Penicillium marneffei infection in a non‐HIV infected child

We report a case of Penicillium marneffei infection in a previously healthy 3.5 years‐old Chinese boy and review the literature. The details of the case are described with emphasis on his immune function and treatment outcome. This boy had transient immunodeficiency involving phagocytic and NK cells due to P. marneffei infection which resolved after treatment with gamma interferon and amphotericin B. A prolonged course of fluconazole of 1 year was successful in preventing relapse. Gamma interferon, amphotericin B and a prolonged course of fluconazole may be useful in the treatment of life‐threatening infection by P. marneffei.

[1]  M. Tsukano,et al.  Successful induction of severe destructive arthritis by the transfer of in vitro‐activated synovial fluid T cells from patients with rheumatoid arthritis (RA) in severe combined immunodeficient (SCID) mice , 1996, Clinical and experimental immunology.

[2]  K. Yuen,et al.  Serodiagnosis of Penicillium marneffei infection , 1994, The Lancet.

[3]  K. Nelson,et al.  Disseminated Penicillium marneffei infection in Southeast Asia , 1994, The Lancet.

[4]  T. Sirisanthana,et al.  Disseminated Penicillium marneffei infection diagnosed on examination of a peripheral blood smear of a patient with human immunodeficiency virus infection. , 1994, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[5]  T. Sirisanthana,et al.  Penicillium marneffei infection in children infected with human immunodeficiency virus , 1993, The Pediatric infectious disease journal.

[6]  K. Nelson,et al.  Response to antifungal therapy by human immunodeficiency virus-infected patients with disseminated Penicillium marneffei infections and in vitro susceptibilities of isolates from clinical specimens , 1993, Antimicrobial Agents and Chemotherapy.

[7]  C. Katlama,et al.  Disseminated Penicillium marneffei infection associated with human immunodeficiency virus: a report of two cases and a review of 35 published cases. , 1993, Journal of acquired immune deficiency syndromes.

[8]  T. Sirisanthana,et al.  An efficacy study of itraconazole in the treatment of Penicillium marneffei infection. , 1992, Journal of the Medical Association of Thailand = Chotmaihet thangphaet.

[9]  P. Jones,et al.  Penicillium marneffei infection in patients infected with human immunodeficiency virus: late presentation in an area of nonendemicity. , 1992, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[10]  K. Nelson,et al.  Penicillium marneffei infection in patients infected with human immunodeficiency virus. , 1992, Current topics in medical mycology.

[11]  K. Ma,et al.  Penicillium marneffei: indicator disease for AIDS in South East Asia. , 1992, AIDS.

[12]  D. Tsang,et al.  Fine needle aspiration diagnosis of Penicillium marneffei infection. , 1991, Acta cytologica.

[13]  L. Low,et al.  Defective neutrophil and lymphocyte function in leucocyte adhesion deficiency , 1991, Clinical and experimental immunology.

[14]  E. Yeoh,et al.  Penicillium marneffei: another pathogen to consider in patients infected with human immunodeficiency virus. , 1991, Reviews of Infectious Diseases.

[15]  N. Vanittanakom,et al.  Cutaneous manifestations of disseminated Penicillum marneffei mycosis in five HIV‐infected patients * , 1991, Mycoses.

[16]  Li Js,et al.  Disseminated penicilliosis marneffei in China. Report of three cases. , 1991 .

[17]  Y. Chan,et al.  Ultrastructural observations on Penicillium marneffei in natural human infection. , 1990, Ultrastructural pathology.

[18]  Y. Chan,et al.  Penicillium marneffei osteomyelitis. , 1990, The Journal of bone and joint surgery. British volume.

[19]  J. Chan,et al.  Penicillium marneffei in bronchoalveolar lavage fluid. , 1989, Acta cytologica.

[20]  Piehl Mr,et al.  Disseminated penicilliosis in a patient with acquired immunodeficiency syndrome , 1988 .

[21]  J. Chan,et al.  Penicillium marneffei infection: an underdiagnosed disease? , 1988, Histopathology.

[22]  D. W. Gibson,et al.  Infections caused by Penicillium marneffei in China and Southeast Asia: review of eighteen published cases and report of four more Chinese cases. , 1988, Reviews of infectious diseases.

[23]  C. K. Campbell,et al.  Systemic mycosis due to Penicillium marneffei in a patient with antibody to human immunodeficiency virus. , 1988, The Journal of infection.

[24]  W. Seto,et al.  Chronic lymphadenopathy caused by penicillium marneffei: A condition mimicking tuberculous lymphadenopathy , 1986, The British journal of surgery.

[25]  D. Connor,et al.  Progressive disseminated penicilliosis caused by Penicillium marneffei. Report of eight cases and differentiation of the causative organism from Histoplasma capsulatum. , 1985, American journal of clinical pathology.

[26]  W. Lam,et al.  A case of invasive penicilliosis in Hong Kong with immunologic evaluation. , 1985, The American review of respiratory disease.

[27]  L. Ajello,et al.  Imported penicilliosis marneffei in the United States: report of a second human infection. , 1984, Sabouraudia.

[28]  L. Ajello,et al.  Penicilliosis marneffei in Thailand: report of five human cases. , 1984, The American journal of tropical medicine and hygiene.

[29]  L. Ajello,et al.  Infection caused by Penicillium marneffei: description of first natural infection in man. , 1973, American journal of clinical pathology.

[30]  P. Sureau,et al.  [Penicillosis from Rhizomys sinensis]. , 1956, Bulletin de la Societe de pathologie exotique et de ses filiales.

[31]  I Hannet,et al.  Developmental and maturational changes in human blood lymphocyte subpopulations. , 1992, Immunology today.

[32]  L. Shan,et al.  Disseminated penicilliosis marneffei in China. Report of three cases. , 1991, Chinese medical journal.

[33]  R. L. Kaplan,et al.  Disseminated penicilliosis in a patient with acquired immunodeficiency syndrome. , 1988, Archives of Pathology & Laboratory Medicine.

[34]  K. Pautler.  Imported penicillosis marneffei in the United States : report of a second human infection. Sabouradia , 1984 .

[35]  M. Capponi,et al.  Pénicillose de Rhizomys sinensis. , 1956 .