Adult T cell leukaemia cells are of CD4+ CDw29+ T cell origin and secrete a B cell differentiation factor

Summary. Cells from six cases of adult T cell leukaemia were studied with respect to phenotypical and functional features. All cells were reactive with anti‐CD4 and anti‐CDw29 monoclonal antibodies (antibody against helper inducer T cells) but were unreactive with anti‐CD45R monoclonal antibody (antibody against suppressor inducer T cells). Functionally, these cells secreted a B cell differentiation factor detected by SKW6‐CL4 cell differentiation to IgM‐producing cells, this secretion being enhanced by culture with recombinant IL‐2. Though these results indicate that adult T cell leukaemia cells are of mature helper inducer T cell origin, these cells strongly suppressed PWM‐induced B cell differentiation in the absence of CD8+ suppressor effector T cells.

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