Glomerulonephritis in Miami, Florida; studies on types 12, 4, and Red Lake Group A beta-hemolytic streptococci isolated over a three-year period (1953-1955).

Evidence has been accumulating that acute hemorrhagic glomerulonephritis may occur as a nonsuppurative complication following infection with some strains of certain types of Group A β-hemolytic streptococci. Types 12 and 4, especially, have been implicated in this way, 1 although it is recognized that not all strains of these types are nephritogenic. 2 Other types 3 also have been found to produce nephritis. A new type was recently isolated in an epidemic at Red Lake, Minn.* Many strains of Types 12, 4, and Red Lake were isolated from the throats of school children during a long-term study of the streptococcal epidermiologic pattern in Miami, Fla.† We therefore tried to evaluate these findings in relation to the incidence of nephritis in this area. MATERIAL AND METHODS From February through May, 1953, from October, 1953, through May, 1954, and from October, 1954, through May, 1955, pairs of throat swabs were taken monthly

[1]  C. Reinstein.  Epidemic nephritis at Red Lake, Minnesota. , 1955, The Journal of pediatrics.

[2]  E. Updyke,et al.  Provisional new type of group A streptococci associated with nephritis. , 1955, Science.

[3]  M. Streitfeld.  USE OF A DEHYDRATED CULTURE MEDIUM FOR SIMPLIFIED PREPARATION OF STREPTOCOCCAL CULTURES FOR GRIFFITH'S SLIDE AGGLUTINATION , 1955, Journal of bacteriology.

[4]  M. Saslaw,et al.  Group A beta hemolytic streptococci and rheumatic fever in Miami, Fla.; a preliminary report. , 1954, Public health reports.

[5]  B. Matheson,et al.  Experimental nephritis due to type specific streptococci. II. The effect of repeated exposure to type 12 streptococci. , 1954, The Journal of infectious diseases.

[6]  H. Kleinman.  Epidemic acute glomerulonephritis at Red Lake. , 1954, Minnesota medicine.

[7]  R. S. Weaver,et al.  Acute glomerulonephritis, the significance of the variations in the incidence of the disease. , 1953, The Journal of clinical investigation.

[8]  D. Earle,et al.  The association of type specific hemolytic streptococci with acute glomerulonephritis at the Presbyterian and babies Hospitals, New York, N.Y., in the years 1936-1942. , 1953, The Journal of clinical investigation.

[9]  R. S. Weaver,et al.  Significance of the epidemiological differences between acute nephritis and acute rheumatic fever. , 1952, Transactions of the Association of American Physicians.

[10]  G. Oǧur,et al.  Changes in serum complement during the course and treatment of glomerulonephritis. , 1951, A.M.A. archives of internal medicine.

[11]  M. Saslaw,et al.  The incidence of rheumatic heart disease in native school children of Dade County, Florida. , 1950, American heart journal.

[12]  O. Woolpert,et al.  REACTIONS OF MONKEYS TO EXPERIMENTAL MIXED INFLUENZA AND STREPTOCOCCUS INFECTIONS , 1947, The Journal of experimental medicine.

[13]  D. Seegal,et al.  A COMPARATIVE STUDY OF THE GEOGRAPHIC DISTRIBUTION OF RHEUMATIC FEVER, SCARLET FEVER AND ACUTE GLOMERULONEPHRITIS IN NORTH AMERICA , 1935 .

[14]  F. Griffith.  The Serological Classification of Streptococcus pyogenes , 1934, Epidemiology and Infection.