Inhibition of IKKɛ and TBK1 Improves Glucose Control in a Subset of Patients with Type 2 Diabetes.
暂无分享,去创建一个
T. Chenevert | J. Horowitz | R. Evans | M. Downes | R. Yu | Mohit M. Jain | A. Saltiel | Peng Zhao | Maryam Ahmadian | C. Liddle | Shannon M. Reilly | Andrew V. Gomez | Breanne Poirier | Evgenia Korytnaya | E. Oral | Rasimcan Meral | Adam H. Neidert | Rita Hench | Nevin Ajluni | Diana Rus | Laura Butz | Kim Lehmann | R. Evans
[1] Graham F. Brady,et al. Spectrum of disease associated with partial lipodystrophy: lessons from a trial cohort , 2017, Clinical endocrinology.
[2] A. Garg,et al. Homozygous LIPE mutation in siblings with multiple symmetric lipomatosis, partial lipodystrophy, and myopathy , 2017, American journal of medical genetics. Part A.
[3] D. Ory,et al. Fatty acid synthesis configures the plasma membrane for inflammation in diabetes , 2016, Nature.
[4] K. Alitalo,et al. VEGFB/VEGFR1-Induced Expansion of Adipose Vasculature Counteracts Obesity and Related Metabolic Complications. , 2016, Cell metabolism.
[5] Jerrold M. Olefsky,et al. Regulation of metabolism by the innate immune system , 2016, Nature Reviews Endocrinology.
[6] T. Funahashi,et al. Visualized macrophage dynamics and significance of S100A8 in obese fat , 2015, Proceedings of the National Academy of Sciences.
[7] S. Kliewer,et al. Tissue-specific actions of the metabolic hormones FGF15/19 and FGF21 , 2015, Trends in Endocrinology & Metabolism.
[8] R. Evans,et al. A subcutaneous adipose tissue–liver signalling axis controls hepatic gluconeogenesis , 2015, Nature Communications.
[9] John F. Robinson,et al. A novel LIPE nonsense mutation found using exome sequencing in siblings with late-onset familial partial lipodystrophy. , 2014, The Canadian journal of cardiology.
[10] M. Blüher,et al. Evidence of Early Alterations in Adipose Tissue Biology and Function and Its Association With Obesity-Related Inflammation and Insulin Resistance in Children , 2014, Diabetes.
[11] A. Tall,et al. Adipose tissue macrophages promote myelopoiesis and monocytosis in obesity. , 2014, Cell metabolism.
[12] A. Saltiel,et al. Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKKε and TBK1 , 2013, eLife.
[13] R. Frederich,et al. Clinically relevant reductions in HbA1c without hypoglycaemia: results across four studies of saxagliptin , 2013, International journal of clinical practice.
[14] B. Howard,et al. Cardiovascular Characteristics in Subjects With Increasing Levels of Abnormal Glucose Regulation , 2013, Diabetes Care.
[15] K. Clément,et al. Roles of chemokine ligand-2 (CXCL2) and neutrophils in influencing endothelial cell function and inflammation of human adipose tissue. , 2013, Endocrinology.
[16] I. Hochberg,et al. An inhibitor of the protein kinases TBK1/IKKε improves obesity-related metabolic dysfunctions , 2013, Nature Medicine.
[17] P. Trayhurn. Hypoxia and adipose tissue function and dysfunction in obesity. , 2013, Physiological reviews.
[18] David G Hendrickson,et al. Differential analysis of gene regulation at transcript resolution with RNA-seq , 2012, Nature Biotechnology.
[19] Thomas R. Gingeras,et al. STAR: ultrafast universal RNA-seq aligner , 2013, Bioinform..
[20] J. Rosenstock,et al. Dose-Ranging Effects of Canagliflozin, a Sodium-Glucose Cotransporter 2 Inhibitor, as Add-On to Metformin in Subjects With Type 2 Diabetes , 2012, Diabetes Care.
[21] C. Glass,et al. Inflammation and lipid signaling in the etiology of insulin resistance. , 2012, Cell metabolism.
[22] J. Pollard,et al. Dichotomous effects of VEGF-A on adipose tissue dysfunction , 2012, Proceedings of the National Academy of Sciences.
[23] A. Chawla,et al. Macrophage-mediated inflammation in metabolic disease , 2011, Nature Reviews Immunology.
[24] Carey N Lumeng,et al. Inflammatory links between obesity and metabolic disease. , 2011, The Journal of clinical investigation.
[25] G. Willemsen,et al. The heritability of beta cell function parameters in a mixed meal test design , 2011, Diabetologia.
[26] E. Ravussin,et al. The NALP3/NLRP3 Inflammasome Instigates Obesity-Induced Autoinflammation and Insulin Resistance , 2010, Nature Medicine.
[27] G. Hotamisligil,et al. Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease , 2010, Cell.
[28] L. Lau,et al. Matricellular Protein CCN1 Activates a Proinflammatory Genetic Program in Murine Macrophages , 2010, The Journal of Immunology.
[29] C. Glass,et al. Macrophages, inflammation, and insulin resistance. , 2010, Annual review of physiology.
[30] Mark D. Robinson,et al. edgeR: a Bioconductor package for differential expression analysis of digital gene expression data , 2009, Bioinform..
[31] Nathan R. Qi,et al. The Protein Kinase IKKɛ Regulates Energy Balance in Obese Mice , 2009, Cell.
[32] C. Ersoy,et al. Comparison of composite whole body insulin sensitivity index derived from mixed meal test and oral glucose tolerance test in insulin resistant obese subjects , 2009, Endocrine.
[33] P. Harris,et al. Research electronic data capture (REDCap) - A metadata-driven methodology and workflow process for providing translational research informatics support , 2009, J. Biomed. Informatics.
[34] Brad T. Sherman,et al. Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists , 2008, Nucleic acids research.
[35] S. Reeder,et al. Multiecho water‐fat separation and simultaneous R 2* estimation with multifrequency fat spectrum modeling , 2008, Magnetic resonance in medicine.
[36] Judith Wylie-Rosett,et al. Nutrition Recommendations and Interventions for Diabetes , 2008, Diabetes Care.
[37] Brad T. Sherman,et al. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources , 2008, Nature Protocols.
[38] A. Saltiel,et al. Obesity induces a phenotypic switch in adipose tissue macrophage polarization. , 2007, The Journal of clinical investigation.
[39] R. Leibel,et al. CCR2 modulates inflammatory and metabolic effects of high-fat feeding. , 2006, The Journal of clinical investigation.
[40] A. Hevener,et al. IKK-beta links inflammation to obesity-induced insulin resistance. , 2005, Nature medicine.
[41] Kohjiro Ueki,et al. Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[42] M. Desai,et al. Obesity is associated with macrophage accumulation in adipose tissue. , 2003, The Journal of clinical investigation.
[43] M. White,et al. SOCS-1 and SOCS-3 Block Insulin Signaling by Ubiquitin-mediated Degradation of IRS1 and IRS2* , 2002, The Journal of Biological Chemistry.
[44] J. Horowitz,et al. Whole body and abdominal lipolytic sensitivity to epinephrine is suppressed in upper body obese women. , 2000, American journal of physiology. Endocrinology and metabolism.
[45] S. Collins,et al. Depressed expression of adipocyte β-adrenergic receptors is a common feature of congenital and diet-induced obesity in rodents , 1999, International Journal of Obesity.
[46] P. Arner. Catecholamine-induced lipolysis in obesity , 1999, International Journal of Obesity.
[47] M. Baggiolini,et al. HCC-2, a human chemokine: gene structure, expression pattern, and biological activity. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[48] C. Pecqueur,et al. In vivo resistance of lipolysis to epinephrine. A new feature of childhood onset obesity. , 1997, The Journal of clinical investigation.
[49] B. Lowell,et al. Brown adipose tissue, beta 3-adrenergic receptors, and obesity. , 1997, Annual review of medicine.
[50] Lowell Bb,et al. BROWN ADIPOSE TISSUE, β3-ADRENERGIC RECEPTORS, AND OBESITY , 1997 .
[51] S. Reynisdottir,et al. Multiple lipolysis defects in the insulin resistance (metabolic) syndrome. , 1994, The Journal of clinical investigation.
[52] T. Nakazawa,et al. [Inhibitory effect of amlexanox on asthmatic attacks in an aspirin sensitive asthmatic]. , 1992, Nihon Kyobu Shikkan Gakkai zasshi.
[53] C. Christiansen,et al. Validation of body composition by dual energy X-ray absorptiometry (DEXA). , 1991, Clinical physiology.
[54] K. Sasaki,et al. Pharmacodynamics of Amlexanox (AA-673) in normal and anaphylactic rat conjunctiva and its effect on histamine concentration. , 1990, Ophthalmic research.
[55] Y. Maki,et al. Mechanism of action of an antiallergic agent, amlexanox (AA-673), in inhibiting histamine release from mast cells. Acceleration of cAMP generation and inhibition of phosphodiesterase. , 1987, International archives of allergy and applied immunology.
[56] R. DeFronzo,et al. Glucose clamp technique: a method for quantifying insulin secretion and resistance. , 1979, The American journal of physiology.