Mechanics of cardiac muscle, based on Huxley's model: simulation of active state and force-velocity relation.

Abstract Hill's three-component model for cardiac muscle, incorporating Huxley's sliding filament theory for the contractile element (CE) (Wong, 1971) is extended to study the forcevelocity relation. At any defined contractile state, i.e. fixed time of contraction and CE length, force-velocity curve of CE can be described by Hill's characteristic equation. The hyperbolic relation is not found in force-velocity curve obtained by afterloaded isotonic contraction, but the curve can be fitted by Fung's equation (1970). Inconsistencies and discrepancies in force-velocity data reported in literature are discussed on the basis of the present model.

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