High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal

[1]  Cole Rd,et al.  Specific interaction between H1 histone and high mobility protein HMG1. , 1994 .

[2]  A. Thomson.  The cytokine handbook , 1994 .

[3]  C. Anasetti,et al.  Role of plasmacytoid dendritic cells in immunity and tolerance after allogeneic hematopoietic stem cell transplantation. , 2003, Transplant immunology.

[4]  V. Allfrey,et al.  Estradiol enhanced acetylation of nuclear high mobility group proteins of the uterus of newborn guinea pigs. , 1989, Biochemical and biophysical research communications.

[5]  H. Huttunen,et al.  Receptor for Advanced Glycation End Products (RAGE)-mediated Neurite Outgrowth and Activation of NF-κB Require the Cytoplasmic Domain of the Receptor but Different Downstream Signaling Pathways* , 1999, The Journal of Biological Chemistry.

[6]  I. Douglas,et al.  HMGB1 contributes to the development of acute lung injury after hemorrhage. , 2005, American journal of physiology. Lung cellular and molecular physiology.

[7]  Š. Pospíšilová,et al.  High-affinity binding of tumor-suppressor protein p53 and HMGB1 to hemicatenated DNA loops. , 2004, Biochemistry.

[8]  U. Andersson,et al.  HMGB1 is a potent trigger of arthritis , 2004, Journal of internal medicine.

[9]  T. Ogihara,et al.  Direct in vivo gene introduction into rat kidney. , 1992, Biochemical and biophysical research communications.

[10]  M. Fink,et al.  Ethyl Pyruvate Provides Durable Protection Against Inflammation-Induced Intestinal Epithelial Barrier Dysfunction , 2003, Shock.

[11]  M. Bianchi,et al.  High mobility group box 1 protein, a cue for stem cell recruitment. , 2004, Biochemical pharmacology.

[12]  A. Aguzzi,et al.  The lack of chromosomal protein Hmg1 does not disrupt cell growth but causes lethal hypoglycaemia in newborn mice , 1999, Nature Genetics.

[13]  M. Colonna,et al.  Recruitment of immature plasmacytoid dendritic cells (plasmacytoid monocytes) and myeloid dendritic cells in primary cutaneous melanomas , 2003, The Journal of pathology.

[14]  H. Kuniyasu,et al.  Co-expression of receptor for advanced glycation end products and the ligand amphoterin associates closely with metastasis of colorectal cancer. , 2003, Oncology reports.

[15]  H. Rauvala,et al.  30-kDa heparin-binding protein of brain (amphoterin) involved in neurite outgrowth. Amino acid sequence and localization in the filopodia of the advancing plasma membrane. , 1991, The Journal of biological chemistry.

[16]  A. Reimold,et al.  TNFalpha as therapeutic target: new drugs, more applications. , 2002, Current drug targets. Inflammation and allergy.

[17]  M. Bustin,et al.  Chromosomal Proteins HMGN3a and HMGN3b Regulate the Expression of Glycine Transporter 1 , 2004, Molecular and Cellular Biology.

[18]  H. Harris,et al.  Successful treatment of collagen-induced arthritis in mice and rats by targeting extracellular high mobility group box chromosomal protein 1 activity. , 2003, Arthritis and rheumatism.

[19]  B. Nordén,et al.  Vesicle membrane interactions of penetratin analogues. , 2004, Biochemistry.

[20]  T. Misteli,et al.  Release of chromatin protein HMGB1 by necrotic cells triggers inflammation , 2002, Nature.

[21]  M. Andrassy,et al.  Central role of RAGE-dependent neointimal expansion in arterial restenosis. , 2003, The Journal of clinical investigation.

[22]  A. Schmidt,et al.  Activation of the Receptor for Advanced Glycation End Products Triggers a p21 ras -dependent Mitogen-activated Protein Kinase Pathway Regulated by Oxidant Stress* , 1997, The Journal of Biological Chemistry.

[23]  M. Bianchi,et al.  HMGB1, an architectural chromatin protein and extracellular signalling factor, has a spatially and temporally restricted expression pattern in mouse brain. , 2003, Gene expression patterns : GEP.

[24]  E. Alexandrova,et al.  Differences between HMG1 proteins isolated from normal and tumour cells. , 1987, Biochimica et biophysica acta.

[25]  D. Edwards,et al.  Nuclear accessory factors enhance the binding of progesterone receptor to specific target DNA , 1994, The Journal of Steroid Biochemistry and Molecular Biology.

[26]  J. Stetkiewicz,et al.  High mobility group box 1 protein as a late-acting mediator of acute lung inflammation. , 2004, International journal of occupational medicine and environmental health.

[27]  A. Ridley,et al.  Receptor for advanced glycation end products-binding COOH-terminal motif of amphoterin inhibits invasive migration and metastasis. , 2002, Cancer research.

[28]  H. Rosen,et al.  Direct enumeration and functional assessment of circulating dendritic cells in patients with liver disease , 2004, Hepatology.

[29]  O. Hino,et al.  Recombination Hot Spot of Hepatitis B Virus Genome Binds to Members of the HMG Domain Protein Family and the Y Box Binding Protein Family; Implication of These Proteins in Genomic Instability , 2001, Intervirology.

[30]  M. Bianchi,et al.  The nuclear protein HMGB1 is secreted by monocytes via a non‐classical, vesicle‐mediated secretory pathway , 2002, EMBO reports.

[31]  M. Nakajima,et al.  The receptor for advanced glycation end‐products (RAGE) directly binds to ERK by a D‐domain‐like docking site , 2003, FEBS letters.

[32]  I. Ito,et al.  Conformational difference in HMGB1 proteins of human neutrophils and lymphocytes revealed by epitope mapping of a monoclonal antibody. , 2004, Journal of biochemistry.

[33]  J. Enghild,et al.  Regulation of receptor for advanced glycation end products during bleomycin-induced lung injury. , 2003, American journal of respiratory cell and molecular biology.

[34]  P. Nawroth,et al.  RAGE (receptor for advanced glycation end products): a central player in the inflammatory response. , 2004, Microbes and infection.

[35]  K. Tracey,et al.  HMGB-1, a DNA-binding protein with cytokine activity, induces brain TNF and IL-6 production, and mediates anorexia and taste aversion. , 2002, Cytokine.

[36]  Y. Kuroda,et al.  Expression of receptor for advanced glycation end products (RAGE) and MMP-9 in human pancreatic cancer cells. , 2004, Hepato-gastroenterology.

[37]  R. Harpio,et al.  S100 proteins as cancer biomarkers with focus on S100B in malignant melanoma. , 2004, Clinical biochemistry.

[38]  Masaki Tanaka,et al.  Contributions of high mobility group box protein in experimental and clinical acute lung injury. , 2004, American journal of respiratory and critical care medicine.

[39]  Y. Hata,et al.  Receptor for advanced glycation end‐products is a marker of type I lung alveolar cells , 2004, Genes to cells : devoted to molecular & cellular mechanisms.

[40]  M. Torrisi,et al.  CD8(+) T lymphocytes induce polarized exocytosis of secretory lysosomes by dendritic cells with release of interleukin-1beta and cathepsin D. , 2001, Blood.

[41]  T. Kislinger,et al.  Blockade of RAGE–amphoterin signalling suppresses tumour growth and metastases , 2000, Nature.

[42]  H. Yokozaki,et al.  Expression of receptors for advanced glycation end‐products (RAGE) is closely associated with the invasive and metastatic activity of gastric cancer , 2002, The Journal of pathology.

[43]  D. Schatz,et al.  Synapsis of Recombination Signal Sequences Located in cis and DNA Underwinding in V(D)J Recombination , 2004, Molecular and Cellular Biology.

[44]  K. Takata,et al.  High mobility group box protein‐1 inhibits microglial Aβ clearance and enhances Aβ neurotoxicity , 2004 .

[45]  R. Sitia,et al.  Entry of exogenous polypeptides into the nucleus of living cells: facts and speculations. , 1995, Trends in cell biology.

[46]  K. Preissner,et al.  The Pattern Recognition Receptor (RAGE) Is a Counterreceptor for Leukocyte Integrins , 2003, The Journal of experimental medicine.

[47]  K. Ikuta,et al.  Borna Disease Virus Phosphoprotein Represses p53-Mediated Transcriptional Activity by Interference with HMGB1 , 2003, Journal of Virology.

[48]  G. Mazariegos,et al.  Dendritic Cell Subset Ratio in Peripheral Blood Correlates with Successful Withdrawal of Immunosuppression in Liver Transplant Patients , 2003, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[49]  L. Borrmann,et al.  Variation of HMGB1 expression in breast cancer. , 2001, Anticancer research.

[50]  F. Yuan,et al.  Evidence for Involvement of HMGB1 Protein in Human DNA Mismatch Repair* , 2004, Journal of Biological Chemistry.

[51]  M. Lotze,et al.  Dealing with death: HMGB1 as a novel target for cancer therapy. , 2003, Current opinion in investigational drugs.

[52]  M. Lotze,et al.  Monocytes promote natural killer cell interferon gamma production in response to the endogenous danger signal HMGB1. , 2005, Molecular immunology.

[53]  L. A. Kohlstaedt,et al.  Specific interaction between H1 histone and high mobility protein HMG1. , 1994, Biochemistry.

[54]  K. Tracey,et al.  Extracellular role of HMGB1 in inflammation and sepsis , 2004, Journal of internal medicine.

[55]  J. Enghild,et al.  Purification and Characterization of Mouse Soluble Receptor for Advanced Glycation End Products (sRAGE)* , 2004, Journal of Biological Chemistry.

[56]  K. Tracey,et al.  HMGB1 in the immunology of sepsis (not septic shock) and arthritis. , 2004, Advances in immunology.

[57]  J. Emond,et al.  Blockade of receptor for advanced glycation end product (RAGE) attenuates ischemia and reperfusion injury to the liver in mice , 2004, Hepatology.

[58]  Jun Yu Li,et al.  High mobility group box chromosomal protein 1: a novel proinflammatory mediator in synovitis. , 2002, Arthritis and rheumatism.

[59]  T. Giese,et al.  Identification and functional analysis of tumor-infiltrating plasmacytoid dendritic cells in head and neck cancer. , 2003, Cancer research.

[60]  K. Tracey,et al.  Reversing established sepsis with antagonists of endogenous high-mobility group box 1 , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[61]  I. Grigorov,et al.  HMG-1 as regulatory trans-acting protein in the acute phase-induced expression of the rat liver haptoglobin gene. , 2001, General physiology and biophysics.

[62]  Hoguen Kim,et al.  Overexpression of high mobility group box 1 in gastrointestinal stromal tumors with KIT mutation. , 2003, Cancer research.

[63]  Yan Yu,et al.  [High mobility group box-1 protein activates Janus kinase-signal transducer and activator of transcription pathway in rat peritoneal macrophages]. , 2004, Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue.

[64]  G. Goodwin,et al.  Physical studies of the nonhistone chromosomal proteins HMG-U and HMG-2. , 1976, Biochemistry.

[65]  A. Nakagawara,et al.  HMGB1 and HMGB2 Cell-specifically Down-regulate the p53- and p73-dependent Sequence-specific Transactivation from the Human Bax Gene Promoter* , 2002, The Journal of Biological Chemistry.

[66]  H. Huttunen,et al.  Receptor for Advanced Glycation End Products (RAGE) Signaling Induces CREB-dependent Chromogranin Expression during Neuronal Differentiation* , 2002, The Journal of Biological Chemistry.

[67]  S. Rosenberg,et al.  In vivo administration of purified human interleukin 2. II. Half life, immunologic effects, and expansion of peripheral lymphoid cells in vivo with recombinant IL 2. , 1985, Journal of immunology.

[68]  K. Tracey,et al.  Bacterial endotoxin stimulates macrophages to release HMGB1 partly through CD14‐ and TNF‐dependent mechanisms , 2004, Journal of leukocyte biology.

[69]  Y. Kaneda,et al.  Fusigenic liposome-mediated DNA transfer into cardiac myocytes. , 1996, Journal of molecular and cellular cardiology.

[70]  J. Chu,et al.  The mechanism of cell death during West Nile virus infection is dependent on initial infectious dose. , 2003, The Journal of general virology.

[71]  S. Maier,et al.  Further characterization of high mobility group box 1 (HMGB1) as a proinflammatory cytokine: central nervous system effects. , 2003, Cytokine.

[72]  M. Bianchi,et al.  Recombinant HMG1 protein produced in Pichia pastoris: a nonviral gene delivery agent. , 1997, BioTechniques.

[73]  F. Di Virgilio,et al.  P2X(7) receptor and polykarion formation. , 2000, Molecular biology of the cell.

[74]  M. Müller,et al.  Receptor for advanced glycation endproducts (RAGE) exhibits highly differential cellular and subcellular localisation in rat and human lung. , 1998, Cellular and molecular biology.

[75]  K. Tracey.  Fatal Sequence: The Killer Within , 2005 .

[76]  N. Kalinina,et al.  Increased expression of the DNA-binding cytokine HMGB1 in human atherosclerotic lesions: role of activated macrophages and cytokines. , 2004, Arteriosclerosis, thrombosis, and vascular biology.

[77]  Angela Panoskaltsis-Mortari,et al.  Human Plasmacytoid Dendritic Cells Activated by CpG Oligodeoxynucleotides Induce the Generation of CD4+CD25+ Regulatory T Cells1 , 2004, The Journal of Immunology.

[78]  M. Strauss,et al.  Transfection by DNA-nuclear protein HMG1 complexes: raising of efficiency and role of DNA topology. , 1990, Archiv fur Geschwulstforschung.

[79]  James R. Goldenring,et al.  Gastric Cancer Originating from Bone Marrow-Derived Cells , 2004, Science.

[80]  K. Tracey,et al.  Increased serum concentrations of high-mobility-group protein 1 in haemorrhagic shock , 1999, The Lancet.

[81]  M. Lotze,et al.  Addicted to Death: Invasive Cancer and the Immune Response to Unscheduled Cell Death , 2005, Journal of immunotherapy.

[82]  Michael Bustin,et al.  Inflammation-promoting activity of HMGB1 on human microvascular endothelial cells. , 2003, Blood.

[83]  M. Albert,et al.  Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs , 1998, Nature.

[84]  M. Bianchi,et al.  Extracellular HMGB1, a signal of tissue damage, induces mesoangioblast migration and proliferation , 2004, The Journal of cell biology.

[85]  Chenguang Wang,et al.  Acetylation of nuclear receptors in cellular growth and apoptosis. , 2004, Biochemical pharmacology.

[86]  I. Davis,et al.  ATP gradients inhibit the migratory capacity of specific human dendritic cell types: implications for P2Y11 receptor signaling. , 2003, Blood.

[87]  S. Steinberg,et al.  Combination therapy with interleukin-2 and alpha-interferon for the treatment of patients with advanced cancer. , 1989, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[88]  K. Ikuta,et al.  Borna Disease Virus Phosphoprotein Binds a Neurite Outgrowth Factor, Amphoterin/HMG-1 , 2001, Journal of Virology.

[89]  R. Fisher,et al.  High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: analysis of 270 patients treated between 1985 and 1993. , 1999, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[90]  L. Moreland,et al.  A multicentre, double blind, randomised, placebo controlled trial of anakinra (Kineret), a recombinant interleukin 1 receptor antagonist, in patients with rheumatoid arthritis treated with background methotrexate , 2004, Annals of the rheumatic diseases.

[91]  Gunnar P. H. Dietz,et al.  Delivery of bioactive molecules into the cell: the Trojan horse approach , 2004, Molecular and Cellular Neuroscience.

[92]  K. Tracey,et al.  Activation of gene expression in human neutrophils by high mobility group box 1 protein. , 2003, American journal of physiology. Cell physiology.

[93]  Eithne Costello,et al.  High mobility group chromosomal protein 1 binds to the adeno‐associated virus replication protein (Rep) and promotes Rep‐mediated site‐specific cleavage of DNA, ATPase activity and transcriptional repression , 1997, The EMBO journal.

[94]  F. Vogel,et al.  Condensation of vector DNA by the chromosomal protein HMG1 results in efficient transfection. , 1988, Biochimica et biophysica acta.

[95]  M. Bustin,et al.  Immunological relatedness of high mobility group chromosomal proteins from calf thymus. , 1978, The Journal of biological chemistry.

[96]  V. Pascual,et al.  Blood dendritic cells and DC-poietins in systemic lupus erythematosus. , 2002, Human immunology.

[97]  T. Kislinger,et al.  RAGE limits regeneration after massive liver injury by coordinated suppression of TNF-α and NF-κB , 2005, The Journal of experimental medicine.

[98]  J. Kwekkeboom,et al.  Functional impairment of myeloid and plasmacytoid dendritic cells of patients with chronic hepatitis B , 2004, Hepatology.

[99]  R. Re.  The intracrine hypothesis and intracellular peptide hormone action. , 2003, BioEssays : news and reviews in molecular, cellular and developmental biology.

[100]  S. Rosenberg,et al.  In vivo administration of purified human interleukin 2. I. Half-life and immunologic effects of the Jurkat cell line-derived interleukin 2. , 1985, Journal of immunology.

[101]  K. Tracey,et al.  HMGB1 B box increases the permeability of Caco-2 enterocytic monolayers and impairs intestinal barrier function in mice. , 2002, Gastroenterology.

[102]  F. Katsuoka,et al.  Type II alveolar epithelial cells in lung express receptor for advanced glycation end products (RAGE) gene. , 1997, Biochemical and biophysical research communications.

[103]  Patrick L. Hindmarsh,et al.  HMG Protein Family Members Stimulate Human Immunodeficiency Virus Type 1 and Avian Sarcoma Virus Concerted DNA Integration In Vitro , 1999, Journal of Virology.

[104]  D. Shapiro,et al.  HMG-1 stimulates estrogen response element binding by estrogen receptor from stably transfected HeLa cells. , 1999, Molecular endocrinology.

[105]  Qiang Wu,et al.  Rice HMGB1 protein recognizes DNA structures and bends DNA efficiently. , 2003, Archives of biochemistry and biophysics.

[106]  M. Bustin,et al.  Chromatin subunits elicit species-specific antibodies against nucleoprotein antigenic determinants. , 1980, Biochemistry.

[107]  K. Tracey,et al.  Intracellular high mobility group B1 protein (HMGB1) represses HIV-1 LTR-directed transcription in a promoter- and cell-specific manner. , 2003, Virology.

[108]  J. Palmblad,et al.  High mobility group 1 B‐box mediates activation of human endothelium , 2003, Journal of internal medicine.

[109]  E. Abraham,et al.  Involvement of Toll-like Receptors 2 and 4 in Cellular Activation by High Mobility Group Box 1 Protein* , 2004, Journal of Biological Chemistry.

[110]  W. Trojaborg,et al.  RAGE modulates peripheral nerve regeneration via recruitment of both inflammatory and axonal outgrowth pathways , 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[111]  Tiziana Bonaldi,et al.  Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion , 2003, The EMBO journal.

[112]  F. Smith,et al.  Developmental expression of receptor for advanced glycation end products (RAGE), amphoterin and sulfoglucuronyl (HNK‐1) carbohydrate in mouse cerebellum and their role in neurite outgrowth and cell migration , 2004, Journal of neurochemistry.

[113]  K. Tracey,et al.  CHAPTER 39 – HMGB-1 , 2003 .

[114]  Polly Matzinger,et al.  Hydrophobicity: an ancient damage-associated molecular pattern that initiates innate immune responses , 2004, Nature Reviews Immunology.

[115]  W. Fang,et al.  The Significance of Changes in High Mobility Group-1 Protein mRNA Expression in Rats After Thermal Injury , 2002, Shock.

[116]  K. Tracey,et al.  HMG-1 as a late mediator of endotoxin lethality in mice. , 1999, Science.

[117]  M. Chandler,et al.  Mutual stabilisation of bacteriophage Mu repressor and histone-like proteins in a nucleoprotein structure. , 1995, Journal of molecular biology.

[118]  P. Rouleau,et al.  Proinflammatory Activities of S100: Proteins S100A8, S100A9, and S100A8/A9 Induce Neutrophil Chemotaxis and Adhesion 1 , 2003, The Journal of Immunology.

[119]  Yong‐jun Liu,et al.  Mysterious origin of plasmacytoid dendritic cell precursors. , 2004, Immunity.

[120]  K. Tracey,et al.  The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion , 2005, The Journal of experimental medicine.

[121]  H. Murua Escobar,et al.  Expression pattern of the HMGB1 gene in sarcomas of the dog. , 2004, Anticancer research.

[122]  H. Kuniyasu,et al.  Differential effects between amphoterin and advanced glycation end products on colon cancer cells , 2003, International journal of cancer.

[123]  James E. Evans,et al.  Molecular identification of a danger signal that alerts the immune system to dying cells , 2003, Nature.

[124]  L. Murphy,et al.  S100A7 and the progression of breast cancer , 2004, Breast Cancer Research.

[125]  K. Tracey,et al.  High Mobility Group Box Protein 1: An Endogenous Signal for Dendritic Cell Maturation and Th1 Polarization , 2004, The Journal of Immunology.

[126]  T. Darville,et al.  Cell death, BAX activation, and HMGB1 release during infection with Chlamydia. , 2004, Microbes and infection.

[127]  O. Box.  Functional impairment of myeloid and plasmacytoid dendritic cells of pat ients with chronic hepatitis B , 2005 .

[128]  Z. Izsvák,et al.  The DNA-bending protein HMGB1 is a cellular cofactor of Sleeping Beauty transposition. , 2003, Nucleic acids research.

[129]  K. Tracey,et al.  Lipid unites disparate syndromes of sepsis , 2004, Nature Medicine.

[130]  P. Rouleau,et al.  Proinflammatory Activities of S 100 : Proteins S 100 A 8 , S 100 A 9 , and S 100 A 8 / A 9 Induce Neutrophil Chemotaxis and Adhesion 1 , 2003 .

[131]  H. Clevers,et al.  Ancestry and diversity of the HMG box superfamily. , 1993, Nucleic acids research.

[132]  J. Kuja-Panula,et al.  Regulation of monocyte migration by amphoterin (HMGB1). , 2004, Blood.

[133]  W. Zong,et al.  Alkylating DNA damage stimulates a regulated form of necrotic cell death. , 2004, Genes & development.

[134]  J. Wang,et al.  Nonhistone proteins HMG1 and HMG2 change the DNA helical structure. , 1978, Science.

[135]  S. Knapp,et al.  The long acidic tail of high mobility group box 1 (HMGB1) protein forms an extended and flexible structure that interacts with specific residues within and between the HMG boxes. , 2004, Biochemistry.

[136]  C. Dinarello,et al.  The precursor form of IL-1alpha is an intracrine proinflammatory activator of transcription. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[137]  S. Müller,et al.  HMGB1 is an endogenous immune adjuvant released by necrotic cells , 2004, EMBO reports.

[138]  Giovanna Angelini,et al.  NK/iDC interaction results in IL-18 secretion by DCs at the synaptic cleft followed by NK cell activation and release of the DC maturation factor HMGB1. , 2005, Blood.

[139]  U. Andersson,et al.  RAGE is the Major Receptor for the Proinflammatory Activity of HMGB1 in Rodent Macrophages , 2005, Scandinavian journal of immunology.

[140]  K. Tracey,et al.  Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis , 2004, Nature Medicine.

[141]  P. Hersey,et al.  The histone deacetylase inhibitor suberic bishydroxamate regulates the expression of multiple apoptotic mediators and induces mitochondria-dependent apoptosis of melanoma cells. , 2004, Molecular cancer therapeutics.