TRANSUNGUAL DRUG DELIVERY SYSTEM A REVIEW

Transungual drug delivery is considered to be highly desirable to treat nail disorders due to its localized effects, improved adherence which results in minimal adverse systemic events. Hence the effectiveness of topical therapy is limited due to minimal drug permeability through the nail plate. Nail permeability is quite low and limits topical therapy to early/mild disease states such as Onychomycosis, Leuconychia, Onychogrypos and Onychatrophia etc. Hence the absorption of drugs into the nail unit, to the nail plate, is highly desirable to treat nail disorders. Current review focuses on the anatomy of a human nail, diseases related to nail plate, altering the nail plate barrier by means of chemical treatments, penetration enhancers as well as physical and mechanical methods used to enhance the topical bioavailability of the drugs across the nail and latest trends in drug delivery across the nail.

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