Targeting multiple signal transduction pathways through inhibition of Hsp90
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[1] D. Auclair,et al. BAY 43-9006 Exhibits Broad Spectrum Oral Antitumor Activity and Targets the RAF/MEK/ERK Pathway and Receptor Tyrosine Kinases Involved in Tumor Progression and Angiogenesis , 2004, Cancer Research.
[2] W. Hiddemann,et al. Mutations in the tyrosine kinase domain of FLT3 define a new molecular mechanism of acquired drug resistance to PTK inhibitors in FLT3-ITD-transformed hematopoietic cells. , 2004, Blood.
[3] Yosef Yarden,et al. The Achilles Heel of ErbB-2/HER2: Regulation by the Hsp90 Chaperone Machine and Potential for Pharmacological Intervention , 2004, Cell cycle.
[4] L. Neckers,et al. Heat shock protein 90 , 2003, Current opinion in oncology.
[5] John H Kersey,et al. FLT3 expressing leukemias are selectively sensitive to inhibitors of the molecular chaperone heat shock protein 90 through destabilization of signal transduction-associated kinases. , 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.
[6] E. Sausville,et al. Clinical development of 17-allylamino, 17-demethoxygeldanamycin. , 2003, Current cancer drug targets.
[7] L. Pearl,et al. Structure and functional relationships of Hsp90. , 2003, Current cancer drug targets.
[8] L. Fritz,et al. A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors , 2003, Nature.
[9] J. Radich,et al. The role of FLT3 in haematopoietic malignancies , 2003, Nature Reviews Cancer.
[10] I. Bernstein,et al. Activating mutations of RTK/ras signal transduction pathway in pediatric acute myeloid leukemia. , 2003, Blood.
[11] Shile Huang,et al. Targeting mTOR signaling for cancer therapy. , 2003, Current opinion in pharmacology.
[12] G. Mills,et al. Loss of PTEN/MMAC1/TEP in EGF receptor-expressing tumor cells counteracts the antitumor action of EGFR tyrosine kinase inhibitors , 2003, Oncogene.
[13] A. Olshen,et al. Inhibition of heat shock protein 90 function down-regulates Akt kinase and sensitizes tumors to Taxol. , 2003, Cancer research.
[14] L. Neckers. Development of small molecule Hsp90 inhibitors: utilizing both forward and reverse chemical genomics for drug identification. , 2003, Current medicinal chemistry.
[15] J. Marshall,et al. Activity of the Raf kinase inhibitor BAY 43-9006 in patients with advanced solid tumors. , 2003, Clinical colorectal cancer.
[16] P. Ladenson,et al. BRAF mutation in papillary thyroid carcinoma. , 2003, Journal of the National Cancer Institute.
[17] S. Silberman,et al. Imatinib: a targeted clinical drug development. , 2003, Seminars in hematology.
[18] C. Arteaga. Inhibiting Tyrosine Kinases: Successes and Limitations , 2003, Cancer biology & therapy.
[19] H. Fuse,et al. Involvement of heat-shock protein 90 in the interleukin-6-mediated signaling pathway through STAT3. , 2003, Biochemical and biophysical research communications.
[20] N. Rosen,et al. Development of a purine-scaffold novel class of Hsp90 binders that inhibit the proliferation of cancer cells and induce the degradation of Her2 tyrosine kinase. , 2002, Bioorganic & medicinal chemistry.
[21] S. Wilhelm,et al. BAY 43-9006: preclinical data. , 2002, Current pharmaceutical design.
[22] N. Rosen,et al. Akt Forms an Intracellular Complex with Heat Shock Protein 90 (Hsp90) and Cdc37 and Is Destabilized by Inhibitors of Hsp90 Function* , 2002, The Journal of Biological Chemistry.
[23] R. Jove,et al. Molecular characterization and sensitivity of STI-571 (imatinib mesylate, Gleevec)-resistant, Bcr-Abl-positive, human acute leukemia cells to SRC kinase inhibitor PD180970 and 17-allylamino-17-demethoxygeldanamycin. , 2002, Cancer research.
[24] Gabriela Chiosis,et al. BCR-ABL point mutants isolated from patients with imatinib mesylate-resistant chronic myeloid leukemia remain sensitive to inhibitors of the BCR-ABL chaperone heat shock protein 90. , 2002, Blood.
[25] K. Gibson,et al. ZD1839 (Iressa): an orally active inhibitor of epidermal growth factor signaling with potential for cancer therapy. , 2002, Cancer research.
[26] J. Dancey. Clinical development of mammalian target of rapamycin inhibitors. , 2002, Hematology/oncology clinics of North America.
[27] P. Chène,et al. ATPases as drug targets: learning from their structure , 2002, Nature Reviews Drug Discovery.
[28] R. Bookstein,et al. Mutations to CCI-779 PTEN Enhanced Sensitivity of Multiple Myeloma Cells Containing Updated Version , 2002 .
[29] C. Sawyers,et al. The phosphatidylinositol 3-Kinase–AKT pathway in human cancer , 2002, Nature Reviews Cancer.
[30] A. Nicholson,et al. Mutations of the BRAF gene in human cancer , 2002, Nature.
[31] A. Ishida,et al. Involvement of Hsp90 in Signaling and Stability of 3-Phosphoinositide-dependent Kinase-1* , 2002, The Journal of Biological Chemistry.
[32] P. Csermely,et al. A Nucleotide-dependent Molecular Switch Controls Atp Binding at the C-terminal Domain of Hsp90 N-terminal Nucleotide Binding Unmasks a C-terminal Binding Pocket* , 2022 .
[33] N. Rosen,et al. Ansamycin antibiotics inhibit Akt activation and cyclin D expression in breast cancer cells that overexpress HER2 , 2002, Oncogene.
[34] D. Goeddel,et al. TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90. , 2002, Molecular cell.
[35] P. Workman,et al. HSP90 as a new therapeutic target for cancer therapy: the story unfolds , 2002, Expert opinion on biological therapy.
[36] M. Shimizu,et al. Stereospecific antitumor activity of radicicol oxime derivatives , 2001, Cancer Chemotherapy and Pharmacology.
[37] R. Gaynor,et al. Regulation of β-Catenin Function by the IκB Kinases* , 2001, The Journal of Biological Chemistry.
[38] G. Bollag,et al. Discovery of a novel Raf kinase inhibitor. , 2001, Endocrine-related cancer.
[39] D. Schrump,et al. Enhancement of paclitaxel-mediated cytotoxicity in lung cancer cells by 17-allylamino geldanamycin: in vitro and in vivo analysis. , 2001, The Annals of thoracic surgery.
[40] T. Naoe,et al. FLT3 tyrosine kinase as a target molecule for selective antileukemia therapy , 2001, Cancer Chemotherapy and Pharmacology.
[41] P. N. Rao,et al. Clinical Resistance to STI-571 Cancer Therapy Caused by BCR-ABL Gene Mutation or Amplification , 2001, Science.
[42] K. Bhalla,et al. Geldanamycin and its analogue 17-allylamino-17-demethoxygeldanamycin lowers Bcr-Abl levels and induces apoptosis and differentiation of Bcr-Abl-positive human leukemic blasts. , 2001, Cancer research.
[43] N. Rosen,et al. A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells. , 2001, Chemistry & biology.
[44] Y. Yarden,et al. Sensitivity of Mature ErbB2 to Geldanamycin Is Conferred by Its Kinase Domain and Is Mediated by the Chaperone Protein Hsp90* , 2001, The Journal of Biological Chemistry.
[45] J. Turkson,et al. Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression. , 2001, The Journal of clinical investigation.
[46] L. Neckers,et al. The Heat Shock Protein 90 Antagonist Novobiocin Interacts with a Previously Unrecognized ATP-binding Domain in the Carboxyl Terminus of the Chaperone* , 2000, The Journal of Biological Chemistry.
[47] T. Tsuruo,et al. Modulation of Akt kinase activity by binding to Hsp90. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[48] L. Neckers,et al. Novel oxime derivatives of radicicol induce erythroid differentiation associated with preferential G1 phase accumulation against chronic myelogenous leukemia cells through destabilization of Bcr-Abl with Hsp90 complex , 2000 .
[49] P. Polakis. Wnt signaling and cancer. , 2000, Genes & development.
[50] Roy Garcia,et al. STATs in oncogenesis , 2000, Oncogene.
[51] L. Neckers,et al. Novobiocin and related coumarins and depletion of heat shock protein 90-dependent signaling proteins. , 2000, Journal of the National Cancer Institute.
[52] Michael Karin,et al. The IκB kinase (IKK) and NF-κB: key elements of proinflammatory signalling , 2000 .
[53] H. Itoh,et al. A novel chaperone-activity-reducing mechanism of the 90-kDa molecular chaperone HSP90. , 1999, The Biochemical journal.
[54] Sreenath V. Sharma,et al. Interaction of radicicol with members of the heat shock protein 90 family of molecular chaperones. , 1999, Molecular endocrinology.
[55] M. Sliwkowski,et al. Nonclinical studies addressing the mechanism of action of trastuzumab (Herceptin). , 1999, Seminars in oncology.
[56] L. Neckers,et al. KF25706, a novel oxime derivative of radicicol, exhibits in vivo antitumor activity via selective depletion of Hsp90 binding signaling molecules. , 1999, Cancer research.
[57] L. Pearl,et al. Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin. , 1999, Journal of medicinal chemistry.
[58] B. Geiger,et al. Differential molecular interactions of beta-catenin and plakoglobin in adhesion, signaling and cancer. , 1998, Current opinion in cell biology.
[59] L. Neckers,et al. Antibiotic radicicol binds to the N-terminal domain of Hsp90 and shares important biologic activities with geldanamycin. , 1998, Cell stress & chaperones.
[60] Sreenath V. Sharma,et al. Targeting of the protein chaperone, HSP90, by the transformation suppressing agent, radicicol , 1998, Oncogene.
[61] L. Pearl,et al. Identification and Structural Characterization of the ATP/ADP-Binding Site in the Hsp90 Molecular Chaperone , 1997, Cell.
[62] M. Zalutsky. Growth factor receptors as molecular targets for cancer diagnosis and therapy. , 1997, The quarterly journal of nuclear medicine : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology.
[63] Neal Rosen,et al. Crystal Structure of an Hsp90–Geldanamycin Complex: Targeting of a Protein Chaperone by an Antitumor Agent , 1997, Cell.
[64] L. Neckers,et al. Destabilization of Raf-1 by geldanamycin leads to disruption of the Raf-1-MEK-mitogen-activated protein kinase signalling pathway , 1996, Molecular and cellular biology.
[65] W. Kolch,et al. Nerve Growth Factor-mediated Activation of the Mitogen-activated Protein (MAP) Kinase Cascade Involves a Signaling Complex Containing B-Raf and HSP90* , 1996, The Journal of Biological Chemistry.
[66] D. Birnbaum,et al. Human FLT3/FLK2 receptor tyrosine kinase is expressed at the surface of normal and malignant hematopoietic cells. , 1996, Leukemia.
[67] M. Borowitz,et al. Expression of the hematopoietic growth factor receptor FLT3 (STK-1/Flk2) in human leukemias. , 1996, Blood.
[68] Mikhail V. Blagosklonny,et al. Disruption of the Raf-1-Hsp90 Molecular Complex Results in Destabilization of Raf-1 and Loss of Raf-1-Ras Association (*) , 1995, The Journal of Biological Chemistry.
[69] H. Nakano,et al. Suppression of RAS and MOS transformation by radicicol. , 1995, Oncogene.
[70] P. McCrea,et al. Overexpression of cadherins and underexpression of β-catenin inhibit dorsal mesoderm induction in early Xenopus embryos , 1994, Cell.
[71] L. Neckers,et al. Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[72] G. Carpenter,et al. Differential heat stress stability of epidermal growth factor receptor and erbB‐2 receptor tyrosine kinase activities , 1993, Journal of cellular physiology.
[73] H. Kwon,et al. Radicicol, an agent inducing the reversal of transformed phenotypes of src-transformed fibroblasts. , 1992, Bioscience, biotechnology, and biochemistry.
[74] H Umezawa,et al. Phenotypic change from transformed to normal induced by benzoquinonoid ansamycins accompanies inactivation of p60src in rat kidney cells infected with Rous sarcoma virus , 1986, Molecular and cellular biology.
[75] C. Deboer,et al. Geldanamycin, a new antibiotic. , 1970, The Journal of antibiotics.
[76] Brian Dymock,et al. Adenine derived inhibitors of the molecular chaperone HSP90-SAR explained through multiple X-ray structures. , 2004, Bioorganic & medicinal chemistry letters.
[77] Oliver Hantschel,et al. Regulation of the c-Abl and Bcr–Abl tyrosine kinases , 2004, Nature Reviews Molecular Cell Biology.
[78] B. Mellado,et al. Mechanism of action of anti-HER2 monoclonal antibodies: scientific update on trastuzumab and 2C4. , 2003, Advances in experimental medicine and biology.
[79] R. Gaynor,et al. Regulation of beta-catenin function by the IkappaB kinases. , 2001, The Journal of biological chemistry.
[80] M. Campiglio,et al. HER2 overexpression in various tumor types, focussing on its relationship to the development of invasive breast cancer. , 2001, Annals of oncology : official journal of the European Society for Medical Oncology.
[81] M. Karin,et al. Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. , 2000, Annual review of immunology.
[82] M. Karin,et al. The I kappa B kinase (IKK) and NF-kappa B: key elements of proinflammatory signalling. , 2000, Seminars in immunology.
[83] L. Neckers,et al. Novel oxime derivatives of radicicol induce erythroid differentiation associated with preferential G(1) phase accumulation against chronic myelogenous leukemia cells through destabilization of Bcr-Abl with Hsp90 complex. , 2000, Blood.
[84] L. Neckers,et al. The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin , 1998, Cancer Chemotherapy and Pharmacology.