A candidate regulatory variant at the TREM gene cluster associates with decreased Alzheimer's disease risk and increased TREML1 and TREM2 brain gene expression

[1]  Manolis Kellis,et al.  HaploReg v4: systematic mining of putative causal variants, cell types, regulators and target genes for human complex traits and disease , 2015, Nucleic Acids Res..

[2]  D. Rujescu,et al.  The role of TREM2 R47H as a risk factor for Alzheimer's disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson's disease , 2015, Alzheimer's & Dementia.

[3]  Guiyou Liu.  No association of TREM1 rs6910730 and TREM2 rs7759295 with Alzheimer disease , 2015, Annals of neurology.

[4]  R. Tanzi.  TREM2 and Risk of Alzheimer's Disease--Friend or Foe? , 2015, The New England journal of medicine.

[5]  R. Ransohoff,et al.  TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer’s disease mouse models , 2015, The Journal of experimental medicine.

[6]  Charles C. White,et al.  A TREM1 variant alters the accumulation of Alzheimer‐related amyloid pathology , 2015, Annals of neurology.

[7]  D. Holtzman,et al.  TREM2 lipid sensing sustains microglia response in an Alzheimer’s disease model , 2015, Cell.

[8]  L. Lue,et al.  TREM2 Protein Expression Changes Correlate with Alzheimer's Disease Neurodegenerative Pathologies in Post‐Mortem Temporal Cortices , 2014, Brain pathology.

[9]  F. Jessen,et al.  The rare TREM2 R47H variant exerts only a modest effect on Alzheimer disease risk , 2014, Neurology.

[10]  T. Maniatis,et al.  An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex , 2014, The Journal of Neuroscience.

[11]  J. Molinuevo,et al.  TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis , 2014, Science Translational Medicine.

[12]  Michelle K. Lupton,et al.  Missense variant in TREML2 protects against Alzheimer's disease , 2014, Neurobiology of Aging.

[13]  R. Kacimi,et al.  Abstract 9: Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) deficiency Attenuates Phagocytic Activities of Microglia and Exacerbates Ischemic Damage in Experimental Stroke , 2014, Stroke.

[14]  M. Bullido,et al.  Assessing the role of the TREM2 p.R47H variant as a risk factor for Alzheimer's disease and frontotemporal dementia , 2014, Neurobiology of Aging.

[15]  Jennifer M. Pocock,et al.  Insights into TREM2 biology by network analysis of human brain gene expression data , 2013, Neurobiology of Aging.

[16]  Mark T. W. Ebbert,et al.  Assessment of TREM2 rs75932628 association with Alzheimer's disease in a population-based sample: the Cache County Study , 2013, Neurobiology of Aging.

[17]  Nick C Fox,et al.  Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease , 2013, Nature Genetics.

[18]  C. Cruchaga,et al.  TREM2 is associated with the risk of Alzheimer's disease in Spanish population , 2013, Neurobiology of Aging.

[19]  Matthew H. Bailey,et al.  GWAS of Cerebrospinal Fluid Tau Levels Identifies Risk Variants for Alzheimer’s Disease , 2013, Neuron.

[20]  A. Singleton,et al.  TREM2 variants in Alzheimer's disease. , 2013, The New England journal of medicine.

[21]  A. Hofman,et al.  Variant of TREM2 associated with the risk of Alzheimer's disease. , 2013, The New England journal of medicine.

[22]  Eurie L. Hong,et al.  Annotation of functional variation in personal genomes using RegulomeDB , 2012, Genome research.

[23]  J. Schneider,et al.  Overview and findings from the religious orders study. , 2012, Current Alzheimer research.

[24]  Margaret A. Pericak-Vance,et al.  Brain Expression Genome-Wide Association Study (eGWAS) Identifies Human Disease-Associated Variants , 2012, PLoS genetics.

[25]  F. Massin,et al.  Soluble Trem-like Transcript-1 Regulates Leukocyte Activation and Controls Microbial Sepsis , 2012, The Journal of Immunology.

[26]  K. Sakamoto,et al.  The Role of the Transcription Factor CREB in Immune Function , 2010, The Journal of Immunology.

[27]  T. Mikkelsen,et al.  The NIH Roadmap Epigenomics Mapping Consortium , 2010, Nature Biotechnology.

[28]  Yun Li,et al.  METAL: fast and efficient meta-analysis of genomewide association scans , 2010, Bioinform..

[29]  A. Dutra,et al.  TREM-like transcript-1 protects against inflammation-associated hemorrhage by facilitating platelet aggregation in mice and humans. , 2009, The Journal of clinical investigation.

[30]  D. McVicar,et al.  TREM and TREM-like receptors in inflammation and disease. , 2009, Current opinion in immunology.

[31]  Manuel A. R. Ferreira,et al.  PLINK: a tool set for whole-genome association and population-based linkage analyses. , 2007, American journal of human genetics.

[32]  J. Plutzky,et al.  Peroxisome proliferator-activated receptors as transcriptional nodal points and therapeutic targets. , 2007, Circulation.

[33]  Brantley R. Herrin,et al.  Trem-Like Transcript 2 Is Expressed on Cells of the Myeloid/Granuloid and B Lymphoid Lineage and Is Up-Regulated in Response to Inflammation , 2006, The Journal of Immunology.

[34]  David A. Bennett,et al.  The Rush Memory and Aging Project: Study Design and Baseline Characteristics of the Study Cohort , 2005, Neuroepidemiology.

[35]  Edward H. Cho,et al.  A TREM family member, TLT-1, is found exclusively in the alpha-granules of megakaryocytes and platelets. , 2004, Blood.

[36]  D. Campion,et al.  TREM2 R47H variant as a risk factor for early-onset Alzheimer's disease. , 2013, Journal of Alzheimer's disease : JAD.