Sensitivity and Resistance of MET Exon 14 Mutations in Lung Cancer to Eight MET Tyrosine Kinase Inhibitors In Vitro.
暂无分享,去创建一个
T. Mitsudomi | T. Koga | Yoshihisa Kobayashi | M. Chiba | K. Suda | M. Shimoji | K. Tomizawa | S. Ohara | T. Fujino | M. Nishino | T. Takemoto
[1] E. Smit,et al. Overcoming EGFRG724S-mediated osimertinib resistance through unique binding characteristics of second-generation EGFR inhibitors , 2018, Nature Communications.
[2] Charles M. Rudin,et al. Activation of KRAS Mediates Resistance to Targeted Therapy in MET Exon 14–mutant Non–small Cell Lung Cancer , 2018, Clinical Cancer Research.
[3] S. C. Wang,et al. OA12.02 Updated Antitumor Activity of Crizotinib in Patients with MET Exon 14-Altered Advanced Non-Small Cell Lung Cancer , 2018, Journal of Thoracic Oncology.
[4] P. Paik,et al. OA12.01 Phase II Data for the MET Inhibitor Tepotinib in Patients with Advanced NSCLC and MET Exon 14-Skipping Mutations , 2018, Journal of Thoracic Oncology.
[5] H. Groen,et al. Results of the GEOMETRY mono-1 phase II study for evaluation of the MET inhibitor capmatinib (INC280) in patients (pts) with METΔex14 mutated advanced non-small cell lung cancer (NSCLC). , 2018, Annals of oncology : official journal of the European Society for Medical Oncology.
[6] S. Ou,et al. Next generation sequencing reveals a novel ALK G1128A mutation resistant to crizotinib in an ALK-Rearranged NSCLC patient. , 2018, Lung cancer.
[7] C. Paweletz,et al. Amplification of Wild-type KRAS Imparts Resistance to Crizotinib in MET Exon 14 Mutant Non–Small Cell Lung Cancer , 2018, Clinical Cancer Research.
[8] F. Peng,et al. Acquired resistance to crizotinib in advanced lung adenocarcinoma with MET exon 14 skipping. , 2017, Lung cancer.
[9] Angela N. Brooks,et al. MET Exon 14 Mutation Encodes an Actionable Therapeutic Target in Lung Adenocarcinoma. , 2017, Cancer research.
[10] P. Jänne,et al. Glesatinib Exhibits Antitumor Activity in Lung Cancer Models and Patients Harboring MET Exon 14 Mutations and Overcomes Mutation-mediated Resistance to Type I MET Inhibitors in Nonclinical Models , 2017, Clinical Cancer Research.
[11] Elizabeth A. Tovar,et al. MET in human cancer: germline and somatic mutations. , 2017, Annals of translational medicine.
[12] V. Miller,et al. Mutation of MET Y1230 as an Acquired Mechanism of Crizotinib Resistance in NSCLC with MET Exon 14 Skipping. , 2017, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.
[13] Yi-long Wu,et al. Acquired MET Y1248H and D1246N Mutations Mediate Resistance to MET Inhibitors in Non–Small Cell Lung Cancer , 2017, Clinical Cancer Research.
[14] M. Stratton,et al. Genome-wide chemical mutagenesis screens allow unbiased saturation of the cancer genome and identification of drug resistance mutations , 2017, bioRxiv.
[15] Young Hak Kim,et al. Characterization of EGFR T790M, L792F, and C797S Mutations as Mechanisms of Acquired Resistance to Afatinib in Lung Cancer , 2016, Molecular Cancer Therapeutics.
[16] P. Li,et al. Response and acquired resistance to crizotinib in Chinese patients with lung adenocarcinomas harboring MET Exon 14 splicing alternations. , 2016, Lung cancer.
[17] C. Paweletz,et al. Acquired METD1228V Mutation and Resistance to MET Inhibition in Lung Cancer. , 2016, Cancer discovery.
[18] P. Stephens,et al. Characterization of 298 Patients with Lung Cancer Harboring MET Exon 14 Skipping Alterations , 2016, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.
[19] Jeffrey W. Clark,et al. Acquired Resistance to Crizotinib in NSCLC with MET Exon 14 Skipping , 2016, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.
[20] P. Jänne,et al. MET Exon 14 Mutations in Non-Small-Cell Lung Cancer Are Associated With Advanced Age and Stage-Dependent MET Genomic Amplification and c-Met Overexpression. , 2016, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[21] T. Mitsudomi,et al. MET gene exon 14 deletion created using the CRISPR/Cas9 system enhances cellular growth and sensitivity to a MET inhibitor. , 2015, Lung cancer.
[22] Sheryl K Elkin,et al. Response to Crizotinib in a Patient With Lung Adenocarcinoma Harboring a MET Splice Site Mutation. , 2015, Clinical lung cancer.
[23] P. Ma. MET receptor juxtamembrane exon 14 alternative spliced variant: novel cancer genomic predictive biomarker. , 2015, Cancer discovery.
[24] Mark Rosenzweig,et al. Activation of MET via diverse exon 14 splicing alterations occurs in multiple tumor types and confers clinical sensitivity to MET inhibitors. , 2015, Cancer discovery.
[25] N. Schultz,et al. Response to MET inhibitors in patients with stage IV lung adenocarcinomas harboring MET mutations causing exon 14 skipping. , 2015, Cancer discovery.
[26] Steven J. M. Jones,et al. Comprehensive molecular profiling of lung adenocarcinoma , 2014, Nature.
[27] Mari Mino-Kenudson,et al. Acquired resistance to crizotinib from a mutation in CD74-ROS1. , 2013, The New England journal of medicine.
[28] Angela N. Brooks,et al. Mapping the Hallmarks of Lung Adenocarcinoma with Massively Parallel Sequencing , 2012, Cell.
[29] Levi A Garraway,et al. Circumventing cancer drug resistance in the era of personalized medicine. , 2012, Cancer discovery.
[30] A. Iafrate,et al. Mechanisms of Acquired Crizotinib Resistance in ALK-Rearranged Lung Cancers , 2012, Science Translational Medicine.
[31] Carmen Birchmeier,et al. Targeting MET in cancer: rationale and progress , 2012, Nature Reviews Cancer.
[32] I. Okamoto,et al. MET Tyrosine Kinase Inhibitor Crizotinib (PF-02341066) Shows Differential Antitumor Effects in Non-small Cell Lung Cancer According to MET Alterations , 2011, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.
[33] Joseph Schoepfer,et al. A drug resistance screen using a selective MET inhibitor reveals a spectrum of mutations that partially overlap with activating mutations found in cancer patients. , 2011, Cancer research.
[34] S. Digumarthy,et al. Genotypic and Histological Evolution of Lung Cancers Acquiring Resistance to EGFR Inhibitors , 2011, Science Translational Medicine.
[35] Y. Yatabe,et al. Activation of MET by Gene Amplification or by Splice Mutations Deleting the Juxtamembrane Domain in Primary Resected Lung Cancers , 2009, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.
[36] Delong Liu,et al. P-loop mutations and novel therapeutic approaches for imatinib failures in chronic myeloid leukemia , 2008, Journal of hematology & oncology.
[37] Brian H. Dunford-Shore,et al. Somatic mutations affect key pathways in lung adenocarcinoma , 2008, Nature.
[38] Ravi Salgia,et al. Functional expression and mutations of c-Met and its therapeutic inhibition with SU11274 and small interfering RNA in non-small cell lung cancer. , 2005, Cancer research.
[39] J. Christensen,et al. A novel small molecule met inhibitor induces apoptosis in cells transformed by the oncogenic TPR-MET tyrosine kinase. , 2003, Cancer research.
[40] H. Band,et al. Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein. , 2001, Molecular cell.
[41] N. Horiya,et al. Mutations induced in male germ cells after treatment of transgenic mice with ethylnitrosourea. , 1997, Mutation research.
[42] C. Cooper,et al. Molecular cloning of a new transforming gene from a chemically transformed human cell line , 1984, Nature.
[43] B. Taylor,et al. Prospective Comprehensive Molecular Characterization of Lung Adenocarcinomas for Efficient Patient Matching to Approved and Emerging Therapies. , 2017, Cancer discovery.
[44] S. Ou,et al. Emergence of Preexisting MET Y1230C Mutation as a Resistance Mechanism to Crizotinib in NSCLC with MET Exon 14 Skipping , 2017, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.
[45] S. Ou,et al. The race to target MET exon 14 skipping alterations in non-small cell lung cancer: The Why, the How, the Who, the Unknown, and the Inevitable. , 2017, Lung cancer.
[46] R. Roskoski. Classification of small molecule protein kinase inhibitors based upon the structures of their drug-enzyme complexes. , 2016, Pharmacological research.
[47] Somasekar Seshagiri,et al. Somatic mutations lead to an oncogenic deletion of met in lung cancer. , 2006, Cancer research.