Neural correlates of error detection and error correction: is there a common neuroanatomical substrate?

Successful behaviour requires error detection resulting in remedial actions, such as immediate error correction. The present event‐related functional magnetic resonance imaging study in humans examined the neural correlates of error detection and error correction using a speeded modified flankers task. In order to investigate corrective behaviour, participants were randomly divided into two groups. The correction instructed group was asked to correct all encountered errors immediately. The correction not instructed group was unaware that corrective responses were recorded. The intention to correct errors significantly increased the correction rate. Brain activations correlating with error detection were isolated in the rostral cingulate zone and in the pre‐supplementary motor area, supporting their important role in error processing. Error correction activated similar brain regions, suggesting a common neuroanatomical substrate. Additional activations were found in the parietal cortex, representing an interconnected cortical network, which processes somatosensory information of tactile stimuli.

[1]  W. Penfield,et al.  SOMATIC MOTOR AND SENSORY REPRESENTATION IN THE CEREBRAL CORTEX OF MAN AS STUDIED BY ELECTRICAL STIMULATION , 1937 .

[2]  P. M. A. RABBITT,et al.  Error Correction Time without External Error Signals , 1966, Nature.

[3]  P. Rabbitt.  Time to detect errors as a function of factors affecting choice-response time. , 1967, Acta psychologica.

[4]  R W Angel,et al.  Correction of tracking errors without sensory feedback. , 1970, Journal of experimental psychology.

[5]  R. Angel.  Efference copy in the control of movement , 1976, Neurology.

[6]  Virginia A. Diggles,et al.  Rapid error correction during human arm movements: evidence for central monitoring. , 1984, Journal of motor behavior.

[7]  RP Dum,et al.  The origin of corticospinal projections from the premotor areas in the frontal lobe , 1991, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[8]  P. Strick,et al.  Cingulate Motor Areas , 1993 .

[9]  D. Meyer,et al.  A Neural System for Error Detection and Compensation , 1993 .

[10]  J. Tanji.  The supplementary motor area in the cerebral cortex , 1994, Neuroscience Research.

[11]  M. Posner,et al.  Localization of a Neural System for Error Detection and Compensation , 1994 .

[12]  Karl J. Friston,et al.  Statistical parametric maps in functional imaging: A general linear approach , 1994 .

[13]  Karl J. Friston,et al.  Analysis of fMRI Time-Series Revisited—Again , 1995, NeuroImage.

[14]  P. Strick,et al.  Motor areas of the medial wall: a review of their location and functional activation. , 1996, Cerebral cortex.

[15]  M. D’Esposito,et al.  Empirical Analyses of BOLD fMRI Statistics , 1997, NeuroImage.

[16]  M. Botvinick,et al.  Anterior cingulate cortex, error detection, and the online monitoring of performance. , 1998, Science.

[17]  R. Turner,et al.  Event-Related fMRI: Characterizing Differential Responses , 1998, NeuroImage.

[18]  J. Tanji,et al.  Role for cingulate motor area cells in voluntary movement selection based on reward. , 1998, Science.

[19]  Jonathan D. Cohen,et al.  Con ̄ ict monitoring versus selection-for-action in anterior cingulate cortex , 1999 .

[20]  T. Mima,et al.  Brain structures related to active and passive finger movements in man. , 1999, Brain : a journal of neurology.

[21]  R. J. Seitz,et al.  A fronto‐parietal circuit for object manipulation in man: evidence from an fMRI‐study , 1999, The European journal of neuroscience.

[22]  Jonathan D. Cohen,et al.  Conflict monitoring versus selection-for-action in anterior cingulate cortex , 1999, Nature.

[23]  J. Cohen,et al.  Dissociating the role of the dorsolateral prefrontal and anterior cingulate cortex in cognitive control. , 2000, Science.

[24]  K. Kiehl,et al.  Error processing and the rostral anterior cingulate: an event-related fMRI study. , 2000, Psychophysiology.

[25]  W.J.R. Dunseath,et al.  fMRI of the Responses to Vibratory Stimulation of Digit Tips , 2000, NeuroImage.

[26]  S. Petersen,et al.  Characterizing the Hemodynamic Response: Effects of Presentation Rate, Sampling Procedure, and the Possibility of Ordering Brain Activity Based on Relative Timing , 2000, NeuroImage.

[27]  D. V. Cramon,et al.  Subprocesses of Performance Monitoring: A Dissociation of Error Processing and Response Competition Revealed by Event-Related fMRI and ERPs , 2001, NeuroImage.

[28]  P. Strick,et al.  Imaging the premotor areas , 2001, Current Opinion in Neurobiology.

[29]  G Lohmann,et al.  LIPSIA--a new software system for the evaluation of functional magnetic resonance images of the human brain. , 2001, Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society.

[30]  Harold Burton.  Cerebral Cortical Regions Devoted to the Somatosensory System: Results from Brain Imaging Studies in Humans , 2001 .

[31]  A. Turken,et al.  Dissociation between conflict detection and error monitoring in the human anterior cingulate cortex , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[32]  H. Garavan,et al.  Dissociable Executive Functions in the Dynamic Control of Behavior: Inhibition, Error Detection, and Correction , 2002, NeuroImage.

[33]  Thomas F Münte,et al.  Time Course of Error Detection and Correction in Humans: Neurophysiological Evidence , 2002, The Journal of Neuroscience.

[34]  Gabriele Lohmann,et al.  Bayesian second-level analysis of functional magnetic resonance images , 2003, NeuroImage.

[35]  D. V. von Cramon,et al.  Error Monitoring Using External Feedback: Specific Roles of the Habenular Complex, the Reward System, and the Cingulate Motor Area Revealed by Functional Magnetic Resonance Imaging , 2003, The Journal of Neuroscience.

[36]  J. Ford,et al.  Anatomy of an error: ERP and fMRI , 2003, Biological Psychology.

[37]  H Garavan,et al.  A midline dissociation between error-processing and response-conflict monitoring , 2003, NeuroImage.

[38]  Joshua W. Brown,et al.  Performance Monitoring by the Anterior Cingulate Cortex During Saccade Countermanding , 2003, Science.

[39]  Clay B. Holroyd,et al.  Dorsal anterior cingulate cortex shows fMRI response to internal and external error signals , 2004, Nature Neuroscience.

[40]  Jonathan D. Cohen,et al.  The neural basis of error detection: conflict monitoring and the error-related negativity. , 2004, Psychological review.

[41]  D. Yves von Cramon,et al.  Neuroimaging of Performance Monitoring: Error Detection and Beyond , 2004, Cortex.