Plasma haemoglobin concentrations and other influx variables in blood in connection with transurethral resection of the prostate using distilled water as an irrigating fluid.

Eight patients undergoing transurethral resection of the prostate (TURP) using sterile distilled water as an irrigating fluid were studied. The concentrations of plasma haemoglobin, serum sodium, serum prostatic acid phosphatase protein (PAP) and plasma osmolality were determined as possible indicators of absorption of irrigating fluid. In 3 patients there was a marked increase in plasma haemoglobin immediately postoperatively with a maximum of 3.3 g haemoglobin/l plasma. In the remaining 5 patients the plasma haemoglobin level did not exceed 0.7 g/l immediately postoperatively. In all cases there was a fairly rapid return of the elevated plasma haemoglobin level to preoperative values. There was also a postoperative increase in the serum PAP level which was not correlated with the simultaneous increase in plasma haemoglobin concentration. There was no significant change in the sodium, potassium or albumin concentration in serum nor in plasma osmolality postoperatively. There was some decrease in the postoperative serum creatinine and uric acid levels. The preoperative serum creatinine concentration was within reference limits in 7 patients and borderline high in 1 patient. The haemoglobin binding plasma protein haptoglobin showed a slight non-significant increase immediately postoperatively and a significant decrease in concentration 2 hours postoperatively. The mean plasma haemoglobin concentration immediately postoperatively did not exceed the mean preoperative haemoglobin binding capacity of serum. The mean preoperative haemoglobin binding capacity was 1.2 g/l and the mean plasma haemoglobin level was 1.2 g/l immediately postoperatively. Two hours later the mean plasma haemoglobin level was 0.8 g/l. The mean serum haptoglobin concentration was 2.4 g/l preoperatively, 2.6 g/l immediately postoperatively and 2.0 g/l 2 hours later.(ABSTRACT TRUNCATED AT 250 WORDS)

[1]  L. Allgén,et al.  Sorbitol concentrations in plasma in connection with transurethral resection of the prostate using sorbitol solution as an irrigating fluid. , 1986, Scandinavian journal of urology and nephrology.

[2]  R. Bendz,et al.  Influence of various irrigation fluids on serum enzyme patterns following transurethral resection of the prostate. , 1986, Scandinavian journal of urology and nephrology.

[3]  E. Vinnars,et al.  Glycine solution as an irrigating agent during transurethral prostatic resection. Glycine concentrations in blood plasma. , 1986, Scandinavian journal of urology and nephrology.

[4]  R. Kahnoski,et al.  Transurethral prostatic resection syndrome--a new perspective: encephalopathy with associated hyperammonemia. , 1983, The Journal of urology.

[5]  G. A. Rose,et al.  Hyperoxaluria following glycine irrigation for transurethral prostatectomy. , 1981, British journal of urology.

[6]  S. Reiz,et al.  Non‐Cardiogenic Pulmonary Oedema. A Serious Complication of Transurethral Prostatectomy. A Case Report , 1981, Acta anaesthesiologica Scandinavica.

[7]  K. Korttila,et al.  Comparison of Laryngotracheal and Ultrasonic Nebulizer Administration of Lidocaine in Local Anaesthesia for Bronchoscopy , 1981, Acta anaesthesiologica Scandinavica.

[8]  E. Gomperts,et al.  Hemolytic-uremic syndrome. , 1972, The Journal of pediatrics.

[9]  U. Muller-eberhard,et al.  Quantitative determination of hemoglobin and cytochemical staining for peroxidase using 3,3',5,5'-tetramethylbenzidine dihydrochloride, a safe substitute for benzidine. , 1979, Analytical biochemistry.

[10]  U. Stams,et al.  [Hemolysis in not the cause of the TUR-syndrome. The use of non-hemolytic solutions does not prevent its occurrence (author's transl)]. , 1975, Der Urologe (Ausg. A).

[11]  P. Byé.  The utilization and metabolism of intravenous sorbitol , 1969, British Journal of Surgery.

[12]  H. Bunn,et al.  THE RENAL HANDLING OF HEMOGLOBIN , 1969, The Journal of experimental medicine.

[13]  E. Gabrieli,et al.  Plasma hemoglobin clearance: a clinical study. , 1966, Journal of the Reticuloendothelial Society.

[14]  Madsen Po,et al.  Clinical and experimental evaluation of different irrigating fluids for transurethral surgery. , 1965, Investigative urology.

[15]  N. Shock,et al.  The glomerular clearance and renal transport of hemoglobin in adult males. , 1961, The Journal of clinical investigation.

[16]  B. Davis,et al.  The demonstration and localization of renal tubular reabosorption of hemoglobin by stop flow analysis. , 1960, The Journal of clinical investigation.

[17]  J. Owen,et al.  A SIMPLE METHOD FOR THE DETERMINATION OF SERUM HAPTOGLOBINS , 1960, Journal of clinical pathology.

[18]  W. Lathem.  The renal excretion of hemoglobin: regulatory mechanisms and the differential excretion of free and protein-bound hemoglobin. , 1959, The Journal of clinical investigation.

[19]  M. Nyman,et al.  Studies on the serum haptoglobin level in hemoglobinemia and its influence on renal excretion of hemoglobin. , 1957, Blood.

[20]  J. Robison,et al.  Dilutional hyponatremic shock: another concept of the transurethral prostatic resection reaction. , 1956, The Journal of urology.

[21]  A. Steck,et al.  [Hemolytic-uremic syndrome: bilateral necrosis of the renal cortex in acute acquired hemolytic anemia]. , 1955, Schweizerische medizinische Wochenschrift.

[22]  R. Hagstrom,et al.  Studies on fluid absorption during transurethral prostatic resection. , 1955, The Journal of urology.

[23]  L. M. Woodruff,et al.  Hemoglobinemia and hemoglobinuric nephrosis complicating transurethral resection of the prostate. , 1949, Journal of Urology.

[24]  C. D. Creevy.  Hemolytic reactions during transurethral prostatic resection. , 1947, The Journal of urology.

[25]  Webb Ea,et al.  A fatal hemolytic reaction following transurethral resection of the prostate gland; a discussion of its prevention and treatment. , 1947 .

[26]  Homer W. Smith,et al.  RENAL EXCRETION OF HEXITOLS (SORBITOL, MANNITOL, AND DULCITOL) AND THEIR DERIVATIVES (SORBITAN, ISOMANNIDE, AND SORBIDE) AND OF ENDOGENOUS CREATININE-LIKE CHROMOGEN IN DOG AND MAN , 1940 .