A relational approach to knowledge spillovers in biotech. Network structures as drivers of inter-organizational citation patterns

In this paper, we analyze the geography of knowledge spillovers in biotech by investigating the way in which knowledge ties are organized. Following a relational account on knowledge spillovers, we depict knowledge networks as complex evolving structures that build on pre-existing knowledge and previously formed ties. In economic geography, there is still little understanding of how structural network forces (like preferential attachment and closure) shape the structure and formation of knowledge spillover networks in space. Our study investigates the knowledge spillover networks of biotech firms by means of inter-organizational citation patterns based on USPTO biotech patents in the years 2008-2010. Using a Stochastic Actor-Oriented Model (SAOM), we explain the driving forces behind the decision of actors to cite patents produced by other actors. Doing so, we address directly the endogenous forces of knowledge dynamics.

[1]  Ruth M. Ripley,et al.  Manual for RSiena , 2011 .

[2]  R. Boschma,et al.  The Spatial Evolution of Innovation Networks: A Proximity Perspective , 2010 .

[3]  Haiyang Zhang,et al.  What is Behind the Recent Surge in Patenting in China , 2010 .

[4]  Jan W. Rivkin,et al.  Complexity, Networks and Knowledge Flow , 2002 .

[5]  Samuel Kortum,et al.  What is behind the recent surge in patenting , 1999 .

[6]  R. Tijssen,et al.  Research collaboration at a distance: Changing spatial patterns of scientific collaboration within Europe , 2010 .

[7]  A. C. Chang,et al.  Construction of biologically functional bacterial plasmids in vitro. , 1973, Proceedings of the National Academy of Sciences of the United States of America.

[8]  Jorge Niosi,et al.  The Competencies of Regions – Canada's Clusters in Biotechnology , 2001 .

[9]  M. Castells The rise of the network society , 1996 .

[10]  Anne L. J. Ter Wal,et al.  Applying social network analysis in economic geography: framing some key analytic issues , 2009 .

[11]  J. Hoekman,et al.  The geography of collaborative knowledge production in Europe , 2009 .

[12]  Maryann P. Feldman The geography of innovation , 1994 .

[13]  John Cantwell,et al.  special issue: The new geography of corporate research in Information and Communications Technology (ICT) , 2002 .

[14]  Johannes Glückler Economic Geography and the Evolution of Networks , 2007 .

[15]  Koen Frenken,et al.  The geographical and institutional proximity of research collaboration , 2007 .

[16]  Stefano Breschi,et al.  Mobility of inventors and the geography of knowledge spillovers. New evidence on US data , 2006 .

[17]  Michelle Gittelman,et al.  Does Good Science Lead to Valuable Knowledge? Biotechnology Firms and the Evolutionary Logic of Citation Patterns , 2003, Manag. Sci..

[18]  John Hagedoorn,et al.  R&D partnership portfolios and the inflow of technological knowledge , 2012 .

[19]  T. Snijders The statistical evaluation of social network dynamics , 2001 .

[20]  S. Breschi,et al.  Knowledge Spillovers And Local Innovation Systems: A Critical Survey , 2001 .

[21]  R&D spillovers and innovative activity , 1994 .

[22]  Rafael A. Corredoira,et al.  Should auld acquaintance be forgot? the reverse transfer of knowledge through mobility ties , 2009 .

[23]  Robert Bud,et al.  The Uses of Life: A History of Biotechnology , 1993 .

[24]  C. Steglich,et al.  DYNAMIC NETWORKS AND BEHAVIOR: SEPARATING SELECTION FROM INFLUENCE: separating selection from influence , 2010 .

[25]  Mario A. Maggioni,et al.  Space vs. Networks in the Geography of Innovation: A European Analysis , 2006 .

[26]  Mario A. Maggioni,et al.  Space Vs. Networks in the Geography of Innovation: A European Analysis , 2007 .

[27]  Jeongsik Jay Lee,et al.  Heterogeneity, Brokerage and Innovative Performance: Endogenous Formation of Collaborative Inventor Networks , 2008, Organ. Sci..

[28]  Michael Taylor,et al.  The handbook of evolutionary economic geography , 2011 .

[29]  Andrea Bonaccorsi,et al.  The Evolution of Knowledge and the Dynamics of an Industry Network , 1997 .

[30]  S. Breschi,et al.  Networks of inventors and the role of academia: an exploration of Italian patent data , 2004 .

[31]  E. Giuliani The Selective Nature of Knowledge Networks in Clusters: Evidence from the Wine Industry , 2007 .

[32]  M. Brewer,et al.  Intellectual Capital and the Birth of U.S. Biotechnology Enterprises , 1994 .

[33]  J. Christensen Proximity and Innovation: A Critical Assessment , 2008 .

[34]  R. Boschma,et al.  Papers in Evolutionary Economic Geography # 11 . 14 The Dynamics of Interfirm Networks along the Industry Life Cycle : The Case of the Global Video Games Industry 1987-2007 , 2011 .

[35]  M. Caniels Knowledge Spillovers and Economic Growth , 2000 .

[36]  Roger Guimerà,et al.  Modeling the world-wide airport network , 2004 .

[37]  Jan W. Rivkin,et al.  Complexity, Networks and Knowledge Flow , 2002 .

[38]  M. Feldman,et al.  R&D spillovers and the ge-ography of innovation and production , 1996 .

[39]  W. Powell,et al.  Network Dynamics and Field Evolution: The Growth of Interorganizational Collaboration in the Life Sciences1 , 2005, American Journal of Sociology.

[40]  Juan Alcácer,et al.  Location Strategies and Knowledge Spillovers , 2007, Manag. Sci..

[41]  Daniel K. N. Johnson Not Far From the Madding Crowd: The Role of Proximity in Biotechnology Innovation , 2009 .

[42]  Albert,et al.  Emergence of scaling in random networks , 1999, Science.

[43]  Sara B. Soderstrom,et al.  Dynamics of Dyads in Social Networks: Assortative, Relational, and Proximity Mechanisms , 2010 .

[44]  Pierre-Alexandre Balland,et al.  Proximity and the Evolution of Collaboration Networks: Evidence from Research and Development Projects within the Global Navigation Satellite System (GNSS) Industry , 2012 .

[45]  Jasjit Singh,et al.  Collaborative Networks as Determinants of Knowledge Diffusion Patterns , 2005, Manag. Sci..

[46]  Tom A. B. Snijders,et al.  Introduction to stochastic actor-based models for network dynamics , 2010, Soc. Networks.

[47]  Charlie Karlsson,et al.  Interregional Inventor Networks as Studied by Patent Co-inventorships , 2006 .

[48]  Adam B. Jaffe,et al.  Do alliances promote knowledge flows , 2006 .

[49]  Marjolein C.J. Caniëls,et al.  Knowledge spillovers and economic growth : regional growth differentials across Europe , 2000 .

[50]  Petter Holme,et al.  Structure and time evolution of an Internet dating community , 2002, Soc. Networks.

[51]  B. Kogut,et al.  Localization of Knowledge and the Mobility of Engineers in Regional Networks , 1999 .

[52]  Muge Ozman,et al.  Inter-firm networks and innovation: a survey of literature , 2009 .

[53]  S. Breschi,et al.  Mobility of Skilled Workers and Co-Invention Networks: An Anatomy of Localized Knowledge Flows , 2009 .

[54]  Pierre-Alexandre Balland,et al.  Proximity and the Evolution of Collaboration Networks: Evidence from R&D projects within the GNSS industry , 2009 .

[55]  F. Lissoni,et al.  METHODOLOGICAL ISSUES AND PRELIMINARY RESULTS , 2003 .

[56]  L. Anselin,et al.  Patents and innovation counts as measures of regional production of new knowledge , 2002 .

[57]  W. Powell,et al.  Interorganizational Collaboration and the Locus of Innovation: Networks of Learning in Biotechnology. , 1996 .

[58]  M. Storper The Limits to Globalization: Technology Districts and International Trade , 1992 .

[59]  Mark E. J. Newman,et al.  The Structure and Function of Complex Networks , 2003, SIAM Rev..

[60]  Christopher Marquis,et al.  Egocentric, sociocentric, or dyadic?: Identifying the appropriate level of analysis in the study of organizational networks , 2006, Soc. Networks.

[61]  Elisa Giuliani,et al.  Papers in Evolutionary Economic Geography # 10 . 14 Network Dynamics in Regional Clusters : The Perspective of an Emerging Economy , 2010 .

[62]  G. Santangelo,et al.  The new geography of corporate research in Information and Communications Technology (ICT) , 2002 .