Cordycepin: A Biotherapeutic Molecule from Medicinal Mushroom

[1]  E. A. Elsayed,et al.  Optimization of cordycepin extraction from cordyceps militaris fermentation broth , 2017 .

[2]  Jing-song Zhang,et al.  Preparative isolation of cordycepin, N(6)-(2-hydroxyethyl)-adenosine and adenosine from Cordyceps militaris by macroporous resin and purification by recycling high-speed counter-current chromatography. , 2016, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[3]  T. Hou,et al.  Cordycepin Prevents Bone Loss through Inhibiting Osteoclastogenesis by Scavenging ROS Generation , 2016, Nutrients.

[4]  Y. Mu,et al.  Cordycepin induced MA-10 mouse Leydig tumor cell apoptosis by regulating p38 MAPKs and PI3K/AKT signaling pathways , 2015, Scientific Reports.

[5]  Hye-Jin Park Ethanol extract of Cordyceps militaris grown on germinated soybeans inhibits 2, 4-dinitrophenolfluorobenzene-induced allergic contact dermatitis. , 2015 .

[6]  Jiye Zhang,et al.  Cordycepin alleviates airway hyperreactivity in a murine model of asthma by attenuating the inflammatory process. , 2015, International immunopharmacology.

[7]  M. Du,et al.  Cordycepin from Cordyceps militaris prevents hyperglycemia in alloxan-induced diabetic mice. , 2015, Nutrition research.

[8]  Ping Wang,et al.  Effects of Cordycepin on the Microglia-Overactivation-Induced Impairments of Growth and Development of Hippocampal Cultured Neurons , 2015, PloS one.

[9]  Wei Qi,et al.  Osteoprotective Effect of Cordycepin on Estrogen Deficiency-Induced Osteoporosis In Vitro and In Vivo , 2015, BioMed research international.

[10]  Xue-hong Qiu,et al.  Identification of the Genes Involved in the Fruiting Body Production and Cordycepin Formation of Cordyceps militaris Fungus , 2015, Mycobiology.

[11]  Dong-Ha Lee,et al.  Effect of Cordycepin-Enriched WIB801C from Cordyceps militaris Suppressing Fibrinogen Binding to Glycoprotein IIb/IIIa , 2015, Biomolecules & therapeutics.

[12]  Jiamin Li,et al.  Effects of Cooking on the Contents of Adenosine and Cordycepin in Cordyceps Militaris , 2015 .

[13]  Chang-Wei Hsieh,et al.  Optimization of Ultrasonic-Assisted Extraction of Cordycepin from Cordyceps militaris Using Orthogonal Experimental Design , 2014, Molecules.

[14]  Yung-Hyun Choi,et al.  Anti-inflammatory effects of cordycepin in lipopolysaccharide-stimulated RAW 264.7 macrophages through Toll-like receptor 4-mediated suppression of mitogen-activated protein kinases and NF-κB signaling pathways , 2014, Drug design, development and therapy.

[15]  K. Hyde,et al.  Optimization of Large-Scale Culture Conditions for the Production of Cordycepin with Cordyceps militaris by Liquid Static Culture , 2014, TheScientificWorldJournal.

[16]  W. Meng,et al.  Modulation effects of cordycepin on the skeletal muscle contraction of toad gastrocnemius muscle. , 2014, European journal of pharmacology.

[17]  M. Hatashita,et al.  Efficient production of cordycepin by the Cordyceps militaris mutant G81-3 for practical use , 2014 .

[18]  Zhu Li,et al.  OPTIMIZATION OF FERMENTATION CONDITIONS AND PURIFICATION OF CORDYCEPIN FROM Cordyceps militaris , 2014, Preparative biochemistry & biotechnology.

[19]  P. Zhu,et al.  Cordycepin activates AMP-activated protein kinase (AMPK) via interaction with the γ1 subunit , 2013, Journal of cellular and molecular medicine.

[20]  S. Sandhu,et al.  OPTIMIZATION OF EXTRACTION CONDITIONS AND ANTIMICROBIAL POTENTIAL OF A BIOACTIVE METABOLITE, CORDYCEPIN FROM CORDYCEPS MILITARIS 3936 , 2014 .

[21]  R. Hatti-Kaul,et al.  Mushroom immunomodulators: unique molecules with unlimited applications. , 2013, Trends in biotechnology.

[22]  E. A. Elsayed,et al.  Mushrooms and Truffles: Historical Biofactories for Complementary Medicine in Africa and in the Middle East , 2013, Evidence-based complementary and alternative medicine : eCAM.

[23]  D. Reidpath,et al.  Religiosity and Spirituality and the Intake of Fruit, Vegetable, and Fat: A Systematic Review , 2013, Evidence-based complementary and alternative medicine : eCAM.

[24]  Min-Jeong Seo,et al.  Cordycepin-enriched Cordyceps militaris induces immunomodulation and tumor growth delay in mouse-derived breast cancer. , 2013, Oncology reports.

[25]  B. Ko,et al.  Cordycepin Regulates GSK-3β/β-Catenin Signaling in Human Leukemia Cells , 2013, PloS one.

[26]  H. Kamyab,et al.  Molecular weight (mw) and monosaccharide composition (mc): two major factors affecting the therapeutic action of polysaccharides extracted from cordyceps sinensis-mini review , 2013 .

[27]  J. Hong,et al.  Cordycepin Increases Nonrapid Eye Movement Sleep via Adenosine Receptors in Rats , 2013, Evidence-based complementary and alternative medicine : eCAM.

[28]  Zhi-Gang Chen,et al.  Highly efficient and regioselective acylation of pharmacologically interesting cordycepin catalyzed by lipase in the eco-friendly solvent 2-methyltetrahydrofuran. , 2013, Bioresource technology.

[29]  S. Sandhu,et al.  Pharmacological and therapeutic potential of Cordyceps with special reference to Cordycepin , 2013, 3 Biotech.

[30]  Zhenghua Ren,et al.  Cordycepin suppresses TNF-α-induced NF-κB activation by reducing p65 transcriptional activity, inhibiting IκBα phosphorylation, and blocking IKKγ ubiquitination. , 2012, International immunopharmacology.

[31]  Si-Kwan Kim,et al.  Cordycepin (3′-deoxyadenosine) attenuates age-related oxidative stress and ameliorates antioxidant capacity in rats , 2012, Experimental Gerontology.

[32]  C. Che,et al.  Protective roles of Cordyceps on lung fibrosis in cellular and rat models , 2012, Journal of Ethnopharmacology.

[33]  Wun-Jae Kim,et al.  Ras/ERK1 pathway regulation of p27KIP1-mediated G1-phase cell-cycle arrest in cordycepin-induced inhibition of the proliferation of vascular smooth muscle cells. , 2012, European journal of pharmacology.

[34]  Wei Wang,et al.  Enhancement of cordycepin production in submerged cultures of Cordyceps militaris by addition of ferrous sulfate , 2012 .

[35]  B. Jeon,et al.  Cordycepin-induced apoptosis and autophagy in breast cancer cells are independent of the estrogen receptor. , 2011, Toxicology and applied pharmacology.

[36]  Guo-Ping Zhao,et al.  Genome sequence of the insect pathogenic fungus Cordyceps militaris, a valued traditional chinese medicine , 2011, Genome Biology.

[37]  Wen-Wen Yan,et al.  Cordycepin decreases activity of hippocampal CA1 pyramidal neuron through membrane hyperpolarization , 2011, Neuroscience Letters.

[38]  Wei He,et al.  Cordycepin protects against cerebral ischemia/reperfusion injury in vivo and in vitro. , 2011, European journal of pharmacology.

[39]  Y. Yoo,et al.  Induction of apoptosis by cordycepin via reactive oxygen species generation in human leukemia cells. , 2011, Toxicology in vitro : an international journal published in association with BIBRA.

[40]  C. B. Oliveira,et al.  Susceptibility of Trypanosoma evansi to cordycepin. , 2011, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[41]  Kai Qu,et al.  Beneficial effects of cordycepin on metabolic profiles of liver and plasma from hyperlipidemic hamsters , 2011, Journal of Asian natural products research.

[42]  Yong Liang,et al.  PREPARATIVE SEPARATION OF HIGH-PURITY CORDYCEPIN FROM CORDYCEPS MILITARIS(L.) LINK BY HIGH-SPEED COUNTERCURRENT CHROMATOGRAPHY , 2011, Journal of liquid chromatography & related technologies.

[43]  M. Hatashita,et al.  Production of cordycepin by a repeated batch culture of a Cordyceps militaris mutant obtained by proton beam irradiation. , 2011, Journal of bioscience and bioengineering.

[44]  Won‐Kyo Jung,et al.  Anti-inflammatory effects of cordycepin via suppression of inflammatory mediators in BV2 microglial cells. , 2010, International immunopharmacology.

[45]  K. Feng,et al.  Determination of nucleotides, nucleosides and their transformation products in Cordyceps by ion-pairing reversed-phase liquid chromatography-mass spectrometry. , 2010, Journal of chromatography. A.

[46]  J. Xie,et al.  Analysis of the Main Nucleosides in Cordyceps Sinensis by LC/ESI-MS , 2010, Molecules.

[47]  Wun-Jae Kim,et al.  c-Jun N-terminal kinase 1 is required for cordycepin-mediated induction of G2/M cell-cycle arrest via p21WAF1 expression in human colon cancer cells. , 2010, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[48]  M. Masuda,et al.  Efficient Production of Anticancer Agent Cordycepin by Repeated Batch Culture of Cordyceps militaris Mutant , 2010 .

[49]  M. Clemens,et al.  Cordycepin Inhibits Protein Synthesis and Cell Adhesion through Effects on Signal Transduction* , 2009, The Journal of Biological Chemistry.

[50]  Wun-Jae Kim,et al.  Cordycepin causes p21WAF1-mediated G2/M cell-cycle arrest by regulating c-Jun N-terminal kinase activation in human bladder cancer cells. , 2009, Archives of biochemistry and biophysics.

[51]  Shao-Ping Li,et al.  Determination of nucleosides and nucleobases in different species of Cordyceps by capillary electrophoresis-mass spectrometry. , 2009, Journal of pharmaceutical and biomedical analysis.

[52]  He Ni,et al.  Column chromatographic extraction and preparation of cordycepin from Cordyceps militaris waster medium. , 2009, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[53]  S. Das,et al.  Effects of additives on cordycepin production using a Cordyceps militaris mutant induced by ion beam irradiation , 2009 .

[54]  Zhaojie Cui,et al.  Supercritical fluid extraction of cordycepin and adenosine from Cordyceps kyushuensis and purification by high-speed counter-current chromatography , 2009 .

[55]  A. Jacquier,et al.  Cordycepin interferes with 3' end formation in yeast independently of its potential to terminate RNA chain elongation. , 2009, RNA.

[56]  Z. Chen,et al.  Synthesis and pharmacokinetic evaluation of novel N-acyl-cordycepin derivatives with a normal alkyl chain. , 2009, European journal of medicinal chemistry.

[57]  Heesang Song,et al.  Cordycepin inhibits vascular smooth muscle cell proliferation. , 2008, European journal of pharmacology.

[58]  K. Haraguchi,et al.  Synthesis of 4′-benzoyloxycordycepin from adenosine , 2008 .

[59]  B. Chiang,et al.  Anti-tumor activity of the fermentation broth of Cordyceps militaris cultured in the medium of Radix astragali , 2008 .

[60]  Lisa S. Chen,et al.  RNA‐directed agent, cordycepin, induces cell death in multiple myeloma cells , 2008, British journal of haematology.

[61]  P. Leung,et al.  Effects of ammonium feeding on the production of bioactive metabolites (cordycepin and exopolysaccharides) in mycelial culture of a Cordyceps sinensis fungus , 2007, Journal of applied microbiology.

[62]  S P Li,et al.  Fast simultaneous determination of 14 nucleosides and nucleobases in cultured Cordyceps using ultra-performance liquid chromatography. , 2007, Talanta.

[63]  Dong‐sheng Li,et al.  Submerged Culture of Mushrooms in Bioreactors – Challenges, Current State-of-the-Art, and Future Prospects , 2007 .

[64]  M. Rhee,et al.  Cordycepin (3'-deoxyadenosine) inhibits human platelet aggregation in a cyclic AMP- and cyclic GMP-dependent manner. , 2007, European journal of pharmacology.

[65]  Per Hagander,et al.  Bioreactor control using a probing feeding strategy and mid-ranging control , 2007 .

[66]  Jian Yong Wu,et al.  Inhibitory effects of ethyl acetate extract of Cordyceps sinensis mycelium on various cancer cells in culture and B16 melanoma in C57BL/6 mice. , 2007, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[67]  Jing Yang,et al.  Synthesis and properties of cordycepin intercalates of Mg-Al-nitrate layered double hydroxides. , 2006, International journal of pharmaceutics.

[68]  Y. Jang,et al.  Cordycepin inhibits lipopolysaccharide-induced inflammation by the suppression of NF-kappaB through Akt and p38 inhibition in RAW 264.7 macrophage cells. , 2006, European journal of pharmacology.

[69]  M. Sakakibara,et al.  Enhanced production of cordycepin by surface culture using the medicinal mushroom Cordyceps militaris , 2006 .

[70]  P. Leung,et al.  Mycelium cultivation, chemical composition and antitumour activity of a Tolypocladium sp. fungus isolated from wild Cordyceps sinensis , 2006, Journal of applied microbiology.

[71]  Fengqing Yang,et al.  Qualitative and quantitative determination of nucleosides, bases and their analogues in natural and cultured Cordyceps by pressurized liquid extraction and high performance liquid chromatography–electrospray ionization tandem mass spectrometry (HPLC–ESI–MS/MS) , 2006 .

[72]  Y. Tzeng,et al.  A simple and rapid method for identification and determination of cordycepin in Cordyceps militaris by capillary electrophoresis , 2006 .

[73]  Wu Yalin,et al.  Studies on isolation and structural features of a polysaccharide from the mycelium of an Chinese edible fungus (Cordyceps sinensis) , 2006 .

[74]  J. Zhong,et al.  Significant effect of NH4+ on cordycepin production by submerged cultivation of medicinal mushroom Cordyceps militaris , 2006 .

[75]  T. Ng,et al.  Pharmacological actions of Cordyceps, a prized folk medicine , 2005, The Journal of pharmacy and pharmacology.

[76]  J. Yun,et al.  A comparative study on the production of exopolysaccharides between two entomopathogenic fungi Cordyceps militaris and Cordyceps sinensis in submerged mycelial cultures , 2005, Journal of applied microbiology.

[77]  J. Zhong,et al.  Optimization of carbon source and carbon/nitrogen ratio for cordycepin production by submerged cultivation of medicinal mushroom Cordyceps militaris , 2005 .

[78]  C. Su,et al.  Free radical scavenging and apoptotic effects of Cordyceps sinensis fractionated by supercritical carbon dioxide. , 2005, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[79]  E. Park,et al.  Anti-inflammatory and related pharmacological activities of cultured mycelia and fruiting bodies of Cordyceps militaris. , 2005, Journal of ethnopharmacology.

[80]  B. Bauer,et al.  The traditional Chinese medicine Cordyceps sinensis and its effects on apoptotic homeostasis. , 2005, Journal of ethnopharmacology.

[81]  Kazuki Nakamura,et al.  Effect of cordycepin (3'-deoxyadenosine) on hematogenic lung metastatic model mice. , 2005, In vivo.

[82]  Kazuki Nakamura,et al.  ANTITUMOUR ACTIVITY OF CORDYCEPIN IN MICE , 2004, Clinical and experimental pharmacology & physiology.

[83]  R. Yu,et al.  Isolation, purification and identification of polysaccharides from cultured Cordyceps militaris. , 2004, Fitoterapia.

[84]  Wen Bin,et al.  Isolation and biological properties of polysaccharide CPS-1 from cultured Cordyceps militaris. , 2004, Fitoterapia.

[85]  T. Dong,et al.  Simultaneous determination of ergosterol, nucleosides and their bases from natural and cultured Cordyceps by pressurised liquid extraction and high-performance liquid chromatography. , 2004, Journal of chromatography. A.

[86]  J. Zhong,et al.  Hyperproduction of Cordycepin by Two‐Stage Dissolved Oxygen Control in Submerged Cultivation of Medicinal Mushroom Cordyceps militaris in Bioreactors , 2004, Biotechnology progress.

[87]  S. Ko,et al.  Anti-diabetic Effects of CCCA, CMKSS, and Cordycepin from Cordyceps militaris and the Immune Responses in Streptozotocin-induced Diabetic Mice , 2003 .

[88]  S. Wasser Wasser Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides , 2022 .

[89]  F. Zepp,et al.  Effect of cordycepin on interleukin-10 production of human peripheral blood mononuclear cells. , 2002, European journal of pharmacology.

[90]  J. Ling,et al.  Measurement of cordycepin and adenosine in stroma of Cordyceps sp. by capillary zone electrophoresis (CZE). , 2002, Journal of bioscience and bioengineering.

[91]  Chienyan Hsieh,et al.  A comparison of the chemical composition and bioactive ingredients of the Chinese medicinal mushroom DongChongXiaCao, its counterfeit and mimic, and fermented mycelium of Cordyceps sinensis , 2002 .

[92]  D. Anderson,et al.  From Adenosine to 3‘-Deoxyadenosine: Development and Scale Up , 2000 .

[93]  S. G. Lee,et al.  Cordycepin: selective growth inhibitor derived from liquid culture of Cordyceps militaris against Clostridium spp. , 2000, Journal of agricultural and food chemistry.

[94]  H. Mitsuya,et al.  Antileukemic activity and mechanism of action of cordycepin against terminal deoxynucleotidyl transferase-positive (TdT+) leukemic cells. , 2000, Biochemical pharmacology.

[95]  J. Bok,et al.  Antitumor sterols from the mycelia of Cordyceps sinensis. , 1999, Phytochemistry.

[96]  Takashi Mizuno,et al.  Medicinal Effects and Utilization of Cordyceps (Fr.) Link (Ascomycetes) and Isaria Fr. (Mitosporic Fungi) Chinese Caterpillar Fungi, "Tochukaso" (Review) , 1999 .

[97]  K. Jones,et al.  The scientific rediscovery of an ancient Chinese herbal medicine: Cordyceps sinensis: part I. , 1998, Journal of alternative and complementary medicine.

[98]  T. Kiho,et al.  Tochukaso (Semitake and others), Cordyceps species , 1995 .

[99]  T. Okumoto,et al.  Fungal metabolites. Part 11. A potent immunosuppressive activity found in Isaria sinclairii metabolite. , 1994, The Journal of antibiotics.

[100]  D. Pegler,et al.  The Chinese ‘Caterpillar Fungus’ , 1994 .

[101]  L. Leserman,et al.  Cordycepin analogues of 2',5'-oligoadenylate inhibit human immunodeficiency virus infection via inhibition of reverse transcriptase. , 1991, Biochemistry.

[102]  F. Hansske,et al.  Regiospecific and stereoselective conversion of ribonucleosides to 3′-deoxynucleosides. A high yield three-stage synthesis of cordycepin from adenosine. , 1985 .

[103]  J. G. Cory,et al.  Incorporation of cordycepin (3'-deoxyadenosine) into ribonucleic acid and deoxyribonucleic acid of human tumor cells. , 1965, Biochimica et biophysica acta.

[104]  J. G. Cory,et al.  INHIBITION OF HUMAN TUMOR CELLS BY CORDYCEPIN. , 1965, Biochimica et biophysica acta.

[105]  J. G. Cory,et al.  FURTHER EVIDENCE FOR THE BIOSYNTHESIS OF CORDYCEPIN AND PROOF OF THE STRUCTURE OF 3-DEOXYRIBOSE. , 1964, Biochimica et biophysica acta.

[106]  F. Rottman,et al.  THE INHIBITION OF PHOSPHORIBOSYL-PYROPHOSPHATE AMIDOTRANSFERASE ACTIVITY BY CORDYCEPIN MONOPHOSPHATE. , 1964, Biochimica et biophysica acta.

[107]  K. Overgaard-Hansen THE INHIBITION OF 5-PHOSPHORIBOSYL-1-PYROPHOSPHATE FORMATION BY CORDYCEPIN TRIPHOSPHATE IN EXTRACTS OF EHRLICH ASCITES TUMOR CELLS. , 1964, Biochimica et biophysica acta.

[108]  H. Klenow FORMATION OF THE MONO-, DI- AND TRIPHOSPHATE OF CORDYCEPIN IN EHRLICH ASCITES-TUMOR CELLS IN VITRO. , 1963, Biochimica et biophysica acta.

[109]  S. A. Hutchinson,et al.  508. Cordycepin, a metabolic product from cultures of Cordyceps militaris(Linn.) link. Part I. Isolation and characterisation , 1951 .