Biosynthesis of tailored poly-γ-glutamic acid: Recent achievements, diverse applications and future perspectives

[1]  M. Dharne,et al.  Poly-gamma-glutamic acid biopolymer: a sleeping giant with diverse applications and unique opportunities for commercialization , 2021, Biomass conversion and biorefinery.

[2]  Zhiying Yan,et al.  Production of poly-γ-glutamic acid (γ-PGA) from xylose-glucose mixtures by Bacillus amyloliquefaciens C1 , 2021, 3 Biotech.

[3]  Sha Li,et al.  CRISPRi-based dynamic regulation of hydrolase for synthesis of poly-γ-glutamic acid with variable molecular weights. , 2020, ACS synthetic biology.

[4]  Nikhil U. Nair,et al.  Characterization of a membrane enzymatic complex for heterologous production of poly-γ-glutamate in E. coli , 2020, bioRxiv.

[5]  Qin Wang,et al.  Engineering Expression Cassette of pgdS for Efficient Production of Poly-γ-Glutamic Acids With Specific Molecular Weights in Bacillus licheniformis , 2020, Frontiers in Bioengineering and Biotechnology.

[6]  Sha Li,et al.  Development of a Robust Bacillus amyloliquefaciens Cell Factory for Efficient Poly(γ-glutamic acid) Production from Jerusalem Artichoke , 2020 .

[7]  Sungbeom Lee,et al.  High-level production of poly-γ-glutamic acid from untreated molasses by Bacillus siamensis IR10 , 2020, Microbial Cell Factories.

[8]  Sha Li,et al.  Efficient biosynthesis of low-molecular-weight poly-γ-glutamic acid based on stereochemistry regulation in Bacillus amyloliquefaciens. , 2020, ACS synthetic biology.

[9]  W. Lv,et al.  Effects of application rates of poly-γ-glutamic acid on vegetable growth and soil bacterial community structure , 2020 .

[10]  A. D. Semwal,et al.  Optimized production of poly (γ‐glutamic acid) (γ‐PGA) using Bacillus licheniformis and its application as cryoprotectant for probiotics , 2019, Biotechnology and applied biochemistry.

[11]  Huihui Dong,et al.  Biosynthesis of poly‐γ‐glutamic acid in Escherichia coli by heterologous expression of pgsBCAE operon from Bacillus , 2019, Journal of applied microbiology.

[12]  M. Koffas,et al.  Engineering Corynebacterium glutamicum for the de novo biosynthesis of tailored poly-γ-glutamic acid. , 2019, Metabolic engineering.

[13]  D. Charalampopoulos,et al.  Poly-(γ-glutamic acid) Production and Optimization from Agro-Industrial Bioresources as Renewable Substrates by Bacillus sp. FBL-2 through Response Surface Methodology , 2019, Biomolecules.

[14]  M. Azuma,et al.  Knockout of pgdS and ggt gene changes poly-γ-glutamic acid production in Bacillus licheniformis RK14-46. , 2019, Journal of biotechnology.

[15]  E. Fukusaki,et al.  Tailor-made poly-γ-glutamic acid production. , 2019, Metabolic engineering.

[16]  Young-Min Kim,et al.  Optimized Production of Poly(γ-glutamic acid) By Bacillus sp. FBL-2 Through Response Surface Methodology Using Central Composite Design. , 2019, Journal of microbiology and biotechnology.

[17]  Y. Sakakibara,et al.  Poly-γ-glutamic acid production of Bacillus subtilis (natto) in the absence of DegQ: A gain-of-function mutation in yabJ gene. , 2019, Journal of bioscience and bioengineering.

[18]  Chao Yang,et al.  Metabolic engineering of Bacillus amyloliquefaciens LL3 for enhanced poly‐γ‐glutamic acid synthesis , 2019, Microbial biotechnology.

[19]  Sha Li,et al.  Efficient Biosynthesis of Low-Molecular-Weight Poly-γ-glutamic Acid by Stable Overexpression of PgdS Hydrolase in Bacillus amyloliquefaciens NB. , 2018, Journal of agricultural and food chemistry.

[20]  Z. Wen,et al.  Rewiring glycerol metabolism for enhanced production of poly-γ-glutamic acid in Bacillus licheniformis , 2018, Biotechnology for Biofuels.

[21]  M. L. Focarete,et al.  Poly-Gamma-Glutamic Acid (γ-PGA)-Based Encapsulation of Adenovirus to Evade Neutralizing Antibodies , 2018, Molecules.

[22]  Y. Chisti,et al.  Genetic and metabolic engineering for microbial production of poly-γ-glutamic acid. , 2018, Biotechnology advances.

[23]  Christoph Wittmann,et al.  Metabolically engineered Corynebacterium glutamicum for bio-based production of chemicals, fuels, materials, and healthcare products. , 2018, Metabolic engineering.

[24]  Kai-Yao Huang,et al.  Poly-γ-glutamic Acid Synthesis, Gene Regulation, Phylogenetic Relationships, and Role in Fermentation , 2017, International journal of molecular sciences.

[25]  A. Eldar,et al.  Self-sensing in Bacillus subtilis quorum-sensing systems , 2017, Nature Microbiology.

[26]  Qingshan Shi,et al.  Improved production of poly-γ-glutamic acid with low molecular weight under high ferric ion concentration stress in Bacillus licheniformis ATCC 9945a , 2017 .

[27]  M. Azuma,et al.  Flocculation of Real Sewage Sludge Using Poly-γ-glutamic Acid Produced by Bacillus sp. Isolated from Soil , 2017 .

[28]  Youqing Shen,et al.  Poly-γ-glutamic acid-based GGT-targeting and surface camouflage strategy for improving cervical cancer gene therapy. , 2017, Journal of materials chemistry. B.

[29]  Qingbiao Li,et al.  Effect of glucose on poly-γ-glutamic acid metabolism in Bacillus licheniformis , 2017, Microbial Cell Factories.

[30]  Yang Ge,et al.  Regulation of stereochemical composition of poly-γ-glutamic acids produced by Bacillus licheniformis within various Mn 2 + concentration , 2017 .

[31]  Hong Xu,et al.  Improvement of poly-γ-glutamic acid biosynthesis in a moving bed biofilm reactor by Bacillus subtilis NX-2. , 2016, Bioresource technology.

[32]  Mouming Zhao,et al.  Microbial synthesis of poly-γ-glutamic acid: current progress, challenges, and future perspectives , 2016, Biotechnology for Biofuels.

[33]  Chao Yang,et al.  Improved poly-γ-glutamic acid production in Bacillus amyloliquefaciens by modular pathway engineering. , 2015, Metabolic engineering.

[34]  Y. Chisti,et al.  Production of poly-γ-glutamic acid by glutamic acid-independent Bacillus licheniformis TISTR 1010 using different feeding strategies , 2015 .

[35]  Shouwen Chen,et al.  Enhanced expression of pgdS gene for high production of poly-γ-glutamic aicd with lower molecular weight in Bacillus licheniformis WX-02 , 2014 .

[36]  Chao Yang,et al.  Functions of poly-gamma-glutamic acid (γ-PGA) degradation genes in γ-PGA synthesis and cell morphology maintenance , 2014, Applied Microbiology and Biotechnology.

[37]  W. Zeng,et al.  Metabolic studies of temperature control strategy on poly(γ-glutamic acid) production in a thermophilic strain Bacillus subtilis GXA-28. , 2014, Bioresource technology.

[38]  Ping Zheng,et al.  Engineering of recombinant Escherichia coli cells co-expressing poly-γ-glutamic acid (γ-PGA) synthetase and glutamate racemase for differential yielding of γ-PGA , 2013, Microbial biotechnology.

[39]  M. Ashiuchi Microbial production and chemical transformation of poly-γ-glutamate , 2013, Microbial biotechnology.

[40]  Lin Xu,et al.  Production of Ultra-high Molecular Weight Poly-γ-Glutamic Acid with Bacillus licheniformis P-104 and Characterization of its Flocculation Properties , 2013, Applied Biochemistry and Biotechnology.

[41]  P. Ouyang,et al.  Improvement of poly(γ-glutamic acid) biosynthesis and quantitative metabolic flux analysis of a two-stage strategy for agitation speed control in the culture of Bacillus subtilis NX-2 , 2011 .

[42]  M. Ashiuchi Analytical approaches to poly-γ-glutamate: quantification, molecular size determination, and stereochemistry investigation. , 2011, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[43]  Jun Liu,et al.  Expression of glr gene encoding glutamate racemase in Bacillus licheniformis WX-02 and its regulatory effects on synthesis of poly-γ-glutamic acid , 2011, Biotechnology Letters.

[44]  R. Singhal,et al.  Poly (glutamic acid)--an emerging biopolymer of commercial interest. , 2011, Bioresource technology.

[45]  Shufang Wang,et al.  Glutamic acid independent production of poly-γ-glutamic acid by Bacillus amyloliquefaciens LL3 and cloning of pgsBCA genes. , 2011, Bioresource technology.

[46]  Peiyong Qin,et al.  Effects of CaCl2 on viscosity of culture broth, and on activities of enzymes around the 2-oxoglutarate branch, in Bacillus subtilis CGMCC 2108 producing poly-(γ-glutamic acid). , 2011, Bioresource technology.

[47]  Qunhui Wang,et al.  Biosynthesis of Polyglutamic Acid and its Application on Agriculture , 2011 .

[48]  M. Ashiuchi,et al.  Bacillus subtilis pgsE (Formerly ywtC) stimulates poly-γ-glutamate production in the presence of zinc. , 2011, Biotechnology and bioengineering.

[49]  Shufang Wang,et al.  Synthesis of poly (γ-glutamic acid) and heterologous expression of pgsBCA genes , 2010 .

[50]  B. Rehm Bacterial polymers: biosynthesis, modifications and applications , 2010, Nature Reviews Microbiology.

[51]  Xueping Guo,et al.  Improved poly-gamma-glutamic acid production by chromosomal integration of the Vitreoscilla hemoglobin gene (vgb) in Bacillus subtilis. , 2010, Bioresource technology.

[52]  Qun Wu,et al.  Contribution of Glycerol on Production of Poly(γ-Glutamic Acid) in Bacillus subtilis NX-2 , 2010, Applied biochemistry and biotechnology.

[53]  G. Amati,et al.  SwrAA activates poly-gamma-glutamate synthesis in addition to swarming in Bacillus subtilis. , 2009, Microbiology.

[54]  P. Ouyang,et al.  Investigation on enzymatic degradation of γ-polyglutamic acid from Bacillus subtilis NX-2 , 2009 .

[55]  M. Ashiuchi,et al.  Genetic design of conditional D-glutamate auxotrophy for Bacillus subtilis: use of a vector-borne poly-gamma-glutamate synthetic system. , 2007, Biochemical and biophysical research communications.

[56]  Tae Woo Kim,et al.  Oral Administration of High Molecular Mass Poly-γ-Glutamate Induces NK Cell-Mediated Antitumor Immunity1 , 2007, The Journal of Immunology.

[57]  P. Bonomi Paclitaxel poliglumex (PPX, CT-2103): macromolecular medicine for advanced non-small-cell lung cancer , 2007, Expert review of anticancer therapy.

[58]  Joerg M. Buescher,et al.  Microbial Biosynthesis of Polyglutamic Acid Biopolymer and Applications in the Biopharmaceutical, Biomedical and Food Industries , 2007, Critical reviews in biotechnology.

[59]  Longan Shang,et al.  Optimal Production of Poly-γ-glutamic Acid by Metabolically Engineered Escherichia coli , 2006, Biotechnology Letters.

[60]  A. Fouet,et al.  Poly‐gamma‐glutamate in bacteria , 2006, Molecular microbiology.

[61]  M. Mock,et al.  CapE, a 47-Amino-Acid Peptide, Is Necessary for Bacillus anthracis Polyglutamate Capsule Synthesis , 2005, Journal of bacteriology.

[62]  Y. Wee,et al.  Influences of cultural medium component on the production of poly(γ-glutamic acid) byBacillus sp. RKY3 , 2005 .

[63]  A. Fouet,et al.  Bacillus anthracis CapD, belonging to the γ‐glutamyltranspeptidase family, is required for the covalent anchoring of capsule to peptidoglycan , 2005, Molecular microbiology.

[64]  M. Sung,et al.  Natural and edible biopolymer poly‐γ‐glutamic acid: synthesis, production, and applications , 2005 .

[65]  F. Kawamura,et al.  Glr, a glutamate racemase, supplies d‐glutamate to both peptidoglycan synthesis and poly‐γ‐glutamate production in γ‐PGA‐producing Bacillus subtilis , 2004 .

[66]  M. Sung,et al.  Enzymatic Synthesis of High-Molecular-Mass Poly-γ-Glutamate and Regulation of Its Stereochemistry , 2004, Applied and Environmental Microbiology.

[67]  M. Kunioka,et al.  Biosynthesis of poly (γ-glutamic acid) from l-glutamine, citric acid and ammonium sulfate in Bacillus subtilis IFO3335 , 1994, Applied Microbiology and Biotechnology.

[68]  P. Dubruel,et al.  Poly-l-glutamic acid derivatives as multifunctional vectors for gene delivery. Part A. Synthesis and physicochemical evaluation. , 2003, Biomacromolecules.

[69]  H. Misono,et al.  Biochemistry and molecular genetics of poly-γ-glutamate synthesis , 2002, Applied Microbiology and Biotechnology.

[70]  M. Sung,et al.  Isolation of Bacillus subtilis (chungkookjang), a poly-γ-glutamate producer with high genetic competence , 2001, Applied Microbiology and Biotechnology.

[71]  I. Shih,et al.  The production of poly-(γ-glutamic acid) from microorganisms and its various applications , 2001 .

[72]  S. Muñoz-Guerra,et al.  Biosynthesis and ultrasonic degradation of bacterial poly(γ-glutamic acid) , 1999 .

[73]  K. Soda,et al.  Properties of Glutamate Racemase from Bacillus subtilis IFO 3336 Producing Poly-γ-Glutamate , 1998 .

[74]  Y. Ogawa,et al.  Efficient Production of γ-Polyglutamic Acid by Bacillus subtilis (natto) in Jar Fermenters. , 1997, Bioscience, biotechnology, and biochemistry.

[75]  M. Kunioka,et al.  Biosynthesis and chemical reactions of poly(amino acid)s from microorganisms , 1997, Applied Microbiology and Biotechnology.

[76]  S. Makino,et al.  Molecular characterization and protein analysis of the cap region, which is essential for encapsulation in Bacillus anthracis , 1989, Journal of bacteriology.

[77]  C. B. Thorne,et al.  PRODUCTION OF GLUTAMYL POLYPEPTIDE BY BACILLUS SUBTILIS , 1954, Journal of bacteriology.