Engineering of synthetic cellular microenvironments: implications for immunity.

[1]  B. Geiger,et al.  The integrin adhesome: from genes and proteins to human disease , 2014, Nature Reviews Molecular Cell Biology.

[2]  Debashis Sahoo,et al.  Discriminating cellular heterogeneity using microwell-based RNA cytometry , 2014, Nature Communications.

[3]  S. Tay,et al.  Microfluidic single-cell analysis for systems immunology. , 2014, Lab on a chip.

[4]  Mario Roederer,et al.  Single-cell technologies for monitoring immune systems , 2014, Nature Immunology.

[5]  E. A. Cavalcanti-Adam,et al.  Soft/elastic nanopatterned biointerfaces in the service of cell biology. , 2014, Methods in cell biology.

[6]  Michael Loran Dustin,et al.  T Cell Activation is Determined by the Number of Presented Antigens , 2013, Nano letters.

[7]  A. Scheffold,et al.  Fine Tuning and Efficient T Cell Activation with Stimulatory aCD3 Nanoarrays , 2013, Nano letters.

[8]  J. Spatz,et al.  Artificial Antigen-Presenting Interfaces in the Service of Immunology , 2013 .

[9]  P. Invernizzi.  Liver auto-immunology: the paradox of autoimmunity in a tolerogenic organ. , 2013, Journal of autoimmunity.

[10]  R. Mitchell.  Learning from rejection: what transplantation teaches us about (other) vascular pathologies. , 2013, Journal of autoimmunity.

[11]  Y. Shoenfeld,et al.  Abul Abbas: an epitome of scholarship. , 2013, Journal of autoimmunity.

[12]  J. Spatz,et al.  Surface Properties of Nanostructured Bio-Active Interfaces: Impacts of Surface Stiffness and Topography on Cell-Surface Interactions. , 2013, RSC advances.

[13]  Andrew Filby,et al.  Regulation of asymmetric cell division and polarity by Scribble is not required for humoral immunity , 2013, Nature Communications.

[14]  Omar Khan,et al.  Secondary T cell–T cell synaptic interactions drive the differentiation of protective CD8+ T cells , 2013, Nature Immunology.

[15]  N. Friedman,et al.  Dynamic single-cell measurements of gene expression in primary lymphocytes: challenges, tools and prospects. , 2013, Briefings in functional genomics.

[16]  J. Spatz,et al.  Synthesis of Nanostructured and Biofunctionalized Water-in-Oil Droplets as Tools for Homing T Cells , 2013, Journal of the American Chemical Society.

[17]  R. Zaidel-Bar.  Cadherin adhesome at a glance , 2013, Journal of Cell Science.

[18]  Mark M. Davis,et al.  How the immune system talks to itself: the varied role of synapses , 2013, Immunological reviews.

[19]  J Christopher Love,et al.  Functional single-cell analysis of T-cell activation by supported lipid bilayer-tethered ligands on arrays of nanowells. , 2012, Lab on a chip.

[20]  Elisabeth Wong,et al.  Microfluidic chambers for monitoring leukocyte trafficking and humanized nano-proresolving medicines interactions , 2012, Proceedings of the National Academy of Sciences.

[21]  Mark Coles,et al.  Application of tissue engineering to the immune system: development of artificial lymph nodes , 2012, Front. Immun..

[22]  Nir Friedman,et al.  Monitoring the dynamics of primary T cell activation and differentiation using long term live cell imaging in microwell arrays. , 2012, Lab on a chip.

[23]  C. Ware,et al.  Lymphotoxin-β receptor signaling through NF-κB2-RelB pathway reprograms adipocyte precursors as lymph node stromal cells. , 2012, Immunity.

[24]  Nathan J. Castro,et al.  Electrospun fibrous scaffolds for bone and cartilage tissue generation: recent progress and future developments. , 2012, Tissue engineering. Part B, Reviews.

[25]  Wayne W. Hancock,et al.  Substrate Rigidity Regulates Human T Cell Activation and Proliferation , 2012, The Journal of Immunology.

[26]  J Christopher Love,et al.  Single-cell analysis of the dynamics and functional outcomes of interactions between human natural killer cells and target cells. , 2012, Integrative biology : quantitative biosciences from nano to macro.

[27]  Thomas D. Perroud,et al.  Microfluidically-unified cell culture, sample preparation, imaging and flow cytometry for measurement of cell signaling pathways with single cell resolution. , 2012, Lab on a chip.

[28]  Ying Zheng,et al.  In vitro microvessels for the study of angiogenesis and thrombosis , 2012, Proceedings of the National Academy of Sciences.

[29]  Steven A. Rosenberg,et al.  Adoptive immunotherapy for cancer: harnessing the T cell response , 2012, Nature Reviews Immunology.

[30]  Jhagvaral Hasbold,et al.  Activation-Induced B Cell Fates Are Selected by Intracellular Stochastic Competition , 2012, Science.

[31]  Sudha Kumari,et al.  Mechanosensing in T lymphocyte activation. , 2012, Biophysical journal.

[32]  Douglas A. Lauffenburger,et al.  Polyfunctional responses by human T cells result from sequential release of cytokines , 2011, Proceedings of the National Academy of Sciences.

[33]  J Christopher Love,et al.  A high-throughput single-cell analysis of human CD8⁺ T cell functions reveals discordance for cytokine secretion and cytolysis. , 2011, The Journal of clinical investigation.

[34]  Yuka Kobayashi,et al.  Synthesis of functional artificial lymphoid tissues. , 2011, Discovery medicine.

[35]  P. Friedl,et al.  Cytotoxic T lymphocyte migration and effector function in the tumor microenvironment. , 2011, Immunology letters.

[36]  Rong Fan,et al.  A Clinical Microchip for Evaluation of Single Immune Cells Reveals High Functional Heterogeneity in Phenotypically Similar T Cells Nih Public Access Author Manuscript Design Rationale and Detection Limit of the Scbc Online Methods Microchip Fabrication On-chip Secretion Profiling Supplementary Mater , 2022 .

[37]  Rong Fan,et al.  Protein signaling networks from single cell fluctuations and information theory profiling. , 2011, Biophysical journal.

[38]  Joachim P Spatz,et al.  Impact of local versus global ligand density on cellular adhesion. , 2011, Nano letters.

[39]  Fabien Guillemot,et al.  Cell patterning technologies for organotypic tissue fabrication. , 2011, Trends in biotechnology.

[40]  Mingming Wu,et al.  Dendritic cell chemotaxis in 3D under defined chemokine gradients reveals differential response to ligands CCL21 and CCL19 , 2011, Proceedings of the National Academy of Sciences.

[41]  Joachim P Spatz,et al.  Nanopatterning by block copolymer micelle nanolithography and bioinspired applications. , 2011, Biointerphases.

[42]  Sylvie Ricard-Blum,et al.  MatrixDB, the extracellular matrix interaction database , 2010, Nucleic Acids Res..

[43]  Helene Andersson-Svahn,et al.  Imaging Immune Surveillance of Individual Natural Killer Cells Confined in Microwell Arrays , 2010, PloS one.

[44]  S. Quake,et al.  Variability in G-protein-coupled signaling studied with microfluidic devices. , 2010, Biophysical journal.

[45]  Uwe Marx,et al.  Immunological substance testing on human lymphatic micro-organoids in vitro. , 2010, Journal of biotechnology.

[46]  Timothy K Lee,et al.  Single-cell NF-κB dynamics reveal digital activation and analogue information processing , 2010, Nature.

[47]  Cheng-han Yu,et al.  Engineering supported membranes for cell biology , 2010, Medical & Biological Engineering & Computing.

[48]  Sangeeta N Bhatia,et al.  Microfluidics-integrated time-lapse imaging for analysis of cellular dynamics. , 2010, Integrative biology : quantitative biosciences from nano to macro.

[49]  N. Zurgil,et al.  Polymer live-cell array for real-time kinetic imaging of immune cells. , 2010, Biomaterials.

[50]  Mi-Hua Tao,et al.  Cutting Edge: Mechanical Forces Acting on T Cells Immobilized via the TCR Complex Can Trigger TCR Signaling , 2010, The Journal of Immunology.

[51]  G. Lajoie,et al.  Matrigel: A complex protein mixture required for optimal growth of cell culture , 2010, Proteomics.

[52]  Benjamin Geiger,et al.  The switchable integrin adhesome , 2010, Journal of Cell Science.

[53]  Junsang Doh,et al.  Cell-laden microwells for the study of multicellularity in lymphocyte fate decisions. , 2010, Biomaterials.

[54]  K. Maniura‐Weber,et al.  Stem cell plasticity, osteogenic differentiation and the third dimension , 2010, Journal of materials science. Materials in medicine.

[55]  Evan W. Newell,et al.  TCR–peptide–MHC interactions in situ show accelerated kinetics and increased affinity , 2010, Nature.

[56]  U. Schwarz,et al.  Cell adhesion strength is controlled by intermolecular spacing of adhesion receptors. , 2010, Biophysical journal.

[57]  B. Önfelt,et al.  Imaging immune surveillance by individual Natural Killer cells isolated in arrays of nanoliter wells , 2010 .

[58]  Takeshi Watanabe,et al.  Artificial engineering of secondary lymphoid organs. , 2010, Advances in immunology.

[59]  M. Gunzer,et al.  Immune synapse formation determines interaction forces between T cells and antigen-presenting cells measured by atomic force microscopy , 2009, Proceedings of the National Academy of Sciences.

[60]  L. Kam.  Capturing the nanoscale complexity of cellular membranes in supported lipid bilayers. , 2009, Journal of structural biology.

[61]  Lance C. Kam,et al.  Self-aligned supported lipid bilayers for patterning the cell-substrate interface. , 2009, Journal of the American Chemical Society.

[62]  Donald Wlodkowic,et al.  Microfluidic single cell arrays to interrogate signalling dynamics of individual, patient-derived hematopoietic stem cells. , 2009, Lab on a chip.

[63]  N. Henry,et al.  Correction: T-Cell Artificial Focal Triggering Tools: Linking Surface Interactions with Cell Response , 2009, PLoS ONE.

[64]  Mark W. Tibbitt,et al.  Hydrogels as extracellular matrix mimics for 3D cell culture. , 2009, Biotechnology and bioengineering.

[65]  Daniel Aydin,et al.  Micro-nanostructured protein arrays: a tool for geometrically controlled ligand presentation. , 2009, Small.

[66]  Amy E Herr,et al.  Fully integrated microfluidic platform enabling automated phosphoprofiling of macrophage response. , 2009, Analytical chemistry.

[67]  N. Henry,et al.  T-Cell Artificial Focal Triggering Tools: Linking Surface Interactions with Cell Response , 2009, PloS one.

[68]  Andre Levchenko,et al.  High Content Cell Screening in a Microfluidic Device*S , 2009, Molecular & Cellular Proteomics.

[69]  Daniel Day,et al.  A method for prolonged imaging of motile lymphocytes , 2009, Immunology and cell biology.

[70]  Christopher S. Chen.  Mechanotransduction – a field pulling together? , 2008, Journal of Cell Science.

[71]  E. A. Cavalcanti-Adam,et al.  Cell adhesion and response to synthetic nanopatterned environments by steering receptor clustering and spatial location , 2008, HFSP journal.

[72]  H. Kessler,et al.  Cell adhesion and polarisation on molecularly defined spacing gradient surfaces of cyclic RGDfK peptide patches. , 2008, European journal of cell biology.

[73]  Benjamin Geiger,et al.  Induction of cell polarization and migration by a gradient of nanoscale variations in adhesive ligand spacing. , 2008, Nano letters.

[74]  Donald E Ingber,et al.  Directional control of cell motility through focal adhesion positioning and spatial control of Rac activation , 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[75]  K. Mossman,et al.  T cell receptor microcluster transport through molecular mazes reveals mechanism of translocation. , 2008, Biophysical journal.

[76]  D. Irvine,et al.  Lymphoid tissue engineering: invoking lymphoid tissue neogenesis in immunotherapy and models of immunity. , 2008, Seminars in immunology.

[77]  Peter Fratzl,et al.  The effect of geometry on three-dimensional tissue growth , 2008, Journal of The Royal Society Interface.

[78]  Jinjun Shi,et al.  Sub-100 nm patterning of supported bilayers by nanoshaving lithography. , 2008, Journal of the American Chemical Society.

[79]  Staffan Strömblad,et al.  Cell-matrix adhesion complexes: master control machinery of cell migration. , 2008, Seminars in cancer biology.

[80]  Kenneth M. Yamada,et al.  Cell–matrix adhesion , 2007, Journal of cellular physiology.

[81]  S. Itzkovitz,et al.  Functional atlas of the integrin adhesome , 2007, Nature Cell Biology.

[82]  Jessica Melin,et al.  Microfluidic large-scale integration: the evolution of design rules for biological automation. , 2007, Annual review of biophysics and biomolecular structure.

[83]  Noriaki Okamoto,et al.  Artificial lymph nodes induce potent secondary immune responses in naive and immunodeficient mice. , 2007, The Journal of clinical investigation.

[84]  Joachim P Spatz,et al.  Mimicking cellular environments by nanostructured soft interfaces. , 2007, Nano letters.

[85]  Nicholas H Brown,et al.  Integrins and the actin cytoskeleton. , 2007, Current opinion in cell biology.

[86]  Benjamin Geiger,et al.  Molecular engineering of cellular environments: cell adhesion to nano-digital surfaces. , 2007, Methods in cell biology.

[87]  Michael Loran Dustin,et al.  Force as a facilitator of integrin conformational changes during leukocyte arrest on blood vessels and antigen-presenting cells. , 2007, Immunity.

[88]  Manuel Théry,et al.  Anisotropy of cell adhesive microenvironment governs cell internal organization and orientation of polarity , 2006, Proceedings of the National Academy of Sciences.

[89]  G. Whitesides,et al.  Applications of microfluidics in chemical biology. , 2006, Current opinion in chemical biology.

[90]  Luke P. Lee,et al.  Dynamic single cell culture array. , 2006, Lab on a chip.

[91]  Benjamin Geiger,et al.  Adhesion-mediated mechanosensitivity: a time to experiment, and a time to theorize. , 2006, Current opinion in cell biology.

[92]  S. Sen,et al.  Matrix Elasticity Directs Stem Cell Lineage Specification , 2006, Cell.

[93]  C. Willard-Mack.  Normal Structure, Function, and Histology of Lymph Nodes , 2006, Toxicologic pathology.

[94]  J. Fisher,et al.  Development and characterization of an acellular human pericardial matrix for tissue engineering. , 2006, Tissue engineering.

[95]  S. Rosenberg,et al.  Adoptive immunotherapy for cancer: building on success , 2006, Nature Reviews Immunology.

[96]  Junsang Doh,et al.  Immunological synapse arrays: patterned protein surfaces that modulate immunological synapse structure formation in T cells. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[97]  M. Sheetz,et al.  Local force and geometry sensing regulate cell functions , 2006, Nature Reviews Molecular Cell Biology.

[98]  N. Friedman,et al.  Stochastic protein expression in individual cells at the single molecule level , 2006, Nature.

[99]  K. Mossman,et al.  Altered TCR Signaling from Geometrically Repatterned Immunological Synapses , 2005, Science.

[100]  P. Janmey,et al.  Tissue Cells Feel and Respond to the Stiffness of Their Substrate , 2005, Science.

[101]  Rajat Varma,et al.  Actin and agonist MHC–peptide complex–dependent T cell receptor microclusters as scaffolds for signaling , 2005, The Journal of experimental medicine.

[102]  A. Folch,et al.  Large-scale single-cell trapping and imaging using microwell arrays. , 2005, Analytical chemistry.

[103]  Y. Wan,et al.  Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[104]  Takeshi Watanabe,et al.  Generation of a synthetic lymphoid tissue–like organoid in mice , 2004, Nature Biotechnology.

[105]  Joe Tien,et al.  Mechanotransduction at cell-matrix and cell-cell contacts. , 2004, Annual review of biomedical engineering.

[106]  Joachim P Spatz,et al.  Activation of integrin function by nanopatterned adhesive interfaces. , 2004, Chemphyschem : a European journal of chemical physics and physical chemistry.

[107]  Yongwon Choi,et al.  An essential function for the nuclear receptor RORγt in the generation of fetal lymphoid tissue inducer cells , 2004, Nature Immunology.

[108]  N. Balaban,et al.  Adhesion-dependent cell mechanosensitivity. , 2003, Annual review of cell and developmental biology.

[109]  Horst Kessler,et al.  RGD modified polymers: biomaterials for stimulated cell adhesion and beyond. , 2003, Biomaterials.

[110]  Ulrich H. von Andrian,et al.  Homing and cellular traffic in lymph nodes , 2003, Nature Reviews Immunology.

[111]  J. Spatz,et al.  Block Copolymer Micelle Nanolithography , 2003 .

[112]  Steven A. Rosenberg,et al.  Adoptive-cell-transfer therapy for the treatment of patients with cancer , 2003, Nature Reviews Cancer.

[113]  J. Groves,et al.  Supported planar bilayers in studies on immune cell adhesion and communication. , 2003, Journal of immunological methods.

[114]  Arnoud Sonnenberg,et al.  The fibronectin-binding integrins α5β1 and αvβ3 differentially modulate RhoA–GTP loading, organization of cell matrix adhesions, and fibronectin fibrillogenesis , 2002, The Journal of cell biology.

[115]  Benjamin Geiger,et al.  Exploring the Neighborhood Adhesion-Coupled Cell Mechanosensors , 2002, Cell.

[116]  A S G Curtis,et al.  In vitro reaction of endothelial cells to polymer demixed nanotopography. , 2002, Biomaterials.

[117]  R. Germain.  T-cell development and the CD4–CD8 lineage decision , 2002, Nature Reviews Immunology.

[118]  Kenneth M. Yamada,et al.  Taking Cell-Matrix Adhesions to the Third Dimension , 2001, Science.

[119]  E. Kaldjian,et al.  Spatial and molecular organization of lymph node T cell cortex: a labyrinthine cavity bounded by an epithelium-like monolayer of fibroblastic reticular cells anchored to basement membrane-like extracellular matrix. , 2001, International immunology.

[120]  Steven A. Rosenberg,et al.  Progress in human tumour immunology and immunotherapy , 2001, Nature.

[121]  A Curtis,et al.  Tissue engineering: the biophysical background. , 2001, Physics in medicine and biology.

[122]  Kenneth M. Yamada,et al.  Physical state of the extracellular matrix regulates the structure and molecular composition of cell-matrix adhesions. , 2000, Molecular biology of the cell.

[123]  S. Dzik,et al.  The immunological synapse: A molecular machine controlling T cell activation , 2000 .

[124]  M. Cahalan,et al.  Mapping the sensitivity of T cells with an optical trap: polarity and minimal number of receptors for Ca(2+) signaling. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[125]  R. Kedl,et al.  CD8+ T cells become nonresponsive (anergic) following activation in the presence of costimulation. , 1999, Journal of immunology.

[126]  M. Mescher,et al.  ICAM‐1 and B7‐1 provide similar but distinct costimulation for CD8+ T cells, while CD4+ T cells are poorly costimulated by ICAM‐1 , 1999, European journal of immunology.

[127]  M. Connors,et al.  Effects of CD28 costimulation on long-term proliferation of CD4+ T cells in the absence of exogenous feeder cells. , 1997, Journal of immunology.

[128]  C. S. Chen,et al.  Geometric control of cell life and death. , 1997, Science.

[129]  G. Bokoch,et al.  Sophisticated strategies for information encounter in the lymph node: the reticular network as a conduit of soluble information and a highway for cell traffic. , 1996, Journal of immunology.

[130]  E. Sackmann,et al.  Supported Membranes: Scientific and Practical Applications , 1996, Science.

[131]  M. Mescher.  Surface contact requirements for activation of cytotoxic T lymphocytes. , 1992, Journal of immunology.

[132]  A. Gearing,et al.  Expression and cell distribution of the intercellular adhesion molecule, vascular cell adhesion molecule, endothelial leukocyte adhesion molecule, and endothelial cell adhesion molecule (CD31) in reactive human lymph nodes and in Hodgkin's disease. , 1992, The American journal of pathology.

[133]  A. Meshorer,et al.  Protection against Experimental Allergic Encephalomyelitis , 1972, Nature.

[134]  M. Sela,et al.  Studies on the chemical basis of the antigenicity of proteins. 6. Antigenic specificity of some synthetic polypeptides containing tyrosine. , 1963, Biochemical Journal.

[135]  M. Sela,et al.  Studies on the chemical basis of the antigenicity of proteins. 3. The role of rigidity in the antigenicity of polypeptidyl gelatins. , 1960, The Biochemical journal.

[136]  M. Sela,et al.  Studies on the chemical basis of the antigenicity of proteins. 2. Antigenic specificity of polytyrosyl gelatins. , 1960, The Biochemical journal.

[137]  M. Sela,et al.  Studies on the chemical basis of the antigenicity of proteins. 1. Antigenicity of polypeptidyl gelatins. , 1960, The Biochemical journal.