Cholinergic activation of phasic activity in the isolated bladder: possible evidence for M3‐ and M2‐dependent components of a motor/sensory system

To analyse pressure changes induced by muscarinic agonists on the isolated bladder in order to examine whether there are different responses representing different components of a motor/sensory system within the bladder wall.

[1]  J. de Vente,et al.  Interstitial cells and phasic activity in the isolated mouse bladder , 2006, BJU international.

[2]  K. Andersson,et al.  Antimuscarinic drugs in detrusor overactivity and the overactive bladder syndrome: motor or sensory actions? , 2006, BJU international.

[3]  T. Streng,et al.  Phasic non‐micturition contractions in the bladder of the anaesthetized and awake rat , 2006, BJU international.

[4]  J. Vente,et al.  Sensory collaterals, intramural ganglia and motor nerves in the guinea-pig bladder: evidence for intramural neural circuits , 2006, Cell and Tissue Research.

[5]  J. de Vente,et al.  Interstitial cells and cholinergic signalling in the outer muscle layers of the guinea‐pig bladder , 2006, BJU international.

[6]  N. Oyama,et al.  Effects of tolterodine on an overactive bladder depend on suppression of C-fiber bladder afferent activity in rats. , 2005, The Journal of urology.

[7]  J. Gillespie A developing view of the origins of urgency: the importance of animal models , 2005, BJU international.

[8]  K. McCloskey,et al.  Morphology and localization of interstitial cells in the guinea pig bladder: structural relationships with smooth muscle and neurons. , 2005, The Journal of urology.

[9]  J. Gillespie Inhibitory actions of calcitonin gene‐related peptide and capsaicin: evidence for local axonal reflexes in the bladder wall , 2005, BJU international.

[10]  M. Chancellor,et al.  Antimuscarinic agents exhibit local inhibitory effects on muscarinic receptors in bladder-afferent pathways. , 2005, Urology.

[11]  A. Wein,et al.  Pharmacology of the Lower Urinary Tract: Basis for Current and Future Treatments of Urinary Incontinence , 2004, Pharmacological Reviews.

[12]  J. de Vente,et al.  cGMP‐generating cells in the bladder wall: identification of distinct networks of interstitial cells , 2004, BJU international.

[13]  H. Hashitani,et al.  Role of interstitial cells and gap junctions in the transmission of spontaneous Ca2+ signals in detrusor smooth muscles of the guinea‐pig urinary bladder , 2004, The Journal of physiology.

[14]  A. Arner,et al.  Urinary bladder contraction and relaxation: physiology and pathophysiology. , 2004, Physiological reviews.

[15]  J. Gillespie Phosphodiesterase‐linked inhibition of nonmicturition activity in the isolated bladder , 2004, BJU international.

[16]  R. Chess-Williams Potential therapeutic targets for the treatment of detrusor overactivity , 2004, Expert opinion on therapeutic targets.

[17]  J. Gillespie The autonomous bladder: a view of the origin of bladder overactivity and sensory urge , 2004, BJU international.

[18]  J. Gillespie Noradrenaline inhibits autonomous activity in the isolated guinea pig bladder , 2004, BJU international.

[19]  J. Gillespie,et al.  Modulation of autonomous contractile activity in the isolated whole bladder of the guinea pig , 2004, BJU international.

[20]  M. Drake,et al.  Agonist‐ and Nerve‐Induced Phasic Activity in the Isolated Whole Bladder of the Guinea Pig: Evidence for Two types of Bladder Activity , 2003, Experimental physiology.

[21]  M. Drake,et al.  Autonomous Activity in the Isolated Guinea Pig Bladder , 2003, Experimental physiology.

[22]  K. Andersson,et al.  Antimuscarinics and the overactive detrusor--which is the main mechanism of action? , 2003, European urology.

[23]  K. Andersson Bladder activation: afferent mechanisms. , 2002, Urology.

[24]  Magnus Fall,et al.  The standardisation of terminology in lower urinary tract function: report from the standardisation sub-committee of the International Continence Society. , 2003, Urology.

[25]  A. Gurney,et al.  Kit positive cells in the guinea pig bladder. , 2001, The Journal of urology.

[26]  R. Chess-Williams,et al.  The role of M2 muscarinic receptor subtypes in mediating contraction of the pig bladder base after cyclic adenosine monophosphate elevation and/or selective M3 inactivation. , 2002, The Journal of urology.

[27]  R. Chess-Williams,et al.  Which muscarinic receptor is important in the bladder? , 2001, World Journal of Urology.

[28]  P. Abrams,et al.  How widespread are the symptoms of an overactive bladder and how are they managed? A population‐based prevalence study , 2001, BJU international.

[29]  R. Eglen,et al.  Functional role of M2 and M3 muscarinic receptors in the urinary bladder of rats in vitro and in vivo , 1997, British journal of pharmacology.

[30]  J. Vente,et al.  Distribution of nitric oxide synthase-immunoreactive nerves and identification of the cellular targets of nitric oxide in guinea-pig and human urinary bladder by cGMP immunohistochemistry , 1996, Neuroscience.

[31]  C. Vaughan,et al.  Urine storage mechanisms , 1995, Progress in Neurobiology.

[32]  H. Yamamura,et al.  Cloning of the rat M3, M4 and M5 muscarinic acetylcholine receptor genes by the polymerase chain reaction (PCR) and the pharmacological characterization of the expressed genes. , 1992, Life sciences.

[33]  R. Barlow,et al.  A further search for selective antagonists at M2‐muscarinic receptors , 1986, British journal of pharmacology.

[34]  H. Ladinsky,et al.  Binding profile of a novel cardioselective muscarine receptor antagonist, AF-DX 116, to membranes of peripheral tissues and brain in the rat. , 1986, Life sciences.

[35]  R. Barlow,et al.  The relative potencies of some agonists at M2 muscarinic receptors in guinea‐pig ileum, atria and bronchi , 1985, British journal of pharmacology.

[36]  C. Sherrington Notes on the Arrangement of some Motor Fibres in the Lumbo‐Sacral Plexus , 1892, The Journal of physiology.

[37]  R. Clarke Elements of Human Physiology , 1940, Nature.