Live-cell imaging RNAi screen identifies PP2A–B55α and importin-β1 as key mitotic exit regulators in human cells

[1]  Bernd Fischer,et al.  CellCognition: time-resolved phenotype annotation in high-throughput live cell imaging , 2010, Nature Methods.

[2]  P. Jallepalli,et al.  Vertebrate cells genetically deficient for Cdc14A or Cdc14B retain DNA damage checkpoint proficiency but are impaired in DNA repair , 2010, The Journal of cell biology.

[3]  R. Durbin,et al.  Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes , 2010, Nature.

[4]  Jason W. Chin,et al.  Encoding multiple unnatural amino acids via evolution of a quadruplet-decoding ribosome , 2010, Nature.

[5]  Yigong Shi.  Serine/Threonine Phosphatases: Mechanism through Structure , 2009, Cell.

[6]  T. Mitchison,et al.  Evidence that mitotic exit is a better cancer therapeutic target than spindle assembly. , 2009, Cancer cell.

[7]  D. Gerlich,et al.  Mitotic phosphatases: from entry guards to exit guides. , 2009, Trends in cell biology.

[8]  Tim Hunt,et al.  Regulated activity of PP2A–B55δ is crucial for controlling entry into and exit from mitosis in Xenopus egg extracts , 2009, The EMBO journal.

[9]  A. Nairn,et al.  PP1-mediated dephosphorylation of phosphoproteins at mitotic exit is controlled by inhibitor-1 and PP1 phosphorylation , 2009, Nature Cell Biology.

[10]  I. Landrieu,et al.  Alzheimer disease specific phosphoepitopes of Tau interfere with assembly of tubulin but not binding to microtubules , 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[11]  D. Gerlich,et al.  Aurora B-Mediated Abscission Checkpoint Protects against Tetraploidization , 2009, Cell.

[12]  D. Gerlich,et al.  Automated live microscopy to study mitotic gene function in fluorescent reporter cell lines. , 2009, Methods in molecular biology.

[13]  F. Uhlmann,et al.  Cdk-counteracting phosphatases unlock mitotic exit , 2008, Current opinion in cell biology.

[14]  Yigong Shi,et al.  Structure of a protein phosphatase 2A holoenzyme: insights into B55-mediated Tau dephosphorylation. , 2008, Molecular cell.

[15]  P. Jallepalli,et al.  The nucleolar phosphatase Cdc14B is dispensable for chromosome segregation and mitotic exit in human cells , 2008, Cell cycle.

[16]  Karl Mechtler,et al.  BAC TransgeneOmics: a high-throughput method for exploration of protein function in mammals , 2008, Nature Methods.

[17]  J. Ellenberg,et al.  Systematic kinetic analysis of mitotic dis- and reassembly of the nuclear pore in living cells , 2008, The Journal of cell biology.

[18]  V. Janssens,et al.  PP2A holoenzyme assembly: in cauda venenum (the sting is in the tail). , 2008, Trends in biochemical sciences.

[19]  R. Margolis,et al.  Mitosis persists in the absence of Cdk1 activity when proteolysis or protein phosphatase activity is suppressed , 2007, The Journal of cell biology.

[20]  Tomoko Nishiyama,et al.  Transient activation of calcineurin is essential to initiate embryonic development in Xenopus laevis. , 2007, Nature.

[21]  T. Hunt,et al.  Calcineurin is required to release Xenopus egg extracts from meiotic M phase. , 2007, Nature.

[22]  V. Janssens,et al.  Selection of Protein Phosphatase 2A Regulatory Subunits Is Mediated by the C Terminus of the Catalytic Subunit* , 2007, Journal of Biological Chemistry.

[23]  Karl Mechtler,et al.  Tandem affinity purification of functional TAP-tagged proteins from human cells , 2007, Nature Protocols.

[24]  B. Schaub,et al.  Transition of galactosyltransferase 1 from trans-Golgi cisterna to the trans-Golgi network is signal mediated. , 2006, Molecular biology of the cell.

[25]  A. Lamond,et al.  Mitotic phosphatases: no longer silent partners. , 2006, Current opinion in cell biology.

[26]  J. R. Daum,et al.  The reversibility of mitotic exit in vertebrate cells , 2006, Nature.

[27]  Angelika Amon,et al.  Closing mitosis: the functions of the Cdc14 phosphatase and its regulation. , 2004, Annual review of genetics.

[28]  A. Harel,et al.  Importin beta: conducting a much larger cellular symphony. , 2004, Molecular cell.

[29]  J. Lippincott-Schwartz,et al.  Formation of stacked ER cisternae by low affinity protein interactions , 2003, The Journal of cell biology.

[30]  A. Gartner,et al.  The CeCDC-14 phosphatase is required for cytokinesis in the Caenorhabditis elegans embryo , 2002, The Journal of cell biology.

[31]  N. Mailand,et al.  Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation , 2002, Nature Cell Biology.

[32]  H. Leonhardt,et al.  Dynamics of DNA Replication Factories in Living Cells , 2000, The Journal of cell biology.

[33]  T. Uemura,et al.  Drosophila mutants in the 55 kDa regulatory subunit of protein phosphatase 2A show strongly reduced ability to dephosphorylate substrates of p34cdc2. , 1994, Journal of cell science.

[34]  M. Kirschner,et al.  Inhibition of cdc2 activation by INH/PP2A. , 1994, Molecular biology of the cell.

[35]  Z. Damuni,et al.  Autophosphorylation-activated protein kinase phosphorylates and inactivates protein phosphatase 2A. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[36]  Brian A. Hemmings,et al.  The 55 kd regulatory subunit of Drosophila protein phosphatase 2A is required for anaphase , 1993, Cell.

[37]  D. Glover,et al.  One of the protein phosphatase 1 isoenzymes in Drosophila is essential for mitosis , 1990, Cell.

[38]  J. Doonan,et al.  The bimG gene of Aspergillus nidulans, required for completion of anaphase, encodes a homolog of mammalian phosphoprotein phosphatase 1 , 1989, Cell.

[39]  W. Merlevede,et al.  Purification and properties of polycation-stimulated phosphorylase phosphatases from rabbit skeletal muscle. , 1987, The Journal of biological chemistry.

[40]  P. Chock,et al.  Properties of a Mr = 38,000 phosphoprotein phosphatase. Modulation by divalent cations, ATP, and fluoride. , 1983, The Journal of biological chemistry.