The anti-coagulants ASIS or APC do not protect against renal ischemia/ reperfusion injury

[1]  José A Fernández,et al.  Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective , 2003, Nature Medicine.

[2]  W. Buurman,et al.  Apoptosis and inflammation in renal reperfusion injury , 2002, Transplantation.

[3]  P. Vandenabeele,et al.  Functional Protection by Acute Phase Proteins &agr;1-Acid Glycoprotein and &agr;1-Antitrypsin Against Ischemia/Reperfusion Injury by Preventing Apoptosis and Inflammation , 2000, Circulation.

[4]  C. Esmon,et al.  Activated Protein C Protects Against Myocardial Ischemia/ Reperfusion Injury via Inhibition of Apoptosis and Inflammation , 2009, Arteriosclerosis, thrombosis, and vascular biology.

[5]  J. Thurman.  Triggers of inflammation after renal ischemia/reperfusion. , 2007, Clinical immunology.

[6]  S. Akira,et al.  Renal-associated TLR2 mediates ischemia/reperfusion injury in the kidney. , 2005, The Journal of clinical investigation.

[7]  N. Mackman,et al.  Tissue factor deficiency and PAR-1 deficiency are protective against renal ischemia reperfusion injury. , 2007, Blood.

[8]  José A Fernández,et al.  Activated Protein C Reduces Graft Neutrophil Activation in Clinical Renal Transplantation , 2005, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[9]  J. Berrou,et al.  Role of thrombin receptors in the kidney: lessons from PAR1 knock-out mice. , 2001, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[10]  M. Condorelli,et al.  Recombinant human, active site-blocked factor VIIa reduces infarct size and no-reflow phenomenon in rabbits. , 2000, American journal of physiology. Heart and circulatory physiology.

[11]  N. Mackman,et al.  The synthetic pentasaccharide fondaparinux reduces coagulation, inflammation and neutrophil accumulation in kidney ischemia–reperfusion injury , 2005, Journal of thrombosis and haemostasis : JTH.

[12]  T. Noguchi,et al.  Activated protein C reduces ischemia/reperfusion-induced renal injury in rats by inhibiting leukocyte activation. , 2000, Blood.

[13]  T. Noguchi,et al.  Antithrombin reduces ischemia/reperfusion-induced renal injury in rats by inhibiting leukocyte activation through promotion of prostacyclin production. , 2003, Blood.

[14]  M. Daha,et al.  Cardiovascular, Pulmonary and Renal Pathology Myeloperoxidase Is Critically Involved in the Induction of Organ Damage after Renal Ischemia Reperfusion , 2007 .

[15]  Berislav V. Zlokovic,et al.  Anti-Inflammatory, Antithrombotic, and Neuroprotective Effects of Activated Protein C in a Murine Model of Focal Ischemic Stroke , 2001, Circulation.

[16]  W. Buurman,et al.  APOPTOSIS AND CHEMOKINE INDUCTION AFTER RENAL ISCHEMIA-REPERFUSION1 , 2001, Transplantation.

[17]  H. Okabe,et al.  Activated Protein C Reduces the Ischemia/Reperfusion-Induced Spinal Cord Injury in Rats by Inhibiting Neutrophil Activation , 2000, Annals of surgery.

[18]  P. Dagher.  Apoptosis in ischemic renal injury: roles of GTP depletion and p53. , 2004, Kidney international.

[19]  H. Druid,et al.  Fibrin deposition in the kidney in post-ischaemic renal damage. , 1988, British journal of experimental pathology.

[20]  P. Vandenabeele,et al.  Inhibition of apoptosis induced by ischemia-reperfusion prevents inflammation. , 1999, The Journal of clinical investigation.

[21]  P. Vandenabeele,et al.  ACTIVATED CASPASE-1 IS NOT A CENTRAL MEDIATOR OF INFLAMMATION IN THE COURSE OF ISCHEMIA-REPERFUSION1 , 2001, Transplantation.

[22]  N. Mackman,et al.  A non-anticoagulant synthetic pentasaccharide reduces inflammation in a murine model of kidney ischemia-reperfusion injury , 2006, Thrombosis and Haemostasis.

[23]  José A Fernández,et al.  Functional recovery after embolic stroke in rodents by activated protein C , 2005, Annals of neurology.

[24]  P. Reitsma,et al.  Inhalation of activated protein C inhibits endotoxin‐induced pulmonary inflammation in mice independent of neutrophil recruitment , 2006, British journal of pharmacology.

[25]  S. Chadban,et al.  TLR4 activation mediates kidney ischemia/reperfusion injury. , 2007, The Journal of clinical investigation.

[26]  J. Richardson,et al.  Maladaptive role of IL-6 in ischemic acute renal failure. , 2005, Journal of the American Society of Nephrology : JASN.

[27]  C. Spek,et al.  Active site inhibited factor VIIa attenuates myocardial ischemia/reperfusion injury in mice , 2009, Journal of thrombosis and haemostasis : JTH.

[28]  P. Reitsma,et al.  Treatment with an Anti-CD14 Monoclonal Antibody Delays and Inhibits Lipopolysaccharide-Induced Gene Expression in Humans in Vivo , 2003, Journal of Clinical Immunology.

[29]  L. Bopp,et al.  Effect of recombinant human activated protein C on the bactericidal activity of human monocytes and modulation of pro-inflammatory cytokines in the presence of antimicrobial agents. , 2007, The Journal of antimicrobial chemotherapy.

[30]  J Ean,et al.  Efficacy and safety of recombinant human activated protein C for severe sepsis. , 2001, The New England journal of medicine.

[31]  J. Griffin,et al.  The cytoprotective protein C pathway. , 2007, Blood.

[32]  N. Marcussen,et al.  Thrombin inhibition with melagatran does not attenuate renal ischaemia-reperfusion injury in rats. , 2007, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[33]  S. Coughlin,et al.  Protease‐activated receptors in hemostasis, thrombosis and vascular biology , 2005, Journal of thrombosis and haemostasis : JTH.

[34]  C. Esmon,et al.  Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis , 2007, Nature Medicine.