Relation Between Retinal Vasculature and Retinal Thickness in Macular Edema

This study has investigated the relationship of the retinal vasculature and the retinal thickness for Macular Edema (ME) subjects. Ninety sets of Fluorescein Angiograph (FA) and Optical Coherence Tomography (OCT) of 54 participants were analyzed. Multivariate analysis using the binary logistic regression model was used to study the association between vessel parameters and retinal thickness. The results reveal retinal vessel feature i.e. fractal dimension (FD) as the most sensitive parameter to the changes in retinal thickness associated with ME. Thus, indicating a direct relationship between the retinal vasculature and retinal thickness which is caused due to neovascular causing exudates, leakages and hemorrhages, with applications for alternate modality for detection of ME.

[1]  Christian Enzinger,et al.  Fractal Dimension and Vessel Complexity in Patients with Cerebral Arteriovenous Malformations , 2012, PloS one.

[2]  Gilda Cennamo,et al.  Evaluation of ischemic diabetic maculopathy with Fourier-domain optical coherence tomography and microperimetry. , 2015, Canadian journal of ophthalmology. Journal canadien d'ophtalmologie.

[3]  G. Guerra,et al.  Fractal dimension as a new tool to analyze optic nerve head vasculature in primary open angle glaucoma. , 2015, In vivo.

[4]  E Reichel,et al.  Topography of diabetic macular edema with optical coherence tomography. , 1998, Ophthalmology.

[5]  Muna Bhende,et al.  Discrepancy between fluorescein angiography and optical coherence tomography in detection of macular disease. , 2009, Retina.

[6]  G. Richard,et al.  OCT bei Makulaödem , 2004, Der Ophthalmologe.

[7]  R. Lerche,et al.  [Optical coherence tomography for macular edema. Classification, quantitative assessment, and rational usage in the clinical practice]. , 2004, Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft.

[8]  D. Boyer,et al.  Efficacy of verteporfin photodynamic therapy on laser-induced choroidal neovascularization and the ancillary effect on diabetic microvasculopathy , 2004, Current eye research.

[9]  D. Kumar,et al.  Relationship between diabetes and grayscale fractal dimensions of retinal vasculature in the Indian population , 2014, BMC Ophthalmology.

[10]  Paul Mitchell,et al.  Retinal fractals and acute lacunar stroke , 2010, Annals of neurology.

[11]  J. Català Mora,et al.  Computer-automated quantification of plus disease in retinopathy of prematurity , 2003 .

[12]  S. Hayreh,et al.  Retinal arteriolar changes in malignant arterial hypertension. , 1989, Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde.

[13]  A. Goldberger.  Non-linear dynamics for clinicians: chaos theory, fractals, and complexity at the bedside , 1996, The Lancet.

[14]  G. Bresnick,et al.  DIABETIC MACULAR EDEMA: A REVIEW , 1986 .

[15]  W. Goebel,et al.  RETINAL THICKNESS IN DIABETIC RETINOPATHY: A Study Using Optical Coherence Tomography (OCT) , 2002, Retina.

[16]  T. Amemiya,et al.  Retinal vascular changes and systemic diseases: corrosion cast demonstration. , 2001, Italian journal of anatomy and embryology = Archivio italiano di anatomia ed embriologia.

[17]  Yin Yuan,et al.  The Relationship of Retinal Vessel Diameters and Fractal Dimensions with Blood Pressure and Cardiovascular Risk Factors , 2014, PloS one.

[18]  Andrew Traill,et al.  Macular thickening in acute anterior uveitis. , 2007, Ophthalmology.

[19]  R. Wevers,et al.  Familial Retinal Arterial Tortuosity Associated With Tortuosity in Nail Bed Capillaries , 2006 .

[20]  Dinesh Kant Kumar,et al.  A novel method for segmentation of Infrared Scanning Laser Ophthalmoscope (IR-SLO) images of retina , 2017, 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC).

[21]  J. Kempen,et al.  Fluorescein angiography versus optical coherence tomography for diagnosis of uveitic macular edema. , 2013, Ophthalmology.

[22]  V. Sundaram,et al.  Intravitreal triamcinolone for the treatment of ischemic macular edema associated with branch retinal vein occlusion. , 2006, American journal of ophthalmology.

[23]  M. Adhi,et al.  Macular Thickness by Age and Gender in Healthy Eyes Using Spectral Domain Optical Coherence Tomography , 2012, PloS one.

[24]  W. Hsu,et al.  Quantitative assessment of retinal thickness in diabetic patients with and without clinically significant macular edema using optical coherence tomography. , 2001, Acta ophthalmologica Scandinavica.

[25]  M. H. Friedman,et al.  Variability of human coronary artery geometry: An angiographic study of the left anterior descending arteries of 30 autopsy hearts , 2006, Annals of Biomedical Engineering.

[26]  Mohd Zulfaezal Che Azemin,et al.  Robust Methodology for Fractal Analysis of the Retinal Vasculature , 2011, IEEE Transactions on Medical Imaging.

[27]  Dinesh Kant Kumar,et al.  Automatic Analysis of Retinal Vascular Parameters for Detection of Diabetes in Indian Patients with No Retinopathy Sign , 2016, International scholarly research notices.

[28]  W. Fung.  Vitrectomy for chronic aphakic cystoid macular edema. Results of a national, collaborative, prospective, randomized investigation. , 1985, Ophthalmology.

[29]  T. Wong,et al.  Microvascular network alterations in the retina of patients with Alzheimer's disease , 2014, Alzheimer's & Dementia.