Prognostic value of hepatocyte nuclear factors 4α and 1α identified by tissue microarray in resectable hepatocellular carcinoma

This study aimed to investigate the prognostic value of expression of hepatocyte nuclear factors (HNFs) involved in hepatic gene transcription in patients undergoing curative resection for hepatocellular carcinoma (HCC).

[1]  R. Santambrogio,et al.  Hepatic Resection for “BCLC Stage A” Hepatocellular Carcinoma. The Prognostic Role of Alpha-Fetoprotein , 2012, Annals of Surgical Oncology.

[2]  Lei Qiu,et al.  Recombinant adenovirus carrying the hepatocyte nuclear factor‐1alpha gene inhibits hepatocellular carcinoma xenograft growth in mice , 2011, Hepatology.

[3]  H. El‐Serag,et al.  Level of α-fetoprotein predicts mortality among patients with hepatitis C-related hepatocellular carcinoma. , 2011, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[4]  Shimul A. Shah,et al.  Rising incidence and demographics of hepatocellular carcinoma in the USA: what does it mean? , 2011, Expert review of gastroenterology & hepatology.

[5]  S. Fan,et al.  Continuous Improvement of Survival Outcomes of Resection of Hepatocellular Carcinoma: A 20-Year Experience , 2011, Annals of surgery.

[6]  J. Bruix,et al.  Management of hepatocellular carcinoma: An update , 2011, Hepatology.

[7]  Ewout W Steyerberg,et al.  Extensions of net reclassification improvement calculations to measure usefulness of new biomarkers , 2011, Statistics in medicine.

[8]  Kun Wu,et al.  Hepatocyte nuclear factor 4 alpha suppresses the development of hepatocellular carcinoma. , 2010, Cancer research.

[9]  M. Makuuchi,et al.  Significance of Alpha-Fetoprotein and Des-γ-Carboxy Prothrombin in Patients with Hepatocellular Carcinoma Undergoing Hepatectomy , 2009, Annals of Surgical Oncology.

[10]  Bei-fang Ning,et al.  Hepatocyte nuclear factor 4α attenuates hepatic fibrosis in rats , 2009, Gut.

[11]  Jun-Ping Zhang,et al.  Differentiation therapy of hepatocellular carcinoma in mice with recombinant adenovirus carrying hepatocyte nuclear factor‐4α gene , 2008, Hepatology.

[12]  E. Yu,et al.  Metastatic tumor antigen 1 is closely associated with frequent postoperative recurrence and poor survival in patients with hepatocellular carcinoma , 2008, Hepatology.

[13]  M. Pencina,et al.  Evaluating the added predictive ability of a new marker: From area under the ROC curve to reclassification and beyond , 2008, Statistics in medicine.

[14]  C. de Toma,et al.  Association of CYP1B1 germ line mutations with hepatocyte nuclear factor 1alpha-mutated hepatocellular adenoma. , 2007, Cancer research.

[15]  G. Tiberio,et al.  Early and Late Recurrence After Liver Resection for Hepatocellular Carcinoma: Prognostic and Therapeutic Implications , 2006, Annals of surgery.

[16]  Sung‐Gyu Lee,et al.  How I do it: assessment of hepatic functional reserve for indication of hepatic resection. , 2005, Journal of hepato-biliary-pancreatic surgery.

[17]  D. Ovchinnikov,et al.  Progression of HCC in mice is associated with a downregulation in the expression of hepatocyte nuclear factors , 2004, Hepatology.

[18]  M. Noguchi,et al.  Expression of HNFs and C/EBPα is correlated with immunocytochemical differentiation of cell lines derived from human hepatocellular carcinomas, hepatoblastomas and immortalized hepatocytes , 2003, Cancer science.

[19]  M. Kojiro,et al.  Immunohistologic study on the expressions of α‐fetoprotein and protein induced by vitamin K absence or antagonist II in surgically resected small hepatocellular carcinoma , 2001, Hepatology.

[20]  S. Fan,et al.  Different risk factors and prognosis for early and late intrahepatic recurrence after resection of hepatocellular carcinoma , 2000, Cancer.

[21]  S. Fan,et al.  Risk factors, prevention, and management of postoperative recurrence after resection of hepatocellular carcinoma. , 2000, Annals of surgery.

[22]  K. Covinsky,et al.  Assessing the Generalizability of Prognostic Information , 1999, Annals of Internal Medicine.

[23]  B. Haddad,et al.  Rescue of the HNF4 --> HNF1alpha pathway in hepatoma variant cells containing human chromosome 12. , 1998, Genomics.

[24]  Y. Hayashi,et al.  Expression of HNF‐1α and HNF‐1β in various histological differentiations of hepatocellular carcinoma , 1998 .

[25]  M. Weiss,et al.  Hepatocyte Nuclear Factor 4 Provokes Expression of Epithelial Marker Genes, Acting As a Morphogen in Dedifferentiated Hepatoma Cells , 1998, The Journal of cell biology.

[26]  M. Kasuga,et al.  Expression ratio of hepatocyte nuclear factor-1 to variant hepatocyte nuclear factor-1 in differentiation of hepatocellular carcinoma and hepatoblastoma. , 1996, Journal of hepatology.

[27]  K. Kaestner,et al.  Expression of hepatocyte-enriched nuclear transcription factors in mouse liver tumours. , 1996, Carcinogenesis.

[28]  M. Yaniv,et al.  Hepatocyte Nuclear Factor 1 Inactivation Results in Hepatic Dysfunction, Phenylketonuria, and Renal Fanconi Syndrome , 1996, Cell.

[29]  S. Cereghini Liver‐enriched transcription factors and hepatocyte differentiation , 1996, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[30]  B. Bois-Joyeux,et al.  Members of the CAAT/enhancer-binding protein, hepatocyte nuclear factor-1 and nuclear factor-1 families can differentially modulate the activities of the rat alpha-fetoprotein promoter and enhancer. , 1994, The Biochemical journal.

[31]  S. Thorgeirsson,et al.  Expression of hepatic transcription factors during liver development and oval cell differentiation , 1994, The Journal of cell biology.

[32]  I. Talianidis,et al.  An indirect negative autoregulatory mechanism involved in hepatocyte nuclear factor-1 gene expression. , 1993, Nucleic acids research.

[33]  H. El‐Serag,et al.  Level of Alpha-Fetoprotein Predicts Mortality among Patients with Hepatitis C-Related Hepatocellular Carcinoma , 2011 .

[34]  N. Lazarevich Molecular mechanisms of alpha-fetoprotein gene expression. , 2000, Biochemistry. Biokhimiia.

[35]  H. Nakabayashi,et al.  Expression of HNF-1 alpha and HNF-1 beta in various histological differentiations of hepatocellular carcinoma. , 1998, The Journal of pathology.