Bcl-xL is associated with the anti-apoptotic effect of IL-15 on the survival of CD56(dim) natural killer cells.

[1]  T. Enver,et al.  CD56bright Human NK Cells Differentiate into CD56dim Cells: Role of Contact with Peripheral Fibroblasts , 2007, The Journal of Immunology.

[2]  L. Moretta,et al.  Molecular analysis of the methylprednisolone-mediated inhibition of NK-cell function: evidence for different susceptibility of IL-2- versus IL-15-activated NK cells. , 2007, Blood.

[3]  A. Thiel,et al.  CD56brightCD16− Killer Ig-Like Receptor− NK Cells Display Longer Telomeres and Acquire Features of CD56dim NK Cells upon Activation1 , 2007, The Journal of Immunology.

[4]  T. Waldmann The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design , 2006, Nature Reviews Immunology.

[5]  Linda V. Sinclair,et al.  Differential regulation of T-cell growth by IL-2 and IL-15. , 2006, Blood.

[6]  L. Klein,et al.  Development and function of agonist-induced CD25+Foxp3+ regulatory T cells in the absence of interleukin 2 signaling , 2005, Nature Immunology.

[7]  A. Rudensky,et al.  A function for interleukin 2 in Foxp3-expressing regulatory T cells , 2005, Nature Immunology.

[8]  M. Caligiuri,et al.  A human CD34(+) subset resides in lymph nodes and differentiates into CD56bright natural killer cells. , 2005, Immunity.

[9]  P. Burkett,et al.  Coordinate Expression and Trans Presentation of Interleukin (IL)-15Rα and IL-15 Supports Natural Killer Cell and Memory CD8+ T Cell Homeostasis , 2004, The Journal of experimental medicine.

[10]  H. Ljunggren,et al.  NK Cells Stimulate Proliferation of T and NK Cells through 2B4/CD48 Interactions1 , 2004, The Journal of Immunology.

[11]  X. Li,et al.  IL-2 and IL-15 exhibit opposing effects on Fas mediated apoptosis. , 2004, Cellular & molecular immunology.

[12]  B. Samten,et al.  NK Cells Regulate CD8+ T Cell Effector Function in Response to an Intracellular Pathogen 1 , 2004, The Journal of Immunology.

[13]  P. Marrack,et al.  Control of T cell viability. , 2003, Annual review of immunology.

[14]  R. Solana,et al.  Selective Depletion of CD56dim NK Cell Subsets and Maintenance of CD56bright NK Cells in Treatment-Naive HIV-1-Seropositive Individuals , 2002, Journal of Clinical Immunology.

[15]  M. Caligiuri,et al.  NK cell and DC interactions. , 2004, Trends in immunology.

[16]  B. Gazzard,et al.  Loss of the CD56hiCD16− NK cell subset and NK cell interferon‐γ production during antiretroviral therapy for HIV‐1: partial recovery by human growth hormone , 2003, Clinical and experimental immunology.

[17]  P. Park,et al.  Human Decidual Natural Killer Cells Are a Unique NK Cell Subset with Immunomodulatory Potential , 2003, The Journal of experimental medicine.

[18]  D. Tough,et al.  IL-15 Promotes the Survival of Naive and Memory Phenotype CD8+ T Cells1 , 2003, The Journal of Immunology.

[19]  M. Caligiuri,et al.  CD56bright natural killer cells are present in human lymph nodes and are activated by T cell-derived IL-2: a potential new link between adaptive and innate immunity. , 2003, Blood.

[20]  M. Caligiuri,et al.  In vivo evidence for a dependence on interleukin 15 for survival of natural killer cells. , 2002, Blood.

[21]  T. Waldmann,et al.  IL-15Rα Recycles and Presents IL-15 In trans to Neighboring Cells , 2002 .

[22]  Masahide Takahashi,et al.  Overexpression of interleukin‐15 prevents the development of murine retrovirus‐induced acquired immunodeficiency syndrome , 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[23]  A. Strasser,et al.  Peripheral Deletion of Autoreactive CD8 T Cells by Cross Presentation of Self-Antigen Occurs by a Bcl-2–inhibitable Pathway Mediated by Bim , 2002, The Journal of experimental medicine.

[24]  T. Hünig,et al.  IL-2 and autoimmune disease. , 2002, Cytokine & growth factor reviews.

[25]  Yanan Zhu,et al.  Molecular mechanisms of activated T cell death in vivo. , 2002, Current opinion in immunology.

[26]  G. d’Ettorre,et al.  Interleukin-15 in HIV infection: immunological and virological interactions in antiretroviral-naive and -treated patients , 2002, AIDS.

[27]  M. Caligiuri,et al.  The biology of human natural killer-cell subsets. , 2001, Trends in immunology.

[28]  R. Jacobs,et al.  CD56bright cells differ in their KIR repertoire and cytotoxic features from CD56dim NK cells , 2001, European journal of immunology.

[29]  A. Masuda,et al.  Interleukin-15 Prevents Mouse Mast Cell Apoptosis through STAT6-mediated Bcl-xL Expression* , 2001, The Journal of Biological Chemistry.

[30]  M. Caligiuri,et al.  Human natural killer cells: a unique innate immunoregulatory role for the CD56bright subset , 2001 .

[31]  M. Caligiuri,et al.  Interleukin 15: biology and relevance to human disease. , 2001, Blood.

[32]  T. Strom,et al.  IL-15 and IL-2: a matter of life and death for T cells in vivo , 2001, Nature Medicine.

[33]  T. Waldmann,et al.  IL-2-induced activation-induced cell death is inhibited in IL-15 transgenic mice. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[34]  A. B. Lyons,et al.  Analysing cell division in vivo and in vitro using flow cytometric measurement of CFSE dye dilution. , 2000, Journal of immunological methods.

[35]  P. Openshaw,et al.  Flow cytometric measurement of intracellular cytokines. , 2000, Journal of immunological methods.

[36]  H. Heiken,et al.  Reconstitution of NK cell activity in HIV-1 infected individuals receiving antiretroviral therapy. , 2000, Immunobiology.

[37]  J. Altman,et al.  Cutting Edge: Increased Expression of Bcl-2 in Antigen-Specific Memory CD8+ T Cells1 , 2000, The Journal of Immunology.

[38]  P. Morrissey,et al.  Reversible Defects in Natural Killer and Memory Cd8 T Cell Lineages in Interleukin 15–Deficient Mice , 2000, The Journal of experimental medicine.

[39]  A. Ma,et al.  The Pleiotropic Functions of Interleukin 15 , 2000, The Journal of experimental medicine.

[40]  S. Miyazaki,et al.  A novel role of IL-15 in the development of osteoclasts: inability to replace its activity with IL-2. , 1999, Journal of immunology.

[41]  M. Caligiuri,et al.  Flt3 Ligand Promotes the Generation of a Distinct CD34+Human Natural Killer Cell Progenitor That Responds to Interleukin-15 , 1998 .

[42]  D. Chao,et al.  BCL-2 family: regulators of cell death. , 1998, Annual review of immunology.

[43]  R. Paus,et al.  Interleukin-15 protects from lethal apoptosis in vivo , 1997, Nature Medicine.

[44]  I. Weissman,et al.  Bcl-2 Rescues T Lymphopoiesis in Interleukin-7 Receptor–Deficient Mice , 1997, Cell.

[45]  C. Croce,et al.  A potential role for interleukin-15 in the regulation of human natural killer cell survival. , 1997, The Journal of clinical investigation.

[46]  Whiteside,et al.  Measurements of Natural Killer (NK) Activity and NK-Cell Quantification , 1996, Methods.

[47]  M. Lenardo Fas and the art of lymphocyte maintenance , 1996, The Journal of experimental medicine.

[48]  R. Dubose,et al.  Identification and cloning of a novel IL‐15 binding protein that is structurally related to the alpha chain of the IL‐2 receptor. , 1995, The EMBO journal.

[49]  D. Cosman,et al.  Utilization of the beta and gamma chains of the IL‐2 receptor by the novel cytokine IL‐15. , 1994, The EMBO journal.

[50]  R. Zinkernagel,et al.  Immune responses in interleukin-2-deficient mice. , 1993, Science.

[51]  G. Trinchieri,et al.  Biology of Natural Killer Cells , 1989, Advances in Immunology.

[52]  L. Lanier,et al.  The relationship of CD16 (Leu-11) and Leu-19 (NKH-1) antigen expression on human peripheral blood NK cells and cytotoxic T lymphocytes. , 1986, Journal of immunology.

[53]  D. Cantrell,et al.  The interleukin-2 T-cell system: a new cell growth model. , 1984, Science.