Beneficial Cardiac Effects of Caloric Restriction Are Lost with Age in a Murine Model of Obesity
暂无分享,去创建一个
A. Bielawska | M. Halushka | M. AlGhatrif | L. Barouch | V. Watts | K. Gabrielson | K. Miller | D. Bedja | K. Fox-Talbot | X. Niu | K. Vandegaer | K. Fox‐Talbot | Majd AlGhatrif | K. L. Miller
[1] P. Rabinovitch,et al. Mitochondria and cardiovascular aging. , 2012, Circulation research.
[2] B. Schnackenburg,et al. Left ventricular diastolic function in type 2 diabetes mellitus is associated with myocardial triglyceride content but not with impaired myocardial perfusion reserve , 2012, Journal of magnetic resonance imaging : JMRI.
[3] E. Weiss,et al. Caloric restriction: powerful protection for the aging heart and vasculature. , 2011, American journal of physiology. Heart and circulatory physiology.
[4] R. Bodmer,et al. Lipotoxicity and cardiac dysfunction in mammals and Drosophila , 2011, Critical reviews in biochemistry and molecular biology.
[5] Y. Hannun,et al. Accumulation of Long-Chain Glycosphingolipids during Aging Is Prevented by Caloric Restriction , 2011, PloS one.
[6] P. Munson,et al. Caloric restriction in leptin deficiency does not correct myocardial steatosis: failure to normalize PPAR{alpha}/PGC1{alpha} and thermogenic glycerolipid/fatty acid cycling. , 2011, Physiological genomics.
[7] E. Abel,et al. Central Leptin Signaling Is Required to Normalize Myocardial Fatty Acid Oxidation Rates in Caloric-Restricted ob/ob Mice , 2011, Diabetes.
[8] Gregg S. Pressman,et al. Impact of obesity on total and cardiovascular mortality—fat or fiction? , 2011, Nature Reviews Cardiology.
[9] Petra C. Kienesberger,et al. Shedding light on the enigma of myocardial lipotoxicity: the involvement of known and putative regulators of fatty acid storage and mobilization. , 2010, American journal of physiology. Endocrinology and metabolism.
[10] L. Wold,et al. Interaction between Age and Obesity on Cardiomyocyte Contractile Function: Role of Leptin and Stress Signaling , 2010, PloS one.
[11] D. Kass,et al. Adverse ventricular remodeling and exacerbated NOS uncoupling from pressure-overload in mice lacking the beta3-adrenoreceptor. , 2009, Journal of molecular and cellular cardiology.
[12] J. Schaffer,et al. DGAT1 Expression Increases Heart Triglyceride Content but Ameliorates Lipotoxicity* , 2009, The Journal of Biological Chemistry.
[13] Sunil K. Kakarla,et al. Aging-Associated Dysfunction of Akt/Protein Kinase B: S-Nitrosylation and Acetaminophen Intervention , 2009, PloS one.
[14] O. Raitakari,et al. Effect of caloric restriction on myocardial fatty acid uptake, left ventricular mass, and cardiac work in obese adults. , 2009, The American journal of cardiology.
[15] S. Bastianini,et al. Sleep Modulates Hypertension in Leptin-Deficient Obese Mice , 2009, Hypertension.
[16] Hanno Pijl,et al. Prolonged caloric restriction in obese patients with type 2 diabetes mellitus decreases myocardial triglyceride content and improves myocardial function. , 2008, Journal of the American College of Cardiology.
[17] G. Sweeney,et al. Cardiac remodeling in obesity. , 2008, Physiological reviews.
[18] E. Abel,et al. Molecular mechanisms for myocardial mitochondrial dysfunction in the metabolic syndrome. , 2008, Clinical science.
[19] Cecilia Hidalgo,et al. Changes in mitochondrial dynamics during ceramide-induced cardiomyocyte early apoptosis. , 2008, Cardiovascular research.
[20] Xiaoming Sheng,et al. Mitochondrial Energetics in the Heart in Obesity-Related Diabetes , 2007, Diabetes.
[21] W. Blaner,et al. Lipids in the heart: a source of fuel and a source of toxins , 2007, Current opinion in lipidology.
[22] A. Bielawska,et al. Simultaneous quantitative analysis of bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry. , 2006, Methods.
[23] A. Phan,et al. Cardiac Myocyte Apoptosis Is Associated With Increased DNA Damage and Decreased Survival in Murine Models of Obesity , 2005, Circulation research.
[24] R. Cooksey,et al. Reduced cardiac efficiency and altered substrate metabolism precedes the onset of hyperglycemia and contractile dysfunction in two mouse models of insulin resistance and obesity. , 2005, Endocrinology.
[25] E. Abel,et al. Reduced Mitochondrial Oxidative Capacity and Increased Mitochondrial Uncoupling Impair Myocardial Energetics in Obesity , 2005, Circulation.
[26] S. Klassen,et al. Ceramide activates a mitochondrial p38 mitogen-activated protein kinase: A potential mechanism for loss of mitochondrial transmembrane potential and apoptosis , 2005, Molecular and Cellular Biochemistry.
[27] D. Kass,et al. Oxidant stress from nitric oxide synthase-3 uncoupling stimulates cardiac pathologic remodeling from chronic pressure load. , 2005, The Journal of clinical investigation.
[28] Z. Madar,et al. Mechanism underlying oxidative stress-mediated lipotoxicity: exposure of J774.2 macrophages to triacylglycerols facilitates mitochondrial reactive oxygen species production and cellular necrosis. , 2005, Free radical biology & medicine.
[29] Robert S. Balaban,et al. Mitochondria, Oxidants, and Aging , 2005, Cell.
[30] D. Kass,et al. Advanced glycation end-product cross-link breakers. A novel approach to cardiovascular pathologies related to the aging process. , 2004, American journal of hypertension.
[31] R. Cooksey,et al. Impaired cardiac efficiency and increased fatty acid oxidation in insulin-resistant ob/ob mouse hearts. , 2004, Diabetes.
[32] E. Bollano,et al. Cardiac lipid accumulation associated with diastolic dysfunction in obese mice. , 2003, Endocrinology.
[33] Robert V Farese,et al. Triglyceride accumulation protects against fatty acid-induced lipotoxicity , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[34] D. Harrison,et al. Detection of Superoxide in Vascular Tissue , 2002, Arteriosclerosis, thrombosis, and vascular biology.
[35] A. Malavazos,et al. Echocardiographic abnormalities in normotensive obese patients: relationship with visceral fat. , 2002, Obesity research.
[36] J. Hare,et al. Disruption of Leptin Signaling Contributes to Cardiac Hypertrophy Independently of Body Weight in Mice , 2002, Circulation.
[37] P. Herrero,et al. A novel mouse model of lipotoxic cardiomyopathy. , 2001, The Journal of clinical investigation.
[38] V. P. Chacko,et al. Effect of leptin deficiency on metabolic rate in ob/ obmice. , 1999, American journal of physiology. Endocrinology and metabolism.
[39] A. Bielawska,et al. Ceramide is involved in triggering of cardiomyocyte apoptosis induced by ischemia and reperfusion. , 1997, The American journal of pathology.
[40] J. D. de Vries,et al. Saturated but not mono-unsaturated fatty acids induce apoptotic cell death in neonatal rat ventricular myocytes. , 1997, Journal of lipid research.
[41] R. Goldring,et al. Role of circulatory congestion in the cardiorespiratory failure of obesity. , 1976, The American journal of medicine.
[42] M. Murata,et al. Impact of long-term caloric restriction on cardiac senescence: caloric restriction ameliorates cardiac diastolic dysfunction associated with aging. , 2011, Journal of molecular and cellular cardiology.
[43] N. Koitabashi,et al. Leptin is essential in maintaining normal vascular compliance independent of body weight , 2010, International Journal of Obesity.
[44] N. Vaziri,et al. Upregulation of endothelial and inducible nitric oxide synthase expression by reactive oxygen species. , 2008, American journal of hypertension.
[45] S. Prabhu,et al. Prolonged oxidative stress inverts the cardiac force-frequency relation: role of altered calcium handling and myofilament calcium responsiveness. , 2006, Journal of molecular and cellular cardiology.
[46] Edward G. LAKATrA. Do hypertension and aging have a similar effect on the myocardium ? , 2005 .
[47] V. P. Chacko,et al. Effect of leptin deficiency on metabolic rate in ob/ob mice. , 1999, The American journal of physiology.
[48] E. Lakatta. Do hypertension and aging have a similar effect on the myocardium? , 1987, Circulation.