Exposure to metal mixtures and human health impacts in a contaminated area in Nanning, China.

Cadmium and lead have been identified as very toxic metals, which are widely present in the environment due to natural and anthropogenic emissions. Many studies have shown that the food chain is the main pathway of cadmium and lead transfer from the environment to humans. It is well documented that many factors will affect their transfer through food chains. Previous investigations on heavy metals were mostly concentrated on one contaminant in isolation. However, in real environments, exposure to mixtures of metals is ubiquitous such that cadmium pollution is invariably being associated with lead and zinc, etc. This study focuses on the contamination and health effects of the metal mixtures. For this purpose, a dietary survey was taken for 3 groups in Nanning in October 2002. Samples of soils, plants (vegetables), urine and blood of humans were measured for Cd, Fe, Cu, Zn, Ca and Pb, in addition, the urinary indicators of renal dysfunction Albumin (ALB), N-acetyl-beta-D-glucosaminidase (NAG), Beta-2-microglobulin (beta2-MG) and Retinol-binding protein (RBP) in urine were also measured. Results showed that soil contamination with metal mixtures had caused significant renal dysfunction of the local residents living in the contaminated area, and the dose-response curve was somewhat altered by the mixed contamination of Cd and Pb as well as the intake of other minerals. The importance of mixtures of metal contamination and human health are also discussed in this paper.

[1]  W. Gao,et al.  Background lead and cadmium exposure of adult women in Xian City and two farming villages in Shaanxi Province, China. , 2000, The Science of the total environment.

[2]  Zhang Wenhua,et al.  Cadmium exposure and health effects among residents in an irrigation area with ore dressing wastewater , 1990 .

[3]  M. Nordberg,et al.  Cadmium biomonitoring and renal dysfunction among a population environmentally exposed to cadmium from smelting in China (ChinaCad) , 2002, Biometals.

[4]  Mike J. McLaughlin,et al.  Metals and micronutrients – food safety issues , 1999 .

[5]  Leticia Carrizales,et al.  Overview of human health and chemical mixtures: problems facing developing countries. , 2002, Environmental health perspectives.

[6]  H. Kay.  Environmental Health Criteria , 1980 .

[7]  R. Chaney,et al.  Interactions of plant zinc and plant species on the bioavailability of plant cadmium to Japanese quail fed lettuce and spinach. , 1992, Environmental research.

[8]  M. Fox.  Nutritional Factors that May Influence Bioavailability of Cadmium , 1988 .

[9]  Zhineng Hu,et al.  Cadmium exposure and health effects among residents in an irrigation area with ore dressing wastewater. , 1990, The Science of the total environment.

[10]  N. Pedersen,et al.  Variation in blood concentrations of cadmium and lead in the elderly. , 1999, Environmental research.

[11]  J. Staessen,et al.  Impact of environmental cadmium pollution on cadmium exposure and body burden. , 1992, Archives of environmental health.

[12]  S. Skerfving,et al.  Cadmium in blood and urine--impact of sex, age, dietary intake, iron status, and former smoking--association of renal effects. , 2002, Environmental health perspectives.

[13]  T. W. Speir,et al.  Review: A bioavailability-based rationale for controlling metal and metalloid contamination of agricultural land in Australia and New Zealand , 2000 .

[14]  Yu-Jing Cui,et al.  Transfer of metals from soil to vegetables in an area near a smelter in Nanning, China. , 2004, Environment international.

[15]  R. Goyer,et al.  Toxic and essential metal interactions. , 1997, Annual review of nutrition.

[16]  G. Nordberg,et al.  Renal dysfunction from cadmium contamination of irrigation water: dose-response analysis in a Chinese population. , 1998, Bulletin of the World Health Organization.

[17]  Raymond S H Yang,et al.  Chemical mixtures research: significance and future perspectives. , 2002, Environmental health perspectives.

[18]  E. Smolders.  Cadmium uptake by plants. , 2001, International journal of occupational medicine and environmental health.

[19]  M. Ishizaki,et al.  A dose-response analysis of cadmium in the general environment with special reference to total cadmium intake limit. , 1989, Environmental research.

[20]  L Järup,et al.  Health effects of cadmium exposure--a review of the literature and a risk estimate. , 1998, Scandinavian journal of work, environment & health.

[21]  J. Domingo,et al.  Levels of metals in soils of Alcalá de Henares, Spain: human health risks. , 2002, Environment international.

[22]  A. Whittemore,et al.  Urinary cadmium and blood pressure: results from the NHANES II survey. , 1991, Environmental health perspectives.

[23]  H. Teranishi,et al.  Renal tubular dysfunction in male inhabitants of a cadmium-polluted area in Toyama, Japan--an eleven-year follow-up study. , 2001, Journal of epidemiology.

[24]  G. Nordberg,et al.  Biological monitoring of cadmium exposure and renal effects in a population group residing in a polluted area in China. , 1997, The Science of the total environment.

[25]  L. Teppo,et al.  Health effects of cadmium exposure - a review of the literature and a risk estimate , 1998 .

[26]  P. G. Reeves,et al.  Mineral status of female rats affects the absorption and organ distribution of dietary cadmium derived from edible sunflower kernels (Helianthus annuus L.). , 2001, Environmental research.

[27]  M. Ikeda,et al.  Urban-rural comparison on cadmium exposure among general populations in Shandong Province, China. , 1998, The Science of the total environment.

[28]  Leticia Carrizales,et al.  Overview of human health and chemical mixtures: problems facing developing countries. , 2002 .