Origin and Biologic Individuality of the Genetic Dictionary

Deoxyribonucleic acid contains sequences complementary to homologous amino-acid transfer ribonucleic acid molecules which serve as the translating device between polyribonucleotides and proteins. This implies that the RNA molecules have their primary origin in DNA. From the amount of DNA participating, one would infer that more than 20 complementary sequences exist per genome, a conclusion consistent with a degenerate code. The fact that complex formation occurs most readily with homologous RNA suggests that, while the language remains universal, each dictionary is uniquely identifiable with its own genome.

[1]  S. Spiegelman,et al.  Homology Test between the Nucleic Acid of an RNA Virus and the DNA in the Host Cell , 1962, Science.

[2]  E. Maxwell Stimulation of amino acid incorporation into protein by natural and synthetic polyribonucleotides in a mammalian cell-free system. , 1962, Proceedings of the National Academy of Sciences of the United States of America.

[3]  Weinstein Ib,et al.  POLYURIDYLIC ACID STIMULATION OF PHENYLALANINE INCORPORATION IN ANIMAL CELL EXTRACTS , 1962 .

[4]  S. Benzer,et al.  A phsyical basis for degeneracy in the amino acid code. , 1962, Proceedings of the National Academy of Sciences of the United States of America.

[5]  S. Spiegelman,et al.  The identification of the ribosomal RNA cistron by sequence complementarity. II. Saturation of and competitive interaction at the RNA cistron. , 1962, Proceedings of the National Academy of Sciences of the United States of America.

[6]  T. Yamane,et al.  Fractionation of amino acyl-acceptor RNA on a methylated albumin column. , 1962, Proceedings of the National Academy of Sciences of the United States of America.

[7]  J. J. Furth,et al.  The role of deoxyribonucleic acid in ribonucleic acid synthesis. III. The inhibition of the enzymatic synthesis of ribonucleic acid and deoxyribonucleic acid by actinomycin D and proflavin. , 1962, Proceedings of the National Academy of Sciences of the United States of America.

[8]  E. Fleissner,et al.  A new enzyme of RNA synthesis: RNA methylase. , 1962, Proceedings of the National Academy of Sciences of the United States of America.

[9]  A. Shatkin,et al.  Action of actinomycin D on animal cells and viruses. , 1962, Proceedings of the National Academy of Sciences of the United States of America.

[10]  W. Fuller,et al.  Determination of the Helical Configuration of Ribonucleic Acid Molecules by X-Ray Diffraction Study of Crystalline Amino-Acid–transfer Ribonucleic Acid , 1962, Nature.

[11]  S. Spiegelman,et al.  The identification of the ribosomal RNA cistron by sequence complementarity. I. Specificity of complex formation. , 1962, Proceedings of the National Academy of Sciences of the United States of America.

[12]  S. Benzer,et al.  On the role of soluble ribonucleic acid in coding for amino acids. , 1962, Proceedings of the National Academy of Sciences of the United States of America.

[13]  J. H. Matthaei,et al.  Demonstration of the messenger role of viral RNA. , 1962, Proceedings of the National Academy of Sciences of the United States of America.

[14]  S. Spiegelman,et al.  The selective synthesis of informational RNA in bacteria. , 1961, Proceedings of the National Academy of Sciences of the United States of America.

[15]  F. Lipmann,et al.  Experiments on hemoglobin biosynthesis. , 1961, Proceedings of the National Academy of Sciences of the United States of America.

[16]  A. D. Hershey,et al.  A fractionating column for analysis of nucleic acids. , 1960, Analytical biochemistry.

[17]  A. Gierer,et al.  Infectivity of Ribonucleic Acid from Tobacco Mosaic Virus , 1956, Nature.

[18]  J. H. Matthaei,et al.  An intermediate in the biosynthesis of polyphenylalanine directed by synthetic template RNA. , 1962, Proceedings of the National Academy of Sciences of the United States of America.

[19]  S. Spiegelman,et al.  SEQUENCE COMPLEMENTARIITY OF T2-DNA AND T2-SPECIFIC RNA* , 2022 .