The International Stroke Trial (IST): a randomised trial of aspirin, subcutaneous heparin, both, or neither among 19 435 patients with acute ischaemic stroke

[1]  H. Adams,et al.  Use of antithrombotic drugs in the treatment of acute ischemic stroke , 1989, Neurology.

[2]  Zheng-Ming Chen,et al.  CAST: randomised placebo-controlled trial of early aspirin use in 20 000 patients with acute ischaemic stroke , 1997, The Lancet.

[3]  H. R. Taylor,et al.  Study design of the International Stroke Trial (IST), baseline data, and outcome in 984 randomised patients in the pilot study. , 1996, Journal of neurology, neurosurgery, and psychiatry.

[4]  J. Slattery,et al.  Antithrombotic therapy in acute ischaemic stroke: an overview of the completed randomised trials. , 1993, Journal of neurology, neurosurgery, and psychiatry.

[5]  P. Koudstaal,et al.  Increased Thromboxane Biosynthesis in Patients With Acute Cerebral Ischemia , 1993, Stroke.

[6]  Alan D. Lopez,et al.  Mortality by cause for eight regions of the world: Global Burden of Disease Study , 1997, The Lancet.

[7]  P. Sandercock,et al.  A prospective study of acute cerebrovascular disease in the community: the Oxfordshire Community Stroke Project--1981-86. 2. Incidence, case fatality rates and overall outcome at one year of cerebral infarction, primary intracerebral and subarachnoid haemorrhage. , 1990, Journal of neurology, neurosurgery, and psychiatry.

[8]  J Bamford,et al.  The frequency, causes and timing of death within 30 days of a first stroke: the Oxfordshire Community Stroke Project. , 1990, Journal of neurology, neurosurgery, and psychiatry.

[9]  Salim Yusuf,et al.  Clinical effects of anticoagulant therapy in suspected acute myocardial infarction: systematic overview of randomised trials , 1996, BMJ.

[10]  C. Warlow,et al.  How Reliable Are Simple Questions in Assessing Outcome after Stroke , 1997 .

[11]  Lindley Ri.  Are very large trials of promising treatments for acute stroke feasible , 1993 .

[12]  A. Ahuja,et al.  Low-molecular-weight heparin for the treatment of acute ischemic stroke , 1995 .

[13]  J Bamford,et al.  Long-term risk of recurrent stroke after a first-ever stroke. The Oxfordshire Community Stroke Project. , 1994, Stroke.

[14]  S. Kitchen,et al.  The Therapeutic Range for Heparin Therapy: Relationship between Six Activated Partial Thromboplastin Time Reagents and Two Heparin Assays , 1996, Thrombosis and Haemostasis.

[15]  J. Slattery,et al.  Atrial fibrillation and stroke: prevalence in different types of stroke and influence on early and long term prognosis (Oxfordshire community stroke project) , 1992, BMJ.

[16]  P. Sandercock,et al.  Acute Stroke Treatment in UK Hospitals: The Stroke Association Survey of Consultant Opinion , 1995, Journal of the Royal College of Physicians of London.

[17]  C. Warlow,et al.  Complications after acute stroke. , 1996, Stroke.

[18]  C. Warlow,et al.  Are Simple Questions a Valid Measure of Outcome after Stroke , 1997 .

[19]  L. Freedman,et al.  Allocation of patients to treatment groups in a controlled clinical study. , 1978, British Journal of Cancer.

[20]  P. Sandercock,et al.  Very Early Prevention of Stroke Recurrence , 1997 .

[21]  Radcliffe Infirmary,et al.  Collaborative overview of randomised trials of antiplatelet therapy - III: Reduction in venous thrombosis and pulmonary embolism by antiplatelet prophylaxis among surgical and medical patients , 1994, BMJ.

[22]  D. Doyle,et al.  Comparison of high-dose with low-dose subcutaneous heparin to prevent left ventricular mural thrombosis in patients with acute transmural anterior myocardial infarction. , 1989, The New England journal of medicine.

[23]  P. Koudstaal,et al.  Evidence for Episodic Platelet Activation in Acute Ischemic Stroke , 1994, Stroke.

[24]  R. Collins,et al.  Aspirin, heparin, and fibrinolytic therapy in suspected acute myocardial infarction. , 1997, The New England journal of medicine.

[25]  J. Grotta,et al.  Guidelines for the Management of Patients With Acute Ischemic Stroke A Statement for Healthcare Professionals , 2005 .