Real-Time Simultaneous Separation and Detection of Chemicals Using Integrated Microcolumn and Surface Plasmon Resonance Imaging Micro-GC

An integrated and miniaturized micro-gas chromatography (GC) with real-time imaging capability for simultaneous chemical separation and detection was developed. Surface plasmon resonance imaging (SPRi) was used as a sensitive and real-time imaging-based detector for various gaseous chemical mixtures, and good gas chromatographs were obtained. The system integrated a home-made miniaturized molecular sieve packed spiral microchannel column with the SPRi chip and real-time chemical separation and detection were demonstrated using alkanes. The chemical separation processes were simulated using COMSOL and matched well with the experimental results. The system enabled the study of chemical separation processes in real-time by miniaturizing and integrating the micro-GC separation and detection units. This approach can be expanded to multidimensional GC development.

[1]  Milan Vala,et al.  High-performance compact SPR sensor for multi-analyte sensing , 2010 .

[2]  Masoud Agah,et al.  Chip-scale gas chromatography: From injection through detection , 2015, Microsystems & Nanoengineering.

[3]  Hongyuan Chen,et al.  Plasmonic imaging and detection of single DNA molecules. , 2014, ACS nano.

[4]  Bong Hyun Chung,et al.  A new palm-sized surface plasmon resonance (SPR) biosensor based on modulation of a light source by a rotating mirror , 2010 .

[5]  Wei Wang,et al.  Plasmonic Imaging of Electrochemical Reactions of Single Nanoparticles. , 2016, Accounts of chemical research.

[6]  J. Gardea-Torresdey,et al.  Gas chromatography. , 2010, Analytical chemistry.

[7]  R. Zimmermann,et al.  Detection of gaseous compounds by needle trap sampling and direct thermal-desorption photoionization mass spectrometry: concept and demonstrative application to breath gas analysis. , 2015, Analytical chemistry.

[8]  R. Grieken,et al.  Atmospheric BTEX-concentrations in an area with intensive street traffic , 2009 .

[9]  Jesse A. Contreras,et al.  Hand-portable gas chromatograph-toroidal ion trap mass spectrometer (GC-TMS) for detection of hazardous compounds , 2008, Journal of the American Society for Mass Spectrometry.

[10]  Nongjian Tao,et al.  High resolution surface plasmon resonance spectroscopy , 1999 .

[11]  Shaopeng Wang,et al.  Imaging Local Electrochemical Current via Surface Plasmon Resonance , 2010, Science.

[12]  Yutao Qin,et al.  A fully electronic microfabricated gas chromatograph with complementary capacitive detectors for indoor pollutants , 2016, Microsystems & Nanoengineering.

[13]  A. Rodrigues,et al.  Adsorption equilibrium and kinetics of branched hexane isomers in pellets of BETA zeolite , 2005 .

[14]  A nanoparticle-coated chemiresistor array as a microscale gas chromatograph detector for explosive marker compounds: flow rate and temperature effects. , 2013, The Analyst.

[15]  Clement E. Furlong,et al.  A commercial solution for surface plasmon sensing , 1996 .

[16]  B. Smit.  Molecular simulations of the adsorption and diffusion of hydrocarbons in molecular sieves , 2007 .

[17]  W. HICKEL,et al.  Surface-plasmon microscopy , 1989, Nature.

[18]  R. Font,et al.  Chemical characterization of emissions from a municipal solid waste treatment plant. , 2014, Waste management.

[19]  W. Peng,et al.  Evaluation of polymer coatings for ammonia vapor sensing with surface plasmon resonance spectroscopy , 2010 .

[20]  M. Riekkola,et al.  Field measurements of biogenic volatile organic compounds in the atmosphere by dynamic solid-phase microextraction and portable gas chromatography-mass spectrometry , 2015 .

[21]  Peter Kauffman,et al.  Portable 24-analyte surface plasmon resonance instruments for rapid, versatile biodetection. , 2007, Biosensors & bioelectronics.

[22]  L. K. Wright,et al.  Microfabricated gas chromatograph for rapid, trace-level determinations of gas-phase explosive marker compounds. , 2014, Analytical chemistry.

[23]  Chia-Jung Lu,et al.  A multidimensional micro gas chromatograph employing a parallel separation multi-column chip and stop-flow μGC × μGCs configuration. , 2013, Lab on a chip.

[24]  B. Smit,et al.  Elucidating alkane adsorption in sodium-exchanged zeolites from molecular simulations to empirical equations , 2005 .

[25]  Cheng Chen,et al.  A Wireless Hybrid Chemical Sensor for Detection of Environmental Volatile Organic Compounds , 2013, IEEE Sensors Journal.

[26]  B. Liedberg,et al.  Surface plasmon resonance for gas detection and biosensing , 1983 .

[27]  A. Fadeev,et al.  Combined nitrogen, hexane, and benzene adsorption characterization of pores and surfaces of lyophobic mesoporous silicas. , 2014, Langmuir : the ACS journal of surfaces and colloids.

[28]  M. Fathizadeh,et al.  Adsorption of benzene from benzene/n-C6 and n-C7 mixture by nano Beta zeolite with different Si/Al ratios , 2014, Arabian Journal of Chemistry.