Syncytial apoptosis signaling network induced by the HIV-1 envelope glycoprotein complex: an overview

[1]  Z. Dlamini,et al.  Human Immunodeficiency Virus-1 (HIV-1)-Mediated Apoptosis: New Therapeutic Targets , 2014, Viruses.

[2]  B. Hartmann,et al.  P2X-Selective Purinergic Antagonists Are Strong Inhibitors of HIV-1 Fusion during both Cell-to-Cell and Cell-Free Infection , 2014, Journal of Virology.

[3]  N. Krogan,et al.  IFI16 DNA Sensor Is Required for Death of Lymphoid CD4 T Cells Abortively Infected with HIV , 2014, Science.

[4]  Xin Geng,et al.  Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection , 2013, Nature.

[5]  J. Berman,et al.  Pannexin1 hemichannels are critical for HIV infection of human primary CD4+ T lymphocytes , 2013, Journal of leukocyte biology.

[6]  J. Perfettini,et al.  Editorial: Pannexin‐1—the hidden gatekeeper for HIV‐1 , 2013, Journal of leukocyte biology.

[7]  Julia L. Drewes,et al.  Adenosine Triphosphate Released from HIV-Infected Macrophages Regulates Glutamatergic Tone and Dendritic Spine Density on Neurons , 2013, Journal of Neuroimmune Pharmacology.

[8]  P. Uchil,et al.  Cell-to-Cell Transmission Can Overcome Multiple Donor and Target Cell Barriers Imposed on Cell-Free HIV , 2013, PloS one.

[9]  A. Badley,et al.  Anti-apoptotic mechanisms of HIV: lessons and novel approaches to curing HIV , 2012, Cellular and Molecular Life Sciences.

[10]  G. Kroemer,et al.  Multifaceted roles of purinergic receptors in viral infection. , 2012, Microbes and infection.

[11]  J. Kanellopoulos,et al.  Cellular alarms and whispers contribute to the polyphonic melody of danger signals required for immunity. , 2012, Microbes and infection.

[12]  H. Garg,et al.  HIV-1 Induced Bystander Apoptosis , 2012, Viruses.

[13]  J. Berman,et al.  Purinergic Receptors Are Required for HIV-1 Infection of Primary Human Macrophages , 2012, The Journal of Immunology.

[14]  G. Kroemer,et al.  Extracellular ATP acts on P2Y2 purinergic receptors to facilitate HIV-1 infection , 2011, The Journal of experimental medicine.

[15]  A. Badley,et al.  Mechanisms of HIV-associated lymphocyte apoptosis: 2010 , 2010, Cell Death and Disease.

[16]  A. D’Incecco,et al.  53BP1 represses mitotic catastrophe in syncytia elicited by the HIV-1 envelope , 2010, Cell Death and Differentiation.

[17]  A. Levine,et al.  The first 30 years of p53: growing ever more complex , 2009, Nature Reviews Cancer.

[18]  E. Rivera-Toledo,et al.  HIV-Envelope–Dependent Cell-Cell Fusion: Quantitative Studies , 2009, TheScientificWorldJournal.

[19]  Nathan H. Roy,et al.  Formation of Syncytia Is Repressed by Tetraspanins in Human Immunodeficiency Virus Type 1-Producing Cells , 2009, Journal of Virology.

[20]  Mario Roederer,et al.  Emerging concepts in the immunopathogenesis of AIDS. , 2009, Annual review of medicine.

[21]  G. Kroemer,et al.  The tumor suppressor protein PML controls apoptosis induced by the HIV-1 envelope , 2009, Cell Death and Differentiation.

[22]  G. Kroemer,et al.  Pro-apoptotic function of checkpoint kinase-2 in syncytia elicited by the HIV-1 envelope , 2009, Cell cycle.

[23]  T. Kuwana,et al.  Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins , 2008, Proceedings of the National Academy of Sciences.

[24]  G. Kroemer,et al.  Critical Involvement of the ATM-Dependent DNA Damage Response in the Apoptotic Demise of HIV-1-Elicited Syncytia , 2008, PloS one.

[25]  H. Garg,et al.  Role of HIV Gp41 mediated fusion/hemifusion in bystander apoptosis , 2008, Cellular and Molecular Life Sciences.

[26]  Rosa Bernardi,et al.  Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies , 2007, Nature Reviews Molecular Cell Biology.

[27]  T. Hope,et al.  Physiological Levels of Virion-Associated Human Immunodeficiency Virus Type 1 Envelope Induce Coreceptor-Dependent Calcium Flux , 2006, Journal of Virology.

[28]  P. Codogno,et al.  Autophagy is involved in T cell death after binding of HIV-1 envelope proteins to CXCR4. , 2006, The Journal of clinical investigation.

[29]  G. Kroemer,et al.  p38 MAP kinase in HIV-1 infection: the enemy within , 2005 .

[30]  L. Larocca,et al.  Characterization of cell death pathways in human immunodeficiency virus-associated encephalitis. , 2005, The American journal of pathology.

[31]  G. Kroemer,et al.  p53-A pro-apoptotic signal transducer involved in AIDS. , 2005, Biochemical and biophysical research communications.

[32]  G. Kroemer,et al.  Cell death mechanisms in HIV-associated dementia: the involvement of syncytia , 2005, Cell Death and Differentiation.

[33]  M. Gougeon To kill or be killed: how HIV exhausts the immune system , 2005, Cell Death and Differentiation.

[34]  T. Ørntoft,et al.  DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis , 2005, Nature.

[35]  G. Kroemer,et al.  Mechanisms of apoptosis induction by the HIV-1 envelope , 2005, Cell Death and Differentiation.

[36]  G. Kroemer,et al.  Essential role of p53 phosphorylation by p38 MAPK in apoptosis induction by the HIV-1 envelope , 2005, The Journal of experimental medicine.

[37]  P. Matarrese,et al.  Tissue Transglutaminase Is a Multifunctional BH3-only Protein* , 2004, Journal of Biological Chemistry.

[38]  S. Shorte,et al.  CXCR4-Tropic HIV-1 Envelope Glycoprotein Functions as a Viral Chemokine in Unstimulated Primary CD4+ T Lymphocytes1 , 2004, The Journal of Immunology.

[39]  G. Kroemer,et al.  Contagious apoptosis facilitated by the HIV-1 envelope: fusion-induced cell-to-cell transmission of a lethal signal , 2004, Journal of Cell Science.

[40]  Q. Sattentau,et al.  Dangerous liaisons at the virological synapse. , 2004, The Journal of clinical investigation.

[41]  V. Robert-Hebmann,et al.  Apoptosis of uninfected cells induced by HIV envelope glycoproteins , 2004, Retrovirology.

[42]  Mauro Piacentini,et al.  NF-κB and p53 Are the Dominant Apoptosis-inducing Transcription Factors Elicited by the HIV-1 Envelope , 2004, The Journal of experimental medicine.

[43]  G. Kroemer,et al.  Mitochondrion-mediated apoptosis in HIV-1 infection. , 2003, Trends in pharmacological sciences.

[44]  Y. Shiloh ATM and related protein kinases: safeguarding genome integrity , 2003, Nature Reviews Cancer.

[45]  K. Kinzler,et al.  PUMA mediates the apoptotic response to p53 in colorectal cancer cells , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[46]  Xin Lu,et al.  Live or let die: the cell's response to p53 , 2002, Nature Reviews Cancer.

[47]  Donald E Ingber,et al.  Sequential involvement of Cdk1, mTOR and p53 in apoptosis induced by the HIV‐1 envelope , 2002, The EMBO journal.

[48]  J. Barretina,et al.  Human Immunodeficiency Virus 1 Envelope Glycoprotein Complex-Induced Apoptosis Involves Mammalian Target of Rapamycin/Fkbp12-Rapamycin–Associated Protein–Mediated P53 Phosphorylation , 2001, The Journal of experimental medicine.

[49]  C. Scheller,et al.  Syncytium formation amplifies apoptotic signals: a new view on apoptosis in HIV infection in vitro. , 2001, Virology.

[50]  K. Vousden,et al.  PUMA, a novel proapoptotic gene, is induced by p53. , 2001, Molecular cell.

[51]  A. Badley,et al.  Mechanisms of HIV-associated lymphocyte apoptosis. , 2000, Blood.

[52]  G. Kroemer,et al.  Apoptosis and karyogamy in syncytia induced by the HIV-1-envelope glycoprotein complex , 2000, Cell Death and Differentiation.

[53]  G. Kroemer,et al.  Apoptosis Control in Syncytia Induced by the HIV Type 1–Envelope Glycoprotein Complex , 2000, The Journal of experimental medicine.

[54]  A. Fauci,et al.  CCR5 Signal Transduction in Macrophages by Human Immunodeficiency Virus and Simian Immunodeficiency Virus Envelopes , 2000, Journal of Virology.

[55]  J. Margolick,et al.  Strong association between failure of T cell homeostasis and the syncytium-inducing phenotype among HIV-1-infected men in the Amsterdam Cohort Study , 2000, AIDS.

[56]  J. Sodroski,et al.  Envelope Glycoprotein Determinants of Increased Fusogenicity in a Pathogenic Simian-Human Immunodeficiency Virus (SHIV-KB9) Passaged In Vivo , 2000, Journal of Virology.

[57]  R. Doms,et al.  HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[58]  H. Su,et al.  Human Immunodeficiency Virus Type 1 Pathogenesis in SCID-hu Mice Correlates with Syncytium-Inducing Phenotype and Viral Replication , 2000, Journal of Virology.

[59]  H. Schuitemaker,et al.  In vivo HIV-1 infection of CD45RA(+)CD4(+) T cells is established primarily by syncytium-inducing variants and correlates with the rate of CD4(+) T cell decline. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[60]  C. Cicala,et al.  HIV-1 envelope induces activation of caspase-3 and cleavage of focal adhesion kinase in primary human CD4(+) T cells. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[61]  Ruedi Aebersold,et al.  Molecular characterization of mitochondrial apoptosis-inducing factor , 1999, Nature.

[62]  G Burnstock,et al.  Receptors for purines and pyrimidines. , 1998, Pharmacological reviews.

[63]  H. Schuitemaker,et al.  Emergence of syncytium-inducing human immunodeficiency virus type 1 variants coincides with a transient increase in viral RNA level and is an independent predictor for progression to AIDS. , 1998, The Journal of infectious diseases.

[64]  D. Weissman,et al.  Macrophage-tropic HIV and SIV envelope proteins induce a signal through the CCR5 chemokine receptor , 1997, Nature.

[65]  Stephen N. Jones,et al.  Regulation of p53 stability by Mdm2 , 1997, Nature.

[66]  D. Soll,et al.  HIV-induced T cell syncytia are self-perpetuating and the primary cause of T cell death in culture. , 1997, Journal of immunology.

[67]  N. Banda,et al.  Indirect mechanisms of HIV pathogenesis: how does HIV kill T cells? , 1994, Current opinion in immunology.

[68]  M. Kieny,et al.  Membrane expression of HIV envelope glycoproteins triggers apoptosis in CD4 cells. , 1993, AIDS research and human retroviruses.

[69]  K. Steimer,et al.  Induction of CD4-dependent cell fusion by the HTLV-III/LAV envelope glycoprotein , 1986, Nature.

[70]  C. Payá,et al.  Apoptosis in AIDS. , 1997, Advances in pharmacology.