Neuron Perspective The Scientific Case for Brain Simulations

Gaute T. Einevoll,1,2,* Alain Destexhe,3,4 Markus Diesmann,5,6,7 Sonja Gr€ un,5,8 Viktor Jirsa,9 Marc de Kamps,10 Michele Migliore,11 Torbjørn V. Ness,1 Hans E. Plesser,1,5 and Felix Sch€ urmann12 1Faculty of Science and Technology, Norwegian University of Life Sciences, 1432 Ås, Norway 2Department of Physics, University of Oslo, 0316 Oslo, Norway 3Paris-Saclay Institute of Neuroscience (NeuroPSI), Centre National de la Recherche Scientifique, 91198 Gif-sur-Yvette, France 4European Institute for Theoretical Neuroscience, 75012 Paris, France 5Institute of Neuroscience and Medicine (INM-6), Institute for Advanced Simulation (IAS-6), and JARA-Institut Brain Structure-Function Relationships (INM-10), J€ ulich Research Centre, 52425 J€ ulich, Germany 6Department of Psychiatry, Psychotherapy, and Psychosomatics, RWTH Aachen University, 52074 Aachen, Germany 7Department of Physics, RWTH Aachen University, 52074 Aachen, Germany 8Theoretical Systems Neurobiology, RWTH Aachen University, 52074 Aachen, Germany 9Institut de Neurosciences des Systèmes (INS), INSERM, Aix Marseille Université, 13005 Marseille, France 10Institute for Artificial and Biological Intelligence, School of Computing, Leeds LS2 9JT, UK 11Institute of Biophysics, National Research Council, 90146 Palermo, Italy 12Blue Brain Project, École Polytechnique Fédérale de Lausanne (EPFL), Campus Biotech, 1202 Geneva, Switzerland *Correspondence: gaute.einevoll@nmbu.no https://doi.org/10.1016/j.neuron.2019.03.027

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