A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the y397 site of focal adhesion kinase decreases tumor growth.
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[1] V. Golubovskaya,et al. p53 regulates FAK expression in human tumor cells , 2008, Molecular carcinogenesis.
[2] Matthew D. Wessel,et al. Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF-562,271. , 2008, Cancer research.
[3] V. Golubovskaya,et al. TAE226‐Induced apoptosis in breast cancer cells with overexpressed Src or EGFR , 2008, Molecular carcinogenesis.
[4] Liz Y. Han,et al. Therapeutic efficacy of a novel focal adhesion kinase inhibitor TAE226 in ovarian carcinoma. , 2007, Cancer research.
[5] Christopher Autry,et al. Cellular Characterization of a Novel Focal Adhesion Kinase Inhibitor* , 2007, Journal of Biological Chemistry.
[6] V. Golubovskaya,et al. N-MYC Regulates Focal Adhesion Kinase Expression in Human Neuroblastoma* , 2007, Journal of Biological Chemistry.
[7] W. Yung,et al. Inhibition of both focal adhesion kinase and insulin-like growth factor-I receptor kinase suppresses glioma proliferation in vitro and in vivo , 2007, Molecular Cancer Therapeutics.
[8] M. Eck,et al. Crystal Structure of the FERM Domain of Focal Adhesion Kinase* , 2006, Journal of Biological Chemistry.
[9] A. Sood,et al. Focal Adhesion Kinase Silencing Augments Docetaxel-Mediated Apoptosis in Ovarian Cancer Cells , 2005, Clinical Cancer Research.
[10] V. Golubovskaya,et al. Effect of focal adhesion kinase (FAK) downregulation with FAK antisense oligonucleotides and 5-fluorouracil on the viability of melanoma cell lines , 2005, Melanoma research.
[11] V. Golubovskaya,et al. Direct Interaction of the N-terminal Domain of Focal Adhesion Kinase with the N-terminal Transactivation Domain of p53* , 2005, Journal of Biological Chemistry.
[12] Neil O. Carragher,et al. The role of focal-adhesion kinase in cancer — a new therapeutic opportunity , 2005, Nature Reviews Cancer.
[13] Xianyue Ma,et al. Identification of 1,2,3,4,5,6-hexabromocyclohexane as a small molecule inhibitor of Jak2 tyrosine kinase autophophorylation , 2005 .
[14] V. Golubovskaya,et al. Dual Inhibition of Focal Adhesion Kinase and Epidermal Growth Factor Receptor Pathways Cooperatively Induces Death Receptor-mediated Apoptosis in Human Breast Cancer Cells* , 2002, The Journal of Biological Chemistry.
[15] D. Brenner,et al. The Focal Adhesion Kinase Suppresses Transformation-associated, Anchorage-independent Apoptosis in Human Breast Cancer Cells , 2000, The Journal of Biological Chemistry.
[16] Y. L. Chen,et al. [Focal adhesion kinase]. , 1999, Sheng li ke xue jin zhan [Progress in physiology].
[17] D. Schlaepfer,et al. Signaling through focal adhesion kinase. , 1999, Progress in biophysics and molecular biology.
[18] S. J. Taylor,et al. Direct interaction of v-Src with the focal adhesion kinase mediated by the Src SH2 domain. , 1994, Molecular biology of the cell.
[19] J. Parsons,et al. Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src , 1994, Molecular and cellular biology.
[20] J. Parsons,et al. Stable association of pp60src and pp59fyn with the focal adhesion-associated protein tyrosine kinase, pp125FAK , 1994, Molecular and cellular biology.
[21] J. Parsons,et al. Identification of sequences required for the efficient localization of the focal adhesion kinase, pp125FAK, to cellular focal adhesions , 1993, The Journal of cell biology.
[22] V. Golubovskaya,et al. Focal adhesion kinase and p53 signaling in cancer cells. , 2007, International review of cytology.
[23] Bob van de Water,et al. Focal adhesion kinase: a potential target in cancer therapy. , 2007, Biochemical pharmacology.
[24] Xianyue Ma,et al. Identification of 1,2,3,4,5,6-hexabromocyclohexane as a small molecule inhibitor of jak2 tyrosine kinase autophosphorylation [correction of autophophorylation]. , 2005, Journal of medicinal chemistry.