Vitamin D Improves Neurogenesis and Cognition in a Mouse Model of Alzheimer’s Disease

[1]  D. Eyles,et al.  Differential expression of vitamin D-associated enzymes and receptors in brain cell subtypes , 2017, The Journal of Steroid Biochemistry and Molecular Biology.

[2]  S. Yılmazer,et al.  Vitamin D Receptor Regulates Amyloid Beta 1-42 Production with Protein Disulfide Isomerase A3. , 2017, ACS Chemical Neuroscience.

[3]  A. Carvalho,et al.  Oxidative stress and frailty: A systematic review and synthesis of the best evidence. , 2017, Maturitas.

[4]  E. Wenger,et al.  Contribution of neuroinflammation and immunity to brain aging and the mitigating effects of physical and cognitive interventions , 2017, Neuroscience & Biobehavioral Reviews.

[5]  W. Peng,et al.  1,25-Dihydroxyvitamin D3 regulates expression of LRP1 and RAGE in vitro and in vivo, enhancing Aβ1–40 brain-to-blood efflux and peripheral uptake transport , 2016, Neuroscience.

[6]  C. Annweiler,et al.  Vitamin D, Cognition and Alzheimer’s Disease: The Therapeutic Benefit is in the D-Tails , 2016, Journal of Alzheimer's disease : JAD.

[7]  R. Sullivan,et al.  Behavioural Effects of Adult Vitamin D Deficiency in BALB/c Mice Are not Associated with Proliferation or Survival of Neurons in the Adult Hippocampus , 2016, PloS one.

[8]  Liming Shen,et al.  Redox Proteomic Profiling of Specifically Carbonylated Proteins in the Serum of Triple Transgenic Alzheimer’s Disease Mice , 2016, International journal of molecular sciences.

[9]  B. Loriod,et al.  Vitamin D interacts with Esr1 and Igf1 to regulate molecular pathways relevant to Alzheimer’s disease , 2016, Molecular Neurodegeneration.

[10]  C. Annweiler.  Vitamin D in dementia prevention , 2016, Annals of the New York Academy of Sciences.

[11]  Ling Chen,et al.  Simvastatin prevents β-amyloid25–35-impaired neurogenesis in hippocampal dentate gyrus through α7nAChR-dependent cascading PI3K-Akt and increasing BDNF via reduction of farnesyl pyrophosphate , 2015, Neuropharmacology.

[12]  J. Budni,et al.  The involvement of BDNF, NGF and GDNF in aging and Alzheimer's disease. , 2015, Aging and disease.

[13]  Felicja Lwow,et al.  Vitamin D receptor gene polymorphisms in Alzheimer's disease patients , 2015, Experimental Gerontology.

[14]  M. Paquet,et al.  Infertility in Female Mice with a Gain-of-Function Mutation in the Luteinizing Hormone Receptor Is Due to Irregular Estrous Cyclicity, Anovulation, Hormonal Alterations, and Polycystic Ovaries1 , 2015, Biology of reproduction.

[15]  M. Soares,et al.  The potential regulatory role of vitamin D in the bioenergetics of inflammation , 2015, Current opinion in clinical nutrition and metabolic care.

[16]  Guang-Xian Zhang,et al.  1,25-Dihydroxyvitamin D3 enhances neural stem cell proliferation and oligodendrocyte differentiation. , 2015, Experimental and molecular pathology.

[17]  A. Tobeña,et al.  Cognitive and emotional alterations in young Alzheimer's disease (3xTgAD) mice: Effects of neonatal handling stimulation and sexual dimorphism , 2015, Behavioural Brain Research.

[18]  Shao Li,et al.  Update on the neuroprotective effect of estrogen receptor alpha against Alzheimer's disease. , 2014, Journal of Alzheimer's disease : JAD.

[19]  J. Kramer,et al.  Longitudinal Inflammation, Cognitive Decline, and Alzheimer's Disease: A Mini‐Review , 2014, Clinical pharmacology and therapeutics.

[20]  B. Loriod,et al.  Temporal gene profiling of the 5XFAD transgenic mouse model highlights the importance of microglial activation in Alzheimer’s disease , 2014, Molecular Neurodegeneration.

[21]  T. Littlejohns,et al.  Vitamin D and the risk of dementia and Alzheimer disease , 2014, Neurology.

[22]  P. Sun,et al.  The improvement of spatial memory deficits in APP/V717I transgenic mice by chronic anti-stroke herb treatment , 2014, Experimental biology and medicine.

[23]  Lei Wang,et al.  Dihydrotestosterone treatment delays the conversion from mild cognitive impairment to Alzheimer's disease in SAMP8 mice , 2014, Hormones and Behavior.

[24]  H. Noh,et al.  Age-dependent effects of valproic acid in Alzheimer’s disease (AD) mice are associated with nerve growth factor (NGF) regulation , 2014, Neuroscience.

[25]  F. Schmitt,et al.  Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models , 2014, Front. Genet..

[26]  I. Mook‐Jung,et al.  Impaired hippocampal neurogenesis and its enhancement with ghrelin in 5XFAD mice. , 2014, Journal of Alzheimer's disease : JAD.

[27]  S. Yılmazer,et al.  Why vitamin D in Alzheimer's disease? The hypothesis. , 2014, Journal of Alzheimer's disease : JAD.

[28]  P. Vallotton,et al.  Vitamin D2-Enriched Button Mushroom (Agaricus bisporus) Improves Memory in Both Wild Type and APPswe/PS1dE9 Transgenic Mice , 2013, PloS one.

[29]  G. Ebers,et al.  Review: The role of vitamin D in nervous system health and disease , 2013, Neuropathology and applied neurobiology.

[30]  M. Khrestchatisky,et al.  Cholecalciferol (Vitamin D3) Improves Myelination and Recovery after Nerve Injury , 2013, PloS one.

[31]  J. Ávila,et al.  Role of Neuroinflammation in Adult Neurogenesis and Alzheimer Disease: Therapeutic Approaches , 2013, Mediators of inflammation.

[32]  H. Steinbusch,et al.  Behavioral and neurobiological effects of prenatal stress exposure in male and female APPswe/PS1dE9 mice , 2013, Neurobiology of Aging.

[33]  J. McGrath,et al.  Vitamin D, effects on brain development, adult brain function and the links between low levels of vitamin D and neuropsychiatric disease , 2013, Frontiers in Neuroendocrinology.

[34]  H. Pant,et al.  A truncated peptide from p35, a Cdk5 activator, prevents Alzheimer's disease phenotypes in model mice , 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[35]  M. van Buchem,et al.  Longitudinal monitoring of sex-related in vivo metabolic changes in the brain of Alzheimer's disease transgenic mouse using magnetic resonance spectroscopy. , 2013, Journal of Alzheimer's disease : JAD.

[36]  H. Darwish,et al.  Vitamin D mitigates age-related cognitive decline through the modulation of pro-inflammatory state and decrease in amyloid burden , 2012, Journal of Neuroinflammation.

[37]  J. Gilbert,et al.  Vitamin D receptor and Alzheimer's disease: a genetic and functional study , 2012, Neurobiology of Aging.

[38]  I. Nemere,et al.  Diosgenin is an exogenous activator of 1,25D3-MARRS/Pdia3/ERp57 and improves Alzheimer's disease pathologies in 5XFAD mice , 2012, Scientific Reports.

[39]  Ying Zhu,et al.  Abnormal neurogenesis in the dentate gyrus of adult mice lacking 1,25‐dihydroxy vitamin D3 (1,25‐(OH)2D3) , 2012, Hippocampus.

[40]  Jason S. Snyder,et al.  Could adult hippocampal neurogenesis be relevant for human behavior? , 2012, Behavioural Brain Research.

[41]  L. Lue,et al.  Broad-based nutritional supplementation in 3xTg mice corrects mitochondrial function and indicates sex-specificity in response to Alzheimer's disease intervention. , 2012, Journal of Alzheimer's disease : JAD.

[42]  P. Griffin,et al.  Genomic and nongenomic signaling induced by 1α,25(OH)2-vitamin D3 promotes the recovery of amyloid-β phagocytosis by Alzheimer's disease macrophages. , 2012, Journal of Alzheimer's disease : JAD.

[43]  F. Gage,et al.  Adult hippocampal neurogenesis and its role in Alzheimer's disease , 2011, Molecular Neurodegeneration.

[44]  A. Smith,et al.  The vitamin D receptor gene is associated with Alzheimer's disease , 2011, Neuroscience Letters.

[45]  E. Tan,et al.  The roles of amyloid precursor protein (APP) in neurogenesis , 2011, Cell adhesion & migration.

[46]  G. Ming,et al.  Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions , 2011, Neuron.

[47]  M. Salami,et al.  Vitamin-D-Free Regimen Intensifies the Spatial Learning Deficit in Alzheimer's Disease , 2011, The International journal of neuroscience.

[48]  N. Bhat,et al.  Vitamin D3-enriched diet correlates with a decrease of amyloid plaques in the brain of AβPP transgenic mice. , 2011, Journal of Alzheimer's disease : JAD.

[49]  N. Inestrosa,et al.  Adult hippocampal neurogenesis in aging and Alzheimer's disease. , 2010, Birth defects research. Part C, Embryo today : reviews.

[50]  C. Pike,et al.  Testosterone regulation of Alzheimer-like neuropathology in male 3xTg-AD mice involves both estrogen and androgen pathways , 2010, Brain Research.

[51]  G. Kempermann,et al.  Physical exercise increases Notch activity, proliferation and cell cycle exit of type‐3 progenitor cells in adult hippocampal neurogenesis , 2010, The European journal of neuroscience.

[52]  O. Lazarov,et al.  Impaired neurogenesis is an early event in the etiology of familial Alzheimer's disease in transgenic mice , 2010, Journal of neuroscience research.

[53]  Corinna Burger,et al.  Region-Specific Genetic Alterations in the Aging Hippocampus: Implications For Cognitive Aging , 2010, Front. Ag. Neurosci..

[54]  C. Wahlestedt,et al.  Adult neurogenesis: a potential tool for early diagnosis in Alzheimer's disease? , 2010, Journal of Alzheimer's disease : JAD.

[55]  D. Eyles,et al.  Vitamin D, a neuro-immunomodulator: Implications for neurodegenerative and autoimmune diseases , 2009, Psychoneuroendocrinology.

[56]  M. Delong,et al.  Prevalence of vitamin d insufficiency in patients with Parkinson disease and Alzheimer disease. , 2008, Archives of neurology.

[57]  L. Gan,et al.  Neurogenic responses to amyloid-beta plaques in the brain of Alzheimer’s disease-like transgenic (pPDGF-APPSw,Ind) mice , 2008, Neurobiology of Disease.

[58]  Murat Emre,et al.  Association between vitamin D receptor gene polymorphism and Alzheimer's disease. , 2007, The Tohoku journal of experimental medicine.

[59]  C. Rampon,et al.  Alzheimer's-Type Amyloidosis in Transgenic Mice Impairs Survival of Newborn Neurons Derived from Adult Hippocampal Neurogenesis , 2007, The Journal of Neuroscience.

[60]  A. Mackay-Sim,et al.  Maternal vitamin D depletion alters neurogenesis in the developing rat brain , 2007, International Journal of Developmental Neuroscience.

[61]  A. Mackay-Sim,et al.  Developmental vitamin D deficiency alters the expression of genes encoding mitochondrial, cytoskeletal and synaptic proteins in the adult rat brain , 2007, The Journal of Steroid Biochemistry and Molecular Biology.

[62]  A. Mackay-Sim,et al.  Developmental vitamin D deficiency alters brain protein expression in the adult rat: Implications for neuropsychiatric disorders , 2007, Proteomics.

[63]  G. Kempermann,et al.  Neurogenesis in the adult hippocampus , 2007, Cell and Tissue Research.

[64]  M. Ohno,et al.  Intraneuronal β-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation , 2006, The Journal of Neuroscience.

[65]  John H. White,et al.  Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. , 2005, Molecular endocrinology.

[66]  A. Mackay-Sim,et al.  Developmental Vitamin D3 deficiency alters the adult rat brain , 2005, Brain Research Bulletin.

[67]  Jürgen Winkler,et al.  Doublecortin expression levels in adult brain reflect neurogenesis , 2005, The European journal of neuroscience.

[68]  F. Boussin,et al.  Amyloid-beta peptide triggers Fas-independent apoptosis and differentiation of neural progenitor cells. , 2005, Neurobiology of disease.

[69]  A. Shetty,et al.  Efficacy of doublecortin as a marker to analyse the absolute number anddendritic growth of newly generated neurons in the adult dentate gyrus , 2004, The European journal of neuroscience.

[70]  A. Norman,et al.  The vitamin D receptor is present in caveolae-enriched plasma membranes and binds 1 alpha,25(OH)2-vitamin D3 in vivo and in vitro. , 2004, Molecular endocrinology.

[71]  Lin Xie,et al.  Increased hippocampal neurogenesis in Alzheimer's disease , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[72]  R. Yolken,et al.  Low maternal vitamin D as a risk factor for schizophrenia: a pilot study using banked sera , 2003, Schizophrenia Research.

[73]  P. Dhawan,et al.  New insights into the mechanisms of vitamin D action , 2003, Journal of cellular biochemistry.

[74]  M. Mattson,et al.  Disruption of neurogenesis by amyloid β‐peptide, and perturbed neural progenitor cell homeostasis, in models of Alzheimer's disease , 2002, Journal of neurochemistry.

[75]  Avi Chaudhuri,et al.  Task-dependent transfer of perceptual to memory representations during delayed spatial frequency discrimination , 2002, Vision Research.

[76]  J. P. Herman,et al.  Evidence of functional vitamin D receptors in rat hippocampus , 2001, Neuroscience.

[77]  Yoshihiro Sato,et al.  High prevalence of vitamin D deficiency and reduced bone mass in elderly women with Alzheimer's disease. , 1998, Bone.

[78]  T. Palmer,et al.  Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation , 1996, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[79]  M. Somerville,et al.  Reduction of vitamin D hormone receptor mRNA levels in Alzheimer as compared to Huntington hippocampus: correlation with calbindin-28k mRNA levels. , 1992, Brain research. Molecular brain research.