Prostaglandin E2 is activated by airway injury and regulates fibroblast cytoskeletal dynamics

To characterize the activation of cyclooxygenase (COX)‐2/prostaglandin (PG) E2 signaling during airway mucosal repair and its subsequent role during the wound healing process.

[1]  A. Yoshimura,et al.  Prostaglandin E2 is a major soluble factor produced by stromal cells for preventing inflammatory cytokine production from dendritic cells. , 2008, International immunology.

[2]  P. Hebda,et al.  Acute and chronic changes in the subglottis induced by graded carbon dioxide laser injury in the rabbit airway. , 2008, Archives of otolaryngology--head & neck surgery.

[3]  M. Matthay,et al.  Prostaglandin E2 Mediates IL-1β-Related Fibroblast Mitogenic Effects in Acute Lung Injury through Differential Utilization of Prostanoid Receptors1 , 2008, The Journal of Immunology.

[4]  Vlad C Sandulache,et al.  Fetal dermal fibroblasts retain a hyperactive migratory and contractile phenotype under 2-and 3-dimensional constraints compared to normal adult fibroblasts. , 2007, Tissue engineering.

[5]  A. López Bernal,et al.  PTGER1 and PTGER2 receptors mediate regulation of progesterone synthesis and type 1 11β-hydroxysteroid dehydrogenase activity by prostaglandin E2 in human granulosa–lutein cells , 2007, The Journal of endocrinology.

[6]  P. Hebda,et al.  Elucidating the role of interleukin 1beta and prostaglandin E2 in upper airway mucosal wound healing. , 2007, Archives of otolaryngology--head & neck surgery.

[7]  P. Hebda,et al.  Graded carbon dioxide laser-induced subglottic injury in the rabbit model. , 2007, Archives of otolaryngology--head & neck surgery.

[8]  T. Schmitz,et al.  Prostaglandin E2 Receptor Expression in Fetal Baboon Lung at 0.7 Gestation After Betamethasone Exposure , 2007, Pediatric Research.

[9]  P. Hebda,et al.  Prostaglandin E2 differentially modulates human fetal and adult dermal fibroblast migration and contraction: implication for wound healing , 2006, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[10]  Y. Bezugla,et al.  COX-1 and COX-2 contribute differentially to the LPS-induced release of PGE2 and TxA2 in liver macrophages. , 2006, Prostaglandins & other lipid mediators.

[11]  J. Lutterbaugh,et al.  15-Hydroxyprostaglandin dehydrogenase, a COX-2 oncogene antagonist, is a TGF-beta-induced suppressor of human gastrointestinal cancers. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[12]  V. Bergdall,et al.  The impact of cyclooxygenase-2 mediated inflammation on scarless fetal wound healing. , 2004, The American journal of pathology.

[13]  C. Clelland,et al.  Reduced expression of cyclooxygenase (COX) in idiopathic pulmonary fibrosis and sarcoidosis , 2003, Histopathology.

[14]  H. Harizi,et al.  Prostaglandin E2 modulates dendritic cell function via EP2 and EP4 receptor subtypes , 2003, Journal of leukocyte biology.

[15]  M. Nijland,et al.  Effect of Gestational Age, Corticosteroids, and Birth on Expression of Prostanoid EP Receptor Genes in Lamb and Baboon Ductus Arteriosus , 2001, Journal of cardiovascular pharmacology.

[16]  H. S. Li,et al.  Up-regulation of prostaglandin EP4 receptor messenger RNA in fetal rabbit skin wound. , 2000, Archives of otolaryngology--head & neck surgery.

[17]  T. Crombleholme,et al.  Fetal wound repair results in scar formation in interleukin-10-deficient mice in a syngeneic murine model of scarless fetal wound repair. , 2000, Journal of pediatric surgery.

[18]  S. Shapshay,et al.  Endoscopic Laryngotracheoplasty and Graft Soldering with the Carbon Dioxide Laser , 1997, The Annals of otology, rhinology, and laryngology.

[19]  L. Tan,et al.  The effect of a synthetic analogue of prostaglandin E2 on wound healing in rats. , 1996, Annals of clinical and laboratory science.

[20]  M. Burdick,et al.  Cultured lung fibroblasts isolated from patients with idiopathic pulmonary fibrosis have a diminished capacity to synthesize prostaglandin E2 and to express cyclooxygenase-2. , 1995, The Journal of clinical investigation.

[21]  E. Whitehead,et al.  Use of the carbon dioxide laser with the Montgomery T-tube in the management of extensive subglottic stenosis , 1992, The Journal of Laryngology & Otology.

[22]  R. Cotton,et al.  Laryngeal Stenosis following Carbon Dioxide Laser in Subglottic Hemangioma; Report of Three Cases , 1985, The Annals of otology, rhinology, and laryngology.

[23]  P. Hebda,et al.  Prostaglandin E2 inhibition of keloid fibroblast migration, contraction, and transforming growth factor (TGF)‐β1–induced collagen synthesis , 2007, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[24]  H. Ehrlich,et al.  Cell locomotion forces versus cell contraction forces for collagen lattice contraction: an in vitro model of wound contraction. , 1990, Tissue & cell.