Multifactorial genetics: Rat genetics: attachign physiology and pharmacology to the genome

During the past five years, the Rat Genome Project has been rapidly gaining momentum, especially since the announcement in August 2000 of plans to sequence the rat genome. Combined with the wealth of physiological and pharmacological data for the rat, the genome sequence should facilitate the discovery of mammalian genes that underlie the physiological pathways that are involved in disease. Most importantly, this combined physiological and genomic information should also lead to the development of better pre-clinical models of human disease, which will aid in the development of new therapeutics.

[1]  J. Morrison,et al.  Nuclear transfer of adult and genetically modified fetal cells of the rat. , 2001, Physiological genomics.

[2]  Frank Buchholz,et al.  A new logic for DNA engineering using recombination in Escherichia coli , 1998, Nature Genetics.

[3]  Pardis C Sabeti,et al.  Linkage disequilibrium in the human genome , 2001, Nature.

[4]  A. Ooshima,et al.  Genetic analysis of blood pressure in spontaneously hypertensive rats. , 1971, Japanese circulation journal.

[5]  J. Feingold.  [Genes and the environment]. , 2000, Archives de pediatrie : organe officiel de la Societe francaise de pediatrie.

[6]  N. Hollenberg,et al.  A genomic-systems biology map for cardiovascular function. , 2002, Current hypertension reports.

[7]  J. Desemone,et al.  The BB rat. , 1987, Diabetes/metabolism reviews.

[8]  R. Balling,et al.  The battle of two genomes: genetics of bacterial host/pathogen interactions in mice , 2001, Mammalian Genome.

[9]  A. Balmain,et al.  Multigenic control of skin tumour development in mice. , 2007, Ciba Foundation symposium.

[10]  G. Peltz,et al.  In Silico Mapping of Complex Disease-Related Traits in Mice , 2001, Science.

[11]  D. Ganten,et al.  Fulminant hypertension in transgenic rats harbouring the mouse Ren-2 gene , 1990, Nature.

[12]  P. Iannaccone,et al.  Preimplantation and postimplantation development of rat embryos cloned with cumulus cells and fibroblasts , 2001, Zygote.

[13]  S. O’Brien,et al.  The promise of comparative genomics in mammals. , 1999, Science.

[14]  V. Sheffield,et al.  Automated construction of high-density comparative maps between rat, human, and mouse. , 2001, Genome research.

[15]  R. Nemni,et al.  Laminin receptor α6β4 integrin is highly expressed in ENU‐induced glioma in rat , 1999 .

[16]  Z. Pausova,et al.  Hypertension: genes and environment , 1998, Journal of hypertension.

[17]  M. Justice.  Capitalizing on large-scale mouse mutagenesis screens , 2000, Nature Reviews Genetics.

[18]  A. Stewart,et al.  Rapid modification of bacterial artificial chromosomes by ET-recombination. , 1999, Nucleic acids research.

[19]  J. Grisel.  Quantitative Trait Locus Analysis , 2000, Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism.

[20]  G A Churchill,et al.  Concordance of murine quantitative trait loci for salt-induced hypertension with rat and human loci. , 2001, Genomics.

[21]  Jan-Fang Cheng,et al.  Functional screening of 2 Mb of human chromosome 21q22.2 in transgenic mice implicates minibrain in learning defects associated with Down syndrome , 1997, Nature Genetics.

[22]  Tom H. Lindner,et al.  Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus , 2000, Nature Genetics.

[23]  M. Maffei,et al.  Positional cloning of the mouse obese gene and its human homologue , 1995, Nature.

[24]  N. Risch,et al.  Multilocus linkage of familial hyperkalaemia and hypertension, pseudohypoaldosteronism type II, to chromosomes 1q31-42 and 17p11-q21 , 1997, Nature Genetics.

[25]  R. Wayne,et al.  Natural selection mapping of the warfarin-resistance gene. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[26]  Trudy F. C. Mackay,et al.  Quantitative trait loci in Drosophila , 2001, Nature Reviews Genetics.

[27]  James Scott,et al.  Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats , 1999, Nature Genetics.

[28]  J. Staessen,et al.  The deletion/insertion polymorphism of the angiotensin converting enzyme gene and cardiovascular‐renal risk , 1997, Journal of hypertension.

[29]  M. M. Griffiths,et al.  Mapping autoimmunity genes. , 1999, Current opinion in immunology.

[30]  T. Seemayer,et al.  Spontaneous diabetes mellitus syndrome in the rat. IV. Immunogenetic interactions of MHC and non-MHC components of the syndrome. , 1983, Metabolism: clinical and experimental.

[31]  E. Snyder,et al.  The human obesity gene map: the 2000 update. , 2001, Obesity research.

[32]  J P Rapp,et al.  Genetic analysis of inherited hypertension in the rat. , 2000, Physiological reviews.

[33]  Jonathan Flint,et al.  Finding the molecular basis of quatitative traits: successes and pitfalls , 2001, Nature Reviews Genetics.

[34]  David W. Fulker,et al.  High-resolution mapping of quantitative trait loci in outbred mice , 1999, Nature Genetics.

[35]  G. J. Smith,et al.  The rat as an experimental animal. , 1989, Science.

[36]  Acknowledgements , 1992, Experimental Gerontology.

[37]  Ritsert C. Jansen,et al.  Complex interactions of new quantitative trait loci, Sluc1, Sluc2, Sluc3, and Sluc4, that influence the susceptibility to lung cancer in the mouse , 1996, Nature Genetics.

[38]  T. Kurtz,et al.  Transgenic rescue of defective Cd36 ameliorates insulin resistance in spontaneously hypertensive rats , 2001, Nature Genetics.

[39]  J. Flint,et al.  Quantitative trait loci for cellular defects in glucose and fatty acid metabolism in hypertensive rats , 1997, Nature Genetics.

[40]  G. M. Lathrop,et al.  Chromosomal mapping of two genetic loci associated with blood-pressure regulation in hereditary hypertensive rats , 1991, Nature.

[41]  Mourad Sahbatou,et al.  Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease , 2001, Nature.

[42]  Judy H. Cho,et al.  [Letters to Nature] , 1975, Nature.

[43]  Zhuowei Wang,et al.  Modulation of Circulating Leptin Levels by Its Soluble Receptor* , 2001, The Journal of Biological Chemistry.

[44]  R G Steen,et al.  A high-density integrated genetic linkage and radiation hybrid map of the laboratory rat. , 1999, Genome research.

[45]  Joseph H. Nadeau,et al.  The roads from phenotypic variation to gene discovery: mutagenesis versus QTLs , 2000, Nature Genetics.

[46]  E. Lander,et al.  Analysing complex genetic traits with chromosome substitution strains , 2000, Nature Genetics.

[47]  E. Lander,et al.  The recombinant congenic strains for analysis of multigenic traits: genetic composition , 1992, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[48]  J. Todd,et al.  Suggestive evidence for association of human chromosome 18q12-q21 and its orthologue on rat and mouse chromosome 18 with several autoimmune diseases. , 2001, Diabetes.

[49]  N. Zanesi,et al.  Linkage disequilibrium and haplotype mapping of a skin cancer susceptibility locus in outbred mice , 2000, Mammalian Genome.

[50]  N. Samani,et al.  A pharmacogenetic approach to blood pressure in Lyon hypertensive rats. A chromosome 2 locus influences the response to a calcium antagonist. , 1997, The Journal of clinical investigation.

[51]  M. Maffei,et al.  Positional cloning of the mouse obese gene and its human homologue , 1994, Nature.

[52]  H. Morse.  Origins of inbred mice. , 1978 .

[53]  J. Trent,et al.  Clustering of non-major histocompatibility complex susceptibility candidate loci in human autoimmune diseases. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[54]  K. Blenman,et al.  The major murine systemic lupus erythematosus susceptibility locus, Sle1, is a cluster of functionally related genes. , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[55]  Y. Nishioka.  The origin of common laboratory mice. , 1995, Genome.

[56]  T. C. Nesbitt,et al.  fw2.2: a quantitative trait locus key to the evolution of tomato fruit size. , 2000, Science.

[57]  Benjamin A. Taylor,et al.  RECOMBINANT INBRED STRAINS: USE IN GENE MAPPING1 , 1978 .

[58]  J. Todd,et al.  Identification of susceptibility loci for insulin-dependent diabetes mellitus by trans-racial gene mapping , 1989, Nature.

[59]  J. Terwilliger,et al.  Genetic susceptibility for human familial essential hypertension in a region of homology with blood pressure linkage on rat chromosome 10. , 1997, Human molecular genetics.

[60]  Robert J. Unwin,et al.  Human Hypertension Caused by Mutations in WNK Kinases , 2001, Science.

[61]  P Klír,et al.  An analysis of spontaneous hypertension in spontaneously hypertensive rats by means of new recombinant inbred strains. , 1989, Journal of hypertension.

[62]  Eric S. Lander,et al.  Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive rat , 1991, Cell.

[63]  K. Frazer,et al.  Functional screening of an asthma QTL in YAC transgenic mice , 1999, Nature Genetics.

[64]  Ting-kai Li,et al.  Genomic screen for QTLs underlying alcohol consumption in the P and NP rat lines , 1998, Mammalian Genome.

[65]  H. Jacob,et al.  New target regions for human hypertension via comparative genomics. , 2000, Genome research.

[66]  Eric S. Lander,et al.  Resolution of quantitative traits into Mendelian factors by using a complete linkage map of restriction fragment length polymorphisms , 1988, Nature.

[67]  W. Frankel,et al.  A major effect QTL determined by multiple genes in epileptic EL mice. , 2000, Genome research.

[68]  J. Todd,et al.  From genome to aetiology in a multifactorial disease, type 1 diabetes , 1999, BioEssays : news and reviews in molecular, cellular and developmental biology.

[69]  J. E. Wagner,et al.  Characterization of strain specific typing antisera for genetic monitoring of inbred strains of rats. , 1985, Laboratory animal science.