Lower extremity foot ulcers and amputations in diabetes

Lower extremity ulcers and amputations are an increasing problem among individuals with diabetes. Data from the 1983-90 National Hospital Discharge Surveys (NHDS) indicate that 6% of hospitalizations listing diabetes on the discharge record also listed a lower extremity ulcer condition. Chronic ulcers were present in 2.7% of all hospitalizations that listed diabetes. The average length of stay (LOS) for diabetes discharges with ulcer conditions was 59% longer than for diabetes discharges without them. Clinical epidemiologic studies suggest that foot ulcers precede ~85% of nontraumatic lower extremity amputations (LEAs) in individuals with diabetes.

[1]  Pecoraro Re The nonhealing diabetic ulcer--a major cause for limb loss. , 1991 .

[2]  L T Cotton,et al.  Improved survival of the diabetic foot: the role of a specialized foot clinic. , 1986, The Quarterly journal of medicine.

[3]  J. Runyan The Memphis Chronic Disease Program Comparisons in Outcome and the Nurse's Extended Role , 1976, JAMA.

[4]  R. Baddeley,et al.  A trial of conservative amputations for lesions of the feet in diabetes mellitus , 1965, The American surgeon.

[5]  M. Spraul,et al.  How Effective is Cushioned Therapeutic Footwear in Protecting Diabetic Feet? A Clinical Study , 1990, Diabetic medicine : a journal of the British Diabetic Association.

[6]  S. Rith-Najarian,et al.  Identifying Diabetic Patients at High Risk for Lower-Extremity Amputation in a Primary Health Care Setting: A prospective evaluation of simple screening criteria , 1992, Diabetes Care.

[7]  S. Ogston,et al.  Lower limb amputee survival , 1992, Prosthetics and orthotics international.

[8]  F. Lithner,et al.  The Epidemiology of Foot Lesions in Diabetic Patients Aged 15–50 Years , 1990, Diabetic medicine : a journal of the British Diabetic Association.

[9]  I. Ruszkowski [Amputation of the lower extremity in children]. , 1954, Acta chirurgica Iugoslavica.

[10]  J. Hayes,et al.  Autonomic Function in Neuropathic Diabetic Patients With Foot Ulceration , 1993, Diabetes Care.

[11]  R. Klein Hyperglycemie and Microvascular and Macrovascular Disease in Diabetes , 1995, Diabetes Care.

[12]  U. Rosenqvist An epidemiological survey of diabetic foot problems in the Stockholm County 1982. , 2009, Acta medica Scandinavica. Supplementum.

[13]  F. Logerfo,et al.  Improved quality of diabetic foot care, 1984 vs 1990. Reduced length of stay and costs, insufficient reimbursement. , 1993, Archives of surgery.

[14]  G. Reiber,et al.  Pathways to Diabetic Limb Amputation: Basis for Prevention , 1990, Diabetes Care.

[15]  A. Fronek,et al.  The role of non-invasive vascular studies in determining levels of amputation. , 1988, The Journal of bone and joint surgery. American volume.

[16]  Jennifer S. Lee,et al.  Lower-Extremity Amputation: Incidence, Risk Factors, and Mortality in the Oklahoma Indian Diabetes Study , 1993, Diabetes.

[17]  W. Abbott,et al.  Utility of transcutaneous oxygen tension measurements in peripheral arterial occlusive disease. , 1984, Journal of vascular surgery.

[18]  D G Smith,et al.  The Independent Contributions of Diabetic Neuropathy and Yasculopatny in Foot Ulceration: How great are the risks? , 1995, Diabetes Care.

[19]  T. Koepsell,et al.  How Does Provider and Patient Awareness of High-Risk Status for Lower-Extremity Amputation Influence Foot-Care Practice? , 1994, Diabetes Care.

[20]  D. Shopland,et al.  Toward the 1990 objectives for smoking: measuring the progress with 1985 NHIS data. , 1987, Public health reports.

[21]  P Sinnock,et al.  The Epidemiology of Lower Extremity Amputations in Diabetic Individuals , 1983, Diabetes Care.

[22]  C. Agardh,et al.  Wound Classification is More Important Than Site of Ulceration in the Outcome of Diabetic Foot Ulcers , 1989, Diabetic medicine : a journal of the British Diabetic Association.

[23]  S. Genuth,et al.  The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. , 1993, The New England journal of medicine.

[24]  P. McNamara,et al.  Morbidity and Mortality in Diabetics In the Framingham Population: Sixteen Year Follow-up Study , 1974, Diabetes.

[25]  T. Koepsell,et al.  Risk Factors for Amputation in Patients with Diabetes Mellitus , 1992, Annals of Internal Medicine.

[26]  R. Crowther,et al.  Clinical and Etiologic Heterogeneity of Idiopathic Diabetes Mellitus , 1978, Diabetes.

[27]  E. Miller,et al.  Diabetes-related lower extremity amputations in New Jersey, 1979 to 1981. , 1985, The Journal of the Medical Society of New Jersey.

[28]  D. Bild,et al.  Reduction of Lower Extremity Clinical Abnormalities in Patients with Non-Insulin-Dependent Diabetes Mellitus , 1993, Annals of Internal Medicine.

[29]  Reiber Ge Who is at risk of limb loss and what to do about it , 1994 .

[30]  L. Delbridge,et al.  Factors associated with development of foot lesions in the diabetic. , 1983, Surgery.

[31]  B. Howard,et al.  Diabetes and atherosclerosis in the Pima Indians. , 1982, The Mount Sinai journal of medicine, New York.

[32]  J. Assal,et al.  Additional Factors Associated with Plantar Ulcers in Diabetic Neuropathy , 1988, Diabetic medicine : a journal of the British Diabetic Association.

[33]  K. M. West Epidemiology of diabetes and its vascular lesions , 1978 .

[34]  G A Colditz,et al.  The economic costs of non-insulin-dependent diabetes mellitus. , 1989, JAMA.

[35]  K. S. Christensen,et al.  Results of amputation for gangrene in diabetic and non-diabetic patients. Selection of amputation level using photoelectric measurements of skin-perfusion pressure. , 1988, The Journal of bone and joint surgery. American volume.

[36]  B. Ebskov,et al.  Incidence of reamputation and death after gangrene of the lower extremity , 1980, Prosthetics and orthotics international.

[37]  R. Busuttil,et al.  Cost of treating advanced leg ischemia. Bypass graft vs primary amputation. , 1988, Archives of surgery.

[38]  D. Bild,et al.  Comparison of Quantitative Sensory-Threshold Measures for Their Association With Foot Ulceration in Diabetic Patients , 1990, Diabetes Care.

[39]  R. Finch,et al.  A Clinico‐pathological Study of Diabetic Foot Ulcers , 1987, Diabetic medicine : a journal of the British Diabetic Association.

[40]  M. Block,et al.  The Later Life of the Diabetic Amputee: Another Look at Fate of the Second Leg , 1968, Diabetes.

[41]  M. Ecker,et al.  Lower Extremity Amputation in Diabetic Patients , 1970, Diabetes.

[42]  W. Kannel,et al.  Predisposition to atherosclerosis in the head, heart, and legs. The Framingham study. , 1972, JAMA.

[43]  M. Mars Transcutaneous oxygen tension as a predictor of success after an amputation. , 1988, The Journal of bone and joint surgery. American volume.

[44]  G. Knatterud,et al.  The Course of Peripheral Vascular Disease in Non-insulin-dependent Diabetes , 1985, Diabetes Care.

[45]  R. Heidel,et al.  Healthy People 2000: national health promotion and disease prevention objectives (excerpts). US Public Health Service. , 1991, Journal of allied health.

[46]  R. E. Pecoraro,et al.  The nonhealing diabetic ulcer--a major cause for limb loss. , 1991, Progress in clinical and biological research.

[47]  G. Beebe,et al.  The “Geriatric” Amputee , 1972, Annals of surgery.

[48]  S. Silbert Amputation of the Lower Extremity in Diabetes Mellitus: A Follow-Up Study of 294 Cases , 1952, Diabetes.

[49]  T. O'donnell,et al.  The costs of surgery for limb-threatening ischemia. , 1986, Surgery.

[50]  J. Runyan The Memphis chronic disease program. Comparisons in outcome and the nurse's extended role. , 1975 .

[51]  L. Ebskov Level of lower limb amputation in relation to etiology: An epidemiological study , 1992, Prosthetics and orthotics international.

[52]  R. Klein,et al.  The prevalence and incidence of lower extremity amputation in a diabetic population. , 1992, Archives of internal medicine.

[53]  J. Wooldridge,et al.  Evaluation of the Costs to Medicare of Covering Therapeutic Shoes for Diabetic Patients , 1994, Diabetes Care.

[54]  P. Home,et al.  A Survey of Lower Limb Amputation in Diabetic Patients , 1992, Diabetic medicine : a journal of the British Diabetic Association.

[55]  B. Persson,et al.  Amputation for occlusive arterial disease. A prospective multicentre study of 177 amputees. , 1992, International orthopaedics.

[56]  M. Mullee,et al.  The Distribution and Severity of Diabetic Foot Disease: a Community Study with Comparison to a Non‐diabetic Group , 1992, Diabetic medicine : a journal of the British Diabetic Association.

[57]  W. Knowler,et al.  Lower-Extremity Amputations in NIDDM: 12-Yr Follow-Up Study in Pima Indians , 1988, Diabetes Care.

[58]  A. Ramani,et al.  Aetiology of diabetic foot ulceration. , 1990, The Journal of the Association of Physicians of India.

[59]  W. Kannel,et al.  Diabetes and cardiovascular disease. The Framingham study. , 1979, JAMA.

[60]  I. Faris,et al.  Vascular disease and vascular function in the lower limb in diabetes. , 1984, Diabetes research.

[61]  M. Laakso,et al.  Lipid and lipoprotein abnormalities in diabetic patients with peripheral vascular disease. , 1988, Atherosclerosis.

[62]  R. Young,et al.  The Prevalence of Foot Ulceration and its Correlates in Type 2 Diabetic Patients: a Population‐based Study , 1994, Diabetic medicine : a journal of the British Diabetic Association.