Developing Process Designs for Biorefineries—Definitions, Categories, and Unit Operations

In this review, we focus on the literature that described the various unit operations in a process design flowsheet of biorefineries. We begin by establishing the accepted definitions of a biorefinery, go on to describe how to categorize biorefineries, and finally review the literature on biorefinery process designs by listing the unit operation in each process design. Distinguishing biorefineries based on feedstock, the types of processing units, and the products emanating from the biorefinery are discussed.

[1]  A. Wardrop The structure of the cell wall in lignifield collenchyma of Eryngium sp. (Umbelliferae) , 1969 .

[2]  H. Wenzl,et al.  The Chemical Technology of Wood , 1970 .

[3]  R. Overend,et al.  Solvent Effects on Liquefaction: Solubilization Profiles of a Tropical Prototype Wood, Eucalyptus, in the Presence of Simple Alcohols, Ethylene Glycol, Water and Phenols , 1988 .

[4]  Anthony V. Bridgwater,et al.  Production costs of liquid fuels from biomass , 1991 .

[5]  Alexander N. Glazer,et al.  Microbial Biotechnology: Fundamentals of Applied Microbiology , 1995 .

[6]  J. E. Sells,et al.  Determining the Profitability of a Wholecrop Biorefinery , 1997 .

[7]  G. Zacchi,et al.  The generation of fermentation inhibitors during dilute acid hydrolysis of softwood , 1999 .

[8]  J. Parajó,et al.  Hydrothermal processing of lignocellulosic materials , 1999, Holz als Roh- und Werkstoff.

[9]  M. Ruth,et al.  Lignocellulosic Biomass to Ethanol Process Design and Economics Utilizing Co-Current Dilute Acid Prehydrolysis and Enzymatic Hydrolysis Current and Futuristic Scenarios , 1999 .

[10]  M. Dubé,et al.  Biodiesel production from waste cooking oil: 1. Process design and technological assessment. , 2003, Bioresource technology.

[11]  M. Dubé,et al.  Biodiesel production from waste cooking oil: 2. Economic assessment and sensitivity analysis. , 2003, Bioresource technology.

[12]  Bruce E. Dale,et al.  'Greening' the chemical industry: Research and development priorities for biobased industrial products , 2003 .

[13]  R. Bothast,et al.  Biotechnological processes for conversion of corn into ethanol , 2005, Applied Microbiology and Biotechnology.

[14]  Johnathan E. Holladay,et al.  Top Value Added Chemicals From Biomass. Volume 1 - Results of Screening for Potential Candidates From Sugars and Synthesis Gas , 2004 .

[15]  B. Wachter,et al.  The Green Biorefinery Austria: Development of an integrated system for green biomass utilization , 2004 .

[16]  Niels Bohrs,et al.  Manufacturing of Stabilised Brown Juice for L-lysine production - from University Lab Scale over Pilot Scale to Industrial Production. , 2004 .

[17]  Birgit Kamm,et al.  Biorefineries – Industrial Processes and Products , 2005 .

[18]  D. Johnson,et al.  Strategic Biorefinery Analysis: Analysis of Biorefineries , 2005 .

[19]  P. M. Pelagagge,et al.  Economics of biomass energy utilization in combustion and gasification plants: effects of logistic variables , 2005 .

[20]  C. Wyman,et al.  Features of promising technologies for pretreatment of lignocellulosic biomass. , 2005, Bioresource technology.

[21]  N. Jacobsen Industrial Symbiosis in Kalundborg, Denmark: A Quantitative Assessment of Economic and Environmental Aspects , 2006 .

[22]  Colin Webb,et al.  A whole crop biorefinery system: A closed system for the manufacture of non-food products from cereals. , 2006 .

[23]  Shiro Saka,et al.  Bioconversion of hybrid poplar to ethanol and co‐products using an organosolv fractionation process: Optimization of process yields , 2006, Biotechnology and bioengineering.

[24]  T. Ezeji,et al.  Production of acetone butanol (AB) from liquefied corn starch, a commercial substrate, using Clostridium beijerinckii coupled with product recovery by gas stripping , 2007, Journal of Industrial Microbiology & Biotechnology.

[25]  L. Verchot,et al.  Jatropha biodiesel fueling sustainability? , 2007 .

[26]  B. Kamm,et al.  Biorefineries--multi product processes. , 2007, Advances in biochemical engineering/biotechnology.

[27]  M. Galbe,et al.  Process engineering economics of bioethanol production. , 2007, Advances in biochemical engineering/biotechnology.

[28]  David K. Johnson,et al.  Top Value-Added Chemicals from Biomass - Volume II—Results of Screening for Potential Candidates from Biorefinery Lignin , 2007 .

[29]  S. Duff,et al.  A kinetic model for production of glucose by hydrolysis of levoglucosan and cellobiosan from pyrolysis oil. , 2007, Carbohydrate research.

[30]  许旱峤,et al.  Kirk-Othmer Encyclopedia of Chemical Technology数据库介绍及实例 , 2007 .

[31]  Charles Jackson,et al.  Toward an integrated straw‐based biorefinery , 2007 .

[32]  Chih-Chung Lin,et al.  An analysis of biodiesel fuel from waste edible oil in Taiwan , 2007 .

[33]  J. R. Hess,et al.  Cellulosic biomass feedstocks and logistics for ethanol production , 2007 .

[34]  Wei Yuan,et al.  Optimal biorefinery product allocation by combining process and economic modeling , 2008 .

[35]  Subhash Bhatia,et al.  Catalytic processes towards the production of biofuels in a palm oil and oil palm biomass-based biorefinery. , 2008, Bioresource technology.

[36]  E. Gnansounou,et al.  Techno-economic and environmental evaluation of lignocellulosic biochemical refineries : need for a modular platform for integrated assessment (MPIA) , 2008 .

[37]  Wallace E. Tyner,et al.  The US Ethanol and Biofuels Boom: Its Origins, Current Status, and Future Prospects , 2008 .

[38]  M. Taherzadeh,et al.  Pretreatment of Lignocellulosic Wastes to Improve Ethanol and Biogas Production: A Review , 2008, International journal of molecular sciences.

[39]  P. Kaparaju,et al.  Bioethanol, biohydrogen and biogas production from wheat straw in a biorefinery concept. , 2009, Bioresource technology.

[40]  S. Stournas,et al.  Transesterification of Vegetable Oils with Ethanol and Characterization of the Key Fuel Properties of Ethyl Esters , 2009 .

[41]  Nilay Shah,et al.  Multiscale modelling of hydrothermal biomass pretreatment for chip size optimization. , 2009, Bioresource technology.

[42]  Bruce E. Dale,et al.  Projected mature technology scenarios for conversion of cellulosic biomass to ethanol with coproduction thermochemical fuels, power, and/or animal feed protein , 2009 .

[43]  Nickolas J. Themelis,et al.  Technical and Economic Analysis of Pre-Shredding Municipal Solid Wastes Prior to Disposal , 2009 .

[44]  M. H. Thomsen,et al.  Identification and characterization of fermentation inhibitors formed during hydrothermal treatment and following SSF of wheat straw , 2009, Applied Microbiology and Biotechnology.

[45]  Kj Krzysztof Ptasinski,et al.  Exergetic evaluation of 5 biowastes-to-biofuels routes via gasification , 2010 .

[46]  Jamie Stephen,et al.  The impact of agricultural residue yield range on the delivered cost to a biorefinery in the Peace River region of Alberta, Canada , 2010 .

[47]  Francesco Cherubini,et al.  The biorefinery concept: Using biomass instead of oil for producing energy and chemicals , 2010 .

[48]  Solange I. Mussatto,et al.  Lignocellulose as raw material in fermentation processes , 2010 .

[49]  Amit Kumar,et al.  Large-scale biohydrogen production from bio-oil. , 2010, Bioresource technology.

[50]  Gjalt Huppes,et al.  Biorefining of lignocellulosic feedstock--Technical, economic and environmental considerations. , 2010, Bioresource technology.

[51]  Prasant Kumar Rout,et al.  Production of first and second generation biofuels: A comprehensive review , 2010 .

[52]  Ayhan Demirbas,et al.  Biorefinery Technologies for Biomass Upgrading , 2010 .

[53]  Daren E. Daugaard,et al.  Techno-Economic Analysis of Biomass Fast Pyrolysis to Transportation Fuels , 2010 .

[54]  Aidong Yang,et al.  On the use of systems technologies and a systematic approach for the synthesis and the design of future biorefineries , 2010, Comput. Chem. Eng..

[55]  L. F. M. Marton,et al.  Biomass Refinery as a Renewable Complement to the Petroleum Refinery , 2010 .

[56]  Philip Owende,et al.  Biofuels from microalgae—A review of technologies for production, processing, and extractions of biofuels and co-products , 2010 .

[57]  Joseph J. Bozell,et al.  Technology development for the production of biobased products from biorefinery carbohydrates—the US Department of Energy’s “Top 10” revisited , 2010 .

[58]  Michael Taylor,et al.  An overview of second generation biofuel technologies. , 2010, Bioresource technology.

[59]  Abhijit Dutta,et al.  Techno-Economic Analysis of Biochemical Scenarios for Production of Cellulosic Ethanol , 2010 .

[60]  Francesco Cherubini,et al.  LCA of a biorefinery concept producing bioethanol, bioenergy, and chemicals from switchgrass , 2010 .

[61]  Blake A. Simmons,et al.  Techno‐economic analysis of a lignocellulosic ethanol biorefinery with ionic liquid pre‐treatment , 2011 .

[62]  Xiaohui Xu,et al.  Hydrogen and methane production from lipid-extracted microalgal biomass residues , 2011 .

[63]  Denny K. S. Ng,et al.  Fuzzy Optimization Approach for the Synthesis of a Sustainable Integrated Biorefinery , 2011 .

[64]  José A. Romagnoli,et al.  A decision support tool for strategic planning of sustainable biorefineries , 2011, Comput. Chem. Eng..

[65]  Kamal Abdel Radi Ismail,et al.  Energy and environmental potential of solid waste in Brazil , 2011 .

[66]  Jo‐Shu Chang,et al.  Cultivation, photobioreactor design and harvesting of microalgae for biodiesel production: a critical review. , 2011, Bioresource technology.

[67]  Amit Kumar,et al.  Biofuels and biochemicals production from forest biomass in Western Canada , 2011 .

[68]  Julian R.H. Ross,et al.  Catalysis for conversion of biomass to fuels via pyrolysis and gasification: A review , 2011 .

[69]  Mahmoud M. El-Halwagi,et al.  A shortcut method for the preliminary synthesis of process-technology pathways: An optimization approach and application for the conceptual design of integrated biorefineries , 2011, Comput. Chem. Eng..

[70]  L. Lynd,et al.  High Ethanol Titers from Cellulose by Using Metabolically Engineered Thermophilic, Anaerobic Microbes , 2011, Applied and Environmental Microbiology.

[71]  Kefa Cen,et al.  Cogeneration of hydrogen and methane from Arthrospira maxima biomass with bacteria domestication and , 2011 .

[72]  Siglinda Perathoner,et al.  Analysis of the alternative routes in the catalytic transformation of lignocellulosic materials , 2011 .

[73]  A. Stromman,et al.  Principles of Biorefining , 2011 .

[74]  Ryan Davis,et al.  Process Design and Economics for Biochemical Conversion of Lignocellulosic Biomass to Ethanol: Dilute-Acid Pretreatment and Enzymatic Hydrolysis of Corn Stover , 2011 .

[75]  Theodoros Damartzis,et al.  Thermochemical conversion of biomass to second generation biofuels through integrated process design—A review , 2011 .

[76]  Mahmoud M. El-Halwagi,et al.  A comparison of pretreatment methods for bioethanol production from lignocellulosic materials , 2012 .

[77]  Amit Kumar,et al.  Techno-economic assessment of triticale straw for power generation , 2012 .

[78]  N. H. Ravindranath,et al.  Jatropha cultivation in southern India: assessing farmers' experiences , 2012 .

[79]  Abhijit Sarkar,et al.  Comparative economic assessment of ABE fermentation based on cellulosic and non-cellulosic feedstocks , 2012 .

[80]  M. B. Silva,et al.  The realm of cellulases in biorefinery development , 2012, Critical reviews in biotechnology.

[81]  Paul C. Struik,et al.  II. Economic assessment for first generation green biorefinery (GBR): Scenarios for an Irish GBR blueprint , 2012 .

[82]  Mahmoud M. El-Halwagi,et al.  Process synthesis and optimization of biorefinery configurations , 2012 .

[83]  Paul Chen,et al.  Hydrothermal pretreatment of microalgae for production of pyrolytic bio-oil with a low nitrogen content. , 2012, Bioresource technology.

[84]  Heinz A. Preisig,et al.  Thinking towards synergistic green refineries , 2012 .

[85]  Kyung A Jung,et al.  Potentials of macroalgae as feedstocks for biorefinery. , 2013, Bioresource technology.

[86]  Yebo Li,et al.  Solid state anaerobic co-digestion of yard waste and food waste for biogas production. , 2013, Bioresource technology.

[87]  Mahmoud M El-Halwagi,et al.  Techno-economic analysis for a sugarcane biorefinery: Colombian case. , 2013, Bioresource technology.

[88]  Susanne B. Jones,et al.  Techno-economic analysis of corn stover fungal fermentation to ethanol , 2013 .

[89]  Christodoulos A. Floudas,et al.  Biomass and Natural Gas to Liquid Transportation Fuels: Process Synthesis, Global Optimization, and Topology Analysis , 2013 .

[90]  Carlos A. Cardona,et al.  Selection of Process Pathways for Biorefinery Design Using Optimization Tools: A Colombian Case for Conversion of Sugarcane Bagasse to Ethanol, Poly-3-hydroxybutyrate (PHB), and Energy , 2013 .

[91]  Jonathan Moncada,et al.  Techno-economic analysis of bioethanol production from lignocellulosic residues in Colombia: a process simulation approach. , 2013, Bioresource technology.

[92]  N. Qureshi,et al.  An economic evaluation of biological conversion of wheat straw to butanol: A biofuel , 2013 .

[93]  Pedro Haro,et al.  Bio-syngas to gasoline and olefins via DME – A comprehensive techno-economic assessment , 2013 .

[94]  Anna Ekman,et al.  Bioresource utilisation by sustainable technologies in new value-added biorefinery concepts - two case studies from food and forest industry , 2013 .

[95]  Abhijit Dutta,et al.  Process Design and Economics for the Conversion of Lignocellulosic Biomass to Hydrocarbon Fuels: Fast Pyrolysis and Hydrotreating Bio-Oil Pathway , 2013 .

[96]  Rene H Wijffels,et al.  Biorefinery of microalgae for food and fuel. , 2013, Bioresource technology.

[97]  Frank Schultmann,et al.  Comprehensive techno-economic assessment of dimethyl ether (DME) synthesis and Fischer–Tropsch synthesis as alternative process steps within biomass-to-liquid production , 2013 .

[98]  Kefa Cen,et al.  Comparison in dark hydrogen fermentation followed by photo hydrogen fermentation and methanogenesis between protein and carbohydrate compositions in Nannochloropsis oceanica biomass. , 2013, Bioresource technology.

[99]  Mahmoud M. El-Halwagi,et al.  Integrated Biorefineries : Design, Analysis, and Optimization , 2013 .

[100]  Rubens Maciel Filho,et al.  Butanol production in a first-generation Brazilian sugarcane biorefinery: technical aspects and economics of greenfield projects. , 2013, Bioresource technology.

[101]  R. Sheldon Green and sustainable manufacture of chemicals from biomass: state of the art , 2014 .

[102]  Ryan Davis,et al.  NREL 2012 Achievement of Ethanol Cost Targets: Biochemical Ethanol Fermentation via Dilute-Acid Pretreatment and Enzymatic Hydrolysis of Corn Stover , 2014 .

[103]  Xiaoyu Tang,et al.  Bamboo: a new source of carbohydrate for biorefinery. , 2014, Carbohydrate polymers.

[104]  Carlos A. Cardona,et al.  Integrating first, second, and third generation biorefineries: Incorporating microalgae into the sugarcane biorefinery , 2014 .

[105]  Electo Eduardo Silva Lora,et al.  Techno-economic analysis and environmental impact assessment of energy recovery from Municipal Solid Waste (MSW) in Brazil , 2014 .

[106]  Mohammad J. Taherzadeh,et al.  Uncertainty over techno-economic potentials of biogas from municipal solid waste (MSW): A case study on an industrial process , 2014 .

[107]  Julie B Zimmerman,et al.  Evaluating microalgal integrated biorefinery schemes: empirical controlled growth studies and life cycle assessment. , 2014, Bioresource technology.

[108]  T. Tan,et al.  Reviewing the anaerobic digestion of food waste for biogas production , 2014 .

[109]  P. Daoutidis,et al.  Process synthesis of biorefineries: Optimization of biomass conversion to fuels and chemicals , 2014 .

[110]  Antonis C. Kokossis,et al.  Integrated Designs of Microalgae Biorefineries Using a Fixed Selection of Halophytic Algae , 2014 .

[111]  Largus T. Angenent,et al.  Techno-economic assessment of biomass slow pyrolysis into different biochar and methanol concepts , 2014 .

[112]  Ryan Davis,et al.  Process Design and Economics for the Conversion of Algal Biomass to Biofuels: Algal Biomass Fractionation to Lipid- and Carbohydrate-Derived Fuel Products , 2014 .

[113]  Zsófia Kádár,et al.  Chemical characterization and hydrothermal pretreatment of Salicornia bigelovii straw for enhanced enzymatic hydrolysis and bioethanol potential. , 2014, Bioresource technology.

[114]  J. Parajó,et al.  Optimization of corn stover biorefinery for coproduction of oligomers and second generation bioethanol using non-isothermal autohydrolysis , 2014 .

[115]  G. Bochmann,et al.  Pretreatment of feedstock for enhanced biogas production , 2014 .

[116]  Yuqing Su,et al.  An overview of biofuels policies and industrialization in the major biofuel producing countries , 2015 .

[117]  Abhijit Dutta,et al.  Process Design and Economics for the Conversion of Lignocellulosic Biomass to Hydrocarbon Fuels: Thermochemical Research Pathways with In Situ and Ex Situ Upgrading of Fast Pyrolysis Vapors , 2015 .

[118]  Rafiqul Gani,et al.  Process synthesis, design and analysis using a process-group contribution method , 2015, Comput. Chem. Eng..

[119]  S. Papanikolaou,et al.  Integrated sunflower-based biorefinery for the production of antioxidants, protein isolate and poly(3-hydroxybutyrate) , 2015 .

[120]  Jailani Salihon,et al.  Case study for a palm biomass biorefinery utilizing renewable non-food sugars from oil palm frond for the production of poly(3-hydroxybutyrate) bioplastic , 2015 .

[121]  Krist V. Gernaey,et al.  Upgrading of lignocellulosic biorefinery to value-added chemicals: Sustainability and economics of bioethanol-derivatives , 2015 .

[122]  M. Kircher,et al.  Sustainability of biofuels and renewable chemicals production from biomass. , 2015, Current opinion in chemical biology.

[123]  Mohammed Abdul Raqeeb,et al.  Biodiesel production from waste cooking oil , 2015 .

[124]  Mary J. Biddy,et al.  Process Design and Economics for the Conversion of Lignocellulosic Biomass to Hydrocarbons via Indirect Liquefaction. Thermochemical Research Pathway to High-Octane Gasoline Blendstock Through Methanol/Dimethyl Ether Intermediates , 2015 .

[125]  Jegannathan Kenthorai Raman,et al.  Furfural production from empty fruit bunch - A biorefinery approach , 2015 .

[126]  Liandong Zhu,et al.  Biorefinery as a promising approach to promote microalgae industry: An innovative framework , 2015 .

[127]  F. Huber,et al.  Wheat bran biorefinery--an insight into the process chain for the production of lactic acid. , 2015, Bioresource technology.

[128]  Jun Fang,et al.  Techno-economic evaluation of a combined bioprocess for fermentative hydrogen production from food waste. , 2016, Bioresource technology.

[129]  Moktar Hamdi,et al.  Potential of Tunisian Alfa (Stipa tenassicima) fibers for energy recovery to 2G bioethanol: Study of pretreatment, enzymatic saccharification and fermentation , 2016 .

[130]  Christopher J. Scarlata,et al.  Chemicals from Biomass: A Market Assessment of Bioproducts with Near-Term Potential , 2016 .

[131]  George Stephanopoulos,et al.  Optimization of Lignocellulosic Waste Biorefinery using Multi-Actor Multi-Objective Mathematical Framework , 2016 .

[132]  Wei-Cheng Wang,et al.  Techno-economic analysis of a bio-refinery process for producing Hydro-processed Renewable Jet fuel from Jatropha , 2016 .

[133]  Charlotte K. Williams,et al.  Techno-economic assessment of the production of phthalic anhydride from corn stover , 2016 .

[134]  P. Westermann,et al.  Fermentative production of butyric acid from wheat straw: Economic evaluation , 2017 .

[135]  Arturo Sánchez,et al.  Lignocellulosic n-butanol co-production in an advanced biorefinery using mixed cultures , 2017 .

[136]  Onur Onel,et al.  Municipal solid waste to liquid transportation fuels, olefins, and aromatics: Process synthesis and deterministic global optimization , 2017, Comput. Chem. Eng..

[137]  Martin Koller,et al.  Techno-economic feasibility of waste biorefinery: Using slaughtering waste streams as starting material for biopolyester production. , 2017, Waste management.

[138]  Jianming Yu,et al.  Integrated bioethanol production from mixtures of corn and corn stover. , 2018, Bioresource technology.

[139]  D. Macfarlane,et al.  Process design and techno-economic analysis of an integrated mango processing waste biorefinery , 2018, Industrial Crops and Products.

[140]  Myung-Oh Jang,et al.  Techno-economic analysis of butanol production from lignocellulosic biomass by concentrated acid pretreatment and hydrolysis plus continuous fermentation , 2018, Biochemical Engineering Journal.

[141]  D. Pleissner,et al.  Technical and economic assessment of food waste valorization through a biorefinery chain , 2018, Renewable and Sustainable Energy Reviews.

[142]  Zhaoyang Yuan,et al.  Evaluation of an organosolv-based biorefinery process to fractionate wheat straw into ethanol and co-products , 2018, Industrial Crops and Products.

[143]  Beatriz Molinuevo-Salces,et al.  Biogas potential of green biomass after protein extraction in an organic biorefinery concept for feed, fuel and fertilizer production , 2017, Renewable Energy.

[144]  Eulogio Castro,et al.  Engineering aspects of hydrothermal pretreatment: From batch to continuous operation, scale-up and pilot reactor under biorefinery concept. , 2019, Bioresource technology.

[145]  Lignin , 2020, Springer Series on Polymer and Composite Materials.