Single‐nucleotide polymorphism in the E‐cadherin gene promoter modifies the risk of prostate cancer

E‐cadherin plays a major role in intercellular adhesion, cell polarity and tissue architecture. We determined the relative risk of PCa associated with a previously reported C/A SNP at −160 bp relative to the transcription‐start site of the E‐cadherin gene promoter. Eighty‐two PCa patients and 188 controls were genotyped. Genotype and allele frequencies differed significantly among cases and controls. A‐allele carriers had a higher relative risk of PCa (OR = 3.6, 95% CI 2.0–6.4) compared to C‐only carriers. AC and AA genotypes had an increased risk of PCa (OR = 3.8, 95% CI 2.1–6.8 and OR = 1.7, 95% CI 0.4–6.6, respectively) compared to CC genotypes. © 2002 Wiley‐Liss, Inc.

[1]  J. Carpten,et al.  Linkage and association studies of prostate cancer susceptibility: evidence for linkage at 8p22-23. , 2001, American journal of human genetics.

[2]  A. Whittemore,et al.  A genome screen of families with multiple cases of prostate cancer: evidence of genetic heterogeneity. , 2001, American journal of human genetics.

[3]  C. Yue,et al.  Mechanisms of inactivation of E-cadherin in breast carcinoma: modification of the two-hit hypothesis of tumor suppressor gene , 2001, Oncogene.

[4]  C. Caldas,et al.  E-cadherin gene (CDH1) promoter methylation as the second hit in sporadic diffuse gastric carcinoma , 2001, Oncogene.

[5]  J. Stanford,et al.  Genetics of prostate cancer: too many loci, too few genes. , 2000, American journal of human genetics.

[6]  R. Eeles,et al.  Molecular markers for predicting prostate cancer stage and survival , 2000, BJU international.

[7]  P. Polakis.  Wnt signaling and cancer. , 2000, Genes & development.

[8]  P. Carroll,et al.  A single nucleotide polymorphism in the E-cadherin gene promoter alters transcriptional activities. , 2000, Cancer research.

[9]  M. Pike,et al.  Association of mis-sense substitution in SRD5A2 gene with prostate cancer in African-American and Hispanic men in Los Angeles, USA , 1999, The Lancet.

[10]  H. Höfler,et al.  Diffuse type gastric and lobular breast carcinoma in a familial gastric cancer patient with an E-cadherin germline mutation. , 1999, The American journal of pathology.

[11]  Meir J. Stampfer,et al.  Plasma Insulin-Like Growth Factor-I and Prostate Cancer Risk: A Prospective Study , 1998 .

[12]  J. Stanford,et al.  Polymorphic repeats in the androgen receptor gene: molecular markers of prostate cancer risk. , 1997, Cancer research.

[13]  G. Coetzee,et al.  Association of prostate cancer risk with genetic polymorphisms in vitamin D receptor and androgen receptor. , 1997, Journal of the National Cancer Institute.

[14]  W. Isaacs,et al.  Decreased E-cadherin expression is associated with poor prognosis in patients with prostate cancer. , 1994, Cancer research.

[15]  T. Beaty,et al.  Mendelian inheritance of familial prostate cancer. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[16]  W. Birchmeier,et al.  E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells , 1991, The Journal of cell biology.