properties. , 1990, Journal of biomechanical engineering.

[75]  F. Grinnell,et al.  Extracellular matrix organization modulates fibroblast growth and growth factor responsiveness. , 1989, Experimental cell research.

[76]  H. Weintraub,et al.  Expression of a single transfected cDNA converts fibroblasts to myoblasts , 1987, Cell.

[77]  U. Rutishauser Developmental biology of a neural cell adhesion molecule , 1984, Nature.