Clinical practice guidelines by the infectious diseases society of america for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children: executive summary.

Evidence-based guidelines for the management of patients with methicillin-resistant Staphylococcus aureus (MRSA) infections were prepared by an Expert Panel of the Infectious Diseases Society of America (IDSA). The guidelines are intended for use by health care providers who care for adult and pediatric patients with MRSA infections. The guidelines discuss the management of a variety of clinical syndromes associated with MRSA disease, including skin and soft tissue infections (SSTI), bacteremia and endocarditis, pneumonia, bone and joint infections, and central nervous system (CNS) infections. Recommendations are provided regarding vancomycin dosing and monitoring, management of infections due to MRSA strains with reduced susceptibility to vancomycin, and vancomycin treatment failures.

[1]  J. Sehouli,et al.  Systematic review and meta-analysis of antibiotic therapy for bone and joint infections. , 2001, The Lancet. Infectious diseases.

[2]  G. Eliopoulos,et al.  Efficacy of Daptomycin in Experimental Endocarditis Due to Methicillin-Resistant Staphylococcusaureus , 2003, Antimicrobial Agents and Chemotherapy.

[3]  V. Fowler,et al.  Telavancin versus vancomycin for the treatment of complicated skin and skin-structure infections caused by gram-positive organisms. , 2008, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[4]  J. Journeycake,et al.  Venous thrombosis and thromboembolism in children with osteomyelitis. , 2006, The Journal of pediatrics.

[5]  G. Nagashima,et al.  Effect of linezolid against postneurosurgical meningitis caused by methicillin-resistant Staphylococcus epidermidis: case report , 2008, Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.

[6]  I. Sia,et al.  Infection and musculoskeletal conditions: Osteomyelitis. , 2006, Best practice & research. Clinical rheumatology.

[7]  S. Pillai,et al.  Emergence of a Clinical Daptomycin-Resistant Staphylococcus aureus Isolate during Treatment of Methicillin-Resistant Staphylococcus aureus Bacteremia and Osteomyelitis , 2006, Journal of Clinical Microbiology.

[8]  M. Peterson,et al.  ECONOMIC IMPACT OF THE COMMUNITY-ACQUIRED METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS EPIDEMIC ON THE DRISCOLL CHILDREN'S HEALTH PLAN , 2005, The Pediatric infectious disease journal.

[9]  D. Nicolau,et al.  Comparison of vancomycin pharmacodynamics (1 g every 12 or 24 h) against methicillin-resistant staphylococci. , 2000, International journal of antimicrobial agents.

[10]  Richard G Wunderink,et al.  Continuation of a randomized, double-blind, multicenter study of linezolid versus vancomycin in the treatment of patients with nosocomial pneumonia. , 2003, Clinical therapeutics.

[11]  B. Markewitz,et al.  Decreased Serum Linezolid Levels in a Critically Ill Patient Receiving Concomitant Linezolid and Rifampin , 2007, Pharmacotherapy.

[12]  G. Eliopoulos,et al.  Relationship of MIC and Bactericidal Activity to Efficacy of Vancomycin for Treatment of Methicillin-Resistant Staphylococcus aureus Bacteremia , 2004, Journal of Clinical Microbiology.

[13]  Hoang Q Pham,et al.  Incidence and clinical characteristics of methicillin-resistant Staphylococcus aureus necrotizing fasciitis in a large urban hospital. , 2007, American journal of surgery.

[14]  S. Kaplan,et al.  Venous Thrombosis Associated With Staphylococcal Osteomyelitis in Children , 2006, Pediatrics.

[15]  J. Ruhe,et al.  Tetracyclines as an Oral Treatment Option for Patients with Community Onset Skin and Soft Tissue Infections Caused by Methicillin-Resistant Staphylococcus aureus , 2007, Antimicrobial Agents and Chemotherapy.

[16]  E. Loh,et al.  Safety and Efficacy of Tigecycline in Treatment of Skin and Skin Structure Infections: Results of a Double-Blind Phase 3 Comparison Study with Vancomycin-Aztreonam , 2005, Antimicrobial Agents and Chemotherapy.

[17]  C. Anderson,et al.  ABSCESS: applied bedside sonography for convenient evaluation of superficial soft tissue infections. , 2005, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[18]  J. Powers,et al.  Strategies for Clinical Management of MRSA in the Community: Summary of an Experts' Meeting Convened by the Centers for Disease Control and Prevention , 2006 .

[19]  L. Argaud,et al.  Loading dose of vancomycin in critically ill patients: 15 mg/kg is a better choice than 500 mg. , 2006, International journal of antimicrobial agents.

[20]  About Jama,et al.  Severe Methicillin-Resistant Staphylococcus aureus Community-Acquired Pneumonia Associated With Influenza— Louisiana and Georgia, December 2006-January 2007 , 2007 .

[21]  M. Sande,et al.  TREATMENT OF RIGHT-SIDED STAPHYLOCOCCUS AUREUS ENDOCARDITIS IN INTRAVENOUS DRUG USERS WITH CIPROFLOXACIN AND RIFAMPICIN , 1989, The Lancet.

[22]  J. Quinn,et al.  Development of Daptomycin Resistance In Vivo in Methicillin-Resistant Staphylococcus aureus , 2005, Journal of Clinical Microbiology.

[23]  Stephan Harbarth,et al.  Randomized, Placebo-Controlled, Double-Blind Trial To Evaluate the Efficacy of Mupirocin for Eradicating Carriage of Methicillin-Resistant Staphylococcus aureus , 1999, Antimicrobial Agents and Chemotherapy.

[24]  G. Rahav,et al.  Clinical features of heteroresistant vancomycin-intermediate Staphylococcus aureus bacteremia versus those of methicillin-resistant S. aureus bacteremia. , 2009, The Journal of infectious diseases.

[25]  M. Ieven,et al.  Central nervous system invasion by community-acquired meticillin-resistant Staphylococcus aureus. , 2009, Journal of medical microbiology.

[26]  Gilbert Habib,et al.  Predictors of death and impact of surgery in Staphylococcus aureus infective endocarditis. , 2007, The Annals of thoracic surgery.

[27]  J. Versalovic,et al.  Three-year surveillance of community-acquired Staphylococcus aureus infections in children. , 2005, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[28]  E. Loh,et al.  The efficacy and safety of tigecycline in the treatment of skin and skin-structure infections: results of 2 double-blind phase 3 comparison studies with vancomycin-aztreonam. , 2005, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[29]  D. Stevens,et al.  Successful treatment of staphylococcal toxic shock syndrome with linezolid: a case report and in vitro evaluation of the production of toxic shock syndrome toxin type 1 in the presence of antibiotics. , 2006, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[30]  D. Raveh,et al.  Risk factors for Clostridium difficile toxin-positive nosocomial diarrhoea. , 2006, International journal of antimicrobial agents.

[31]  C. Bridges,et al.  Severe Community-acquired Pneumonia Due to Staphylococcus aureus, 2003–04 Influenza Season , 2006, Emerging infectious diseases.

[32]  G. Drusano,et al.  Larger Vancomycin Doses (at Least Four Grams per Day) Are Associated with an Increased Incidence of Nephrotoxicity , 2008, Antimicrobial Agents and Chemotherapy.

[33]  C. Mathews,et al.  Septic arthritis: current diagnostic and therapeutic algorithm , 2008, Current opinion in rheumatology.

[34]  F. Martínez Sagasti,et al.  Clinical outbreak of linezolid-resistant Staphylococcus aureus in an intensive care unit. , 2010, JAMA.

[35]  A. MacGowan,et al.  In vitro activity of 21 antimicrobials against vancomycin-resistant Staphylococcus aureus (VRSA) and heteroVRSA (hVRSA). , 2002, The Journal of antimicrobial chemotherapy.

[36]  L. Brammer,et al.  Influenza-Associated Pediatric Mortality in the United States: Increase of Staphylococcus aureus Coinfection , 2008, Pediatrics.

[37]  P. Dineen,et al.  Clinical experience: respiratory tract. Trimethoprim-sulfamethoxazole versus penicillin G in the treatment of group A beta-hemolytic streptococcal pharyngitis and tonsillitis. , 1973, The Journal of infectious diseases.

[38]  S. Cosgrove,et al.  Management of methicillin-resistant Staphylococcus aureus bacteremia. , 2008, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[39]  C. Libertin,et al.  Effects of trimethoprim-sulfamethoxazole and incubation atmosphere on isolation of group A streptococci , 1983, Journal of clinical microbiology.

[40]  E. Coskun,et al.  A retrospective study of central nervous system shunt infections diagnosed in a university hospital during a 4-year period , 2006, BMC infectious diseases.

[41]  D. Raoult,et al.  Ambulatory Treatment of Multidrug-ResistantStaphylococcus-Infected Orthopedic Implants with High-Dose Oral Co-trimoxazole (Trimethoprim-Sulfamethoxazole) , 1998, Antimicrobial Agents and Chemotherapy.

[42]  Elizabeth Weekes,et al.  Addition of Rifampin to Standard Therapy for Treatment of Native Valve Infective Endocarditis Caused by Staphylococcus aureus , 2008, Antimicrobial Agents and Chemotherapy.

[43]  J. Miro,et al.  Addition of Gentamicin or Rifampin Does Not Enhance the Effectiveness of Daptomycin in Treatment of Experimental Endocarditis Due to Methicillin-Resistant Staphylococcus aureus , 2009, Antimicrobial Agents and Chemotherapy.

[44]  G. Martel,et al.  A case of spontaneous methicillin-resistant Staphylococcus aureus meningitis in a health care worker. , 2004, The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale.

[45]  L. Mortin,et al.  Inhibition of daptomycin by pulmonary surfactant: in vitro modeling and clinical impact. , 2005, The Journal of infectious diseases.

[46]  Jerome J. Schentag,et al.  Linezolid in the Treatment of Osteomyelitis: Results of Compassionate Use Experience , 2004, Infection.

[47]  J. Perfect,et al.  Safety and efficacy of quinupristin/dalfopristin for treatment of invasive Gram-positive infections in pediatric patients , 2002, The Pediatric infectious disease journal.

[48]  M. Moore,et al.  Vancomycin Treatment Failure Associated with Heterogeneous Vancomycin-Intermediate Staphylococcus aureus in a Patient with Endocarditis and in the Rabbit Model of Endocarditis , 2003, Antimicrobial Agents and Chemotherapy.

[49]  N. Kim,et al.  Outcome of Vancomycin Treatment in Patients with Methicillin-Susceptible Staphylococcus aureus Bacteremia , 2007, Antimicrobial Agents and Chemotherapy.

[50]  D. Musher,et al.  Outcomes of treatment for hematogenous Staphylococcus aureus vertebral osteomyelitis in the MRSA ERA. , 2008, The Journal of infection.

[51]  Joshua A. Doherty,et al.  A retrospective analysis of possible renal toxicity associated with vancomycin in patients with health care-associated methicillin-resistant Staphylococcus aureus pneumonia. , 2007, Clinical therapeutics.

[52]  Patrick F. Smith,et al.  In Vitro Antagonism with the Combination of Vancomycin and Clindamycin Against Staphylococcus aureus , 2004 .

[53]  Jaime Moreno,et al.  Clinical and Microbiological Aspects of Linezolid Resistance Mediated by the cfr Gene Encoding a 23S rRNA Methyltransferase , 2008, Journal of Clinical Microbiology.

[54]  A. Nierhaus,et al.  Use of polyclonal immunoglobulins as adjunctive therapy for sepsis or septic shock * , 2007, Critical care medicine.

[55]  M. Weinstein,et al.  Characterisation of a Staphylococcus aureus strain with progressive loss of susceptibility to vancomycin and daptomycin during therapy. , 2009, International journal of antimicrobial agents.

[56]  K. Kümmerer,et al.  Linezolid and Rifampin: Drug Interaction Contrary to Expectations? , 2005, Clinical pharmacology and therapeutics.

[57]  S. O'Hanlon,et al.  A population-based study of the incidence and molecular epidemiology of methicillin-resistant Staphylococcus aureus disease in San Francisco, 2004-2005. , 2008, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[58]  L. Teixeira,et al.  Antimicrobial susceptibility and survey of macrolide resistance mechanisms among Streptococcus pyogenes isolated in Rio de Janeiro, Brazil. , 2003, Microbial drug resistance.

[59]  L. Koeth,et al.  Clinical Progression of Methicillin-Resistant Staphylococcus aureus Vertebral Osteomyelitis Associated with Reduced Susceptibility to Daptomycin , 2005, Journal of Clinical Microbiology.

[60]  P. Newton,et al.  A Comparison of Early Versus Late Conversion From Intravenous to Oral Therapy in the Treatment of Septic Arthritis , 2009, Journal of pediatric orthopedics.

[61]  A. Widmer,et al.  Correlation between in vivo and in vitro efficacy of antimicrobial agents against foreign body infections. , 1990, The Journal of infectious diseases.

[62]  M. Rybak,et al.  Novel Daptomycin Combinations against Daptomycin-Nonsusceptible Methicillin-Resistant Staphylococcus aureus in an In Vitro Model of Simulated Endocardial Vegetations , 2010, Antimicrobial Agents and Chemotherapy.

[63]  C Flexner,et al.  Oral antibiotic treatment of right-sided staphylococcal endocarditis in injection drug users: prospective randomized comparison with parenteral therapy. , 1996, The American journal of medicine.

[64]  J. Patel,et al.  An association between reduced susceptibility to daptomycin and reduced susceptibility to vancomycin in Staphylococcus aureus. , 2006, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[65]  A. Simpson,et al.  Chronic osteomyelitis. The effect of the extent of surgical resection on infection-free survival. , 2001, The Journal of bone and joint surgery. British volume.

[66]  G. Eliopoulos,et al.  Daptomycin Nonsusceptibility in Staphylococcus aureus with Reduced Vancomycin Susceptibility Is Independent of Alterations in MprF , 2007, Antimicrobial Agents and Chemotherapy.

[67]  M. Kollef,et al.  Methicillin-resistant Staphylococcus aureus prolongs intensive care unit stay in ventilator-associated pneumonia, despite initially appropriate antibiotic therapy , 2006, Critical care medicine.

[68]  W. Epstein,et al.  Clindamycin levels in various body tissues and fluids. , 1972, The Journal of clinical pharmacology and new drugs.

[69]  P. Lee,et al.  Fine-needle aspiration biopsy in diagnosis of soft tissue infections , 1985, Journal of clinical microbiology.

[70]  Jerome J. Schentag,et al.  Pharmacodynamics of Vancomycin and Other Antimicrobials in Patients with Staphylococcus aureus Lower Respiratory Tract Infections , 2004, Clinical pharmacokinetics.

[71]  J. Quinn,et al.  Clindamycin treatment of methicillin-resistant Staphylococcus aureus infections in children , 2002, The Pediatric infectious disease journal.

[72]  J. Peacock,et al.  Hematogenous Vertebral Osteomyelitis Due to Staphylococcus aureus in the Adult: Clinical Features and Therapeutic Outcomes , 2005, Southern medical journal.

[73]  P. Ward,et al.  Clinical features associated with bacteremia due to heterogeneous vancomycin-intermediate Staphylococcus aureus. , 2004, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[74]  C. Chiu,et al.  Experience With Linezolid Therapy in Children With Osteoarticular Infections , 2007, The Pediatric infectious disease journal.

[75]  M. Kollef,et al.  Pleuropulmonary complications of Panton-Valentine leukocidin-positive community-acquired methicillin-resistant Staphylococcus aureus: importance of treatment with antimicrobials inhibiting exotoxin production. , 2005, Chest.

[76]  D. Lee,et al.  Successful treatment of methicillin-resistant staphylococcus aureus meningitis with daptomycin. , 2008, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[77]  S. Kaplan,et al.  USA300 is the Predominant Genotype Causing Staphylococcus aureus Septic Arthritis in Children , 2009, The Pediatric infectious disease journal.

[78]  D. Hospenthal,et al.  Targeted Intranasal Mupirocin To Prevent Colonization and Infection by Community-Associated Methicillin-Resistant Staphylococcus aureus Strains in Soldiers: a Cluster Randomized Controlled Trial , 2007, Antimicrobial Agents and Chemotherapy.

[79]  L. Gutmann,et al.  In Vitro Bactericidal Activities of Linezolid in Combination with Vancomycin, Gentamicin, Ciprofloxacin, Fusidic Acid, and Rifampin against Staphylococcus aureus , 2003, Antimicrobial Agents and Chemotherapy.

[80]  G. Eliopoulos,et al.  Induction of Daptomycin Heterogeneous Susceptibility in Staphylococcus aureus by Exposure to Vancomycin , 2006, Antimicrobial Agents and Chemotherapy.

[81]  N. Kim,et al.  Salvage treatment for persistent methicillin-resistant Staphylococcus aureus bacteremia: efficacy of linezolid with or without carbapenem. , 2009, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[82]  P L Hibberd,et al.  Staphylococcus aureus prosthetic valve endocarditis: optimal management and risk factors for death. , 1998, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[83]  P E Ochsner,et al.  Role of rifampin for treatment of orthopedic implant-related staphylococcal infections: a randomized controlled trial. Foreign-Body Infection (FBI) Study Group. , 1998, JAMA.

[84]  M. Rybak,et al.  Evaluation of Daptomycin Pharmacodynamics and Resistance at Various Dosage Regimens against Staphylococcus aureus Isolates with Reduced Susceptibilities to Daptomycin in an In Vitro Pharmacodynamic Model with Simulated Endocardial Vegetations , 2008, Antimicrobial Agents and Chemotherapy.

[85]  M. Loeb,et al.  Antimicrobial drugs for treating methicillin-resistant Staphylococcus aureus colonization. , 2003, The Cochrane database of systematic reviews.

[86]  M. Dudley,et al.  Pharmacokinetics of trimethoprim and sulfamethoxazole in serum and cerebrospinal fluid of adult patients with normal meninges , 1984, Antimicrobial Agents and Chemotherapy.

[87]  P. Schlievert,et al.  Clindamycin-induced suppression of toxic-shock syndrome--associated exotoxin production. , 1984, The Journal of infectious diseases.

[88]  Vance G Fowler,et al.  Daptomycin versus standard therapy for bacteremia and endocarditis caused by Staphylococcus aureus. , 2006, The New England journal of medicine.

[89]  J. Fergie,et al.  Epidemic of community-acquired methicillin-resistant Staphylococcus aureus infections: a 14-year study at Driscoll Children's Hospital. , 2005, Archives of pediatrics & adolescent medicine.

[90]  S. Kent,et al.  Importance of transesophageal echocardiography in the evaluation of Staphylococcus aureus bacteremia. , 2005, The Journal of heart valve disease.

[91]  S. Kaplan,et al.  Linezolid for the treatment of complicated skin and skin structure infections in children , 2003, The Pediatric infectious disease journal.

[92]  R. S. Mitchell,et al.  Valve replacement in patients with native valve endocarditis: what really determines operative outcome? , 1985, The Annals of thoracic surgery.

[93]  K. Lawrence,et al.  Trimethoprim/Sulfamethoxazole for Treatment of Severe Staphylococcus aureus Infections , 2004, The Annals of pharmacotherapy.

[94]  M. Goetz,et al.  Serotonin syndrome and linezolid. , 2002, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[95]  M. Klempner,et al.  In vitro evaluation of clindamycin in combination with oxacillin, rifampin, or vancomycin against Staphylococcus aureus. , 1986, Diagnostic microbiology and infectious disease.

[96]  G. Sensabaugh,et al.  Emergence of Multidrug-Resistant, Community-Associated, Methicillin-Resistant Staphylococcus aureus Clone USA300 in Men Who Have Sex with Men , 2008, Annals of Internal Medicine.

[97]  J. Ariza,et al.  Pilot Study of Ampicillin-Ceftriaxone Combination for Treatment of Orthopedic Infections Due to Enterococcus faecalis , 2009, Antimicrobial Agents and Chemotherapy.

[98]  A. Troelstra,et al.  Preventing surgical-site infections in nasal carriers of Staphylococcus aureus. , 2010, The New England journal of medicine.

[99]  B. Murray,et al.  Point: Vancomycin is not obsolete for the treatment of infection caused by methicillin-resistant Staphylococcus aureus. , 2007, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[100]  D. Levine,et al.  Impact of Empirical-Therapy Selection on Outcomes of Intravenous Drug Users with Infective Endocarditis Caused by Methicillin-Susceptible Staphylococcus aureus , 2007, Antimicrobial Agents and Chemotherapy.

[101]  P. Choong,et al.  Treatment of staphylococcal prosthetic joint infections with debridement, prosthesis retention and oral rifampicin and fusidic acid. , 2007, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

[102]  E. Bouza,et al.  Linezolid therapy for infective endocarditis. , 2007, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

[103]  Susan K. Johnson,et al.  Comparison of community- and health care-associated methicillin-resistant Staphylococcus aureus infection. , 2003, JAMA.

[104]  Guiqing Wang,et al.  Increased Vancomycin MICs for Staphylococcus aureus Clinical Isolates from a University Hospital during a 5-Year Period , 2006, Journal of Clinical Microbiology.

[105]  A. Mejias,et al.  Daptomycin Therapy for Invasive Gram-Positive Bacterial Infections in Children , 2007, The Pediatric infectious disease journal.

[106]  J. Ariza,et al.  Long-Term Follow-Up Trial of Oral Rifampin-Cotrimoxazole Combination versus Intravenous Cloxacillin in Treatment of Chronic Staphylococcal Osteomyelitis , 2009, Antimicrobial Agents and Chemotherapy.

[107]  Vance G. Fowler,et al.  Staphylococcus aureus Bacteremia in Patients With Permanent Pacemakers or Implantable Cardioverter-Defibrillators , 2001, Circulation.

[108]  B. Bruguerolle,et al.  Cerebrospinal Fluid Penetration and Pharmacokinetics of Vancomycin Administered by Continuous Infusion to Mechanically Ventilated Patients in an Intensive Care Unit , 2000, Antimicrobial Agents and Chemotherapy.

[109]  Brad Spellberg,et al.  Necrotizing fasciitis caused by community-associated methicillin-resistant Staphylococcus aureus in Los Angeles. , 2005, The New England journal of medicine.

[110]  J. Beaumont,et al.  Topical Therapy for Methicillin-Resistant Staphylococcus aureus Colonization Impact on Infection Risk , 2009, Infection Control & Hospital Epidemiology.

[111]  H. Jafri,et al.  Single-Dose Pharmacokinetics of Daptomycin in Children With Suspected or Proved Gram-Positive Infections , 2008, The Pediatric infectious disease journal.

[112]  J. Patel,et al.  Characterization of a Strain of Community-AssociatedMethicillin-Resistant Staphylococcus aureus WidelyDisseminated in the UnitedStates , 2006, Journal of Clinical Microbiology.

[113]  G. Mccracken,et al.  Inducible Clindamycin Resistance and Molecular Epidemiologic Trends of Pediatric Community-Acquired Methicillin-Resistant Staphylococcus aureus in Dallas, Texas , 2005, Antimicrobial Agents and Chemotherapy.

[114]  Rebecca L. Chain,et al.  HYPOCHLORITE KILLING OF COMMUNITY-ASSOCIATED METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS , 2008, The Pediatric infectious disease journal.

[115]  J. Thys,et al.  Double-blind, placebo-controlled study of oxacillin combined with rifampin in the treatment of staphylococcal infections , 1985, Antimicrobial Agents and Chemotherapy.

[116]  Shuo Wang,et al.  Postoperatively administered vancomycin reaches therapeutic concentration in the cerebral spinal fluid of neurosurgical patients. , 2008, Surgical neurology.

[117]  J. Patel,et al.  High Frequencies of Clindamycin and Tetracycline Resistance in Methicillin-Resistant Staphylococcus aureus Pulsed-Field Type USA300 Isolates Collected at a Boston Ambulatory Health Center , 2007, Journal of Clinical Microbiology.

[118]  C. Norden,et al.  Value of needle aspiration in bacteriologic diagnosis of cellulitis in adults , 1988, Journal of clinical microbiology.

[119]  R. Steele,et al.  Adherence Issues Related to the Selection of Antistaphylococcal or Antifungal Antibiotic Suspensions for Children , 2006, Clinical pediatrics.

[120]  Joshua A. Doherty,et al.  Predictors of mortality for methicillin-resistant Staphylococcus aureus health-care-associated pneumonia: specific evaluation of vancomycin pharmacokinetic indices. , 2006, Chest.

[121]  D. Lauderdale,et al.  Community-acquired methicillin-resistant Staphylococcus aureus in children with no identified predisposing risk. , 1998, JAMA.

[122]  R. Quintiliani,et al.  Trimethoprim-sulfamethoxazole for bacterial meningitis. , 1984, Annals of internal medicine.

[123]  Jerome J. Schentag,et al.  The burden of Staphylococcus aureus infections on hospitals in the United States: an analysis of the 2000 and 2001 Nationwide Inpatient Sample Database. , 2005, Archives of internal medicine.

[124]  H. Boucher,et al.  Perspectives on Daptomycin resistance, with emphasis on resistance in Staphylococcus aureus. , 2007, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[125]  M. Wysocki,et al.  Comparison of continuous with discontinuous intravenous infusion of vancomycin in severe MRSA infections. , 1995, The Journal of antimicrobial chemotherapy.

[126]  B. Diep,et al.  Clinical practice: colonization, fomites, and virulence: rethinking the pathogenesis of community-associated methicillin-resistant Staphylococcus aureus infection. , 2008, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[127]  V. Fowler,et al.  Frequency of Infective Endocarditis Among Infants and Children With Staphylococcus aureus Bacteremia , 2004, Pediatrics.

[128]  Heikki Peltola,et al.  Prospective, randomized trial of 10 days versus 30 days of antimicrobial treatment, including a short-term course of parenteral therapy, for childhood septic arthritis. , 2009, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[129]  M. Salavert,et al.  [Cotrimoxazole plus rifampicin in the treatment of staphylococcal osteoarticular infection]. , 1997, Enfermedades infecciosas y microbiologia clinica.

[130]  D. Stevens,et al.  Impact of antibiotics on expression of virulence-associated exotoxin genes in methicillin-sensitive and methicillin-resistant Staphylococcus aureus. , 2007, The Journal of infectious diseases.

[131]  Walter R Wilson,et al.  Update on cardiovascular implantable electronic device infections and their management: a scientific statement from the American Heart Association. , 2010, Circulation.

[132]  R. Nau,et al.  Penetration of rifampicin into the cerebrospinal fluid of adults with uninflamed meninges. , 1992, The Journal of antimicrobial chemotherapy.

[133]  S. Fridkin,et al.  Epidemiological and microbiological characterization of infections caused by Staphylococcus aureus with reduced susceptibility to vancomycin, United States, 1997-2001. , 2003, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[134]  S. Ludwig,et al.  Cellulitis: a prospective study. , 1980, Annals of emergency medicine.

[135]  H. Gould,et al.  Pediatric mediastinitis as a complication of methicillin-resistant Staphylococcus aureus retropharyngeal abscess. , 2008, Archives of otolaryngology--head & neck surgery.

[136]  B. Farr,et al.  Short-Course Therapy of Catheter-related Staphylococcus aureus Bacteremia , 1993, Annals of Internal Medicine.

[137]  L. Leibovici,et al.  Long-term outcome of infective endocarditis: the impact of early surgical intervention. , 2001, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[138]  B. Meyers,et al.  Concentration of Clindamycin in Human Bone , 1975, Antimicrobial Agents and Chemotherapy.

[139]  S. Müller,et al.  Subinhibitory Concentrations of Linezolid Reduce Staphylococcus aureus Virulence Factor Expression , 2004, Antimicrobial Agents and Chemotherapy.

[140]  R. Raz,et al.  A 1-year trial of nasal mupirocin in the prevention of recurrent staphylococcal nasal colonization and skin infection. , 1996, Archives of internal medicine.

[141]  Arjun Srinivasan,et al.  A clone of methicillin-resistant Staphylococcus aureus among professional football players. , 2005, The New England journal of medicine.

[142]  S. Lerakis,et al.  Staphylococcus aureus bacteremia and endocarditis: the Grady Memorial Hospital experience with methicillin-sensitive S aureus and methicillin-resistant S aureus bacteremia. , 2004, American heart journal.

[143]  G. Fleisher,et al.  Cellulitis: Bacterial etiology, clinical features, and laboratory findings , 1980 .

[144]  S. Kaplan,et al.  Clindamycin treatment of invasive infections caused by community-acquired, methicillin-resistant and methicillin-susceptible Staphylococcus aureus in children , 2003, The Pediatric infectious disease journal.

[145]  M. Falagas,et al.  Oral rifampin for eradication of Staphylococcus aureus carriage from healthy and sick populations: a systematic review of the evidence from comparative trials. , 2007, American journal of infection control.

[146]  N. Jones,et al.  Septic cavernous sinus thrombosis secondary to sinusitis: are anticoagulants indicated? A review of the literature , 2002, The Journal of Laryngology & Otology.

[147]  H. Harris,et al.  An epidemic of methicillin-resistant Staphylococcus aureus soft tissue infections among medically underserved patients. , 2004, Archives of surgery.

[148]  K. Itani,et al.  Linezolid versus Vancomycin in Treatment of Complicated Skin and Soft Tissue Infections , 2005, Antimicrobial Agents and Chemotherapy.

[149]  P. Azimi,et al.  Linezolid versus vancomycin in the treatment of known or suspected resistant Gram-positive infections in neonates , 2003, The Pediatric infectious disease journal.

[150]  Ronald N. Jones Microbiological features of vancomycin in the 21st century: minimum inhibitory concentration creep, bactericidal/static activity, and applied breakpoints to predict clinical outcomes or detect resistant strains. , 2006, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[151]  S. Kaplan,et al.  Evaluation and Treatment of Community-Acquired Staphylococcus aureus Infections in Term and Late-Preterm Previously Healthy Neonates , 2007, Pediatrics.

[152]  R. Arbeit,et al.  The safety and efficacy of daptomycin for the treatment of complicated skin and skin-structure infections. , 2004, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[153]  J. Korth-Bradley,et al.  Serum, tissue and body fluid concentrations of tigecycline after a single 100 mg dose. , 2006, The Journal of antimicrobial chemotherapy.

[154]  J. Quinn,et al.  Acquisition of a natural resistance gene renders a clinical strain of methicillin‐resistant Staphylococcus aureus resistant to the synthetic antibiotic linezolid , 2007, Molecular microbiology.

[155]  K. Lam,et al.  Hematogenous Methicillin-Resistant Staphylococcus Aureus Spondylodiscitis , 2007, Spine.

[156]  J. Jorgensen,et al.  Vancomycin MICs for Methicillin-Resistant Staphylococcus aureus Isolates Differ Based upon the Susceptibility Test Method Used , 2008, Antimicrobial Agents and Chemotherapy.

[157]  L. Saravolatz,et al.  Trimethoprim-Sulfamethoxazole Compared with Vancomycin for the Treatment of Staphylococcus aureus Infection , 1992, Annals of Internal Medicine.

[158]  M. Kollef Limitations of vancomycin in the management of resistant staphylococcal infections. , 2007, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[159]  Brian T. Tsuji,et al.  Short-Course Gentamicin in Combination with Daptomycin or Vancomycin against Staphylococcus aureus in an In Vitro Pharmacodynamic Model with Simulated Endocardial Vegetations , 2005, Antimicrobial Agents and Chemotherapy.

[160]  A. Widmer,et al.  In vivo verification of in vitro model of antibiotic treatment of device-related infection , 1995, Antimicrobial agents and chemotherapy.

[161]  B. R. Reddy,et al.  Slow response to vancomycin or vancomycin plus rifampin in methicillin-resistant Staphylococcus aureus endocarditis. , 1991, Annals of internal medicine.

[162]  S. Kaplan,et al.  Pediatric Antibody Response to Community-Acquired Staphylococcus aureus Infection Is Directed to Panton-Valentine Leukocidin , 2008, Clinical and Vaccine Immunology.

[163]  M. Swartz,et al.  Septic Thrombosis of the Dural Venous Sinuses , 1986, Medicine.

[164]  M. Mete,et al.  Randomized controlled trial of trimethoprim-sulfamethoxazole for uncomplicated skin abscesses in patients at risk for community-associated methicillin-resistant Staphylococcus aureus infection. , 2010, Annals of emergency medicine.

[165]  J. Peters,et al.  Clinical experience with quinupristin-dalfopristin as rescue treatment of critically ill patients infected with methicillin-resistant staphylococci , 2002, Intensive Care Medicine.

[166]  L. Miller,et al.  Adjunctive use of rifampin for the treatment of Staphylococcus aureus infections: a systematic review of the literature. , 2008, Archives of internal medicine.

[167]  A. Tice,et al.  Outcomes of osteomyelitis among patients treated with outpatient parenteral antimicrobial therapy. , 2003, The American journal of medicine.

[168]  F. Vandenesch,et al.  Panton-Valentine Leukocidin and Staphyloccoccal Skin Infections in Schoolchildren , 2004, Emerging infectious diseases.

[169]  D. Levine,et al.  Comparison of conventional dosing versus continuous-infusion vancomycin therapy for patients with suspected or documented gram-positive infections , 1996, Antimicrobial agents and chemotherapy.

[170]  A. Combes,et al.  Impact of methicillin resistance on outcome of Staphylococcus aureus ventilator-associated pneumonia. , 2004, American journal of respiratory and critical care medicine.

[171]  P. Holtom,et al.  Outbreak of community-acquired methicillin-resistant Staphylococcus aureus skin infections among a collegiate football team. , 2006, Journal of athletic training.

[172]  L. Szczech,et al.  Use of vancomycin or first-generation cephalosporins for the treatment of hemodialysis-dependent patients with methicillin-susceptible Staphylococcus aureus bacteremia. , 2007, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[173]  M. Levy,et al.  Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008 , 2007, Intensive Care Medicine.

[174]  A. Kiss,et al.  Randomized controlled trial of chlorhexidine gluconate for washing, intranasal mupirocin, and rifampin and doxycycline versus no treatment for the eradication of methicillin-resistant Staphylococcus aureus colonization. , 2007, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[175]  Jerome J. Schentag,et al.  Accessory gene regulator group II polymorphism in methicillin-resistant Staphylococcus aureus is predictive of failure of vancomycin therapy. , 2004, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[176]  J. Guesdon,et al.  Gene heterogeneity for tetracycline resistance in Staphylococcus spp , 1990, Antimicrobial Agents and Chemotherapy.

[177]  R. Lynfield,et al.  Methicillin-resistant Staphylococcus aureus disease in three communities. , 2005, The New England journal of medicine.

[178]  M. LuisDelpiano Bacteriemia por Staphylococcus aureus y endocarditis infecciosa. Frequency of infective endocarditis among infants and children with Staphylococcus aureus bacteremia. Valente A M, Jain R, Scheurer M, Fowler V, Corey G, Bengur R et al. Pediatrics 2004; 1152: e15-9 , 2005 .

[179]  A. K. Peer,et al.  Ventriculitis due to a hetero strain of vancomycin intermediate Staphylococcus aureus (hVISA): successful treatment with linezolid in combination with intraventricular vancomycin. , 2005, The Journal of infection.

[180]  G. Sakoulas,et al.  Vancomycin Ototoxicity: a Reevaluation in an Era of Increasing Doses , 2008, Antimicrobial Agents and Chemotherapy.

[181]  Jerome J. Schentag,et al.  Clinical Experience With Linezolid in Conjunction With Wound Coverage Techniques for Skin and Soft-Tissue Infections and Postoperative Osteomyelitis , 2004, Annals of plastic surgery.

[182]  J. Versalovic,et al.  Vancomycin MICs for Staphylococcus aureus Vary by Detection Method and Have Subtly Increased in a Pediatric Population Since 2005 , 2009, Journal of Clinical Microbiology.

[183]  Christine H. Lee,et al.  Clinical outcome with oral linezolid and rifampin following recurrent methicillin-resistant Staphylococcus aureus bacteremia despite prolonged vancomycin treatment. , 2004, The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses.

[184]  J. Versalovic,et al.  Three-Year Surveillance of Community Onset Health Care-Associated Staphylococcus aureus Infections in Children , 2006, The Pediatric infectious disease journal.

[185]  G. Oster,et al.  Trends in US Hospital Admissions for Skin and Soft Tissue Infections , 2007, Emerging infectious diseases.

[186]  L. Friedrich,et al.  Clinical experience with daptomycin for the treatment of patients with osteomyelitis. , 2007, The American journal of medicine.

[187]  A. Stucki,et al.  Daptomycin Is Highly Efficacious against Penicillin-Resistant and Penicillin- and Quinolone-Resistant Pneumococci in Experimental Meningitis , 2004, Antimicrobial Agents and Chemotherapy.

[188]  R. Macgregor,et al.  Vancomycin concentrations in infected and noninfected human bone , 1988, Antimicrobial Agents and Chemotherapy.

[189]  Brian T. Tsuji,et al.  Community- and health care-associated methicillin-resistant Staphylococcus aureus: a comparison of molecular epidemiology and antimicrobial activities of various agents. , 2007, Diagnostic microbiology and infectious disease.

[190]  Ronald N. Jones,et al.  Evaluation of Vancomycin and Daptomycin Potency Trends (MIC Creep) against Methicillin-Resistant Staphylococcus aureus Isolates Collected in Nine U.S. Medical Centers from 2002 to 2006 , 2009, Antimicrobial Agents and Chemotherapy.

[191]  J. Ruhe,et al.  Use of long-acting tetracyclines for methicillin-resistant Staphylococcus aureus infections: case series and review of the literature. , 2005, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[192]  D. Dooley,et al.  Comparison of short-course (5 days) and standard (10 days) treatment for uncomplicated cellulitis. , 2004, Archives of internal medicine.

[193]  L. Cui,et al.  Correlation between Reduced Daptomycin Susceptibility and Vancomycin Resistance in Vancomycin-Intermediate Staphylococcus aureus , 2006, Antimicrobial Agents and Chemotherapy.

[194]  E. Brown,et al.  Treatment of external ventricular drain-associated ventriculitis caused by Enterococcus faecalis with intraventricular daptomycin. , 2007, The Journal of antimicrobial chemotherapy.

[195]  S. Yankelev,et al.  Pharmacokinetics and Tolerability of Daptomycin at Doses up to 12 Milligrams per Kilogram of Body Weight Once Daily in Healthy Volunteers , 2006, Antimicrobial Agents and Chemotherapy.

[196]  V. Syriopoulou,et al.  Brain Abscesses Complicating Staphylococcus aureus Sepsis in a Premature Infant , 2005, Infection.

[197]  A. Ganesan,et al.  Chlorhexidine-Impregnated Cloths to Prevent Skin and Soft-Tissue Infection in Marine Recruits: A Cluster-Randomized, Double-Blind, Controlled Effectiveness Trial , 2010, Infection Control & Hospital Epidemiology.

[198]  C. Hamilton,et al.  Efficacy and safety of linezolid for Gram-positive orthopedic infections: a prospective case series. , 2007, Diagnostic microbiology and infectious disease.

[199]  D. Levine,et al.  Therapeutic Monitoring of Vancomycin in Adults , 2009, Pharmacotherapy.

[200]  I. Kronzon,et al.  Sensitivity of transthoracic versus transesophageal echocardiography for the detection of native valve vegetations in the modern era. , 2003, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.

[201]  M. Anagnostaki,et al.  Serum and Cerebrospinal Fluid Concentrations of Linezolid in Neurosurgical Patients , 2006, Antimicrobial Agents and Chemotherapy.

[202]  S. Kaplan,et al.  Community-Acquired, Methicillin-Resistant and Methicillin-Susceptible Staphylococcus aureus Musculoskeletal Infections in Children , 2004, The Pediatric infectious disease journal.

[203]  Roberta B. Carey,et al.  Accuracy of Commercial and Reference Susceptibility Testing Methods for Detecting Vancomycin-Intermediate Staphylococcus aureus , 2009, Journal of Clinical Microbiology.

[204]  K. Winston,et al.  Vancomycin Disposition and Penetration into Ventricular Fluid of the Central Nervous System following Intravenous Therapy in Patients with Cerebrospinal Devices , 2007, Pediatric Neurosurgery.

[205]  L. Aguilar,et al.  Conservative treatment of staphylococcal prosthetic joint infections in elderly patients. , 2006, The American journal of medicine.

[206]  G. Pier,et al.  Antibody-mediated enhancement of community-acquired methicillin-resistant Staphylococcus aureus infection , 2010, Proceedings of the National Academy of Sciences.

[207]  W. Zimmerli,et al.  Prosthetic-joint infections. , 2004, The New England journal of medicine.

[208]  Jerome J. Schentag,et al.  Area under the inhibitory curve and a pneumonia scoring system for predicting outcomes of vancomycin therapy for respiratory infections by Staphylococcus aureus. , 2000, American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.

[209]  G. Eliopoulos,et al.  Linezolid resistance in Staphylococcus aureus: characterization and stability of resistant phenotype. , 2002, The Journal of infectious diseases.

[210]  Benjamin A Lipsky,et al.  Daptomycin for treating infected diabetic foot ulcers: evidence from a randomized, controlled trial comparing daptomycin with vancomycin or semi-synthetic penicillins for complicated skin and skin-structure infections. , 2005, The Journal of antimicrobial chemotherapy.

[211]  F. Chen,et al.  Staphylococcus aureus Meningitis in Adults: A Clinical Comparison of Infections Caused by Methicillin-Resistant and Methicillin-Sensitive Strains , 2001, Infection.

[212]  T. Gomes,et al.  Trimethoprim-sulfamethoxazole-induced hyperkalemia in patients receiving inhibitors of the renin-angiotensin system: a population-based study. , 2010, Archives of internal medicine.

[213]  W. Whitehead,et al.  The Treatment of Cerebrospinal Fluid Shunt Infections , 2001, Pediatric Neurosurgery.

[214]  P. Ward,et al.  Treatment outcomes for serious infections caused by methicillin-resistant Staphylococcus aureus with reduced vancomycin susceptibility. , 2004, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[215]  R. Daum,et al.  Daptomycin-Oxacillin Combinations in Treatment of Experimental Endocarditis Caused by Daptomycin-Nonsusceptible Strains of Methicillin-Resistant Staphylococcus aureus with Evolving Oxacillin Susceptibility (the “Seesaw Effect”) , 2010, Antimicrobial Agents and Chemotherapy.

[216]  J. Perfect,et al.  Treatment of methicillin-resistant Staphylococcus aureus infections with quinupristin–dalfopristin in patients intolerant of or failing prior therapy , 2000 .

[217]  Mian Cai,et al.  Severe community-onset pneumonia in healthy adults caused by methicillin-resistant Staphylococcus aureus carrying the Panton-Valentine leukocidin genes. , 2005, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[218]  L. Saiman,et al.  Safety and tolerability of linezolid in children , 2003, The Pediatric infectious disease journal.

[219]  C. Urban,et al.  Safety of high-dose intravenous daptomycin treatment: three-year cumulative experience in a clinical program. , 2009, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[220]  J. Drake,et al.  Nosocomial bacterial meningitis. , 2010, The New England journal of medicine.

[221]  A. MacGowan,et al.  A Multicenter Study Evaluating the Current Strategies for Isolating Staphylococcus aureus Strains with Reduced Susceptibility to Glycopeptides , 2006, Journal of Clinical Microbiology.

[222]  T. Maurer,et al.  Randomized, Double-Blind, Placebo-Controlled Trial of Cephalexin for Treatment of Uncomplicated Skin Abscesses in a Population at Risk for Community-Acquired Methicillin-Resistant Staphylococcus aureus Infection , 2007, Antimicrobial Agents and Chemotherapy.

[223]  R. Wunderink,et al.  Linezolid vs vancomycin: analysis of two double-blind studies of patients with methicillin-resistant Staphylococcus aureus nosocomial pneumonia. , 2003, Chest.

[224]  Daniel J Pallin,et al.  Increased US emergency department visits for skin and soft tissue infections, and changes in antibiotic choices, during the emergence of community-associated methicillin-resistant Staphylococcus aureus. , 2008, Annals of emergency medicine.

[225]  G. Archer,et al.  Staphylococcus epidermidis causing prosthetic valve endocarditis: microbiologic and clinical observations as guides to therapy. , 1983, Annals of internal medicine.

[226]  A. Widmer,et al.  Microbiological tests to predict treatment outcome in experimental device-related infections due to Staphylococcus aureus. , 1994, The Journal of antimicrobial chemotherapy.

[227]  A. Kourtis,et al.  Treatment of Meningitis Caused by Methicillin-Resistant Staphylococcus aureus with Linezolid , 2007, Infection.

[228]  B. Hutton,et al.  Meta-analysis: Intravenous Immunoglobulin in Critically Ill Adult Patients with Sepsis , 2007, Annals of Internal Medicine.

[229]  P. Small,et al.  Vancomycin for Staphylococcus aureus endocarditis in intravenous drug users , 1990, Antimicrobial Agents and Chemotherapy.

[230]  G. Eliopoulos,et al.  Experience With Daptomycin in Staphylococcus Bone and Joint Infections: Case Series and Emergence of Nonsusceptibility , 2007 .

[231]  S. Markwell,et al.  Randomized, controlled trial of antibiotics in the management of community-acquired skin abscesses in the pediatric patient. , 2010, Annals of emergency medicine.

[232]  M. Falagas,et al.  Linezolid for the treatment of patients with endocarditis: a systematic review of the published evidence. , 2006, The Journal of antimicrobial chemotherapy.

[233]  B. Lorber,et al.  Successful treatment of methicillin-resistant Staphylococcus aureus endocarditis with telavancin. , 2010, The Journal of antimicrobial chemotherapy.

[234]  S. Boyle-Vavra,et al.  Staphylococcus aureus sepsis and the Waterhouse-Friderichsen syndrome in children. , 2005, The New England journal of medicine.

[235]  Joan Buenconsejo,et al.  Impact of valve surgery on 6-month mortality in adults with complicated, left-sided native valve endocarditis: a propensity analysis. , 2003, JAMA.

[236]  Vance G Fowler,et al.  Initial low-dose gentamicin for Staphylococcus aureus bacteremia and endocarditis is nephrotoxic. , 2009, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[237]  F. DeLeo,et al.  Community-associated meticillin-resistant Staphylococcus aureus , 2010, The Lancet.

[238]  Fu-Yu Chiang,et al.  Efficacy of Linezolid Alone or in Combination with Vancomycin for Treatment of Experimental Endocarditis Due to Methicillin-Resistant Staphylococcus aureus , 2003, Antimicrobial Agents and Chemotherapy.

[239]  D. Palmer,et al.  Chronic Osteomyelitis Caused by Staphylococcus aureus: Controlled Clinical Trial of Nafcillin Therapy and Nafcillin-Rifampin Therapy , 1986, Southern medical journal.

[240]  E Rubinstein,et al.  Linezolid (PNU-100766) versus vancomycin in the treatment of hospitalized patients with nosocomial pneumonia: a randomized, double-blind, multicenter study. , 2001, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[241]  Patricia F Triplett,et al.  Staphylococcus aureus Bacteremia: Recurrence and the Impact of Antibiotic Treatment in a Prospective Multicenter Study , 2003, Medicine.

[242]  P. Gøtzsche,et al.  Polyclonal immunoglobulin for treatment of bacterial sepsis: a systematic review. , 2004, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[243]  S. Kaplan,et al.  Pulmonary manifestations in children with invasive community-acquired Staphylococcus aureus infection. , 2005, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[244]  R. Farinotti,et al.  Analysis of vancomycin entry into pulmonary lining fluid by bronchoalveolar lavage in critically ill patients , 1993, Antimicrobial Agents and Chemotherapy.

[245]  B. Miller,et al.  Acute eosinophilic pneumonia secondary to daptomycin: a report of three cases. , 2010, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[246]  K. Stellrecht,et al.  Relationship between Vancomycin MIC and Failure among Patients with Methicillin-Resistant Staphylococcus aureus Bacteremia Treated with Vancomycin , 2008, Antimicrobial Agents and Chemotherapy.

[247]  S. Deresinski Counterpoint: Vancomycin and Staphylococcus aureus--an antibiotic enters obsolescence. , 2007, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[248]  L. Winston,et al.  Clinical failures of appropriately-treated methicillin-resistant Staphylococcus aureus infections. , 2008, The Journal of infection.

[249]  F. Tenover,et al.  The rationale for revising the Clinical and Laboratory Standards Institute vancomycin minimal inhibitory concentration interpretive criteria for Staphylococcus aureus. , 2007, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[250]  G. Mccracken,et al.  Nephrotoxicity associated with vancomycin-aminoglycoside therapy in four children. , 1984, The Journal of pediatrics.

[251]  M. Wootton,et al.  Evaluation of a New Etest Vancomycin-Teicoplanin Strip for Detection of Glycopeptide-Intermediate Staphylococcus aureus (GISA), in Particular, Heterogeneous GISA , 2008, Journal of Clinical Microbiology.

[252]  Helen Burstin,et al.  Strategies to Prevent Transmission of Methicillin-Resistant Staphylococcus aureus in Acute Care Hospitals , 2008, Infection Control & Hospital Epidemiology.

[253]  G. Archer,et al.  Rifampin treatment of prosthetic valve endocarditis due to Staphylococcus epidermidis. , 1983, Reviews of infectious diseases.

[254]  Mary Jane Ferraro,et al.  Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically : approved standard , 2000 .

[255]  C. Ginocchio,et al.  Diminished Susceptibility to Daptomycin Accompanied by Clinical Failure in a Patient With Methicillin-Resistant Staphylococcus aureus Bacteremia , 2006, Infection Control & Hospital Epidemiology.

[256]  Arthur Jeng,et al.  The Role of β-Hemolytic Streptococci in Causing Diffuse, Nonculturable Cellulitis: A Prospective Investigation , 2010, Medicine.

[257]  M. Fitch,et al.  Abscess Incision and Drainage , 2007 .

[258]  K. Mashiko,et al.  Trimethoprim-sulfamethoxazole for the prevention of methicillin-resistant Staphylococcus aureus pneumonia in severely burned patients. , 1998, The Journal of trauma.

[259]  A. MacGowan,et al.  A modified population analysis profile (PAP) method to detect hetero-resistance to vancomycin in Staphylococcus aureus in a UK hospital. , 2001, The Journal of antimicrobial chemotherapy.

[260]  Patchen Dellinger,et al.  Practice guidelines for the diagnosis and management of skin and soft-tissue infections. , 2005, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[261]  R. Beer,et al.  Treatment of staphylococcal ventriculitis associated with external cerebrospinal fluid drains: a prospective randomized trial of intravenous compared with intraventricular vancomycin therapy. , 2003, Journal of neurosurgery.

[262]  Tina Rutar,et al.  Ophthalmic manifestations of infections caused by the USA300 clone of community-associated methicillin-resistant Staphylococcus aureus. , 2006, Ophthalmology.

[263]  H. Hanaki,et al.  Neutralization of staphylococcal exotoxins in vitro by human-origin intravenous immunoglobulin , 2007, Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.

[264]  Roberta B Carey,et al.  Invasive methicillin-resistant Staphylococcus aureus infections in the United States. , 2007, JAMA.

[265]  G. Gottlieb,et al.  Outcome of Staphylococcus aureus bacteremia according to compliance with recommendations of infectious diseases specialists: experience with 244 patients. , 1998, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[266]  C. Quereda,et al.  Clinical Study of 44 Cases of Staphylococcus aureus Meningitis , 2002, European Journal of Clinical Microbiology and Infectious Diseases.

[267]  J. Mandrekar,et al.  The management and outcome of spinal implant infections: contemporary retrospective cohort study. , 2007, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[268]  F. Riordan,et al.  Glycopeptide insensitive Staphylococcus aureus subdural empyema treated with linezolid and rifampicin. , 2008, The Journal of infection.

[269]  B. Söderquist,et al.  Differences in potency of intravenous polyspecific immunoglobulin G against streptococcal and staphylococcal superantigens: implications for therapy of toxic shock syndrome. , 2004, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[270]  Yee-Chun Chen,et al.  Necessity of a loading dose when using vancomycin in critically ill patients. , 2001, The Journal of antimicrobial chemotherapy.

[271]  Warren E. Rose,et al.  Daptomycin Activity against Staphylococcus aureus following Vancomycin Exposure in an In Vitro Pharmacodynamic Model with Simulated Endocardial Vegetations , 2007, Antimicrobial Agents and Chemotherapy.

[272]  M. Swartz,et al.  Clinical practice. Cellulitis. , 2004, The New England journal of medicine.

[273]  C. Zalavras,et al.  Infection Following Operative Treatment of Ankle Fractures , 2009, Clinical orthopaedics and related research.

[274]  L. Friedrich,et al.  Vancomycin MIC creep in non-vancomycin-intermediate Staphylococcus aureus (VISA), vancomycin-susceptible clinical methicillin-resistant S. aureus (MRSA) blood isolates from 2001-05. , 2007, The Journal of antimicrobial chemotherapy.

[275]  G. Kaatz,et al.  Evaluation of daptomycin treatment of Staphylococcus aureus bacterial endocarditis: an in vitro and in vivo simulation using historical and current dosing strategies. , 2007, The Journal of antimicrobial chemotherapy.

[276]  G. Gutkind,et al.  Methicillin-resistant Staphylococcus aureus in community-acquired meningitis , 2006, European Journal of Clinical Microbiology and Infectious Diseases.

[277]  J. Caillon,et al.  In vitro activity of linezolid alone and in combination with gentamicin, vancomycin or rifampicin against methicillin-resistant Staphylococcus aureus by time-kill curve methods. , 2003, The Journal of antimicrobial chemotherapy.

[278]  Roberta B Carey,et al.  Methicillin-resistant S. aureus infections among patients in the emergency department. , 2006, The New England journal of medicine.

[279]  B. Diep,et al.  Doxycycline, not minocycline, induces its own resistance in multidrug-resistant, community-associated methicillin-resistant Staphylococcus aureus clone USA300. , 2009, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[280]  K. Bowker,et al.  Activity of AZD2563, a Novel Oxazolidinone, against Staphylococcus aureus Strains with Reduced Susceptibility to Vancomycin or Linezolid , 2003, Antimicrobial Agents and Chemotherapy.

[281]  H. Norton,et al.  The effect of soft-tissue ultrasound on the management of cellulitis in the emergency department. , 2006, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[282]  I I Lelis,et al.  [Atopic dermatitis]. , 1980, Vestnik dermatologii i venerologii.

[283]  L. Friedman,et al.  Genetic Changes That Correlate with Reduced Susceptibility to Daptomycin in Staphylococcus aureus , 2006, Antimicrobial Agents and Chemotherapy.

[284]  Bruno Hoen,et al.  Staphylococcus aureus endocarditis: a consequence of medical progress. , 2005, Journal of the American Medical Association (JAMA).

[285]  S. Kaplan,et al.  Infective pyomyositis and myositis in children in the era of community-acquired, methicillin-resistant Staphylococcus aureus infection. , 2006, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[286]  J. Golden,et al.  Intrapulmonary Pharmacokinetics of Linezolid , 2002, Antimicrobial Agents and Chemotherapy.

[287]  R. Edwards,et al.  Conservative management of patients with cerebrospinal fluid shunt infections. , 2006, Neurosurgery.

[288]  R. Keren,et al.  Empiric Antimicrobial Therapy for Pediatric Skin and Soft-Tissue Infections in the Era of Methicillin-Resistant Staphylococcus aureus , 2009, Pediatrics.

[289]  Á. Soriano,et al.  Influence of vancomycin minimum inhibitory concentration on the treatment of methicillin-resistant Staphylococcus aureus bacteremia. , 2008, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[290]  D. Levine,et al.  Therapeutic monitoring of vancomycin in adult patients: a consensus review of the American Society of Health-System Pharmacists, the Infectious Diseases Society of America, and the Society of Infectious Diseases Pharmacists. , 2009, American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.

[291]  N. Jin,et al.  Persistent Staphylococcus aureus bacteremia: an analysis of risk factors and outcomes. , 2007, Archives of internal medicine.

[292]  A. Stucki,et al.  Daptomycin is more efficacious than vancomycin against a methicillin-susceptible Staphylococcus aureus in experimental meningitis. , 2006, The Journal of antimicrobial chemotherapy.

[293]  W. Chang,et al.  Adults with meningitis caused by oxacillin-resistant Staphylococcus aureus. , 2000, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[294]  H. Wertheim,et al.  Mupirocin Prophylaxis against Nosocomial Staphylococcus aureus Infections in Nonsurgical Patients , 2004, Annals of Internal Medicine.

[295]  A. MacGowan,et al.  Evaluation of Current Methods for Detection of Staphylococci with Reduced Susceptibility to Glycopeptides , 2001, Journal of Clinical Microbiology.

[296]  M. Rybak,et al.  Impact of High-Inoculum Staphylococcus aureus on the Activities of Nafcillin, Vancomycin, Linezolid, and Daptomycin, Alone and in Combination with Gentamicin, in an In Vitro Pharmacodynamic Model , 2004, Antimicrobial Agents and Chemotherapy.

[297]  M. Fitch,et al.  Videos in clinical medicine. Abscess incision and drainage. , 2007, The New England journal of medicine.

[298]  D. Levine,et al.  Daptomycin versus vancomycin plus gentamicin for treatment of bacteraemia and endocarditis due to Staphylococcus aureus: subset analysis of patients infected with methicillin-resistant isolates , 2008, The Journal of antimicrobial chemotherapy.

[299]  P. Schlievert,et al.  Purpura fulminans due to Staphylococcus aureus. , 2005, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[300]  J. Jorgensen,et al.  Inhibitory Activities of 11 Antimicrobial Agents and Bactericidal Activities of Vancomycin and Daptomycin against Invasive Methicillin-Resistant Staphylococcus aureus Isolates Obtained from 1999 through 2006 , 2007, Antimicrobial Agents and Chemotherapy.

[301]  C. Clec’h,et al.  Is methicillin resistance associated with a worse prognosis in Staphylococcus aureus ventilator-associated pneumonia? , 2005, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[302]  B. Bozdoğan,et al.  Antibacterial susceptibility of a vancomycin-resistant Staphylococcus aureus strain isolated at the Hershey Medical Center. , 2003, The Journal of antimicrobial chemotherapy.

[303]  A. Wong-Beringer,et al.  High-dose vancomycin therapy for methicillin-resistant Staphylococcus aureus infections: efficacy and toxicity. , 2006, Archives of internal medicine.

[304]  M. Rybak,et al.  Bactericidal Activities of Daptomycin, Quinupristin-Dalfopristin, and Linezolid against Vancomycin-Resistant Staphylococcus aureus in an In Vitro Pharmacodynamic Model with Simulated Endocardial Vegetations , 2003, Antimicrobial Agents and Chemotherapy.

[305]  G. Stein,et al.  Telavancin: a novel lipoglycopeptide. , 2009, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[306]  N. Smith,et al.  Community-onset methicillin-resistant Staphylococcus aureus skin and soft-tissue infections: impact of antimicrobial therapy on outcome. , 2007, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[307]  Patrick F. Smith,et al.  Comparative in vitro activities of daptomycin, linezolid, and quinupristin/dalfopristin against Gram-positive bacterial isolates from a large cancer center. , 2005, Diagnostic microbiology and infectious disease.

[308]  R. Wunderink,et al.  Early microbiological response to linezolid vs vancomycin in ventilator-associated pneumonia due to methicillin-resistant Staphylococcus aureus. , 2008, Chest.

[309]  S. Kaplan,et al.  TRIMETHOPRIM-SULFAMETHOXAZOLE OR CLINDAMYCIN FOR TREATMENT OF COMMUNITY-ACQUIRED METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS SKIN AND SOFT TISSUE INFECTIONS , 2009, The Pediatric infectious disease journal.

[310]  M. Rybak,et al.  Evaluation of the Etest GRD for the detection of Staphylococcus aureus with reduced susceptibility to glycopeptides. , 2009, The Journal of antimicrobial chemotherapy.

[311]  K. Lamp,et al.  Safety and Efficacy of Daptomycin in the Treatment of Osteomyelitis: Results from the CORE® Registry , 2009, Journal of chemotherapy.

[312]  J. Bartlett,et al.  Antibiotic levels in infected and sterile subcutaneous abscesses in mice. , 1981, The Journal of infectious diseases.

[313]  J. Alós,et al.  Vancomycin MICs did not creep in Staphylococcus aureus isolates from 2002 to 2006 in a setting with low vancomycin usage. , 2008, The Journal of antimicrobial chemotherapy.

[314]  K. Laupland,et al.  Treatment of Staphylococcus aureus colonization and prophylaxis for infection with topical intranasal mupirocin: an evidence-based review. , 2003, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[315]  Helen Burstin,et al.  Strategies to Prevent Surgical Site Infections in Acute Care Hospitals , 2008, Infection Control & Hospital Epidemiology.

[316]  S. Zimmer,et al.  Peripheral neuropathy associated with prolonged use of linezolid. , 2004, The Lancet. Infectious diseases.

[317]  L. Miller,et al.  Body site colonization in patients with community-associated methicillin-resistant Staphylococcus aureus and other types of S. aureus skin infections. , 2010, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

[318]  K. Mayer,et al.  Treatment and Outcomes of Infections by Methicillin-Resistant Staphylococcus aureus at an Ambulatory Clinic , 2006, Antimicrobial Agents and Chemotherapy.

[319]  R. Wunderink,et al.  Expanded clinical presentation of community-acquired methicillin-resistant Staphylococcus aureus pneumonia. , 2010, Chest.

[320]  D. Levine,et al.  Vancomycin therapeutic guidelines: a summary of consensus recommendations from the infectious diseases Society of America, the American Society of Health-System Pharmacists, and the Society of Infectious Diseases Pharmacists. , 2009, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[321]  G. Drusano,et al.  Prospective Evaluation of the Effect of an Aminoglycoside Dosing Regimen on Rates of Observed Nephrotoxicity and Ototoxicity , 1999, Antimicrobial Agents and Chemotherapy.

[322]  R. Wenzel,et al.  Mupirocin ointment for preventing Staphylococcus aureus infections in nasal carriers. , 2008, The Cochrane database of systematic reviews.

[323]  J. Jorgensen,et al.  Inducible clindamycin resistance in Staphylococci: should clinicians and microbiologists be concerned? , 2005, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[324]  N. Daver,et al.  Oral step-down therapy is comparable to intravenous therapy for Staphylococcus aureus osteomyelitis. , 2007, The Journal of infection.

[325]  A. Jensen,et al.  Bacteremic Staphylococcus aureus spondylitis. , 1998, Archives of internal medicine.

[326]  S. Kaplan,et al.  Hematologic effects of linezolid in young children , 2003, The Pediatric infectious disease journal.

[327]  M. Mielke,et al.  Successful termination of a furunculosis outbreak due to lukS-lukF-positive, methicillin-susceptible Staphylococcus aureus in a German village by stringent decolonization, 2002-2005. , 2007, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[328]  G. Webb,et al.  Modeling the invasion of community-acquired methicillin-resistant Staphylococcus aureus into hospitals. , 2009, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[329]  R. Proctor Role of folate antagonists in the treatment of methicillin-resistant Staphylococcus aureus infection. , 2008, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[330]  R Scott Obach,et al.  Unexpected Effect of Rifampin on the Pharmacokinetics of Linezolid: In Silico and In Vitro Approaches to Explain Its Mechanism , 2011, Journal of clinical pharmacology.

[331]  M. Falagas,et al.  Linezolid for the Treatment of Patients with Central Nervous System Infection , 2007, The Annals of pharmacotherapy.

[332]  A. Delaney,et al.  Polyclonal intravenous immunoglobulin for the treatment of severe sepsis and septic shock in critically ill adults: A systematic review and meta‐analysis * , 2007, Critical care medicine.

[333]  G. Archer,et al.  Successful Therapy of Experimental Endocarditis Caused by Vancomycin-Resistant Staphylococcus aureus with a Combination of Vancomycin and β-Lactam Antibiotics , 2006, Antimicrobial Agents and Chemotherapy.

[334]  D. Kennedy,et al.  Antibiotic Use in Pregnancy and Lactation: What Is and Is Not Known About Teratogenic and Toxic Risks , 2006, Obstetrics and gynecology.

[335]  A. Mejias,et al.  Management and outcome of children with skin and soft tissue abscesses caused by community-acquired methicillin-resistant Staphylococcus aureus , 2004, The Pediatric infectious disease journal.

[336]  Bruno Hoen,et al.  Staphylococcus aureus native valve infective endocarditis: report of 566 episodes from the International Collaboration on Endocarditis Merged Database. , 2005, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[337]  G. Archer,et al.  Combinations of Vancomycin and β-Lactams Are Synergistic against Staphylococci with Reduced Susceptibilities to Vancomycin , 1999, Antimicrobial Agents and Chemotherapy.

[338]  D. Robinson,et al.  Microbiological effects of prior vancomycin use in patients with methicillin-resistant Staphylococcus aureus bacteraemia. , 2007, The Journal of antimicrobial chemotherapy.

[339]  S. Yun,et al.  Effect of vancomycin plus rifampicin in the treatment of nosocomial methicillin-resistant Staphylococcus aureus pneumonia* , 2010, Critical care medicine.

[340]  D. Anderson,et al.  Value of Whole-Body Washing With Chlorhexidine for the Eradication of Methicillin-Resistant Staphylococcus aureus: A Randomized, Placebo-Controlled, Double-Blind Clinical Trial , 2007, Infection Control & Hospital Epidemiology.

[341]  L. Bopp,et al.  Activities of Daptomycin and Comparative Antimicrobials, Singly and in Combination, against Extracellular and Intracellular Staphylococcus aureus and Its Stable Small-Colony Variant in Human Monocyte-Derived Macrophages and in Broth , 2008, Antimicrobial Agents and Chemotherapy.

[342]  E. Concia,et al.  Penetration of vancomycin into human lung tissue. , 1996, The Journal of antimicrobial chemotherapy.

[343]  C. Mullany,et al.  The surgical treatment of infective endocarditis , 1989, World journal of surgery.

[344]  P. Appelbaum,et al.  Activity of Daptomycin Alone and in Combination with Rifampin and Gentamicin against Staphylococcus aureus Assessed by Time-Kill Methodology , 2007, Antimicrobial Agents and Chemotherapy.

[345]  H. Chambers,et al.  Staphylococcus aureus with Heterogeneous Resistance to Vancomycin: Epidemiology, Clinical Significance, and Critical Assessment of Diagnostic Methods , 2003, Antimicrobial Agents and Chemotherapy.

[346]  S. Arnold,et al.  Changing Patterns of Acute Hematogenous Osteomyelitis and Septic Arthritis: Emergence of Community-associated Methicillin-resistant Staphylococcus aureus , 2006, Journal of pediatric orthopedics.

[347]  L. Benet,et al.  Current Recommended Dosing of Vancomycin for Children With Invasive Methicillin-Resistant Staphylococcus aureus Infections Is Inadequate , 2009, The Pediatric infectious disease journal.

[348]  S. Kaplan,et al.  Use of intravenous rifampin in neonates with persistent staphylococcal bacteremia , 1993, Antimicrobial Agents and Chemotherapy.

[349]  D. Skiest Treatment Failure Resulting from Resistance of Staphylococcus aureus to Daptomycin , 2006, Journal of Clinical Microbiology.

[350]  A. Frank,et al.  Treatment of community-acquired methicillin-resistant Staphylococcus aureus in children , 2003, Current opinion in infectious diseases.

[351]  D. Skiest,et al.  Prospective Randomized Trial of Empiric Therapy with Trimethoprim-Sulfamethoxazole or Doxycycline for Outpatient Skin and Soft Tissue Infections in an Area of High Prevalence of Methicillin-Resistant Staphylococcus aureus , 2007, Antimicrobial Agents and Chemotherapy.

[352]  A. MacGowan,et al.  Antibiotic treatment of gram-positive bone and joint infections. , 2004, The Journal of antimicrobial chemotherapy.

[353]  R. Wittler,et al.  Treatment of cerebrospinal fluid shunt infections: a decision analysis , 2002, The Pediatric infectious disease journal.

[354]  Epperly Td The value of needle aspiration in the management of cellulitis. , 1986 .

[355]  G. Gottlieb,et al.  Role of echocardiography in evaluation of patients with Staphylococcus aureus bacteremia: experience in 103 patients. , 1997, Journal of the American College of Cardiology.

[356]  R. Helbok,et al.  Pharmacokinetics of Intravenous Linezolid in Cerebrospinal Fluid and Plasma in Neurointensive Care Patients with Staphylococcal Ventriculitis Associated with External Ventricular Drains , 2006, Antimicrobial Agents and Chemotherapy.