Heart type creatine kinase isoenzyme (CK MB) in acute cerebral disorders.

Heart type creatine kinase isoenzyme (CK MB) was detected in the serum in 23 out of 53 patients (43%) with acute cerebrovascular, traumatic, or infectious brain damage. Electrocardiogram disclosed abnormalities suggestive of acute myocardial injury in 15 of these 23 patients. Eleven of them also showed increased LD1 activity. Subendocardial haemorrhage was detected in 3 out of 8 necropsied patients with serum CK MB activity. Among those 30 patients in whom no CK MB activity was found electrocardiographic abnormalities suggestive of acute myocardial injury were observed in 2 and increased LD1 was seen in 4 cases. The mortality was higher if either CK MB isoenzyme or electrocardiographic abnormalities suggestive of acute myocardial injury were present, compared with the patients lacking these signs (P less than 0.01). Present findings suggest that acute brain damage may secondarily cause myocardial damage more often than has been believed before. Results also indicate that a combination of acute brain damage and acute myocardial injury often indicated a poor prognosis.

[1]  D. Weidler.  Myocardial Damage and Cardiac Arrhythmias After Intracranial Hemorrhage. A Critical Review , 1974, Stroke.

[2]  H. Somer,et al.  Specificity of Serum Creatine Kinase Isoenzymes in Diagnosis of Acute Myocardial Infarction , 1973, British medical journal.

[3]  R. Rosati,et al.  The importance of identification of the myocardial-specific isoenzyme of creatine phosphokinase (MB form) in the diagnosis of acute myocardial infarction. , 1973, Circulation.

[4]  H. Somer,et al.  Demonstration of serum creatine kinase isoenzymes by fluorescence technique. , 1972, Clinica chimica acta; international journal of clinical chemistry.

[5]  G. Wagner,et al.  Combined isoenzyme analysis in the diagnosis of myocardial injury: application of electrophoretic methods for the detection and quantitation of the creatine phosphokinase MB isoenzyme. , 1972, The Journal of laboratory and clinical medicine.

[6]  L. Mchenry,et al.  Cardiac Abnormalities in Subarachnoid Hemorrhage: A Resumé , 1974, Stroke.

[7]  A. Smith,et al.  Creatine kinase MB isoenzyme studies in diagnosis of myocardial infarction. , 1976, British heart journal.

[8]  H. Somer,et al.  Serum enzymes and isozymes. Extrapulmonary sources in acute pulmonary embolism. , 1974, Archives of internal medicine.

[9]  M. Kaste,et al.  Brain-type creatine kinase isoenzyme. Occurrence in serum in acute cerebral disorders. , 1977, Archives of neurology.

[10]  V. Dubowitz,et al.  Creatine kinase isoenzymes in neuromuscular diseases , 1976, Journal of the Neurological Sciences.

[11]  A. Louhija,et al.  Origin of elevated serum enzyme activities after direct-current countershock. , 1969, The New England journal of medicine.

[12]  K. B. Larson,et al.  Estimation of infarct size from serum MB creatine phosphokinase activity: Applications and limitations. , 1976, The American journal of cardiology.

[13]  M. Kaste,et al.  Brain creatine kinase in blood after acute brain injury. , 1975, Journal of neurology, neurosurgery, and psychiatry.

[14]  B. Sobel,et al.  Elevated plasma MB creatine phosphokinase activity. A specific marker for myocardial infarction in perioperative patients. , 1976, Archives of internal medicine.