Effects of tricalcium silicate addition on basic properties of α-tricalcium phosphate cement( Ceramics for Biomedical Applications in Asian Countries)

Addition of tricalcium silicate (Ca3SiO5; alite) to apatite cement (AC) may be effective to increase the osteoconductivity of AC. However, only limited studies have been made so far for the effect of alite addition on the basic setting properties of α-tricalcium phosphate [α-Ca3(PO4)2; α-TCP] based cement. In the present study, effects of added alite on the basic properties of α-TCP based AC was studied. α-TCP powder containing 0.0, 2.5, 5.0, 10.0, and 20.0 mass% alite were mixed with 0.25 mol/L sodium dihydrogen phosphate solution (NaH2PO4) and the obtained cement pastes were stored in 100% relative humidity at 37°C. Initial setting time was delayed with increase in alite content. The 2.5-5.0 mass% of alite added cements were completely transformed into apatite within 24 h and the final mechanical strength of the set cement increased reaching approximately 15 MPa in terms of diametral tensile strength when compared with alite-free cement which showed approximately 9 MPa. However, 10.0-20.0 mass% of alite addition suppressed the apatite formation and decreased the mechanical strength of the set cement. We concluded therefore, that addition of appropriate amount of alite to α-TCP is desirable with respect to the setting properties of AC.

[1]  Yingjun Wang,et al.  Self-setting properties of a beta-dicalcium silicate reinforced calcium phosphate cement. , 2007, Journal of biomedical materials research. Part B, Applied biomaterials.

[2]  K. Ishikawa,et al.  Comparison of the Effects of Added α- and β- Tricalcium Phosphate on the Basic Properties of Apatite Cement , 2007 .

[3]  S. Saint-Jean,et al.  Material characterization and in vivo behavior of silicon substituted alpha-tricalcium phosphate cement. , 2006, Journal of biomedical materials research. Part B, Applied biomaterials.

[4]  Jiang Chang,et al.  The self-setting properties and in vitro bioactivity of tricalcium silicate. , 2005, Biomaterials.

[5]  J. Powell,et al.  Dietary silicon and bone health , 2005 .

[6]  R. Curtis,et al.  The constitution of mineral trioxide aggregate. , 2005, Dental materials : official publication of the Academy of Dental Materials.

[7]  Matthias Epple,et al.  Biological and medical significance of calcium phosphates. , 2002, Angewandte Chemie.

[8]  I. Odler,et al.  Initial hydration of tricalcium silicate as studied by secondary neutrals mass spectrometry: II. Results and discussion , 2002 .

[9]  D. Kiel,et al.  Dietary silicon intake and absorption. , 2002, The American journal of clinical nutrition.

[10]  A. Ito,et al.  Fabrication of Zn containing apatite cement and its initial evaluation using human osteoblastic cells. , 2002, Biomaterials.

[11]  C. Ekmekcioglu.  The role of trace elements for the health of elderly individuals. , 2001, Die Nahrung.

[12]  M. Sayer,et al.  Resorbable bioceramics based on stabilized calcium phosphates. Part II: evaluation of biological response. , 2001, Biomaterials.

[13]  C. Snyderman,et al.  Reconstruction of the frontal sinus and frontofacial skeleton with hydroxyapatite cement. , 2000, Archives of facial plastic surgery.

[14]  C. Friedman,et al.  Indications for hydroxyapatite cement reconstruction in lateral skull base surgery. , 1995, The American journal of otology.

[15]  C. Snyderman,et al.  Hydroxyapatite cement: a new method for achieving watertight closure in transtemporal surgery. , 1994, The American journal of otology.

[16]  Larry L. Hench,et al.  Bioceramics: From Concept to Clinic , 1991 .

[17]  T. Yamamuro,et al.  Compositional Dependence of Bioactivity of Glasses in the System CaO-SiO2-P2O5 , 1991 .

[18]  E. M. Carlisle.  A silicon requirement for normal skull formation in chicks. , 1980, The Journal of nutrition.

[19]  H. Monma,et al.  The hydration of .ALPHA.-tricalcium phosphate. , 1976 .

[20]  E. M. Carlisle.  Silicon: An Essential Element for the Chick , 1972, Science.

[21]  K. Schwarz,et al.  Growth-promoting Effects of Silicon in Rats , 1972, Nature.