The relationship between hepatic immunoglobulin production and CD154 expression in chronic liver diseases

Abstract: Background: CD40–CD154 is a receptor–ligand pair that provides key communication signals between cells of the adaptive immune system in states of inflammation and autoimmunity. The CD40 receptor is expressed constitutively on B lymphocytes, for which it provides important signals regulating clonal expansion and antibody production. CD154 is a member of the tumor necrosis factor superfamily, which is primarily expressed by activated T cells.

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