Effect of treatment with phytosterols in three herds with porcine respiratory disease complex.

This case study includes three pig production systems belonging to two companies in Spain. Mortality, percent culls, average daily gain (ADG), and feed efficiency in Production Systems One and Two were incorporated into a database program and analyzed using statistical process control (SPC) techniques to assess changes in performance before and after phytosterols, natural substances that act as immunomodulators, were added to the feed. Inmunicin Maymo (Maymo Laboratories SA, Barcelona, Spain), a commercial phytosterol product, was administered in feed during the nursery and finishing periods, from 4 weeks before until 4 weeks after the predicted date of an outbreak of porcine respiratory disease complex (PRDC). In Production System Three, data obtained for batches treated or not treated with Inmunicin Maymo were compared using a one-way ANOVA, with the level of significance set at .05. In all three production systems, finisher mortality and percent culls were lower and production parameters were best when the immunomodulator was applied. Differences were statistically significant for all parameters evaluated, except feed conversion ratio, when assessed using SPC criteria in Systems One and Two and one-way ANOVA in System Three. Phytosterols may be useful to control endemic PRDC under field conditions.

[1]  H. W. Jackeman.  Diseases of Swine. , 1940, Canadian journal of comparative medicine and veterinary science.

[2]  G. Wright.  Diseases of the respiratory system. , 1951, Annual review of medicine.

[3]  S. Kyriakis,et al.  Effect of a paramunity inducer on reproductive performance of gilts. , 1996, Zentralblatt fur Veterinarmedizin. Reihe A.

[4]  S. Dee.  The porcine respiratory disease complex: are subpopulations important? , 1996 .

[5]  D. Lyras,et al.  Effect of an inactivated Parapoxvirus based immunomodulator (Baypamun) on post weaning diarrhoea syndrome and wasting pig syndrome of piglets. , 1998, Research in veterinary science.

[6]  J. Segalés,et al.  Pathological, immunohistochemical, and in-situ hybridization studies of natural cases of postweaning multisystemic wasting syndrome (PMWS) in pigs. , 1999, Journal of comparative pathology.

[7]  M. Cook.  Nutritional effects on vaccination. , 1999, Advances in veterinary medicine.

[8]  A. Saalmüller,et al.  Poxvirus-Induced Immunostimulating Effects on Porcine Leukocytes , 2000, Journal of Virology.

[9]  G. Hardy,et al.  Nutraceuticals and functional foods: introduction and meaning. , 2000, Nutrition.

[10]  F. Blecha.  Immunomodulators for prevention and treatment of infectious diseases in food-producing animals. , 2001, The Veterinary clinics of North America. Food animal practice.

[11]  P. Bouic,et al.  The role of phytosterols and phytosterolins in immune modulation: a review of the past 10 years , 2001, Current opinion in clinical nutrition and metabolic care.

[12]  P. Bouic,et al.  FLOW CYTOMETRIC ANALYSIS OF THE TH1–TH2 BALANCE IN HEALTHY INDIVIDUALS AND PATIENTS INFECTED WITH THE HUMAN IMMUNODEFICIENCY VIRUS (HIV) RECEIVING A PLANT STEROL/STEROLIN MIXTURE , 2001, Cell biology international.

[13]  E. Thacker.  Immunology of the Porcine Respiratory Disease Complex , 2001, Veterinary Clinics of North America: Food Animal Practice.

[14]  A B Kay,et al.  Allergy and allergic diseases. First of two parts. , 2001, The New England journal of medicine.

[15]  P. Bouic.  Sterols and sterolins: new drugs for the immune system? , 2002, Drug discovery today.

[16]  E. Mateu,et al.  Short Communication Genetic diversity and phylogenetic analysis of glycoprotein 5 of European-type porcine reproductive and respiratory virus strains in Spain , 2003 .

[17]  J. Segalés,et al.  Pathogenesis of postweaning multisystemic wasting syndrome caused by Porcine circovirus 2: an immune riddle , 2004, Archives of Virology.

[18]  J. Benneyan,et al.  Statistical process control as a tool for research and healthcare improvement , 2003, Quality & safety in health care.

[19]  J. Segalés,et al.  Porcine circovirus diseases , 2005, Animal Health Research Reviews.

[20]  Colin D. Johnson,et al.  Assessment of the economic impact of porcine reproductive and respiratory syndrome on swine production in the United States. , 2005, Journal of the American Veterinary Medical Association.

[21]  E. Pajor,et al.  Supplemental vitamin C and yeast cell wall beta-glucan as growth enhancers in newborn pigs and as immunomodulators after an endotoxin challenge after weaning. , 2006, Journal of animal science.

[22]  Jeffrey K Reneau,et al.  Using statistical process control methods to improve herd performance. , 2006, The Veterinary clinics of North America. Food animal practice.

[23]  V. Sekar,et al.  Adjuvant and immunostimulatory effects of beta-glucan administration in combination with lipopolysaccharide enhances survival and some immune parameters in carp challenged with Aeromonas hydrophila. , 2006, Veterinary immunology and immunopathology.

[24]  E. Thacker.  Lung inflammatory responses. , 2006, Veterinary research.

[25]  P. Sahoo,et al.  Dietary immunostimulants influence specific immune response and resistance of healthy and immunocompromised Asian catfish Clarias batrachus to Aeromonas hydrophila infection. , 2006, Diseases of aquatic organisms.

[26]  Joo-Hwan Kim,et al.  Effects of lactose-beta-sitosterol and beta-sitosterol on ovalbumin-induced lung inflammation in actively sensitized mice. , 2007, International immunopharmacology.

[27]  J. Y. Lee,et al.  Immunoregulatory activity by daucosterol, a beta-sitosterol glycoside, induces protective Th1 immune response against disseminated Candidiasis in mice. , 2007, Vaccine.

[28]  T. Shan,et al.  Effect of dietary lactoferrin on the immune functions and serum iron level of weanling piglets. , 2007, Journal of animal science.

[29]  W. Pearson,et al.  Low-dose ginseng (Panax quinquefolium) modulates the course and magnitude of the antibody response to vaccination against equid herpesvirus I in horses. , 2007, Canadian journal of veterinary research = Revue canadienne de recherche veterinaire.

[30]  Joo-Hwan Kim,et al.  Effects of lactose-β-sitosterol and β-sitosterol on ovalbumin-induced lung inflammation in actively sensitized mice , 2007 .

[31]  Peter Schierack,et al.  Bacillus cereus var. toyoi enhanced systemic immune response in piglets. , 2007, Veterinary immunology and immunopathology.

[32]  R. D. Boyd,et al.  Structured process for evaluating new products for production systems: Animal science perspective , 2007 .

[33]  I. Díaz,et al.  The challenge of PRRS immunology , 2007, The Veterinary Journal.