A Lentiviral Vector Allowing Physiologically Regulated Membrane-anchored and Secreted Antibody Expression Depending on B-cell Maturation Status.

[1]  D. Burton,et al.  Broadly neutralizing antibodies abrogate established hepatitis C virus infection , 2014, Science Translational Medicine.

[2]  M. Grompe,et al.  Extensive double humanization of both liver and hematopoiesis in FRGN mice , 2014, Stem cell research.

[3]  F. Cosset,et al.  Baboon envelope pseudotyped LVs outperform VSV-G-LVs for gene transfer into early-cytokine-stimulated and resting HSCs. , 2014, Blood.

[4]  D. Baltimore,et al.  Vectored antibody gene delivery protects against Plasmodium falciparum sporozoite challenge in mice , 2014, Proceedings of the National Academy of Sciences.

[5]  T. Cheng,et al.  High-Throughput Sorting of the Highest Producing Cell via a Transiently Protein-Anchored System , 2014, PloS one.

[6]  B. Torbett,et al.  Mystery solved: VSV-G-LVs do not allow efficient gene transfer into unstimulated T cells, B cells, and HSCs because they lack the LDL receptor. , 2014, Blood.

[7]  A. Salvetti,et al.  AAV Vectors Vaccines Against Infectious Diseases , 2014, Front. Immunol..

[8]  Shibo Jiang,et al.  Simultaneous Expression of Displayed and Secreted Antibodies for Antibody Screen , 2013, PloS one.

[9]  D. Baltimore,et al.  Broad protection against influenza infection by vectored immunoprophylaxis in mice , 2013, Nature Biotechnology.

[10]  P. Bowers,et al.  Simultaneous Surface Display and Secretion of Proteins from Mammalian Cells Facilitate Efficient in Vitro Selection and Maturation of Antibodies , 2013, The Journal of Biological Chemistry.

[11]  T. Weber,et al.  Pre-existing anti-adeno-associated virus antibodies as a challenge in AAV gene therapy. , 2013, Human gene therapy methods.

[12]  D. Baltimore,et al.  Use of Mutated Self-Cleaving 2A Peptides as a Molecular Rheostat to Direct Simultaneous Formation of Membrane and Secreted Anti-HIV Immunoglobulins , 2012, PloS one.

[13]  P. Mangeot,et al.  A Prime-Boost Strategy Using Virus-Like Particles Pseudotyped for HCV Proteins Triggers Broadly Neutralizing Antibodies in Macaques , 2011, Science Translational Medicine.

[14]  R. Bartenschlager,et al.  A Concerted Action of Hepatitis C Virus P7 and Nonstructural Protein 2 Regulates Core Localization at the Endoplasmic Reticulum and Virus Assembly , 2011, PLoS pathogens.

[15]  K. Ohta,et al.  B-cell display-based one-step method to generate chimeric human IgG monoclonal antibodies , 2010, Nucleic acids research.

[16]  H. Prats,et al.  Alternative-splicing-based bicistronic vectors for ratio-controlled protein expression and application to recombinant antibody production , 2009, Nucleic acids research.

[17]  Youliang Wang,et al.  Engineered cell surface expression of membrane immunoglobulin as a means to identify monoclonal antibody-secreting hybridomas. , 2009, Journal of immunological methods.

[18]  Ryan M. O’Connell,et al.  Engineering human hematopoietic stem/progenitor cells to produce a broadly neutralizing anti-HIV antibody after in vitro maturation to human B lymphocytes. , 2009, Blood.

[19]  M. L. Peterson,et al.  Multiple Features Contribute to the Use of the Immunoglobulin M Secretion-Specific Poly(A) Signal but Are Not Required for Developmental Regulation , 2006, Molecular and Cellular Biology.

[20]  F. Saltel,et al.  The Endoplasmic Reticulum Is a Key Component of the Plasma Cell Death Pathway1 , 2006, The Journal of Immunology.

[21]  C. Gaillard,et al.  Real-time quantitative PCR for the design of lentiviral vector analytical assays , 2005, Gene Therapy.

[22]  K. Jooss,et al.  Stable antibody expression at therapeutic levels using the 2A peptide , 2005, Nature Biotechnology.

[23]  M. Prevost,et al.  Lower levels of surface B-cell-receptor expression in chronic lymphocytic leukemia are associated with glycosylation and folding defects of the mu and CD79a chains. , 2005, Blood.

[24]  L. Naldini,et al.  Molecular evidence of inefficient transduction of proliferating human B lymphocytes by VSV-pseudotyped HIV-1-derived lentivectors. , 2004, Virology.

[25]  M. L. Peterson,et al.  B-cell and plasma-cell splicing differences: a potential role in regulated immunoglobulin RNA processing. , 2003, RNA.

[26]  H. Renz,et al.  Levels of Antibodies Specific to Tetanus Toxoid, Haemophilus influenzae Type b, and Pneumococcal Capsular Polysaccharide in Healthy Children and Adults , 2003, Clinical Diagnostic Laboratory Immunology.

[27]  D. Trono,et al.  Efficient transduction of primary human B lymphocytes and nondividing myeloma B cells with HIV-1-derived lentiviral vectors. , 2003, Blood.

[28]  W. Janssens,et al.  Efficiency of onco-retroviral and lentiviral gene transfer into primary mouse and human B-lymphocytes is pseudotype dependent. , 2003, Human gene therapy.

[29]  T. Takai Roles of Fc receptors in autoimmunity , 2002, Nature Reviews Immunology.

[30]  David Baltimore,et al.  Germline Transmission and Tissue-Specific Expression of Transgenes Delivered by Lentiviral Vectors , 2002, Science.

[31]  E. ten Dam,et al.  The 'cleavage' activities of foot-and-mouth disease virus 2A site-directed mutants and naturally occurring '2A-like' sequences. , 2001, The Journal of general virology.

[32]  T. Hope,et al.  Woodchuck Hepatitis Virus Posttranscriptional Regulatory Element Enhances Expression of Transgenes Delivered by Retroviral Vectors , 1999, Journal of Virology.

[33]  David Haussler,et al.  Improved splice site detection in Genie , 1997, RECOMB '97.

[34]  C. Borrebaeck,et al.  Enhancement of specific immunoglobulin production in SCID-hu-PBL mice after in vitro priming of human B cells with superantigen. , 1995, Immunology.

[35]  T. Miyawaki,et al.  Mature helper T cell requirement for immunoglobulin production by neonatal naive B cells injected intraperitoneally into severe combined immunodeficient (SCID) mice , 1994, Clinical and experimental immunology.

[36]  R. Kelly,et al.  The membrane IgM-associated proteins MB-1 and Ig-beta are sufficient to promote surface expression of a partially functional B-cell antigen receptor in a nonlymphoid cell line. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[37]  N. Proudfoot,et al.  A pause site for RNA polymerase II is associated with termination of transcription. , 1991, The EMBO journal.

[38]  L. Hendershot,et al.  Regulation of IgM and IgD expression in human B-lineage cells. , 1991, Journal of immunology.

[39]  M. Reth,et al.  Identification of the genes encoding the IgM‐α and Ig‐β components of the IgM antigen receptor complex by amino‐terminal sequencing , 1990, European journal of immunology.

[40]  N. Proudfoot,et al.  Definition of an efficient synthetic poly(A) site. , 1989, Genes & development.

[41]  R. Mulligan,et al.  Lineage-specific expression of a human β-globin gene in murine bone marrow transplant recipients reconstituted with retrovirus-transduced stem cells , 1988, Nature.

[42]  C. M. Steel,et al.  Variant sublines of the human B-lymphoma cells Namalwa are at different stages of differentiation. , 1987, Immunology.

[43]  C. M. Steel,et al.  MHC class II antigen and immunoglobulin expression in spontaneous phenotypic variants of the Burkitt's lymphoma cell line Namalwa. , 1986, Immunology.

[44]  M. L. Peterson,et al.  Regulated production of mu m and mu s mRNA requires linkage of the poly(A) addition sites and is dependent on the length of the mu s-mu m intron. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[45]  C. Milcarek,et al.  Cell-specific expression of secreted versus membrane forms of immunoglobulin gamma 2b mRNA involves selective use of alternate polyadenylation sites , 1985, Molecular and cellular biology.

[46]  T. Miyata,et al.  Nucleotide sequences of gene segments encoding membrane domains of immunoglobulin gamma chains. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[47]  M. L. Peterson,et al.  Immunoglobulin heavy chain gene regulation through polyadenylation and splicing competition , 2011, Wiley interdisciplinary reviews. RNA.

[48]  D. Burton,et al.  Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge , 2008, Nature Medicine.

[49]  M. Peterson Mechanisms controlling production of membrane and secreted immunoglobulin during B cell development , 2007, Immunologic research.

[50]  H. Asaoku,et al.  Heterogeneous expression of CD32 and CD32-mediated growth suppression in human myeloma cells. , 2006, Haematologica.

[51]  C. Milcarek,et al.  Differential mRNA stabilities affect mRNA levels in mutant mouse myeloma cells , 1991, Somatic cell and molecular genetics.