Plasma levels of antidiuretic hormone in man during methoxyflurane anaesthesia and surgery

Anaesthesia and surgery produce oliguria in man. It is well known that the antidiuresis is influenced by solute load, alterations in renal function and the release of antidiuretic hormone ( A D H ) ~ . An increase in plasma ADH with surgical stress has been shown in man2v3. Furthermore, in recent years a new post-operative syndrome has been described in which hyponatremia and renal salt loss, unrelated to either renal or adrenal disease, has been attributed to over-expansion of body fluids resulting from the inappropriate secretion of ADH4-6. Oyama & Kimura7 recently observed a marked elevation in plasma ADH levels during ether anaesthesia in man. In view of these facts, anaesthesiologists should be aware of the role of ADH, and the effects of anaesthesia and surgery on ADH secretion. The present study was designed to investigate the effects of rnethoxyflurane anaesthesia alone on the plasma ADH level of patients and to compare the results with the effects of anaesthesia plus surgery. We attempted to explore the quantitative relationship between plasma ADH levels and the urine volume, urine and blood osmolality in order to evaluate the role of ADH in the antidiuresis produced by anaesthesia.

[1]  T. Oyama,et al.  Plasma levels of antidiuretic hormone in man during diethyl ether anaesthesia and surgery , 1970, Canadian Anaesthetists' Society journal.

[2]  W. Schwartz,et al.  The Syndrome of Inappropriate Secretion of Antidiuretic Hormone , 1970, Journal of the Royal College of Physicians of London.

[3]  M. Lebowitz.  Methoxyflurane and renal toxicity. , 1968, Anesthesia progress.

[4]  M. Ukai,et al.  The Role of Visceral Afferent Pathways on Vasopressin Secretion and Urinary Excretoroy Patterns during Surgical Stress , 1968, Annals of surgery.

[5]  E. Pierce,et al.  Cyclopropane effects on renal function in normal man. , 1967, Anesthesiology.

[6]  L. Share,et al.  Vasopressin, its bioassay and the physiological control of its release. , 1967, The American journal of medicine.

[7]  S. Deutsch,et al.  Effects of Halothane Anesthesia on Renal Function in Normal Man , 1966, Anesthesiology.

[8]  L. Vandam.  Report on methoxyflurane. , 1966, Anesthesiology.

[9]  S. Pappas,et al.  Nephrotoxicity Associated with Methoxyflurane Anesthesia , 1966, Anesthesiology.

[10]  R. Dripps,et al.  Postoperative Hyponatremia with the Inappropriate Release of Antidiuretic Hormone , 1966, Anesthesiology.

[11]  A. Frobese,et al.  METHOXYFLURANE AND RENAL TOXICITY , 1966 .

[12]  D. Streeten,et al.  Measurement of the osmotic threshold for vasopressin release in human subjects, and its modification by cortisol. , 1965, The Journal of clinical endocrinology and metabolism.

[13]  C. R. Stephen,et al.  Hepatic and Renal Effects of Methoxyflurane in Surgical Patients , 1965 .

[14]  A. Boba.  The Effects of Methoxyflurane on the Renal Blood Flow of the Dog , 1965 .

[15]  H. Zauder,et al.  CALIBRATION OF A NEW VAPORIZER. , 1964, Anesthesiology.

[16]  W. Moran,et al.  THE RELATIONSHIP OF ANTIDIURETIC HORMONE SECRETION TO SURGICAL STRESS. , 1964, Surgery.

[17]  E. M. Papper,et al.  The effects of preanesthetic, anesthetic, and postoperative drugs on renal function , 1964, Clinical pharmacology and therapeutics.

[18]  L. Share.  Acute reduction in extracellular fluid volume and the concentration of antidiuretic hormone in blood. , 1961, Endocrinology.

[19]  S. Papper,et al.  Effect of meperidine and secobarbital upon renal excretion of water and solute in man. , 1960, The Journal of laboratory and clinical medicine.

[20]  R. Berne,et al.  VASOPRESSIN IN BLOOD: EFFECT OF HEMORRHAGE1 , 1960 .

[21]  J. Bunker,et al.  The Influence of General Anesthetics on Water and Solute Excretion in Man , 1959, Annals of surgery.

[22]  W. Schwartz,et al.  A syndrome of renal sodium loss and hyponatremia probably resulting from inappropriate secretion of antidiuretic hormone. , 1957, The American journal of medicine.

[23]  F. D. Moore,et al.  STUDIES ON ANTIDIURESIS IN SURGERY: EFFECTS OF ANESTHESIA, SURGERY AND POSTERIOR PITUITARY ANTIDIURETIC HORMONE ON WATER METABOLISM IN MAN , 1954, Annals of surgery.

[24]  C. Winter,et al.  The effect of N-allylnormorphine upon the antidiuretic action of morphine. , 1954, The Journal of pharmacology and experimental therapeutics.

[25]  E. B. Verney,et al.  THE EFFECT OF INCREASED ACTIVITY OF THE SYMPATHETIC SYSTEM IN THE INHIBITION OF WATER‐DIURESIS BY EMOTIONAL STRESS , 1945 .