Isolated Splenic Metastasis from Colon Cancer. Report of a Case

Isolated splenic metastasis is an uncommon event, except in the case of secondary involvement by lymphoma. The most common sites of metastases of colorectal cancer are the regional lymph nodes, liver and peritoneum; lung and bone are rarely involved, the spleen exceptionally. In this paper we report a case of metachronous isolated splenic metastasis of transverse colon cancer in an 80-year-old woman who was successfully treated by splenectomy. The peculiar clinical-pathological aspects of this kind of metastasis are discussed on the basis of our clinical observation and a review is presented of similar cases reported in the literature. Only 14 reported cases of isolated splenic metastasis from colorectal cancer were found in Medline.

[1]  N. Kim,et al.  Isolated Splenic Metastasis from Colorectal Carcinoma , 2006 .

[2]  L. Lauriola,et al.  Isolated splenic metastasis from colon cancer. , 2004, Journal of experimental & clinical cancer research : CR.

[3]  H. Ishikawa,et al.  Isolated splenic metastasis of sigmoid colon cancer: a case report. , 2001, Japanese journal of clinical oncology.

[4]  F. Botti,et al.  Synchronous Isolated Splenic Metastasis From Colon Carcinoma , 2001, American journal of clinical oncology.

[5]  R. Place Isolated Colon Cancer Metastasis to the Spleen , 2001, The American surgeon.

[6]  G. Kang,et al.  Isolated splenic metastasis from colorectal carcinoma: a case report. , 2000, Journal of Korean medical science.

[7]  R. Barakat,et al.  Splenectomy in recurrent epithelial ovarian cancer. , 1999, Gynecologic oncology.

[8]  S. A. Roh,et al.  Adhesive function of carcinoembryonic antigen in the liver metastasis of KM-12c colon carcinoma cell line , 1997, Diseases of the colon and rectum.

[9]  H. Levin,et al.  Isolated splenic metastases from colon cancer. , 1997, Southern medical journal.

[10]  A. Berry,et al.  Solitary splenic metastasis from colorectal carcinoma , 1997, The British journal of surgery.

[11]  A. Laudanna,et al.  Susceptibility of colorectal‐carcinoma cells to natural‐killer‐mediated lysis: Relationship to CEA expression and degree of differentiation , 1995, International journal of cancer.

[12]  C. R. Teixeira,et al.  Carcinoembryonic antigen staining patterns at the invasive tumor margin predict the malignant potential of colorectal carcinoma. , 1994, Oncology.

[13]  R. Pollock,et al.  Isolated splenic metastases from colon carcinoma. , 1993, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.

[14]  J. Skandalakis,et al.  Isolated splenic metastasis from rectal carcinoma. , 1992, Southern medical journal.

[15]  F. Michot,et al.  [Metachronous splenic metastasis of colonic cancer. Apropos of a case]. , 1987, Gastroenterologie clinique et biologique.

[16]  Marianne Steiner,et al.  Splenomegaly and solitary spleen metastasis in solid tumors , 1987, Cancer.

[17]  R. P. Spencer,et al.  Splenectomy for Splenic Metastasis from Carcinoma of Colon , 1986, Clinical nuclear medicine.

[18]  W. Fajman,et al.  An Unusual Cause of an Isolated, Focal Splenic Defect Demonstrated By Liver-Spleen Scintigraphy , 1982, Clinical nuclear medicine.

[19]  T. Berge Splenic metastases. Frequencies and patterns. , 2009, Acta pathologica et microbiologica Scandinavica. Section A, Pathology.

[20]  O. Beahrs,et al.  Solitary splenic metastasis incidental to rectal carcinoma: report of a case. , 1969, Mayo Clinic proceedings.

[21]  S. Warren,et al.  Studies on Tumor Metastasis: V. The Metastases of Carcinoma to the Spleen , 1934 .

[22]  W. Woglom,et al.  Immunity to Transplantable Tumours. , 1929 .