Toxicological studies on a new macrolide antibiotic, midecamycin acetate (miocamycin). Part IV-3. Toxicity of metabolites of miocamycin: subacute toxicity of Mb1 in rats.

Miocamycin (MOM) is a derivative of midecamycin, a macrolide antibiotic and is metabolized into 4 main metabolites of Mb1, Mb2, Mb6 and Mb12. In the previous study, LD0 values of Mb1 were estimated more than 5,000 mg/kg in male and female rats as Mb1 did not exhibited any lethal toxicity even at the maximum physically applicable dose of 5,000 mg/kg. The object of this study was to examine subacute toxicity in male and female rats after repeated p.o. administration of Mb1 for 5 weeks at a daily dosage of 125, 250, 500 and 1,000 mg/kg. It is concluded that no manifest toxicity was observed in this subacute toxicity study on Mb1 in rats.

[1]  T. Itoh,et al.  Toxicological studies on a new macrolide antibiotic, midecamycin acetate (miocamycin). Part IV-1. Toxicity of metabolites of miocamycin: acute toxicity of Mb1 in mice. , 1984, The Japanese journal of antibiotics.

[2]  T. Itoh,et al.  Toxicological studies on a new macrolide antibiotic, midecamycin acetate (miocamycin). Part IV-4. Toxicity of metabolites of miocamycin: acute toxicity of Mb2 in mice. , 1984, The Japanese journal of antibiotics.

[3]  U. Takeda,et al.  Toxicological studies on a new macrolide antibiotic, midecamycin acetate (miocamycin). Part IV-5. Toxicity of metabolites of miocamycin: acute toxicity of Mb2 in rats. , 1984, The Japanese journal of antibiotics.

[4]  U. Takeda,et al.  Toxicological studies on a new macrolide antibiotic, midecamycin acetate (miocamycin). Part IV-11. Toxicity of metabolites of miocamycin: acute toxicity of Mb12 in rats. , 1984, The Japanese journal of antibiotics.

[5]  U. Takeda,et al.  Toxicological studies on a new macrolide antibiotic, midecamycin acetate (miocamycin). Part IV-8. Toxicity of metabolites of miocamycin: acute toxicity of Mb6 in rats. , 1984, The Japanese journal of antibiotics.

[6]  T. Itoh,et al.  Toxicological studies on a new macrolide antibiotic, midecamycin acetate (miocamycin). Part IV-10. Toxicity of metabolites of miocamycin: acute toxicity of Mb12 in mice. , 1984, The Japanese journal of antibiotics.

[7]  M. Suzuki,et al.  Toxicological studies on a new macrolide antibiotic, midecamycin acetate (miokamycin). Part III-3. Chronic toxicity in beagle dogs: 26-week-treatment in female dogs. , 1984, The Japanese journal of antibiotics.

[8]  K. Umemura,et al.  [Metabolism of 9,3"-diacetylmidecamycin. I. The metabolic fate of 9,3"-diacetylmidecamycin]. , 1982, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

[9]  Y. Sekizawa,et al.  In vitro and in vivo antibacterial activity of 9,3"-Di-o-acetyl midecamycin (Mom), a new macrolide antibiotic. , 1981, The Journal of antibiotics.

[10]  T. Niida,et al.  A CONVENIENT METHOD FOR THE PREPARATION OF THE ACYLATED MACROLIDE ANTIBIOTIC MIDECAMYCIN USING MOLECULAR SIEVES AND ACYLCHLORIDE , 1978 .

[11]  T. Koeda,et al.  [Ototoxic effects of some aminoglycoside antibiotics on the inner ear in the spontaneously hypertensive rats (SHR) (author's transl)]. , 1977, The Japanese journal of antibiotics.

[12]  S. Inouye,et al.  Modifications of a macrolide antibiotic midecamycin (SF-837). I. Synthesis and structure of 9,3''-diacetylmidecamycin. , 1976, The Journal of antibiotics.

[13]  K. Tokuda.  [Experimental study of chloroquine retinopathy. Report 1. Influence of chloroquine intravenous injection to the visual fields and to the threshold of light reflex]. , 1974, Nippon Ganka Gakkai zasshi.

[14]  E. Sotaniemi,et al.  Bronchial asthma and toxic hepatitis. , 1968, Annals of allergy.

[15]  K. Nitta,et al.  A new antibiotic, josamycin. II. Biological studies. , 1967, The Journal of antibiotics.

[16]  F. Gilbert.  Cholestatic hepatitis caused by esters of erythromycin and oleandomycin. , 1962, JAMA.

[17]  H. Zimmerman,et al.  Hepatic Dysfunction and Jaundice in Patients Receiving Triacetyloleandomycin , 1962 .

[18]  W. H. Hall,et al.  Allergic hepatitis caused by propionyl erythromycin ester of lauryl sulfate. , 1961, The New England journal of medicine.

[19]  J. W. Steiner.  Investigations of Allergic Liver Injury: I. Light, Fluorescent and Electron Microscopic Study of the Effects of Soluble Immune Aggregates. , 1961, The American journal of pathology.

[20]  P. N. Harris,et al.  Further toxicological studies with ilotycin (erythromycin, Lilly). , 1955, Journal of the American Pharmaceutical Association. American Pharmaceutical Association.

[21]  P. N. Harris,et al.  The toxicity and distribution of ilotycin. , 1952, Journal of the American Pharmaceutical Association. American Pharmaceutical Association.

[22]  T. Itoh,et al.  Toxicological studies on a new macrolide antibiotic, midecamycin acetate (miokamycin). Part I-1. Acute toxicity in mice. , 1984, The Japanese journal of antibiotics.

[23]  U. Takeda,et al.  Toxicological studies on a new macrolide antibiotic, midecamycin acetate (miokamycin). Part I-2. Acute toxicity in rats. , 1984, The Japanese journal of antibiotics.

[24]  K. Umemura,et al.  Toxicology and Pharmacology of Aminoglycoside Antibiotics , 1982 .

[25]  A. Ohbayashi,et al.  Two Cases of Intrahepatic Cholestasis Probably due to Josamycin , 1974 .

[26]  P. N. Harris,et al.  Pharmacology and toxicology of erythromycin propionate. , 1958, Antibiotics annual.