ReviewArticle Targeted Delivery of siRNA

[1]  J. Wilschut,et al.  Reconstituted influenza virus envelopes as an efficient carrier system for cellular delivery of small-interfering RNAs , 2006, Gene Therapy.

[2]  A. Lee,et al.  Design of noninflammatory synthetic siRNA mediating potent gene silencing in vivo. , 2006, Molecular therapy : the journal of the American Society of Gene Therapy.

[3]  B. Bosch,et al.  Soluble Receptor-Mediated Targeting of Mouse Hepatitis Coronavirus to the Human Epidermal Growth Factor Receptor , 2005, Journal of Virology.

[4]  Qi Zhou,et al.  Tumor-targeting nanoimmunoliposome complex for short interfering RNA delivery. , 2005, Human gene therapy.

[5]  Satoshi Gojo,et al.  Sonoporation using microbubble BR14 promotes pDNA/siRNA transduction to murine heart. , 2005, Biochemical and biophysical research communications.

[6]  Hongtao Liao,et al.  Biomembrane-permeable and Ribonuclease-resistant siRNA with enhanced activity. , 2005, Oligonucleotides.

[7]  Y. Omidi,et al.  Toxicogenomics of cationic lipid-based vectors for gene therapy: impact of microarray technology. , 2005, Current drug delivery.

[8]  Peixuan Guo,et al.  Specific delivery of therapeutic RNAs to cancer cells via the dimerization mechanism of phi29 motor pRNA. , 2005, Human gene therapy.

[9]  M. Gottesman,et al.  Efficient delivery of RNA interference effectors via in vitro-packaged SV40 pseudovirions. , 2005, Human Gene Therapy.

[10]  Phillip D. Zamore,et al.  Ribo-gnome: The Big World of Small RNAs , 2005, Science.

[11]  T. Ochiya,et al.  Efficient delivery of small interfering RNA to bone-metastatic tumors by using atelocollagen in vivo. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[12]  J. Seppen,et al.  persistent knockdown of CCR2 function in vivo Lentiviral shRNA silencing of murine bone marrow cell CCR2 leads to , 2013 .

[13]  M. Woodle,et al.  In Vivo Application of RNA Interference: From Functional Genomics to Therapeutics , 2005, Advances in Genetics.

[14]  P. J. Welch,et al.  State-of-the-art modified RNAi compounds for therapeutics. , 2005, IDrugs : the investigational drugs journal.

[15]  A. J. Mixson,et al.  Small interfering RNA targeting Raf-1 inhibits tumor growth in vitro and in vivo , 2005, Cancer Gene Therapy.

[16]  Richard W. Carthew,et al.  Silence from within: Endogenous siRNAs and miRNAs , 2005, Cell.

[17]  Hideyoshi Harashima,et al.  RNA interference induced by siRNAs modified with 4′‐thioribonucleosides in cultured mammalian cells , 2005, FEBS letters.

[18]  Gregory J. Hannon,et al.  MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies , 2005, Nature Cell Biology.

[19]  S. Ashley,et al.  RNA interference: a mammalian SID-1 homologue enhances siRNA uptake and gene silencing efficacy in human cells. , 2005, Biochemical and biophysical research communications.

[20]  B. Polisky,et al.  Activity of stabilized short interfering RNA in a mouse model of hepatitis B virus replication , 2005, Hepatology.

[21]  Judy Lieberman,et al.  Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors , 2005, Nature Biotechnology.

[22]  R. Griffey,et al.  Positional effect of chemical modifications on short interference RNA activity in mammalian cells. , 2005, Journal of Medicinal Chemistry.

[23]  H. Blau,et al.  Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies , 2005, Nature Cell Biology.

[24]  M. Sioud.  Induction of inflammatory cytokines and interferon responses by double-stranded and single-stranded siRNAs is sequence-dependent and requires endosomal localization. , 2005, Journal of molecular biology.

[25]  F. He,et al.  Cationic lipids enhance siRNA-mediated interferon response in mice. , 2005, Biochemical and biophysical research communications.

[26]  I. Ahmad,et al.  Systemic delivery of RafsiRNA using cationic cardiolipin liposomes silences Raf-1 expression and inhibits tumor growth in xenograft model of human prostate cancer. , 2005, International journal of oncology.

[27]  R. Schiffelers,et al.  Effects of treatment with small interfering RNA on joint inflammation in mice with collagen-induced arthritis. , 2005, Arthritis and rheumatism.

[28]  L. Greensmith,et al.  Silencing mutant SOD1 using RNAi protects against neurodegeneration and extends survival in an ALS model , 2005, Nature Medicine.

[29]  C. Boshoff,et al.  Inhibiting primary effusion lymphoma by lentiviral vectors encoding short hairpin RNA. , 2005, Blood.

[30]  C. Henderson,et al.  Lentiviral-mediated silencing of SOD1 through RNA interference retards disease onset and progression in a mouse model of ALS , 2005, Nature Medicine.

[31]  G. Nolan,et al.  Gene therapy progress and prospects: Novel gene therapy approaches for AIDS , 2005, Gene Therapy.

[32]  A. Aigner,et al.  RNAi-mediated gene-targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivo , 2005, Gene Therapy.

[33]  S. Akira,et al.  Sequence-specific potent induction of IFN-α by short interfering RNA in plasmacytoid dendritic cells through TLR7 , 2005, Nature Medicine.

[34]  D. Palmer,et al.  Helper-dependent adenoviral vectors for gene therapy. , 2005, Human gene therapy.

[35]  Qun Zhou,et al.  Viral vectors for cancer gene therapy: viral dissemination and tumor targeting. , 2005, Current gene therapy.

[36]  Sung Ho Hahm,et al.  Retroviral gene therapy: safety issues and possible solutions. , 2005, Current gene therapy.

[37]  F. Chisari,et al.  Clearance of hepatitis B virus from the liver of transgenic mice by short hairpin RNAs. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[38]  T. Rana,et al.  Specific and potent RNAi in the nucleus of human cells , 2005, Nature Structural &Molecular Biology.

[39]  F. Porreca,et al.  An efficient intrathecal delivery of small interfering RNA to the spinal cord and peripheral neurons , 2005, Molecular pain.

[40]  W. Denk,et al.  Lentivirus-based genetic manipulations of cortical neurons and their optical and electrophysiological monitoring in vivo , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[41]  M. Manoharan.  RNA interference and chemically modified small interfering RNAs. , 2004, Current opinion in chemical biology.

[42]  Raymond M Schiffelers,et al.  Inhibition of ocular angiogenesis by siRNA targeting vascular endothelial growth factor pathway genes: therapeutic strategy for herpetic stromal keratitis. , 2004, The American journal of pathology.

[43]  Matthias John,et al.  Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs , 2004, Nature.

[44]  S. Chae,et al.  Requirement for sphingosine 1-phosphate receptor-1 in tumor angiogenesis demonstrated by in vivo RNA interference. , 2004, The Journal of clinical investigation.

[45]  J. Lieberman,et al.  Small interfering RNA targeting Fas protects mice against renal ischemia-reperfusion injury. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[46]  S. Ashley,et al.  Systemic siRNA-Mediated Gene Silencing: A New Approach to Targeted Therapy of Cancer , 2004, Annals of surgery.

[47]  T. Rana,et al.  Visualizing a correlation between siRNA localization, cellular uptake, and RNAi in living cells. , 2004, Chemistry & biology.

[48]  K. Taira,et al.  Adenovirus-mediated transfer of siRNA against survivin induced apoptosis and attenuated tumor cell growth in vitro and in vivo. , 2004, Molecular therapy : the journal of the American Society of Gene Therapy.

[49]  Y. Yuzawa,et al.  A Small Interfering RNA Targeting Vascular Endothelial Growth Factor as Cancer Therapeutics , 2004, Cancer Research.

[50]  Anton P. McCaffrey,et al.  In vivo activity of nuclease-resistant siRNAs. , 2004, RNA.

[51]  M. Eccles,et al.  Conjugate for efficient delivery of short interfering RNA (siRNA) into mammalian cells , 2004, FEBS letters.

[52]  E. H. Feinberg,et al.  Transport of dsRNA into Cells by the Transmembrane Protein SID-1 , 2003, Science.

[53]  T. Rana,et al.  siRNA function in RNAi: a chemical modification analysis. , 2003, RNA.

[54]  Robert H. Silverman,et al.  Activation of the interferon system by short-interfering RNAs , 2003, Nature Cell Biology.

[55]  David R Corey,et al.  RNA interference in mammalian cells by chemically-modified RNA. , 2003, Biochemistry.

[56]  A. Klippel,et al.  Structural variations and stabilising modifications of synthetic siRNAs in mammalian cells. , 2003, Nucleic acids research.

[57]  Mouldy Sioud,et al.  Gene silencing by systemic delivery of synthetic siRNAs in adult mice. , 2003, Journal of molecular biology.

[58]  Thomas Tuschl,et al.  Sequence, chemical, and structural variation of small interfering RNAs and short hairpin RNAs and the effect on mammalian gene silencing. , 2003, Antisense & nucleic acid drug development.

[59]  Jens Kurreck,et al.  Antisense technologies. Improvement through novel chemical modifications. , 2003, European journal of biochemistry.

[60]  P. Monahan,et al.  Safety of adeno-associated virus gene therapy vectors: a current evaluation , 2002, Expert opinion on drug safety.

[61]  J. Kappes,et al.  Safety Considerations in Vector Development , 2001, Somatic cell and molecular genetics.

[62]  T. Tuschl,et al.  Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells , 2001, Nature.

[63]  S. Gambhir,et al.  Imaging chemically modified adenovirus for targeting tumors expressing integrin alphavbeta3 in living mice with mutant herpes simplex virus type 1 thymidine kinase PET reporter gene. , 2006, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[64]  Tadaharu Tsumoto,et al.  RNAi-induced gene silencing by local electroporation in targeting brain region. , 2005, Journal of neurophysiology.

[65]  H. Mizuguchi,et al.  Gene therapy for human small-cell lung carcinoma by inactivation of Skp-2 with virally mediated RNA interference , 2005, Gene Therapy.

[66]  K. Alexander,et al.  RNA interference using boranophosphate siRNAs: structure-activity relationships. , 2004, Nucleic acids research.

[67]  R. Schiffelers,et al.  Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle. , 2004, Nucleic acids research.

[68]  Raymond M. Schiffelers,et al.  Pharmaceutical Prospects for RNA Interference , 2004, Pharmaceutical Research.

[69]  N. Kosaka,et al.  Atelocollagen-mediated synthetic small interfering RNA delivery for effective gene silencing in vitro and in vivo. , 2004, Nucleic acids research.

[70]  M. Famulok,et al.  Functional tuning of nucleic acids by chemical modifications: tailored oligonucleotides as drugs, devices, and diagnostics. , 2003, Chemical record.