Electroosmotic pumps and their applications in microfluidic systems

Electroosmotic pumping is receiving increasing attention in recent years owing to the rapid development in micro total analytical systems. Compared with other micropumps, electroosmotic pumps (EOPs) offer a number of advantages such as creation of constant pulse-free flows and elimination of moving parts. The flow rates and pumping pressures of EOPs matches well with micro analysis systems. The common materials and fabrication technologies make it readily integrateable with lab-on-a-chip devices. This paper reviews the recent progress on EOP fabrications and applications in order to promote the awareness of EOPs to researchers interested in using micro- and nano-fluidic devices. The pros and cons of EOPs are also discussed, which helps these researchers in designing and constructing their micro platforms.

[1]  Suk Won Cha,et al.  Water management in proton exchange membrane fuel cells using integrated electroosmotic pumping , 2006 .

[2]  Iulia M Lazar,et al.  Multiple open-channel electroosmotic pumping system for microfluidic sample handling. , 2002, Analytical chemistry.

[3]  Shaorong Liu,et al.  Microfabricated electroosmotic pump for capillary-based sequential injection analysis , 2004 .

[4]  A. Timperman,et al.  Fabrication and characterization of a fritless microfabricated electroosmotic pump with reduced pH dependence. , 2004, Analytical chemistry.

[5]  Brian J Kirby,et al.  Effects of ammonioalkyl sulfonate internal salts on electrokinetic micropump performance and reversed-phase high-performance liquid chromatographic separations. , 2003, Journal of chromatography. A.

[6]  A. Ajdari,et al.  Pumping liquids using asymmetric electrode arrays , 2000, Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics.

[7]  Yuxing Ben,et al.  Theoretical prediction of fast 3D AC electro-osmotic pumps. , 2006, Lab on a chip.

[8]  Phillip H. Paul,et al.  Electrokinetic Generation of High Pressures using Porous Microstructures , 1998 .

[9]  Eun Kyu Lee,et al.  Continuous dynamic flow micropumps for microfluid manipulation , 2007 .

[10]  Ping Wang,et al.  Electrokinetic micropump and micromixer design based on ac faradaic polarization , 2004 .

[11]  Qin Lu,et al.  High pressure electroosmotic pump based on a packed bed planar microchip , 2008 .

[12]  Juan G. Santiago,et al.  A planar electroosmotic micropump , 2002 .

[13]  Juan G. Santiago,et al.  High-pressure electroosmotic pumps based on porous polymer monoliths , 2004 .

[14]  J. Michael Ramsey,et al.  Integrated microchip device with electrokinetically controlled solvent mixing for isocratic and gradient elution in micellar electrokinetic chromatography , 1997 .

[15]  Shaorong Liu,et al.  Ion-Enrichment and Ion-Depletion Effect of Nanochannel Structures , 2004 .

[16]  Castellanos,et al.  AC Electric-Field-Induced Fluid Flow in Microelectrodes. , 1999, Journal of colloid and interface science.

[17]  M. Mpholo,et al.  Low voltage plug flow pumping using anisotropic electrode arrays , 2003 .

[18]  C. Friedrich,et al.  Macro porous silicon as pump media for electro‐osmotic pumps , 2007 .

[19]  Phillip H. Paul,et al.  Electrokinetic Pump Application in Micro-Total Analysis Systems Mechanical Actuation to HPLC , 2000 .

[20]  Jie Wu,et al.  ac electro-osmotic micropump by asymmetric electrode polarization , 2008 .

[21]  Purnendu K. Dasgupta,et al.  Flow-injection analysis in the capillary format using electroosmotic pumping , 1992 .

[22]  Hsueh-Chia Chang,et al.  A new electro-osmotic pump based on silica monoliths , 2006 .

[23]  Determination of nitrite by sequential injection analysis of electrokinetic flow analysis system. , 2002, Talanta.

[24]  M. Pikal,et al.  The role of electroosmotic flow in transdermal iontophoresis. , 1992, Advanced drug delivery reviews.

[25]  J. Santiago,et al.  Porous glass electroosmotic pumps: design and experiments. , 2003, Journal of colloid and interface science.

[26]  Markus Böhm,et al.  A programmable planar electroosmotic micropump for lab-on-a-chip applications , 2008 .

[27]  A. Rennie,et al.  Pumping of water with ac electric fields applied to asymmetric pairs of microelectrodes. , 2000, Physical review. E, Statistical, nonlinear, and soft matter physics.

[28]  Shaorong Liu,et al.  Electroosmotically pumped capillary format sequential injection analysis with a membrane sampling interface for gaseous analytes , 1995 .

[29]  J. Eijkel,et al.  An AC electroosmotic micropump for circular chromatographic applications. , 2004, Lab on a chip.

[30]  Paul C. H. Li,et al.  Transport, manipulation, and reaction of biological cells on-chip using electrokinetic effects. , 1997, Analytical chemistry.

[31]  G. Luo,et al.  Application of a high-pressure electro-osmotic pump using nanometer silica in capillary liquid chromatography. , 2005, Journal of chromatography. A.

[32]  Greg E Collins,et al.  Electroosmotic flow-based pump for liquid chromatography on a planar microchip. , 2008, Analytical chemistry.

[33]  L. Yang,et al.  Determination of chromium(VI) and lead(II) in drinking water by electrokinetic flow analysis system and graphite furnace atomic absorption spectrometry. , 2001, Talanta.

[34]  A. Ramos,et al.  Experiments on ac electrokinetic pumping of liquids using arrays of microelectrodes , 2005, IEEE International Conference on Dielectric Liquids, 2005. ICDL 2005..

[35]  Lingxin Chen,et al.  An electroosmotic pump for packed capillary liquid chromatography , 2003 .

[36]  Chi-Chuan Wang,et al.  Low-voltage electroosmotic pumping using porous anodic alumina membranes , 2008 .

[37]  Shaorong Liu,et al.  A simple means to increase absorbance detection sensitivity in capillary zone electrophoresis , 1993 .

[38]  Lingxin Chen,et al.  The microfabricated electrokinetic pump: a potential promising drug delivery technique , 2007, Expert opinion on drug delivery.

[39]  F. Prinz,et al.  Water Management at the Cathode of a Planar Air-Breathing Fuel Cell with an Electroosmotic Pump , 2006 .

[40]  Martin Z. Bazant,et al.  Fast ac electro-osmotic micropumps with nonplanar electrodes , 2006 .

[41]  Jörg P Kutter,et al.  Long-term stable electroosmotic pump with ion exchange membranes. , 2005, Lab on a chip.

[42]  Micro-flow injection analysis system: on-chip sample preconcentration, injection and delivery using coupled monolithic electroosmotic pumps. , 2007, Lab on a chip.

[43]  F. F. Reuss.  Sur un Nouvel Effet de l'electricite Galvanique , 1809 .

[44]  Iulia M Lazar,et al.  Microfluidic liquid chromatography system for proteomic applications and biomarker screening. , 2006, Analytical chemistry.

[45]  T. Kenny,et al.  Closed-loop electroosmotic microchannel cooling system for VLSI circuits , 2002 .

[46]  H. Zou,et al.  Monolithic stationary phases for liquid chromatography and capillary electrochromatography. , 2002, Journal of chromatography. A.

[47]  Mark N. Hamblin,et al.  Thin film electro-osmotic pumps for biomicrofluidic applications. , 2007, Biomicrofluidics.

[48]  Juan G. Santiago,et al.  Fabrication and characterization of electroosmotic micropumps , 2001 .

[49]  S. Litster,et al.  Active Water Management for PEM Fuel Cells , 2007 .

[50]  H. Helmholtz,et al.  Studien über electrische Grenzschichten , 1879 .

[51]  Andrew L. Zydney,et al.  Development of an electroosmotic pump for high performance actuation , 2006 .

[52]  P. Dasgupta,et al.  Sequential injection analysis in capillary format with an electroosmotic pump. , 1994, Talanta.

[53]  F. Švec,et al.  Capillary electrochromatography in anion-exchange and normal-phase mode using monolithic stationary phases. , 2001, Journal of chromatography. A.

[54]  James P Landers,et al.  A microchip-based proteolytic digestion system driven by electroosmotic pumping. , 2003, Lab on a chip.

[55]  H. Morgan,et al.  Pumping of liquids with ac voltages applied to asymmetric pairs of microelectrodes. , 2003, Physical review. E, Statistical, nonlinear, and soft matter physics.

[56]  Electroosmosis-based nanopipettor. , 2007, Analytical chemistry.

[57]  Jaromir Růžička,et al.  Flow injection analysis , 1981 .

[58]  B. E. Saltzman.  Colorimetric Microdetermination of Nitrogen Dioxide in Atmosphere , 1954 .

[59]  O. Guenat,et al.  Partial electroosmotic pumping in complex capillary systems: Part 1: Principles and general theoretical approach , 2001 .

[60]  Juan G. Santiago,et al.  Electroosmotic flow pumps with polymer frits , 2002 .

[61]  Suresh V. Garimella,et al.  Recent advances in microscale pumping technologies: a review and evaluation , 2008 .

[62]  Hua Xiao,et al.  Electrochromatographic evaluation of a silica monolith capillary column for separation of basic pharmaceuticals , 2005, Electrophoresis.

[63]  J. Miao,et al.  Micropumps Based on the Enhanced Electroosmotic Effect of Aluminum Oxide Membranes , 2007 .

[64]  Purnendu K. Dasgupta,et al.  Electroosmosis: A reliable fluid propulsion system for flow injection analysis , 1994 .

[65]  Lingxin Chen,et al.  Study of an electroosmotic pump for liquid delivery and its application in capillary column liquid chromatography. , 2004, Journal of chromatography. A.

[66]  Yvan Avenas,et al.  Optimization of High Flow Rate Nanoporous Electroosmotic Pump , 2008 .

[67]  Donald A. McQuarrie,et al.  Electrokinetic flow in a narrow cylindrical capillary , 1980 .

[68]  Juan G. Santiago,et al.  A review of micropumps , 2004 .

[69]  M. Macka,et al.  Robust monolithic silica-based on-chip electro-osmotic micro-pump. , 2007, The Analyst.

[70]  Lingxin Chen,et al.  Development of an Electroosmotic Pump Using Nanosilica Particle Packed Capillary , 2008, IEEE Sensors Journal.

[71]  M. Smoluchowski.  Versuch einer mathematischen Theorie der Koagulationskinetik kolloider Lösungen , 1918 .

[72]  Yafeng Guan,et al.  Generating high-pressure sub-microliter flow rate in packed microchannel by electroosmotic force: potential application in microfluidic systems , 2003 .

[73]  R. Aebersold,et al.  Nanoflow solvent gradient delivery from a microfabricated device for protein identifications by electrospray ionization mass spectrometry. , 1998, Analytical chemistry.

[74]  Electroosmotic Pumps Fabricated From Porous Silicon Membranes , 2004 .

[75]  Segyeong Joo,et al.  A rapid field-free electroosmotic micropump incorporating charged microchannel surfaces , 2007 .

[76]  A. Stemmer,et al.  Electro-osmotic streaming on application of traveling-wave electric fields. , 2004, Physical review. E, Statistical, nonlinear, and soft matter physics.

[77]  H. Morgan,et al.  Pumping of liquids with traveling-wave electroosmosis , 2005 .

[78]  F. Švec,et al.  Molded rigid polymer monoliths as separation media for capillary electrochromatography. , 1997, Analytical chemistry.

[79]  L. Yang,et al.  Mechanism of porous core electroosmotic pump flow injection system and its application to determination of chromium(VI) in waste-water. , 2000, Talanta.

[80]  T. Kubo,et al.  Preparation of glycerol dimethacrylate-based polymer monolith with unusual porous properties achieved via viscoelastic phase separation induced by monodisperse ultra high molecular weight poly(styrene) as a porogen. , 2006, Journal of chromatography. A.

[81]  S. Jacobson,et al.  Microchip device for performing enzyme assays. , 1997, Analytical chemistry.

[82]  Yuzuru Takamura,et al.  Low-Voltage Electroosmosis Pump and Its Application to on-Chip Linear Stepping Pneumatic Pressure Source , 2001 .

[83]  Y. Takamura,et al.  Low‐voltage electroosmosis pump for stand‐alone microfluidics devices , 2003, Electrophoresis.

[84]  S. Litster,et al.  Free Convection Direct Methanol Fuel Cells Powered by Electroosmotic Pumps , 2006 .

[85]  Peter Griess,et al.  Bemerkungen zu der Abhandlung der HH. Weselsky und Benedikt „Ueber einige Azoverbindungen” , 1879 .

[86]  Juan G. Santiago,et al.  High flow rate per power electroosmotic pumping using low ion density solvents , 2008 .

[87]  O. Guenat,et al.  Partial electroosmotic pumping in complex capillary systems: Part 2: Fabrication and application of a micro total analysis system (μTAS) suited for continuous volumetric nanotitrations , 2001 .

[88]  Juan G. Santiago,et al.  A Large Flowrate Electroosmotic Pump With Micron Pores , 2001, Micro-Electro-Mechanical Systems (MEMS).

[89]  Hsueh-Chia Chang,et al.  An electro-osmotic micro-pump based on monolithic silica for micro-flow analyses and electro-sprays , 2005, Analytical and bioanalytical chemistry.

[90]  Damian N. Burch,et al.  The effect of step height on the performance of three-dimensional ac electro-osmotic microfluidic pumps. , 2007, Journal of colloid and interface science.

[91]  V. Studer,et al.  An integrated AC electrokinetic pump in a microfluidic loop for fast and tunable flow control. , 2004, The Analyst.

[92]  V. Pretorius,et al.  Electro-osmosis: A new concept for high-speed liquid chromatography , 1974 .

[93]  Yafeng Guan,et al.  Fabrication and characterization of a multi-stage electroosmotic pump for liquid delivery , 2005 .

[94]  K. Nakanishi,et al.  Monolithic silica columns for high-efficiency chromatographic separations. , 2002, Journal of chromatography. A.

[95]  Qiaosheng Pu,et al.  Electric field-decoupled electroosmotic pump for microfluidic devices. , 2003, Journal of chromatography. A.