Why study diapause?

This review highlights a number of reasons why insect diapause merits attention. Knowledge of diapause is essential for understanding the seasonal biology of an insect species, and such information is also required for the development of effective pest management strategies; manipulating domesticated species used in pollination and silk production; developing accurate predictive models used to forecast periods of pest abundance; and increasing the shelf‐life of parasitoids and predatory mites used in the biological control industry. Mechanisms used by diapausing insects to survive low temperature may provide tips for cryopreserving insect stocks, a vital need within the research community. Diapause also presents an interesting model for probing fundamental questions in development, and we are indebted to diapause studies for early insights into insect hormones. In addition, I argue that insect diapause may provide insights into questions on aging, obesity and disease transmission, and diapausing insects offer a potentially rich source of pharmaceutical agents that may contribute to improvement of human health.

[1]  D. Denlinger,et al.  Diapause hormone in the corn earworm, Helicoverpa zea: Optimum temperature for activity, structure–activity relationships, and efficacy in accelerating flesh fly pupariation , 2008, Peptides.

[2]  D. Denlinger,et al.  High temperature and hexane break pupal diapause in the flesh fly, Sarcophaga crassipalpis, by activating ERK/MAPK. , 2007, Journal of insect physiology.

[3]  Stuart K. Kim Proteins That Promote Long Life , 2007, Science.

[4]  D. Denlinger,et al.  Meeting the energetic demands of insect diapause: nutrient storage and utilization. , 2007, Journal of insect physiology.

[5]  D. Denlinger,et al.  Up-regulation of heat shock proteins is essential for cold survival during insect diapause , 2007, Proceedings of the National Academy of Sciences.

[6]  C. Kyriacou,et al.  Natural Selection Favors a Newly Derived timeless Allele in Drosophila melanogaster , 2007, Science.

[7]  C. Kyriacou,et al.  A Molecular Basis for Natural Selection at the timeless Locus in Drosophila melanogaster , 2007, Science.

[8]  R. Leopold Colony Maintenance and Mass-Rearing: Using Cold Storage Technology for Extending the Shelf-Life of Insects , 2007 .

[9]  T. Yamashita,et al.  A Palmitonyl Conjugate of an Insect Pentapeptide Causes Growth Arrest in Mammalian Cells and Mimics the Action of Diapause Hormone , 2007 .

[10]  D. Denlinger,et al.  A nondiapausing variant of the flesh fly, Sarcophaga bullata, that shows arrhythmic adult eclosion and elevated expression of two circadian clock genes, period and timeless. , 2006, Journal of insect physiology.

[11]  M. Suster,et al.  Natural variation in Drosophila melanogaster diapause due to the insulin-regulated PI3-kinase , 2006, Proceedings of the National Academy of Sciences.

[12]  R. Leopold Cryopreservation of Nonmammalian Metazoan Systems , 2006 .

[13]  T. Yamashita,et al.  A chitinase structurally related to the glycoside hydrolase family 48 is indispensable for the hormonally induced diapause termination in a beetle. , 2006, Biochemical and biophysical research communications.

[14]  S. Dorn,et al.  Mobility of Mass-Reared Diapaused and Nondiapaused Cydia pomonella (Lepidoptera: Tortricidae): Effect of Mating Status and Treatment with Gamma Radiation , 2006 .

[15]  L. A. Foerster,et al.  Cold storage of the egg parasitoids Trissolcus basalis (Wollaston) and Telenomus podisi Ashmead (Hymenoptera: Scelionidae) , 2006 .

[16]  V. Košťál Eco-physiological phases of insect diapause. , 2006, Journal of insect physiology.

[17]  J. Bosch,et al.  Temporal variation in overwintering gene expression and respiration in the solitary bee Megachile rotundata. , 2005, Journal of insect physiology.

[18]  J. Samietz,et al.  Thermal orientation of Anthonomus pomorum (Coleoptera: Curculionidae) in early spring , 2005 .

[19]  D. Denlinger 3.12 – Hormonal Control of Diapause , 2005 .

[20]  J. Samietz,et al.  Significance of shelter traps for spring monitoring of Anthonomus pomorum in apple orchards , 2004 .

[21]  Ping Yang,et al.  Growth Suppression of Rat Hepatoma Cells by a Pentapeptide from Antheraea yamamai , 2004 .

[22]  D. Denlinger,et al.  Molecular characterization of prothoracicotropic hormone and diapause hormone in Heliothis virescens during diapause, and a new role for diapause hormone , 2003, Insect molecular biology.

[23]  T. Yamashita,et al.  Insect diapause-specific peptide from the leaf beetle has consensus with a putative iridovirus peptide , 2003, Peptides.

[24]  D. Denlinger,et al.  Regulation of diapause. , 2003, Annual review of entomology.

[25]  P. Bulet,et al.  Antiviral and antitumor peptides from insects , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[26]  Yoshimi Saito,et al.  Baculovirus-Mediated Production and Antifungal Activity of a Diapause-Specific Peptide, Diapausin, of the Adult Leaf Beetle, Gastrophysa atrocyanea (Coleoptera: Chrysomelidae) , 2002 .

[27]  R. Lanciotti,et al.  West Nile virus in overwintering Culex mosquitoes, New York City, 2000. , 2001, Emerging infectious diseases.

[28]  M. Tatar,et al.  Slow aging during insect reproductive diapause: why butterflies, grasshoppers and flies are like worms , 2001, Experimental Gerontology.

[29]  C. Blair,et al.  Identification and Sequence Determination of mRNAs Detected in Dormant (Diapausing) Aedes triseriatus Mosquito Embryos , 2001, DNA sequence : the journal of DNA sequencing and mapping.

[30]  J. O H N,et al.  Herbivory in global climate change research: direct effects of rising temperature on insect herbivores , 2001 .

[31]  V. Košťál,et al.  Activation of gonads and disruption of imaginal diapause in the apple blossom weevil, Anthonomus pomorum (Coleoptera: Curculionidae), with juvenoids in laboratory and field trials , 2000 .

[32]  Brian Salmons,et al.  Expression of antimicrobial peptides has an antitumour effect in human cells. , 1998, Biochemical and biophysical research communications.

[33]  Koutarou D. Kimura,et al.  daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. , 1997, Science.

[34]  O. Yamashita Diapause hormone of the silkworm, Bombyx mori: Structure, gene expression and function , 1996 .

[35]  R. A. Bell Manipulation of diapause in the gypsy moth, Lymantria dispar L., by application of KK-42 and precocious chilling of eggs , 1996 .

[36]  D. Denlinger,et al.  Diapause-regulated proteins in the gut of pharate first instar larvae of the gypsy moth, Lymantria dispar, and the effect of KK-42 and neck ligation on expression , 1996 .

[37]  F. W. Ravlin,et al.  Further advances toward a model of gypsy moth (Lymantria dispar (L.)) egg phenology: Respiration rates and thermal responsiveness during diapause, and age-dependent developmental rates in postdiapause , 1995 .

[38]  F. William Ravlin,et al.  Landscape framework to predict phenological events for gypsy moth (Lepidoptera: Lymantriidae) management programs , 1995 .

[39]  M. Bibby,et al.  Preliminary experimental anticancer activity of cecropins. , 1994, Peptide research.

[40]  M. Ikeda,et al.  Induction of non-diapause eggs by injection of anti-diapause hormone rabbit serum into the diapause type of the silkworm, Bombyx mori , 1994 .

[41]  D. Denlinger,et al.  Cold Shock and Heat Shock , 1991 .

[42]  D. Denlinger Relationship between Cold Hardiness and Diapause , 1991 .

[43]  J. L. Krysan Fenoxycarb and Diapause: A Possible Method of Control for Pear Psylla (Homoptera: Psyllidae) , 1990 .

[44]  T. Kumagai,et al.  Control mechanism of diapause of the pharate first-instar larvae of the silkmoth Antheraea yamamai , 1990 .

[45]  L. Gilbert,et al.  Induction of diapause in Drosophila melanogaster: photoperiodic regulation and the impact of arrhythmic clock mutations on time measurement. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[46]  W. J. Bell,et al.  Seasonal adaptations of insects. , 1987 .

[47]  D. Denlinger,et al.  Stimulatory effect of organic solvents on initiating development in diapausing pupae of the flesh fly, Sarcophaga crassipalpis, and the tobacco hornworm, Manduca sexta , 1980 .

[48]  D. Denlinger,et al.  Cyclic GMP breaks pupal diapause in the flesh fly Sarcophaga crassipalpis , 1978 .

[49]  M. Hoy Rapid Response to Selection for a Nondiapausing Gypsy Moth , 1977, Science.

[50]  D. Denlinger Preventing insect diapause with hormones and cholera toxin. , 1976, Life sciences.

[51]  M. Berlinger,et al.  MANIPULATION WITH THE PHOTOPERIOD AS A METHOD OF CONTROL OF ADOXOPHYES ORANA (LEPIDOPTERA, TORTRICIDAE) , 1976 .

[52]  W. S. Bowers Discovery of Insect Antiallatotropins , 1976 .

[53]  S. Takeda,et al.  Alteration of egg diapause in Bombyx mori by ouabain injected into diapause egg producers , 1975 .

[54]  R. Bodnaryk Interaction of cyclic nucleotides and ecdysterone in breaking the pupal diapause of the bertha armyworm, Mamestra configurata WLK. , 1975, Life sciences.

[55]  M. Nishimura,et al.  Further Studies on Non-Hormonal Agents Which Mimic Insect Brain Hormone , 1975 .

[56]  V. E. Adler,et al.  The effect of added light pulses on overwintering and diapause, under natural light and temperature conditions, of four species of Lepidoptera. , 1974 .

[57]  M. Vuillaume,et al.  LSD treatment of Pieris brassicae and consequences on the progeny , 1974, Nature.

[58]  C. McDaniel,et al.  Effects of caffeine and aminophylline on adult development of the Cecropia silkmoth. , 1974, Journal of insect physiology.

[59]  M. Schechter,et al.  Photoperiod Manipulation of Insect Diapause: A Method of Pest Control? , 1970, Science.

[60]  J. Wilde,et al.  Humoral and nervous pathways in photoperiodic induction of diapause in Leptinotarsa decemlineata , 1969 .

[61]  G. W. Ankersmit THE PHOTOPERIOD AS A CONTROL AGENT AGAINST ADOXOPHYES RETICULANA (LEPIDOPTERA; TORTRICIDAE) , 1968 .

[62]  J. Wilde,et al.  Physiology of diapause in the adult Colorado beetle—II: Diapause as a case of pseudo-allatectomy , 1961 .

[63]  Carroll M. Williams PHYSIOLOGY OF INSECT DIAPAUSE. IV. THE BRAIN AND PROTHORACIC GLANDS AS AN ENDOCRINE SYSTEM IN THE CECROPIA SILKWORM , 1952 .

[64]  K. Hasegawa Studies on the Voltinism in the Silkworm, Bombyx mori L., with Special Reference to the Organs Concerning Determination of Voltinism , 1952 .

[65]  S. Fukuda Factors Determining the Production of the Non-Diapause Eggs in the Silkworm , 1951 .

[66]  C. M. Williams Physiology of insect diapause interaction between the pupal brain and prothoracic glands in the metamorphosis of the giant silkworm, Platysamia cecropia. , 1947, The Biological bulletin.

[67]  E. Slifer The effects of xylol and other solvents on diapause in the grasshopper egg; together with a possible explanation for the action of these agents. , 1946, The Journal of experimental zoology.

[68]  C N WILLIAMS,et al.  Physiology of insect diapause; the role of the brain in the production and termination of pupal dormancy in the giant silkworm, Platysamia cecropia. , 1946, The Biological bulletin.

[69]  B. B. Pepper Control of Wireworms and Onion Thrips By Carbon Bisulfide Carrying Naphthalene or PDB , 1937 .