Fabrication of low-cost electronic biosensors

The fabrication of miniaturized, low-cost, flexible sensors based on organic electronics via high-throughput techniques (e.g. printing) is expected to provide important benefits for applications in chemical and biological detection. The rapid maturation of synthetic methodology in the field of organic electronics has lead to the creation of new materials at an incredible rate and an increased understanding of semiconductor-analyte interactions. Owing to these advances, we have seen steady improvements in sensitivity, stability, and specificity, in addition to the detection of a wide range of chemical analytes. In this review, we address the fabrication, challenges, and sensor performance of organic transistor-based detection devices with an outlook toward developing sensors capable of operating in biologically relevant media.

[1]  Zhenan Bao,et al.  Organic Field-Effect Transistors , 2007 .

[2]  J. Jacobson,et al.  An electrophoretic ink for all-printed reflective electronic displays , 1998, Nature.

[3]  Michael L. Turner,et al.  A Nitrogen Dioxide Sensor Based on an Organic Transistor Constructed from Amorphous Semiconducting Polymers , 2007 .

[4]  H. Sirringhaus,et al.  High-Resolution Ink-Jet Printing of All-Polymer Transistor Circuits , 2000, Science.

[5]  Michael A. Haase,et al.  Pentacene-based radio-frequency identification circuitry , 2003 .

[6]  K. Stevenson,et al.  High‐Resolution Characterization of Pentacene/Polyaniline Interfaces in Thin‐Film Transistors , 2006 .

[7]  Yang Yang,et al.  High-efficiency solution processable polymer photovoltaic cells by self-organization of polymer blends , 2005 .

[8]  Stephen R. Forrest,et al.  Efficient bulk heterojunction photovoltaic cells using small-molecular-weight organic thin films , 2003, Nature.

[9]  D. M. Leeuw,et al.  Optimization of the charge transport in poly(phenylene vinylene) derivatives by processing and chemical modification , 2005 .

[10]  Mats Andersson,et al.  Laminated fabrication of polymeric photovoltaic diodes , 1998, Nature.

[11]  Henrique L. Gomes,et al.  Effect of oxygen on the electrical characteristics of field effect transistors formed from electrochemically deposited films of poly(3-methylthiophene) , 1991 .

[12]  Ute Zschieschang,et al.  Low-voltage organic transistors with an amorphous molecular gate dielectric , 2004, Nature.

[13]  V. R. Raju,et al.  Paper-like electronic displays: Large-area rubber-stamped plastic sheets of electronics and microencapsulated electrophoretic inks , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[14]  Takao Someya,et al.  Vapor sensing with α,ω-dihexylquarterthiophene field-effect transistors: The role of grain boundaries , 2002 .

[15]  Ping Liu,et al.  High-performance semiconducting polythiophenes for organic thin-film transistors. , 2004, Journal of the American Chemical Society.

[16]  R. N. Marks,et al.  Light-emitting diodes based on conjugated polymers , 1990, Nature.

[17]  J. Fréchet,et al.  Organic semiconducting oligomers for use in thin film transistors. , 2007, Chemical reviews.

[18]  Zhenan Bao,et al.  High-performance plastic transistors fabricated by printing techniques , 1997 .

[19]  Nicole Jaffrezic-Renault,et al.  Influence of ambient atmosphere on the electrical properties of organic thin film transistors , 2006 .

[20]  Jean-Luc Brédas,et al.  Introduction to Organic Thin Film Transistors and Design of n-Channel Organic Semiconductors , 2004 .

[21]  C. Frisbie,et al.  Field Effect Conductance Measurements on Thin Crystals of Sexithiophene , 1999 .

[22]  W. R. Salaneck,et al.  Electroluminescence in conjugated polymers , 1999, Nature.

[23]  Joseph Miragliotta,et al.  Hydroxy-terminated organic semiconductor-based field-effect transistors for phosphonate vapor detection. , 2007, Journal of the American Chemical Society.

[24]  Nicola Cioffi,et al.  Alkoxy-substituted polyterthiophene thin-film-transistors as alcohol sensors , 2004 .

[25]  D. Noort,et al.  Biomonitoring of exposure to chemical warfare agents: a review. , 2002, Toxicology and applied pharmacology.

[26]  D. Janes,et al.  Device considerations for development of conductance-based biosensors. , 2009, Journal of applied physics.

[27]  C. Tang,et al.  Organic Electroluminescent Diodes , 1987 .

[28]  R. Stoltenberg,et al.  Ambipolar, high performance, acene-based organic thin film transistors. , 2008, Journal of the American Chemical Society.

[29]  Richard H. Friend,et al.  High-stability ultrathin spin-on benzocyclobutene gate dielectric for polymer field-effect transistors , 2004 .

[30]  Zhenan Bao,et al.  Water-stable organic transistors and their application in chemical and biological sensors , 2008, Proceedings of the National Academy of Sciences.

[31]  Raoul Schroeder,et al.  One Volt Organic Transistor , 2005 .

[32]  S. Barman,et al.  Self-Sorted, Aligned Nanotube Networks for Thin-Film Transistors , 2008, Science.

[33]  Eugenio Cantatore,et al.  Bias stress in organic thin-film transistors and logic gates , 2001 .

[34]  Ananth Dodabalapur,et al.  Radio frequency rectifiers based on organic thin-film transistors , 2006 .

[35]  Vivek Subramanian,et al.  Organic TFTs as gas sensors for electronic nose applications , 2005 .

[36]  Feng Yan,et al.  Label-free DNA sensor based on organic thin film transistors. , 2009, Biosensors & bioelectronics.

[37]  L. Torsi,et al.  Interface and gate bias dependence responses of sensing organic thin-film transistors. , 2005, Biosensors & bioelectronics.

[38]  Kris Myny,et al.  50 MHz rectifier based on an organic diode , 2005, Nature materials.

[39]  Gilles Horowitz,et al.  Organic thin film transistors: From theory to real devices , 2004 .

[40]  Zhenan Bao,et al.  Electronic sensing of vapors with organic transistors , 2001 .

[41]  Kevin C. See,et al.  Enhanced Response of n‐Channel Naphthalenetetracarboxylic Diimide Transistors to Dimethyl Methylphosphonate Using Phenolic Receptors , 2007 .

[42]  V. Subramanian,et al.  DNA hybridization detection with organic thin film transistors: toward fast and disposable DNA microarray chips. , 2007, Biosensors & bioelectronics.

[43]  H. Klauk,et al.  Ultralow-power organic complementary circuits , 2007, Nature.

[44]  A. Gelperin,et al.  Correlation between Oligothiophene Thin Film Transistor Morphology and Vapor Responses , 2002 .

[45]  H. Sirringhaus,et al.  Integrated optoelectronic devices based on conjugated polymers , 1998, Science.

[46]  John E Anthony,et al.  Functionalized acenes and heteroacenes for organic electronics. , 2006, Chemical reviews.

[47]  R. A. McGill,et al.  Micropreconcentrator for Enhanced Trace Detection of Explosives and Chemical Agents , 2006, IEEE Sensors Journal.

[48]  Nicola Cioffi,et al.  Contact effects in organic thin-film transistor sensors , 2009 .

[49]  Zhenan Bao,et al.  Synthesis of polymer dielectric layers for organic thin film transistors via surface-initiated ring-opening metathesis polymerization. , 2004, Journal of the American Chemical Society.

[50]  Kenneth S Johnson,et al.  Chemical sensor networks for the aquatic environment. , 2007, Chemical reviews.

[51]  Tobin J Marks,et al.  Low-voltage organic field-effect transistors and inverters enabled by ultrathin cross-linked polymers as gate dielectrics. , 2005, Journal of the American Chemical Society.

[52]  H. Katz,et al.  Monolayer‐Dimensional 5,5′‐Bis(4‐hexylphenyl)‐2,2′‐bithiophene Transistors and Chemically Responsive Heterostructures , 2008 .

[53]  Tobin J Marks,et al.  Polymer Gate Dielectric Surface Viscoelasticity Modulates Pentacene Transistor Performance , 2007, Science.

[54]  Tobin J. Marks,et al.  σ-π molecular dielectric multilayers for low-voltage organic thin-film transistors , 2005 .

[55]  M Facchini,et al.  DNA adsorption measured with ultra-thin film organic field effect transistors. , 2009, Biosensors & bioelectronics.

[56]  Luisa Torsi,et al.  A sensitivity-enhanced field-effect chiral sensor. , 2008, Nature materials.

[57]  Vivek Subramanian,et al.  Printable polythiophene gas sensor array for low-cost electronic noses , 2006 .

[58]  B. Servet,et al.  Molecular engineering of organic semiconductors: design of self-assembly properties in conjugated thiophene oligomers , 1993 .

[59]  J. Joo,et al.  Electrical characteristics of pentacene-based thin film transistor with conducting poly(3,4-ethylenedioxythiophene) electrodes , 2006 .

[60]  George G. Malliaras,et al.  Simple glucose sensors with micromolar sensitivity based on organic electrochemical transistors , 2007 .

[61]  Luisa Torsi,et al.  Multi-parameter gas sensors based on organic thin-film-transistors , 2000 .

[62]  Zhenan Bao,et al.  Soluble and processable regioregular poly(3‐hexylthiophene) for thin film field‐effect transistor applications with high mobility , 1996 .

[63]  Zhenan Bao,et al.  Flexible, plastic transistor-based chemical sensors , 2009 .

[64]  Deepak Sharma,et al.  Nanoscale organic and polymeric field-effect transistors as chemical sensors , 2005, Analytical and bioanalytical chemistry.

[65]  Thomas N. Jackson,et al.  Pentacene-based organic thin-film transistors , 1997 .

[66]  Rahul Sarpeshkar,et al.  Organic oscillator and adaptive amplifier circuits for chemical vapor sensing , 2002 .

[67]  Zhenan Bao,et al.  Effect of morphology on organic thin film transistor sensors , 2005, Analytical and bioanalytical chemistry.

[68]  Mats Andersson,et al.  University of Groningen Polymer photovoltaic devices from stratified multilayers of donor-acceptor blends , 2022 .

[69]  Abhishek P. Kulkarni,et al.  Electron Transport Materials for Organic Light-Emitting Diodes , 2004 .

[70]  A. Gelperin,et al.  Integration and Response of Organic Electronics with Aqueous Microfluidics , 2002 .

[71]  M. Baldo,et al.  Combinatorial detection of volatile organic compounds using metal-phthalocyanine field effect transistors. , 2007, Analytical chemistry.

[72]  L. Torsi,et al.  Organic Transistors: Two-Dimensional Transport and Improved Electrical Characteristics , 1995, Science.

[73]  Carmen Bartic,et al.  Organic thin-film transistors as transducers for (bio) analytical applications , 2005, Analytical and bioanalytical chemistry.

[74]  George G. Malliaras,et al.  Humidity sensors based on pentacene thin-film transistors , 2002 .

[75]  George G Malliaras,et al.  Chemical and biological sensors based on organic thin-film transistors , 2005, Analytical and bioanalytical chemistry.

[76]  S. Mannsfeld,et al.  Influence of Molecular Structure and Film Properties on the Water-Stability and Sensor Characteristics of Organic Transistors , 2008 .